Gregory J Moore

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Case study: caudate glutamatergic changes with paroxetine persist after medication discontinuation in pediatric OCD
    J Bolton
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Am Acad Child Adolesc Psychiatry 40:903-6. 2001
  2. ncbi request reprint Magnetic resonance spectroscopy: neurochemistry and treatment effects in affective disorders
    Gregory J Moore
    Brain Imaging Research Division, Departments of Psychiatry and Behavioral Neurosciences and Radiology, Wayne State University School of Medicine, 4201 St Antoine, UHC 9B, Detroit, MI 48201, USA
    Psychopharmacol Bull 36:5-23. 2002
  3. ncbi request reprint Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness
    G J Moore
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Psychiatry 156:1902-8. 1999
  4. ncbi request reprint Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls
    David R Rosenberg
    Departments of Psychiatry, Wayne State University, Detroit, MI, USA
    J Am Acad Child Adolesc Psychiatry 43:1146-53. 2004
  5. ncbi request reprint Increased medial thalamic choline found in pediatric patients with obsessive-compulsive disorder versus major depression or healthy control subjects: a magnetic resonance spectroscopy study
    Ethan A Smith
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biol Psychiatry 54:1399-405. 2003
  6. ncbi request reprint Pituitary volume in treatment-naïve pediatric major depressive disorder
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, and Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Biol Psychiatry 60:862-6. 2006
  7. ncbi request reprint Reduced anterior cingulate glutamate in pediatric major depression: a magnetic resonance spectroscopy study
    David R Rosenberg
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biol Psychiatry 58:700-4. 2005
  8. pmc Amygdala and hippocampal volumes in familial early onset major depressive disorder
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Biol Psychiatry 63:385-90. 2008
  9. ncbi request reprint Pituitary volume in pediatric obsessive-compulsive disorder
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48201, USA
    Biol Psychiatry 59:252-7. 2006
  10. ncbi request reprint Reduced anterior cingulate cortex glutamatergic concentrations in childhood major depression
    Yousha Mirza
    Department of Psychiatry, Wayne State University, Detroit, MI 48201, USA
    J Am Acad Child Adolesc Psychiatry 43:341-8. 2004

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Case study: caudate glutamatergic changes with paroxetine persist after medication discontinuation in pediatric OCD
    J Bolton
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Am Acad Child Adolesc Psychiatry 40:903-6. 2001
    ..These data provide further support for a reversible glutamatergically mediated dysfunction of the caudate nucleus in OCD that may serve as a pathophysiological and treatment response marker...
  2. ncbi request reprint Magnetic resonance spectroscopy: neurochemistry and treatment effects in affective disorders
    Gregory J Moore
    Brain Imaging Research Division, Departments of Psychiatry and Behavioral Neurosciences and Radiology, Wayne State University School of Medicine, 4201 St Antoine, UHC 9B, Detroit, MI 48201, USA
    Psychopharmacol Bull 36:5-23. 2002
    ..This review will afford the reader a fundamental foundation in the applications of MRS in mood disorders and an update on some of the current findings in this rapidly developing discipline...
  3. ncbi request reprint Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness
    G J Moore
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Psychiatry 156:1902-8. 1999
    ..Lithium's effects on in vivo brain myo-inositol levels were investigated longitudinally in 12 adult depressed patients with manic-depressive illness...
  4. ncbi request reprint Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls
    David R Rosenberg
    Departments of Psychiatry, Wayne State University, Detroit, MI, USA
    J Am Acad Child Adolesc Psychiatry 43:1146-53. 2004
    ....
  5. ncbi request reprint Increased medial thalamic choline found in pediatric patients with obsessive-compulsive disorder versus major depression or healthy control subjects: a magnetic resonance spectroscopy study
    Ethan A Smith
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biol Psychiatry 54:1399-405. 2003
    ..Altered brain Cho levels have also been implicated in the pathogenesis of mood disorders...
  6. ncbi request reprint Pituitary volume in treatment-naïve pediatric major depressive disorder
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, and Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Biol Psychiatry 60:862-6. 2006
    ..In this independent sample, we focus on gender differences in pituitary volume in a larger sample of pediatric patients with MDD...
  7. ncbi request reprint Reduced anterior cingulate glutamate in pediatric major depression: a magnetic resonance spectroscopy study
    David R Rosenberg
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biol Psychiatry 58:700-4. 2005
    ..These changes might reflect a change in glutamate, glutamine, or their combination...
  8. pmc Amygdala and hippocampal volumes in familial early onset major depressive disorder
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Biol Psychiatry 63:385-90. 2008
    ..To our knowledge, no prior study has examined amygdala-hippocampus anatomy in pediatric patients with familial MDD (at least one first degree relative with MDD)...
  9. ncbi request reprint Pituitary volume in pediatric obsessive-compulsive disorder
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48201, USA
    Biol Psychiatry 59:252-7. 2006
    ..Abnormalities in the limbic-hypothalamic-pituitary-adrenal (LHPA) axis have been implicated in the pathogenesis of obsessive-compulsive disorder (OCD). To our knowledge, however, no prior study has measured pituitary gland volume in OCD...
  10. ncbi request reprint Reduced anterior cingulate cortex glutamatergic concentrations in childhood major depression
    Yousha Mirza
    Department of Psychiatry, Wayne State University, Detroit, MI 48201, USA
    J Am Acad Child Adolesc Psychiatry 43:341-8. 2004
    ..To examine in vivo glutamatergic neurochemical alterations in the anterior cingulate cortex of children with major depressive disorder (MDD)...
  11. pmc Medial temporal N-acetyl-aspartate in pediatric major depression
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, USA
    Psychiatry Res 164:86-9. 2008
    ..N-acetyl-aspartate was lower in the left MTC (27%) in MDD patients versus controls. Lower N-acetyl-aspartate concentrations in MDD patients may reflect reduced neuronal viability...
  12. ncbi request reprint Localized functional neurochemical marker abnormalities in dorsolateral prefrontal cortex in pediatric obsessive-compulsive disorder
    Aileen Russell
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Child Adolesc Psychopharmacol 13:S31-8. 2003
    ..Although OCD commonly arises during childhood and adolescence, to our knowledge, no prior study has examined prefrontal cortex neurochemistry in pediatric patients with OCD...
  13. ncbi request reprint Real-time fMRI of cortico-limbic brain activity during emotional processing
    K Luan Phan
    Brain Imaging Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 9B University Health Center Rm 18, 4201 St Antoine Blvd, Detroit, MI 48201, USA
    Neuroreport 15:527-32. 2004
    ..Detecting cortico-limbic brain activation during perception and experience of emotionally salient visual stimuli with real-time fMRI technology is feasible...
  14. pmc Development and sexual dimorphism of the pituitary gland
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, and Children s Hospital of Michigan, Detroit, MI 48201, USA
    Life Sci 80:940-4. 2007
    ....
  15. ncbi request reprint Mood disorders: treatment-induced changes in brain neurochemistry and structure
    Debra A Glitz
    Neuropsychiatric Research Unit, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Semin Clin Neuropsychiatry 7:269-80. 2002
    ....
  16. ncbi request reprint Proton echo-planar spectroscopic imaging with highly effective outer volume suppression using combined presaturation and spatially selective echo dephasing
    Archie Chu
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA
    Magn Reson Med 49:817-21. 2003
    ..Metabolite mapping (choline, creatine, and NAA) with a 64 x 64 spatial matrix and 0.3 cm(3) voxels in close proximity to peripheral lipid regions was demonstrated at 1.5 T with a scan time of 32 min using the standard head coil...
  17. ncbi request reprint Increased amygdala: hippocampal volume ratios associated with severity of anxiety in pediatric major depression
    Shauna MacMillan
    Department of Psychiatry, 9B, Wayne State University School of Medicine, 4201 St Antoine Boulevard, Detroit, MI 48201, USA
    J Child Adolesc Psychopharmacol 13:65-73. 2003
    ..Although MDD commonly emerges during childhood and adolescence, to our knowledge, no prior study has examined temporal lobe anatomy in pediatric patients with MDD near the onset of illness before treatment...
  18. ncbi request reprint Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation
    James Y Garbern
    Department of Neurology and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Brain 125:551-61. 2002
    ..Disruption of PLP1-mediated axonal--glial interactions thus probably causes this axonal degeneration. A similar mechanism may be responsible for axonal degeneration and clinical disability that occur in patients with multiple sclerosis...
  19. ncbi request reprint Evidence of altered energy metabolism in autistic children
    D C Chugani
    Department of Pediatrics, Wayne State University School of Medicine, Children s Hospital of Michigan, Detroit, USA
    Prog Neuropsychopharmacol Biol Psychiatry 23:635-41. 1999
    ..The findings of altered brain NAA and lactate in autistic children suggest that MRS may be useful characterizing regional neurochemical and metabolic abnormalities in autistic children...
  20. ncbi request reprint Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine
    D R Rosenberg
    Department of Psychiatry, Wayne State University, Detroit, USA
    J Am Acad Child Adolesc Psychiatry 39:1096-103. 2000
    ..To measure in vivo neurochemical changes in the caudate nucleus in pediatric obsessive-compulsive disorder (OCD) before and after treatment...
  21. ncbi request reprint Prefrontal cortex as the site of estrogen's effect on cognition
    P A Keenan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, UHC 4J, 4201 St Antoine, Detroit, MI 48201, USA
    Psychoneuroendocrinology 26:577-90. 2001
    ....
  22. ncbi request reprint Brain anatomy and chemistry may predict treatment response in paediatric obsessive--compulsive disorder
    D R Rosenberg
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI, USA
    Int J Neuropsychopharmacol 4:179-90. 2001
    ..Developmental neurobiological models for OCD are presented and particular attention is devoted to evaluating neuroimaging studies designed to test these models and how they may help predict treatment response in paediatric OCD...
  23. ncbi request reprint Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness
    H K Manji
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    J Clin Psychiatry 61:82-96. 2000
    ....
  24. ncbi request reprint Increased medial thalamic choline in pediatric obsessive-compulsive disorder as detected by quantitative in vivo spectroscopic imaging
    D R Rosenberg
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    J Child Neurol 16:636-41. 2001
    ..These findings provide new evidence of cytosolic choline abnormalities in the thalamus in pediatric obsessive-compulsive disorder...
  25. ncbi request reprint Neurochemical analyses in pediatric obsessive-compulsive disorder in patients treated with cognitive-behavioral therapy
    Nili R Benazon
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA
    J Am Acad Child Adolesc Psychiatry 42:1279-85. 2003
    ..To investigate neurochemical changes in the caudate nucleus of pediatric obsessive-compulsive disorder (OCD) patients before and after cognitive-behavioral therapy (CBT), and to examine corresponding changes in symptom severity...
  26. ncbi request reprint Prefrontal cortical volume in childhood-onset major depression: preliminary findings
    Carla L Nolan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Arch Gen Psychiatry 59:173-9. 2002
    ..To our knowledge, no prior study has examined prefrontal cortical anatomy in pediatric patients with MDD near the onset of illness before receiving treatment...
  27. ncbi request reprint Real-time fMRI of temporolimbic regions detects amygdala activation during single-trial self-induced sadness
    Stefan Posse
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201 St Antoine, University Health Center 9B, Detroit, MI 48201, USA
    Neuroimage 18:760-8. 2003
    ....
  28. ncbi request reprint Proton magnetic resonance spectroscopic imaging in pediatric major depression
    Tiffany R Farchione
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biol Psychiatry 52:86-92. 2002
    ..Although MDD commonly emerges during childhood and adolescence, to our knowledge, no prior study has examined the DLPFC in pediatric patients with MDD...
  29. ncbi request reprint Neuroplasticity and cellular resilience in mood disorders
    H K Manji
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, USA
    Mol Psychiatry 5:578-93. 2000
    ....
  30. ncbi request reprint Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers
    H K Manji
    Laboratory of Molecular Pathophysiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Br J Psychiatry Suppl 41:s107-19. 2001
    ..New research is dramatically altering our understanding of the molecular mechanisms underlying neuronal communication...
  31. ncbi request reprint Magnetic resonance and spectroscopic imaging in prenatal alcohol-exposed children: preliminary findings in the caudate nucleus
    Bernadette M Cortese
    Department of Psychiatry, Pennsylvania State University, College of Medicine Hershey, PA 17033, USA
    Neurotoxicol Teratol 28:597-606. 2006
    ..The present study demonstrates that prenatal alcohol-exposed children, with or without facial dysmorphology, have abnormal brain anatomy and chemistry...
  32. ncbi request reprint Long-term treatment of rats with haloperidol: lack of an effect on brain N-acetyl aspartate levels
    Juan Bustillo
    Department of Psychiatry, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    Neuropsychopharmacology 31:751-6. 2006
    ..The documented lower NAA in chronically treated schizophrenia patients is most likely not a simple effect of antipsychotic medications...
  33. ncbi request reprint Neural substrates for voluntary suppression of negative affect: a functional magnetic resonance imaging study
    K Luan Phan
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637 1470, USA
    Biol Psychiatry 57:210-9. 2005
    ..Although the capacity to regulate emotions is critical to mental well-being, its neural substrates remain unclear...
  34. ncbi request reprint Anterior cingulate neurochemistry in social anxiety disorder: 1H-MRS at 4 Tesla
    K Luan Phan
    Department of Psychiatry, Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue MC3077 L 461, Chicago, IL, USA
    Neuroreport 16:183-6. 2005
    ..Anterior cingulate glutamate/creatine levels were also correlated with intensity of social anxiety symptoms. These findings provide new evidence of glutamate's involvement in the neural mechanism underlying social phobia...
  35. ncbi request reprint Neural correlates of internally-generated disgust via autobiographical recall: a functional magnetic resonance imaging investigation
    Daniel A Fitzgerald
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, University of Chicago, Chicago, IL, USA
    Neurosci Lett 370:91-6. 2004
    ..These findings suggest that areas previously associated with the perception of disgust (e.g., insula, basal ganglia) are also involved interoceptive experience of disgust...
  36. ncbi request reprint Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorder
    Philip R Szeszko
    Department of Psychiatry Research, Zucker Hilside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 161:1049-56. 2004
    ..The authors investigated structural abnormalities in brain regions comprising cortical-striatal-thalamic-cortical loops in pediatric patients with obsessive-compulsive disorder (OCD)...
  37. ncbi request reprint Amygdala volume reductions in pediatric patients with obsessive-compulsive disorder treated with paroxetine: preliminary findings
    Philip R Szeszko
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 29:826-32. 2004
    ..These preliminary findings suggest that abnormal asymmetry of the amygdala may play a role in the pathogenesis of OCD and that paroxetine treatment may be associated with a reduction in amygdala volume...
  38. ncbi request reprint The use of mood stabilizers as plasticity enhancers in the treatment of neuropsychiatric disorders
    Neil A Gray
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Clin Psychiatry 64:3-17. 2003
    ....