Raymond Mattingly

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi Activation of the Ras-GRF/CDC25Mm exchange factor by lysophosphatidic acid
    R R Mattingly
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Cell Signal 11:603-10. 1999
  2. ncbi Phosphorylation of serine 916 of Ras-GRF1 contributes to the activation of exchange factor activity by muscarinic receptors
    R R Mattingly
    Department of Pharmacology, Wayne State University, Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    J Biol Chem 274:37379-84. 1999
  3. ncbi Down-regulation of growth factor-stimulated MAP kinase signaling in cytotoxic drug-resistant human neuroblastoma cells
    R R Mattingly
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Cell Signal 13:499-505. 2001
  4. ncbi Potent suppression of proliferation of a10 vascular smooth muscle cells by combined treatment with lovastatin and 3-allylfarnesol, an inhibitor of protein farnesyltransferase
    Raymond R Mattingly
    Department of Pharmacology, Wayne State University, Detroit, Michigan 48201, USA
    J Pharmacol Exp Ther 303:74-81. 2002
  5. ncbi The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines
    Raymond R Mattingly
    Department of Pharmacology, Wayne State University, 540 East Canfield Ave, Detroit, MI 48201, USA
    J Pharmacol Exp Ther 316:456-65. 2006
  6. ncbi Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis
    Raymond E Menard
    Department of Pharmacology, Wayne State University, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Neoplasia 7:638-45. 2005
  7. ncbi Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways
    Raymond E Menard
    Department of Pharmacology, Wayne State University, 540 E. Canfield, Room 6326, Detroit, MI 48201, USA
    Cell Signal 15:1099-109. 2003
  8. ncbi Three-dimensional overlay culture models of human breast cancer reveal a critical sensitivity to mitogen-activated protein kinase kinase inhibitors
    Quanwen Li
    Wayne State University, Department of Pharmacology, 540 East Canfield Avenue, Detroit, MI 48201, USA
    J Pharmacol Exp Ther 332:821-8. 2010
  9. ncbi Gbetagamma subunits stimulate p21-activated kinase 1 (PAK1) through activation of PI3-kinase and Akt but act independently of Rac1/Cdc42
    Raymond E Menard
    Department of Pharmacology, Wayne State University, 540 East Canfield Avenue, Room 6326, Detroit, MI 48201, USA
    FEBS Lett 556:187-92. 2004
  10. ncbi Decreased renal perfusion rapidly increases plasma membrane Na-K-ATPase in rat cortex by an angiotensin II-dependent mechanism
    Douglas R Yingst
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Physiol Renal Physiol 297:F1324-9. 2009

Research Grants

  1. Regulation of Ras through the Ras GRF exchange factor
    Raymond Mattingly; Fiscal Year: 2005

Collaborators

Detail Information

Publications28

  1. ncbi Activation of the Ras-GRF/CDC25Mm exchange factor by lysophosphatidic acid
    R R Mattingly
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Cell Signal 11:603-10. 1999
    ....
  2. ncbi Phosphorylation of serine 916 of Ras-GRF1 contributes to the activation of exchange factor activity by muscarinic receptors
    R R Mattingly
    Department of Pharmacology, Wayne State University, Program in Molecular Biology and Genetics, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    J Biol Chem 274:37379-84. 1999
    ..Phosphorylation of serine 916 in response to forskolin treatment did not, however, increase the activity of Ras-GRF1, indicating that it is not sufficient for activation...
  3. ncbi Down-regulation of growth factor-stimulated MAP kinase signaling in cytotoxic drug-resistant human neuroblastoma cells
    R R Mattingly
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Cell Signal 13:499-505. 2001
    ..These results suggest that resistance to cytotoxic drugs in human neuroblastoma cell lines is associated with a decrease in growth factor signaling through the MAPk pathway...
  4. ncbi Potent suppression of proliferation of a10 vascular smooth muscle cells by combined treatment with lovastatin and 3-allylfarnesol, an inhibitor of protein farnesyltransferase
    Raymond R Mattingly
    Department of Pharmacology, Wayne State University, Detroit, Michigan 48201, USA
    J Pharmacol Exp Ther 303:74-81. 2002
    ....
  5. ncbi The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines
    Raymond R Mattingly
    Department of Pharmacology, Wayne State University, 540 East Canfield Ave, Detroit, MI 48201, USA
    J Pharmacol Exp Ther 316:456-65. 2006
    ..PD184352 was also proapoptotic to primary rat Schwann cells. Hence, although PD184352 effectively killed neurofibrosarcoma cells, its effects on normal Schwann cells may limit its usefulness in the clinic...
  6. ncbi Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis
    Raymond E Menard
    Department of Pharmacology, Wayne State University, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Neoplasia 7:638-45. 2005
    ..These results support a role for activated PAK1 in the suppression of anoikis in MCF10A epithelial cells...
  7. ncbi Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways
    Raymond E Menard
    Department of Pharmacology, Wayne State University, 540 E. Canfield, Room 6326, Detroit, MI 48201, USA
    Cell Signal 15:1099-109. 2003
    ..Activation of PAK1 by LPA was independent of PI3-kinase and the EGF receptor, but was inhibited by dominant-negative RhoA. These results identify multiple Ras-dependent pathways to activation of PAK1...
  8. ncbi Three-dimensional overlay culture models of human breast cancer reveal a critical sensitivity to mitogen-activated protein kinase kinase inhibitors
    Quanwen Li
    Wayne State University, Department of Pharmacology, 540 East Canfield Avenue, Detroit, MI 48201, USA
    J Pharmacol Exp Ther 332:821-8. 2010
    ....
  9. ncbi Gbetagamma subunits stimulate p21-activated kinase 1 (PAK1) through activation of PI3-kinase and Akt but act independently of Rac1/Cdc42
    Raymond E Menard
    Department of Pharmacology, Wayne State University, 540 East Canfield Avenue, Room 6326, Detroit, MI 48201, USA
    FEBS Lett 556:187-92. 2004
    ..These results reveal that stimulation of PAK1 by Gbetagamma can occur via a PI3-kinase and Akt pathway that does not require Rac1 or Cdc42...
  10. ncbi Decreased renal perfusion rapidly increases plasma membrane Na-K-ATPase in rat cortex by an angiotensin II-dependent mechanism
    Douglas R Yingst
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Physiol Renal Physiol 297:F1324-9. 2009
    ..46). These results confirm our hypothesis: rapid changes in blood pressure regulate trafficking of Na-K-ATPase in the kidney cortex...
  11. ncbi Angiotensin II stimulates elution of Na-K-ATPase from a digoxin-affinity column by increasing the kinetic response to ligands that trigger the decay of E2-P
    Douglas R Yingst
    Dept of Physiology, Wayne State Univ School of Medicine, 540 E Canfield Ave, Detroit, MI 48201, USA
    Am J Physiol Renal Physiol 294:F990-F1000. 2008
    ..These data suggest that ANG II regulates both the kinetic properties of Na-K-ATPase and its interaction with other proteins by a mechanism(s) involving its NH(2) terminus...
  12. ncbi Angiotensin II directly stimulates activity and alters the phosphorylation of Na-K-ATPase in rat proximal tubule with a rapid time course
    Douglas R Yingst
    Dept of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Am J Physiol Renal Physiol 287:F713-21. 2004
    ..We suggest that the physiological role for rapid direct activation of Na-K-ATPase is greater control of intracellular sodium during sodium reabsorption...
  13. ncbi TNF-alpha-mediated apoptosis in normal human prostate epithelial cells and tumor cell lines
    Dharam P Chopra
    Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201, USA
    Cancer Lett 203:145-54. 2004
    ..The differences in susceptibilities to TNF-alpha induced apoptosis of NP and certain prostate tumor cells offer intriguing possibilities for the treatment of prostate cancer without affecting the normal prostate tissue...
  14. ncbi A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells
    Komal M Sane
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    J Pharmacol Exp Ther 333:23-33. 2010
    ....
  15. ncbi Phosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex
    Huibin Yang
    Department of Pharmacology, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 278:13278-85. 2003
    ..In the prefrontal cortex, there was striking phosphorylation of Ras-GRF1 in the dendritic tree, supporting a role for Ras activation and signal transduction in neurotransmission in this area...
  16. ncbi Restoration of E-cadherin cell-cell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in Ras-transformed breast epithelial cells
    Quanwen Li
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Neoplasia 10:1444-58. 2008
    ....
  17. ncbi p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer
    Quanwen Li
    Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University, 540 East Canfield Ave, Detroit, MI 48201, USA
    Neoplasia 10:314-29. 2008
    ..Our conclusion is that overexpressed and activated PAK1 may be a key coordinator of aberrant cell survival and proteolysis in breast cancer progression...
  18. ncbi Induction of apoptosis in neurofibromatosis type 1 malignant peripheral nerve sheath tumor cell lines by a combination of novel farnesyl transferase inhibitors and lovastatin
    Jonathan W Wojtkowiak
    Department of Pharmacology, Wayne State University, 540 East Canfield Ave, Detroit, MI 48201, USA
    J Pharmacol Exp Ther 326:1-11. 2008
    ..These data support the hypothesis that combination FTI plus lovastatin therapy may be a potential treatment for NF1 MPNSTs...
  19. ncbi Suppression of proliferation of two independent NF1 malignant peripheral nerve sheath tumor cell lines by the pan-ErbB inhibitor CI-1033
    Joshua T Dilworth
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Biol Ther 7:1938-46. 2008
    ..Consequently, targeting both EGFR and ErbB2 may prove an effective strategy for suppressing NF1 MPNST tumor growth in vivo...
  20. ncbi Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta
    Venkateshwar G Keshamouni
    Department of Pathology, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 277:22558-65. 2002
    ..This evaluation of downstream signaling revealed that E(2)-induced Erk activation is mediated by a HRG/HER-2/PKC-delta/Ras pathway that could be crucial for E(2)-dependent growth-promoting effects in early stages of tumor progression...
  21. ncbi Increased expression of Na,K-ATPase and a selective increase in phosphorylation at Ser-11 in the cortex of the 2-kidney, 1-clip hypertensive rat
    Lauren Kava
    Department of Physiology, Wayne State University, School of Medicine, Detroit, Michigan, USA
    Am J Hypertens 25:487-91. 2012
    ..The rationale is Ang II is reported to directly stimulate Na,K-ATPase activity in proximal tubules, which reabsorb 2/3 of filtered sodium, via increased phosphorylation at Ser-11 and Ser-18 and the Na,K-ATPase drives sodium reabsorption...
  22. ncbi Molecular targets for emerging anti-tumor therapies for neurofibromatosis type 1
    Joshua T Dilworth
    Department of Pharmacology, Wayne State University, Detroit, MI, USA
    Biochem Pharmacol 72:1485-92. 2006
    ....
  23. ncbi Aborted autophagy and nonapoptotic death induced by farnesyl transferase inhibitor and lovastatin
    Jonathan W Wojtkowiak
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Pharmacol Exp Ther 337:65-74. 2011
    ..These studies indicate that cotreatment of STS-26T cells with lovastatin and FTI-1 induces an abortive autophagic program and nonapoptotic cell death...
  24. ncbi Mitogen-activated protein kinase signaling in drug-resistant neuroblastoma cells
    Raymond R Mattingly
    Department of Pharmacology, Wayne State University, Detroit, MI, USA
    Methods Mol Biol 218:71-83. 2003
    ....
  25. ncbi Inorganic mercury inhibits the activation of LAT in T-cell receptor-mediated signal transduction
    Stamatina E Ziemba
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Toxicol Sci 89:145-53. 2006
    ..Hypo-phosphorylation of LAT occurs, because upstream of LAT, the LAT reactive tyrosine kinase ZAP-70 is also not properly activated in Hg2+ treated cells...
  26. ncbi Low and nontoxic inorganic mercury burdens attenuate BCR-mediated signal transduction
    Michael J McCabe
    Department of Environmental Medicine, University of Rochester, Rochester, NY, USA
    Toxicol Sci 99:512-21. 2007
    ..Our data suggest that the site of action of Hg(+2) may very well be localized on the plasma membrane. These findings support a connection between Hg(+2) and attenuated BCR signal strength in the etiology of autoimmune disease...
  27. ncbi Synthesis, biochemical, and cellular evaluation of farnesyl monophosphate prodrugs as farnesyltransferase inhibitors
    Michelle K Clark
    Medicinal Chemistry and Molecular Pharmacology and Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Med Chem 50:3274-82. 2007
    ..Indeed, combinations as low as 50 nM lovastatin + 1 microM 5c or 250 nM lovastatin + 50 nM 5c were highly cytostatic in STS-26T cell culture...
  28. ncbi Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells
    Jens Henrik Norum
    Department of Pharmacology, University of Oslo, Norway
    FEBS J 272:2304-16. 2005
    ..Therefore, both cAMP and Ca2+ may contribute to the Ras-dependent ERK1/2 activation after 5-HT7 receptor stimulation, through activation of a guanine nucleotide exchange factor with activity towards Ras...

Research Grants5

  1. Regulation of Ras through the Ras GRF exchange factor
    Raymond Mattingly; Fiscal Year: 2005
    ..The results are likely to be of fundamental importance to our comprehension of the role of the Ras/MAP kinase system in learning and memory. ..