Robert M Mentzer

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. doi request reprint Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study
    Robert M Mentzer
    Wayne State University School of Medicine, 540 East Canfield, 1241 Scott Hall, Detroit, MI 48201, USA
    Ann Thorac Surg 85:1261-70. 2008
  2. ncbi request reprint Effects of perioperative nesiritide in patients with left ventricular dysfunction undergoing cardiac surgery:the NAPA Trial
    Robert M Mentzer
    Division of Cardiothoracic Surgery, Department of Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Am Coll Cardiol 49:716-26. 2007
  3. ncbi request reprint Myocardial protection in heart surgery
    Robert M Mentzer
    Department of Cardiothoracic Surgery and Physiology, WSU Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI, USA
    J Cardiovasc Pharmacol Ther 16:290-7. 2011
  4. ncbi request reprint Oxidative stress and adenosine A1 receptor activation differentially modulate subcellular cardiomyocyte MAPKs
    Cherry Ballard-Croft
    Department of Surgery, University of Kentucky, MN265 Chandler Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Am J Physiol Heart Circ Physiol 294:H263-71. 2008
  5. ncbi request reprint The p38 MAPK inhibitor SB203580 blocks adenosine A(1) receptor-induced attenuation of in vivo myocardial stunning
    Yukihiro Yoshimura
    Department of Surgery, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Cardiovasc Drugs Ther 18:433-40. 2004
  6. ncbi request reprint In vivo adenosine receptor preconditioning reduces myocardial infarct size via subcellular ERK signaling
    Easton A Reid
    Department of Surgery, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    Am J Physiol Heart Circ Physiol 288:H2253-9. 2005
  7. ncbi request reprint The preischemic combination of the sodium-hydrogen exchanger inhibitor cariporide and the adenosine agonist AMP579 acts additively to reduce porcine myocardial infarct size
    Gentian Kristo
    Department of Surgery, University of Kentucky, College of Medicine, Lexington, KY 40536 0084, USA
    J Am Coll Surg 199:586-94. 2004
  8. ncbi request reprint Delayed adenosine A1 receptor preconditioning in rat myocardium is MAPK dependent but iNOS independent
    Robert D Lasley
    Department of Surgery, Univ of Kentucky College of Medicine, MN276, Chandler Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Am J Physiol Heart Circ Physiol 289:H785-91. 2005
  9. ncbi request reprint Aged rat myocardium exhibits normal adenosine receptor-mediated bradycardia and coronary vasodilation but increased adenosine agonist-mediated cardioprotection
    Gentian Kristo
    Department of Surgery, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536 0298, USA
    J Gerontol A Biol Sci Med Sci 60:1399-404. 2005
  10. pmc Acute induction of autophagy as a novel strategy for cardioprotection: getting to the heart of the matter
    Karin Przyklenk
    Cardiovascular Research Institute, Wayne State University, Detroit, MI, USA
    Autophagy 7:432-3. 2011

Research Grants

Collaborators

Detail Information

Publications40

  1. doi request reprint Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study
    Robert M Mentzer
    Wayne State University School of Medicine, 540 East Canfield, 1241 Scott Hall, Detroit, MI 48201, USA
    Ann Thorac Surg 85:1261-70. 2008
    ..The premise was that inhibition of NHE-1 limits intracellcular Na accumulation and thereby limits Na/Ca-exchanger-mediated calcium overload to reduce infarct size...
  2. ncbi request reprint Effects of perioperative nesiritide in patients with left ventricular dysfunction undergoing cardiac surgery:the NAPA Trial
    Robert M Mentzer
    Division of Cardiothoracic Surgery, Department of Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Am Coll Cardiol 49:716-26. 2007
    ..The purpose of this study was to determine the role nesiritide might play in patients with left ventricular dysfunction undergoing coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB)...
  3. ncbi request reprint Myocardial protection in heart surgery
    Robert M Mentzer
    Department of Cardiothoracic Surgery and Physiology, WSU Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI, USA
    J Cardiovasc Pharmacol Ther 16:290-7. 2011
    ....
  4. ncbi request reprint Oxidative stress and adenosine A1 receptor activation differentially modulate subcellular cardiomyocyte MAPKs
    Cherry Ballard-Croft
    Department of Surgery, University of Kentucky, MN265 Chandler Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Am J Physiol Heart Circ Physiol 294:H263-71. 2008
    ..However, the adenosine A(1) receptor-mediated MAPK activation does not involve ROS formation...
  5. ncbi request reprint The p38 MAPK inhibitor SB203580 blocks adenosine A(1) receptor-induced attenuation of in vivo myocardial stunning
    Yukihiro Yoshimura
    Department of Surgery, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Cardiovasc Drugs Ther 18:433-40. 2004
    ..These results provide the first evidence that p38 MAPK activation may play an important role in the mechanism by which adenosine agonists attenuate myocardial stunning...
  6. ncbi request reprint In vivo adenosine receptor preconditioning reduces myocardial infarct size via subcellular ERK signaling
    Easton A Reid
    Department of Surgery, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    Am J Physiol Heart Circ Physiol 288:H2253-9. 2005
    ..These results indicate that the unique adenosine receptor agonist AMP-579 exerts its beneficial effects in vivo via both A1 and A2a receptor modulation of subcellular ERK isoform signaling...
  7. ncbi request reprint The preischemic combination of the sodium-hydrogen exchanger inhibitor cariporide and the adenosine agonist AMP579 acts additively to reduce porcine myocardial infarct size
    Gentian Kristo
    Department of Surgery, University of Kentucky, College of Medicine, Lexington, KY 40536 0084, USA
    J Am Coll Surg 199:586-94. 2004
    ....
  8. ncbi request reprint Delayed adenosine A1 receptor preconditioning in rat myocardium is MAPK dependent but iNOS independent
    Robert D Lasley
    Department of Surgery, Univ of Kentucky College of Medicine, MN276, Chandler Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Am J Physiol Heart Circ Physiol 289:H785-91. 2005
    ..These results indicate that adenosine A1 receptor delayed PC in rats is mediated by MAPK-dependent mechanisms, but this phenomenon is not associated with the early or late expression of iNOS...
  9. ncbi request reprint Aged rat myocardium exhibits normal adenosine receptor-mediated bradycardia and coronary vasodilation but increased adenosine agonist-mediated cardioprotection
    Gentian Kristo
    Department of Surgery, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536 0298, USA
    J Gerontol A Biol Sci Med Sci 60:1399-404. 2005
    ..These findings suggest that adenosine A1 and A(2a) receptor-mediated effects are not diminished in normal aged myocardium, and that aged hearts exhibit increased adenosine agonist-induced infarct reduction...
  10. pmc Acute induction of autophagy as a novel strategy for cardioprotection: getting to the heart of the matter
    Karin Przyklenk
    Cardiovascular Research Institute, Wayne State University, Detroit, MI, USA
    Autophagy 7:432-3. 2011
    ....
  11. ncbi request reprint Invited commentary
    Robert M Mentzer
    Department of Surgery, University of Kentucky College of Medicine, MN264, Lexington, KY 40536 0298, USA
    Ann Thorac Surg 80:1416. 2005
  12. ncbi request reprint The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium
    Robert D Lasley
    Dept of Physiology, Wayne State Univ School of Medicine, 1107 Elliman Bldg, 421 E Canfield, Detroit, MI 48201, USA
    Am J Physiol Heart Circ Physiol 292:H426-31. 2007
    ....
  13. ncbi request reprint Risk-adjusted morbidity in teaching hospitals correlates with reported levels of communication and collaboration on surgical teams but not with scale measures of teamwork climate, safety climate, or working conditions
    Daniel L Davenport
    Department of Surgery, University of Kentucky, Lexington, KY 40536 0298, USA
    J Am Coll Surg 205:778-84. 2007
    ..The goal of this study was to measure the impact of OCSFs on risk-adjusted surgical morbidity and mortality...
  14. doi request reprint Successful implementation of the Department of Veterans Affairs' National Surgical Quality Improvement Program in the private sector: the Patient Safety in Surgery study
    Shukri F Khuri
    Department of Surgery, VA Boston Healthcare System, West Roxbury, MA 02132, USA
    Ann Surg 248:329-36. 2008
    ..We sought to determine if NSQIP methods and risk models were applicable to private sector (PS) hospitals and if implementation of the NSQIP in the PS would be associated with reductions in adverse postoperative outcomes...
  15. ncbi request reprint Acute adenosine preconditioning is mediated by p38 MAPK activation in discrete subcellular compartments
    Cherry Ballard-Croft
    Cardiothoracic Division, Department of Surgery, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Am J Physiol Heart Circ Physiol 288:H1359-66. 2005
    ..These results suggest a role for p38 MAPK activation in discrete subcellular compartments in acute adenosine A(1) receptor PC...
  16. pmc Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury
    Javier A Sala-Mercado
    Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Circulation 122:S179-84. 2010
    ..Our aim was to test this paradigm in a clinically relevant, large animal model of acute myocardial infarction...
  17. ncbi request reprint Multivariable predictors of postoperative cardiac adverse events after general and vascular surgery: results from the patient safety in surgery study
    Daniel L Davenport
    Department of Surgery, University of Kentucky, Lexington, KY 40536 0298, USA
    J Am Coll Surg 204:1199-210. 2007
    ..We used the Patient Safety in Surgery Study database to develop and test a model to predict patient risk for CAEs after general and vascular surgical operations...
  18. ncbi request reprint Sodium-hydrogen exchange inhibition attenuates in vivo porcine myocardial stunning
    Randy M Stevens
    Department of Surgery, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Ann Thorac Surg 77:651-7. 2004
    ..We sought to determine whether cariporide attenuated myocardial stunning in vivo...
  19. pmc Activation of the homeostatic intracellular repair response during cardiac surgery
    Salik M Jahania
    Department of Surgery, Wayne State University School of Medicine, Detroit, MI, USA
    J Am Coll Surg 216:719-26; discussion 726-9. 2013
    ....
  20. pmc National Surgical Quality Improvement Program (NSQIP) risk factors can be used to validate American Society of Anesthesiologists Physical Status Classification (ASA PS) levels
    Daniel L Davenport
    Department of Surgery, University of Kentucky, Lexington, 40536, USA
    Ann Surg 243:636-41; discussion 641-4. 2006
    ....
  21. doi request reprint Surgery resident working conditions and job satisfaction
    Daniel L Davenport
    Department of Surgery, University of Kentucky, Lexington, KY 40536 0298, USA
    Surgery 144:332-338.e5. 2008
    ..This study surveyed surgery residents regarding working conditions and how those conditions influenced their job satisfaction...
  22. ncbi request reprint Intracellular sodium hydrogen exchange inhibition and clinical myocardial protection
    Robert M Mentzer
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    Ann Thorac Surg 75:S700-8. 2003
    ..Although there is strong preclinical and early clinical evidence that NHE inhibitors may be cardioprotective, definitive proof of this concept in humans awaits the results of ongoing clinical trials...
  23. ncbi request reprint The intermediary metabolite pyruvate attenuates stunning and reduces infarct size in in vivo porcine myocardium
    Gentian Kristo
    Department of Surgery, University of Kentucky College of Medicine, Lexington 40536 0298, USA
    Am J Physiol Heart Circ Physiol 286:H517-24. 2004
    ..Metabolic interventions such as pyruvate should be considered when designing the optimal therapeutic strategies for limiting myocardial ischemia-reperfusion injury...
  24. ncbi request reprint Reduction of infarct size by the therapeutic protein TAT-Ndi1 in vivo
    Robert M Mentzer
    1Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI, USA
    J Cardiovasc Pharmacol Ther 19:315-20. 2014
    ..Moreover, these data suggest that cell-permeable delivery of mitochondrial proteins may provide a novel molecular strategy to treat mitochondrial dysfunction in patients. ..
  25. doi request reprint Under-prescribing and non-adherence to medications after coronary bypass surgery in older adults: strategies to improve adherence
    David Sengstock
    Wayne State University, Department of Medicine, Detroit, MI 48124, USA
    Drugs Aging 29:93-103. 2012
    ....
  26. pmc Autophagy, myocardial protection, and the metabolic syndrome
    Zoltan Giricz
    Department of Biology, Donald P Shiley BioScience Center, San Diego State University, San Diego, CA 92182 4650, USA
    J Cardiovasc Pharmacol 60:125-32. 2012
    ..Clinical approaches that involve the induction of cardiac autophagy pharmacologically to enhance the heart's tolerance to ischemia are also discussed...
  27. doi request reprint Autophagy: definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury
    Yi Dong
    Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI, USA
    J Cardiovasc Pharmacol Ther 15:220-30. 2010
    ....
  28. pmc Preoperative risk factors and surgical complexity are more predictive of costs than postoperative complications: a case study using the National Surgical Quality Improvement Program (NSQIP) database
    Daniel L Davenport
    University of Kentucky, Department of Surgery, Lexington, Kentucky 40536, USA
    Ann Surg 242:463-8; discussion 468-71. 2005
    ..This single-center study tested the hypothesis that preoperative risk factors and surgical complexity predict more variation in hospital costs than complications...
  29. ncbi request reprint Replantation: past, present, and future
    Brian Rinker
    University of Kentucky, Department of Surgery, Lexington, Kentucky, USA
    J Ky Med Assoc 102:247-53. 2004
    ....
  30. ncbi request reprint Nasal reconstruction
    Daniel Stewart
    University of Kentucky, Department of Surgery, Lexington, Kentucky, USA
    J Ky Med Assoc 101:280-7. 2003
    ..Careful analysis of the defect and reliance on these general guidelines will allow for less obvious nasal reconstruction and a more natural appearance and function...
  31. ncbi request reprint Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites
    Randy M Stevens
    Department of Surgery, University of Kentucky College of Medicine, Lexington 40536 0298, USA
    Ann Thorac Surg 73:1261-6. 2002
    ..The purpose of this study was to determine the effects of in vivo regional myocardial ischemia on interstitial fluid (ISF) reactive nitrogen species...
  32. pmc Aspirin and postoperative bleeding after coronary artery bypass grafting
    Victor A Ferraris
    Division of Cardiothoracic Surgery, University of Kentucky College of Medicine, Lexington 40536 0084, USA
    Ann Surg 235:820-7. 2002
    ..To evaluate the relationship between aspirin ingestion and postoperative bleeding complications, and to test the hypothesis that there is a subset of patients who are aspirin hyperresponders with a proclivity toward platelet dysfunction...
  33. ncbi request reprint Pancreas transplantation: current status and experience at the University of Kentucky
    K Sudhakar Reddy
    Department of Surgery, University of Kentucky, Lexington, Kentucky, USA
    J Ky Med Assoc 100:278-81. 2002
  34. ncbi request reprint Oral/pharyngeal squamous carcinoma: treatment strategies
    Daniel E Kenady
    Department of Surgery, University of Kentucky College of Medicine, Markey Cancer Center, Lexington, Kentucky, USA
    J Ky Med Assoc 100:488-94. 2002
    ..In advanced disease neither surgery nor radiation therapy can be used as a primary modality, and often combined treatment is necessary. Chemotherapy has a less well-defined role, but is increasing control rates in advanced tumors...
  35. ncbi request reprint Attenuation of postcardioplegia injury with inhibitors of the sodium-hydrogen exchanger
    Jakob Vinten-Johansen
    J Thorac Cardiovasc Surg 126:1265-7. 2003
  36. ncbi request reprint The patient safety in surgery study: background, study design, and patient populations
    Shukri F Khuri
    VA Boston Healthcare System, West Roxbury, MA 02132, USA
    J Am Coll Surg 204:1089-102. 2007
    ..The purpose of this article is to describe the background, design, and patient populations of the Patient Safety in Surgery Study, as a preliminary to the articles in this journal that will report the results of the Study...
  37. ncbi request reprint Does size matter? What is your infarct rate after coronary artery bypass grafting?
    Robert M Mentzer
    J Thorac Cardiovasc Surg 126:326-8. 2003
  38. ncbi request reprint Surveillance venous duplex is not clinically useful after total joint arthroplasty when effective deep venous thrombosis prophylaxis is used
    Thomas H Schwarcz
    Department of Vascular Surgery, Central Baptist Hospital, Lexington, KY, USA
    Ann Vasc Surg 18:193-8. 2004
    ..Therefore, we conclude that postoperative inpatient surveillance duplex scans for DVT provide very minimal benefit and that a routine screening program is not clinically useful for patients managed with effective DVT prophylaxis...
  39. ncbi request reprint Evaluating alternative risk-adjustment strategies for surgery
    Adam Atherly
    Department of Health Policy and Management, Rollins School of Public Health, Emory University, 1518 Clifton Rd N E, Atlanta, GA 30322, USA
    Am J Surg 188:566-70. 2004
    ..Comparison of institutional health care outcomes requires risk adjustment. Risk-adjustment methodology may influence the results of such comparisons...
  40. ncbi request reprint Cardiac myocyte adenosine A2a receptor activation fails to alter cAMP or contractility: role of receptor localization
    Eric L Kilpatrick
    Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Am J Physiol Heart Circ Physiol 282:H1035-40. 2002
    ..These results indicate that although rat ventricular myocytes appear to express adenosine A2a receptors, stimulation with an A2a agonist exerts no functional effects, possibly because of the subcellular localization of the A2a receptor...

Research Grants2

  1. ADENOSINE AND PYRUVATE PROTECTION DURING HEART SURGERY
    Robert Mentzer; Fiscal Year: 2007
    ....