H K Manji

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Signalling pathways in the brain: cellular transduction of mood stabilisation in the treatment of manic-depressive illness
    H K Manji
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Aust N Z J Psychiatry 33:S65-83. 1999
  2. ncbi request reprint Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness
    H K Manji
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    J Clin Psychiatry 61:82-96. 2000
  3. ncbi request reprint Valproate robustly enhances AP-1 mediated gene expression
    G Chen
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, WSU School of Medicine, 2301 Scott Hall, 540 E Canfield Avenue, Detroit, MI 48201, USA
    Brain Res Mol Brain Res 64:52-8. 1999
  4. ncbi request reprint Molecular mechanisms underlying mood stabilization in manic-depressive illness: the phenotype challenge
    O C Ikonomov
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Psychiatry 156:1506-14. 1999
  5. ncbi request reprint The nature of bipolar disorder
    H K Manji
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Mich, USA
    J Clin Psychiatry 61:42-57. 2000
  6. ncbi request reprint Enhancement of hippocampal neurogenesis by lithium
    G Chen
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurochem 75:1729-34. 2000
  7. ncbi request reprint Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers
    H K Manji
    Laboratory of Molecular Pathophysiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Br J Psychiatry Suppl 41:s107-19. 2001
  8. ncbi request reprint Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo
    G Chen
    Department of Psychiatry and Behavioral Neurosciences, WSU School of Medicine, Detroit, MI 48201, USA
    Bipolar Disord 2:217-36. 2000
  9. ncbi request reprint The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth
    P X Yuan
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 276:31674-83. 2001
  10. ncbi request reprint Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness
    G J Moore
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Psychiatry 156:1902-8. 1999

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Signalling pathways in the brain: cellular transduction of mood stabilisation in the treatment of manic-depressive illness
    H K Manji
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Aust N Z J Psychiatry 33:S65-83. 1999
    ....
  2. ncbi request reprint Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness
    H K Manji
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    J Clin Psychiatry 61:82-96. 2000
    ....
  3. ncbi request reprint Valproate robustly enhances AP-1 mediated gene expression
    G Chen
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, WSU School of Medicine, 2301 Scott Hall, 540 E Canfield Avenue, Detroit, MI 48201, USA
    Brain Res Mol Brain Res 64:52-8. 1999
    ....
  4. ncbi request reprint Molecular mechanisms underlying mood stabilization in manic-depressive illness: the phenotype challenge
    O C Ikonomov
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Psychiatry 156:1506-14. 1999
    ..The authors critically examine the evidence supporting the hypothesis that lithium's therapeutic effects in bipolar affective disorder are mediated by alterations in the expression of specific genes in critical neuronal circuits...
  5. ncbi request reprint The nature of bipolar disorder
    H K Manji
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Mich, USA
    J Clin Psychiatry 61:42-57. 2000
    ....
  6. ncbi request reprint Enhancement of hippocampal neurogenesis by lithium
    G Chen
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurochem 75:1729-34. 2000
    ..These results add to the growing body of evidence suggesting that mood stabilizers and antidepressants exert neurotrophic effects and may therefore be of use in the long-term treatment of other neuropsychiatric disorders...
  7. ncbi request reprint Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers
    H K Manji
    Laboratory of Molecular Pathophysiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Br J Psychiatry Suppl 41:s107-19. 2001
    ..New research is dramatically altering our understanding of the molecular mechanisms underlying neuronal communication...
  8. ncbi request reprint Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo
    G Chen
    Department of Psychiatry and Behavioral Neurosciences, WSU School of Medicine, Detroit, MI 48201, USA
    Bipolar Disord 2:217-36. 2000
    ..Together, these results suggest that the PKC signaling pathway and PKC-mediated gene expression may be important mediators of lithium's long-term therapeutic effects in a disorder as complex as BD...
  9. ncbi request reprint The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth
    P X Yuan
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 276:31674-83. 2001
    ..These data demonstrate that VPA is an ERK pathway activator and produces neurotrophic effects...
  10. ncbi request reprint Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness
    G J Moore
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Psychiatry 156:1902-8. 1999
    ..Lithium's effects on in vivo brain myo-inositol levels were investigated longitudinally in 12 adult depressed patients with manic-depressive illness...
  11. ncbi request reprint Neuroplasticity and cellular resilience in mood disorders
    H K Manji
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, USA
    Mol Psychiatry 5:578-93. 2000
    ....
  12. ncbi request reprint The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS
    G Chen
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurochem 72:879-82. 1999
    ..These novel findings represent the first report of medication-induced increases in CNS bcl-2 levels and may have implications not only for mood disorders, but also for long-term treatment of various neurodegenerative disorders...
  13. ncbi request reprint Lithium treatment in ovo: effects on embryonic heart rate, natural death of ciliary ganglion neurons, and brain expression of a highly conserved chicken homolog of human MTG8/ETO
    O C Ikonomov
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, School of Medicine, 4237 Scott Hall, 540 E Canfield, Detroit, MI 48201, USA
    Brain Res Dev Brain Res 123:13-24. 2000
    ..We propose that the induction of ETO expression, in concert with lithium-induced upregulation of other genes, such as PEBP2beta and bcl-2, is participating in the neuroprotective effect of chronic lithium treatment...
  14. ncbi request reprint The effects of lithium on ex vivo cytokine production
    M H Rapaport
    Psychopharmacology Research Program, Department of Psychiatry, University of California, San Diego, California 92037, USA
    Biol Psychiatry 50:217-24. 2001
    ..The study suggests that lithium may have complex time-dependent effects on immune function...