ADHIP N MAJUMDAR

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Age-associated loss of heterozygosity of tumor suppressor genes in the gastric mucosa of humans
    Lathika Moragoda
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Gastrointest Liver Physiol 282:G932-6. 2002
  2. ncbi request reprint Chemopreventive role of folic acid in colorectal cancer
    Adhip P N Majumdar
    Veterans Affairs Medical Center, Karmanos Cancer Institute, Department of Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Front Biosci 9:2725-32. 2004
  3. doi request reprint Metformin: a potential therapeutic agent for recurrent colon cancer
    Pratima Nangia-Makker
    Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan, United States of America Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America Department of Internal Medicine, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 9:e84369. 2014
  4. pmc Difluorinated-curcumin (CDF) restores PTEN expression in colon cancer cells by down-regulating miR-21
    Sanchita Roy
    Department of Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 8:e68543. 2013
  5. pmc Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF
    Sanchita Roy
    Department of Veterans Affairs Medical Center, Wayne State University, Detroit, MI 48201, USA
    J Hematol Oncol 5:58. 2012
  6. pmc Signaling in colon cancer stem cells
    Sanchita Roy
    John D Dingell VA Medical Centre, 4646 John R Room B 4238, Detroit, MI, 48201, USA
    J Mol Signal 7:11. 2012
  7. pmc EGFR regulation of colon cancer stem-like cells during aging and in response to the colonic carcinogen dimethylhydrazine
    Jyoti Nautiyal
    Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
    Am J Physiol Gastrointest Liver Physiol 302:G655-63. 2012
  8. pmc The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres
    Shailender S Kanwar
    Department of Internal Medicine, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Mol Cancer 9:212. 2010
  9. ncbi request reprint Phosphatidylinositol 3-kinase/Akt signaling stimulates colonic mucosal cell survival during aging
    Adhip P N Majumdar
    Veterans Affairs Medical Center, and Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA
    Am J Physiol Gastrointest Liver Physiol 290:G49-55. 2006
  10. ncbi request reprint Therapeutic potential of EGFR-related protein, a universal EGFR family antagonist
    Adhip P N Majumdar
    John D Dingell VA Medical Center, 4646 John R Room B 4238, Detroit, MI 48201, USA
    Future Oncol 1:235-45. 2005

Collaborators

  • Maha Hussain
  • Sanchita Roy
  • Pratima Nangia-Makker
  • Fazlul H Sarkar
  • Sanjeev Banerjee
  • Arun K Rishi
  • O Kucuk
  • E M Schmelz
  • A Tarnawski
  • Kenneth J Chang
  • M D Basson
  • K M Wahidur Rahman
  • Marcia Dawson
  • R M Mohammad
  • James L Abbruzzese
  • Jyoti Nautiyal
  • Yingjie Yu
  • Shailender S Kanwar
  • Edi Levi
  • Richard Jaszewski
  • Hu Xu
  • Yuxiang Zhang
  • Bhaumik B Patel
  • Amro Aboukameel
  • Dorota J Marciniak
  • Kiran K Nagothu
  • Lathika Moragoda
  • Liyue Zhang
  • Zhiwei Wang
  • Sudha Reddy
  • Phil Sun Oh
  • Shailender Singh Kanwar
  • Jianhua Du
  • Ying Jie Yu
  • Radha Sengupta
  • James S Hatfield
  • Dorota Marciniak
  • Woo Sung Moon
  • Bradley N Axelrod
  • Raphaela Finkenauer
  • Zhi Qiang Xiao
  • Chuan Hao Lin
  • Vaishali B Patel
  • Matthew A Sanders
  • Lance K Heilbrun
  • Ikuko Kato
  • Sadia Qazi
  • Jeffrey L Ram
  • Jordan M Nechvatal
  • Hetal Vachhani
  • Anil Wali
  • Volkan Adsay
  • Pralay Majumder
  • Yiwei Li
  • Mingxin Che
  • Nazmi V Adsay
  • Zhi Wei Wang
  • Udayini Kodali
  • Brett Millar
  • Paula Sochacki
  • Kiran Nogothu
  • Jo Anne Naumoff
  • John Frank
  • Martin Tobi
  • Jo Ann Naumoff
  • Jianling Li
  • Murray Ehrinpreis
  • Volkan N Adsay
  • Ravi Dhar
  • Vasundhara Tolia
  • Jeffrey A Moshier
  • Raymond G Schipper
  • Prasad Kulkarni
  • Roy Vijesurier
  • Ye Shih Ho

Detail Information

Publications41

  1. ncbi request reprint Age-associated loss of heterozygosity of tumor suppressor genes in the gastric mucosa of humans
    Lathika Moragoda
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Gastrointest Liver Physiol 282:G932-6. 2002
    ..Our observation that subjects over 60 yr of age show mutation in one or more of the tumor suppressor genes suggests an age-related increase in predisposition of the stomach to neoplasia...
  2. ncbi request reprint Chemopreventive role of folic acid in colorectal cancer
    Adhip P N Majumdar
    Veterans Affairs Medical Center, Karmanos Cancer Institute, Department of Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Front Biosci 9:2725-32. 2004
    ..The folic acid mediated reduction of EGFR function could partly be the result of suppression of EGFR gene through increased methylation of CpG sequences within its promoter...
  3. doi request reprint Metformin: a potential therapeutic agent for recurrent colon cancer
    Pratima Nangia-Makker
    Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan, United States of America Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America Department of Internal Medicine, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 9:e84369. 2014
    ..Our current data suggest that metformin together with conventional chemotherapy could be an effective treatment regimen for recurring colorectal cancer (CRC)...
  4. pmc Difluorinated-curcumin (CDF) restores PTEN expression in colon cancer cells by down-regulating miR-21
    Sanchita Roy
    Department of Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 8:e68543. 2013
    ....
  5. pmc Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF
    Sanchita Roy
    Department of Veterans Affairs Medical Center, Wayne State University, Detroit, MI 48201, USA
    J Hematol Oncol 5:58. 2012
    ..Numerous cellular events, including deregulated expression of microRNAs (miRNAs), specifically the family of miR-34 consisting of miR-34a, b and c, is known to regulate the processes of growth and metastasis...
  6. pmc Signaling in colon cancer stem cells
    Sanchita Roy
    John D Dingell VA Medical Centre, 4646 John R Room B 4238, Detroit, MI, 48201, USA
    J Mol Signal 7:11. 2012
    ..This review focuses on the signaling pathways relevant for CRC to understand the mechanisms leading to tumor progression and therapy resistance, which may help in the development of therapeutic strategies for CRC...
  7. pmc EGFR regulation of colon cancer stem-like cells during aging and in response to the colonic carcinogen dimethylhydrazine
    Jyoti Nautiyal
    Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
    Am J Physiol Gastrointest Liver Physiol 302:G655-63. 2012
    ..EGFR inhibition attenuates these changes, indicating a role for EGFR in age- and mutagen-associated changes in CSLCs...
  8. pmc The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres
    Shailender S Kanwar
    Department of Internal Medicine, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Mol Cancer 9:212. 2010
    ..Human colon cancer cells HCT-116 (p53 wild type; K-ras mutant), HCT-116 (p53 null; K-ras mutant) and HT-29 (p53 mutant) were used...
  9. ncbi request reprint Phosphatidylinositol 3-kinase/Akt signaling stimulates colonic mucosal cell survival during aging
    Adhip P N Majumdar
    Veterans Affairs Medical Center, and Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA
    Am J Physiol Gastrointest Liver Physiol 290:G49-55. 2006
    ..We conclude that the constitutive activation of the PI3K/Akt-signaling pathway is partly responsible for the age-related increase in colonic mucosal cell survival. This is evident throughout the entire length of the colonic crypt...
  10. ncbi request reprint Therapeutic potential of EGFR-related protein, a universal EGFR family antagonist
    Adhip P N Majumdar
    John D Dingell VA Medical Center, 4646 John R Room B 4238, Detroit, MI 48201, USA
    Future Oncol 1:235-45. 2005
    ....
  11. ncbi request reprint Regulation of gastrointestinal mucosal growth during aging
    A P N Majumdar
    Veterans Administration Medical Center, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48322, USA
    J Physiol Pharmacol 54:143-54. 2003
    ....
  12. pmc Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells
    Jyoti Nautiyal
    Veterans Affairs Medical Center, Wayne State University, Detroit, MI 48201, USA
    J Mol Signal 6:7. 2011
    ..Our data suggest that the combination therapy of dasatinib and curcumin may be a therapeutic strategy for re-emergence of chemo-resistant colon cancer by targeting CSC sub-population...
  13. ncbi request reprint Cell cycle and apoptosis regulatory protein-1: a novel regulator of apoptosis in the colonic mucosa during aging
    Adhip P N Majumdar
    Veterans Affairs Medical Center, Wayne State University, Detroit, MI 48201, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1215-22. 2007
    ..Taken together, our data suggest that not only EGFR but also its other members are involved in regulating colonic mucosal growth during aging and that CARP-1 may play a crucial role in transducing EGFRs signals...
  14. ncbi request reprint Curcumin synergizes with resveratrol to inhibit colon cancer
    Adhip P N Majumdar
    John D Dingell VA Medical Center, 4646 John R, Room B 4238, Detroit, MI 48201, USA
    Nutr Cancer 61:544-53. 2009
    ..Our current data suggest that the combination of curcumin and resveratrol could be an effective preventive/therapeutic strategy for colon cancer...
  15. pmc Schlafen-3 decreases cancer stem cell marker expression and autocrine/juxtacrine signaling in FOLFOX-resistant colon cancer cells
    Phil Sun Oh
    Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan, USA
    Am J Physiol Gastrointest Liver Physiol 301:G347-55. 2011
    ..Thus Slfn-3 expression may render colon CSCs more susceptible to cancer chemotherapeutics...
  16. ncbi request reprint EGFR(S) inhibitors in the treatment of gastro-intestinal cancers: what's new?
    Shailender Singh Kanwar
    Veterans Affairs Medical Center, Wayne State University, Detroit, MI 48201, USA
    Curr Drug Targets 11:682-98. 2010
    ..Current review describes the recent role of targeted therapies, specifically EGFR inhibitors in the treatment of GI cancers. Importance of dietary agents in the treatment and prevention of GI cancers is also reviewed...
  17. ncbi request reprint Mechanisms of curcumin- and EGF-receptor related protein (ERRP)-dependent growth inhibition of colon cancer cells
    Sudha Reddy
    Veterans Affairs Medical Center, Karmanos Cancer Institute, Department of Internal Medicine, Michigan 48201, USA
    Nutr Cancer 55:185-94. 2006
    ..The superior effects of the combinatorial treatment could partly be attributed to inhibition of constitutive activation of EGFRs and IGF-1R signaling pathways...
  18. ncbi request reprint Transactivator of transcription-tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of human breast cancer cells in vitro and in vivo
    Liyue Zhang
    Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan 48201, USA
    Mol Cancer Ther 6:1661-72. 2007
    ..We conclude that CARP-1 is a suppressor of human breast cancer growth, and its expression is diminished in tumors, in part, by methylation-dependent silencing...
  19. ncbi request reprint Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R
    Bhaumik B Patel
    John D Dingell VA Medical Center, Wayne State University, Detroit, MI 48201, USA
    Int J Cancer 122:267-73. 2008
    ..We also suggest that inclusion of curcumin to the conventional chemotherapeutic agent(s)/regimen could be an effective therapeutic strategy for colorectal cancer...
  20. ncbi request reprint Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-kappaB in pancreatic cancer
    Yuxiang Zhang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University of Medicine, Detroit, MI 48201, USA
    Cancer Res 66:1025-32. 2006
    ..In summary, our results suggest that ERRP is an effective pan-erbB inhibitor, which could be a potential therapeutic agent for pancreatic cancers expressing different levels and subclasses of erbB family of proteins...
  21. ncbi request reprint Epidermal growth factor receptor-related protein inhibits cell growth and induces apoptosis of BxPC3 pancreatic cancer cells
    Yuxiang Zhang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
    Cancer Res 65:3877-82. 2005
    ..We also suggest that ERRP could be a potential therapeutic agent for pancreatic cancer...
  22. ncbi request reprint Expression of intestinal ornithine decarboxylase during postnatal development in neonatal rats
    Chuan Hao Lin
    Department of Pediatrics, Division of Gastroenterology and Nutrition, Wayne State University and Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit 48201, USA
    Biochim Biophys Acta 1589:298-304. 2002
    ..A better understanding of the regulation of polyamine biosynthesis during postnatal development of the small intestine will provide insights contributing to the maturation of the small intestine...
  23. ncbi request reprint Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa
    Zhi Qiang Xiao
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Gastrointest Liver Physiol 285:G396-403. 2003
    ....
  24. ncbi request reprint Expression of EGF-receptor related protein (ERRP) decreases in gastric mucosa during aging and carcinogenesis
    Adhip P N Majumdar
    Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
    Dig Dis Sci 48:856-64. 2003
    ..We conclude that increased activation of EGFR in the gastric mucosa during aging and carcinogenesis may partly be due to the loss of ERRP...
  25. ncbi request reprint Folic acid mediated attenuation of loss of heterozygosity of DCC tumor suppressor gene in the colonic mucosa of patients with colorectal adenomas
    Kiran K Nagothu
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Detect Prev 27:297-304. 2003
    ..Taken together, our data suggest that one of the ways folate may exert its chemopreventive effect is by stabilizing certain tumor suppressor gene(s) and preventing further increases in proliferation...
  26. ncbi request reprint Folic acid reduces nuclear translocation of beta-catenin in rectal mucosal crypts of patients with colorectal adenomas
    Richard Jaszewski
    Division of Gastroenterology, and Department of Internal Medicine, Veterans Affairs Medical Center, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Lett 206:27-33. 2004
    ..05) and cellular expression of pGSK3beta (P < 0.01) when compared to placebo. Folic acid may exert its chemopreventive effect, at least in part, through inhibition of nuclear translocation of beta-catenin...
  27. ncbi request reprint Folic acid-mediated inhibition of serum-induced activation of EGFR promoter in colon cancer cells
    Kiran K Nagothu
    Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
    Am J Physiol Gastrointest Liver Physiol 287:G541-6. 2004
    ..This could partly be responsible for FA-mediated inhibition of growth-related processes in colorectal neoplasia...
  28. ncbi request reprint Expression of epidermal growth factor-receptor related protein (ERRP) in human colorectal carcinogenesis
    Richard Jaszewski
    Veterans Affairs Medical Center, Karmanos Cancer Institute, Wayne State University School of Medicine, Research Service 151, 4646 John R, Detroit, MI 48201, USA
    Cancer Lett 213:249-55. 2004
    ..002) tumors, respectively. ERRP expression became more attenuated in polyps with increasing grades of dysplasia. In contrast, expression of EGFR was inversely related to ERRP in representative samples of normal and neoplastic tissues...
  29. ncbi request reprint Age-related loss of EGF-receptor related protein (ERRP) in the aging colon is a potential risk factor for colon cancer
    Eva M Schmelz
    Karmanos Cancer Institute, Wayne State University School of Medicine, VA Medical Center 151, 4646 John R Street, Detroit, MI 48201, USA
    Mech Ageing Dev 125:917-22. 2004
    ..We also suggest that loss of ERRP could be a risk factor for developing colorectal cancer in the older population...
  30. ncbi request reprint Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor
    Arun K Rishi
    Veterans Affairs Medical Center, Wayne State Umiversity, Detroit, Michigan 48201, USA
    J Biol Chem 281:13188-98. 2006
    ..Together, data demonstrate that tyrosine 192 of CARP-1 is a target of apoptosis signaling, and CARP-1, in turn, promotes apoptosis by activating p38 MAPK and caspase-9...
  31. ncbi request reprint Epidermal growth factor receptor (EGFR)-related protein inhibits multiple members of the EGFR family in colon and breast cancer cells
    Hu Xu
    John D Dingell Veterans Affairs Medical Center, 4646 John R, Room B 4238, Detroit, MI 48201, USA
    Mol Cancer Ther 4:435-42. 2005
    ..Our results suggest that ERRP is an effective pan-erbB inhibitor and, thus, may be a potential therapeutic agent for a wide variety of epithelial cancers expressing different levels and subclasses of EGFRs...
  32. ncbi request reprint Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437
    Arun K Rishi
    Veterans Affairs Medical Center, Department of Internal Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 278:33422-35. 2003
    ..Identification of CARP-1 as a key mediator of signaling by CD437 or adriamycin allows for delineation of pathways that, in turn, may prove beneficial for design and targeting of novel antitumor agents...
  33. pmc Exfoliated cells in stool: a source for reverse transcription-PCR-based analysis of biomarkers of gastrointestinal cancer
    Ying Jie Yu
    Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA
    Cancer Epidemiol Biomarkers Prev 17:455-8. 2008
    ..Of all the preservative methods tested, RNAlater had the best performance in terms of overall quality, quantity, and level of genomic DNA contamination, and thus deserves further investigation...
  34. ncbi request reprint Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein
    Eva M Schmelz
    Department of Nutrition and Food Science, Wayne State University, Detriot, Michigan 48220, USA
    Cancer Res 67:5389-96. 2007
    ..In conclusion, our data show that ERRP is effective in regressing both early and intermediate intestinal lesions and could be an effective therapeutic agent for colon cancer...
  35. ncbi request reprint Emerging therapies in gastrointestinal cancers
    Jyoti Nautiyal
    Karmanos Cancer Institute, Detroit, MI 48201, United States
    World J Gastroenterol 12:7440-50. 2006
    ..It also emphasizes the need to develop pan-ErbB inhibitors and discusses EGF-Receptor Related Protein, a recently isolated negative regulator of EGFR as a potential pan-ErbB therapeutic for a wide variety of epithelial cancers...
  36. ncbi request reprint Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancer
    Zhiwei Wang
    Departments of Pathology and Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, Detroit, MI 48201, USA
    Cancer Res 66:7653-60. 2006
    ..We conclude that ERRP could be an effective agent for inhibiting tumor growth and invasion for the treatment of pancreatic cancer...
  37. ncbi request reprint EGF receptor-related protein (ERRP) inhibits invasion of colon cancer cells and tubule formation by endothelial cells in vitro
    Arun K Rishi
    Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
    Anticancer Res 26:1029-37. 2006
    ..In summary, it was demonstrated that ERRP not only inhibits cell growth, but also the processes of cell invasion and blood vessel formation that are critical for the development and progression of carcinogenesis...
  38. ncbi request reprint Epidermal growth factor receptor-related peptide inhibits growth of PC-3 prostate cancer cells
    Dorota J Marciniak
    Departments of Internal Medicine and Pathology, John D Dingell Veterans Affairs Medical Center, Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Mol Cancer Ther 3:1615-21. 2004
    ..In summary, our data show that ERRP inhibits the growth of prostate cancer cells by attenuating EGFR signaling processes. ERRP could potentially be an effective therapeutic agent for prostate cancer...
  39. ncbi request reprint EGF-receptor related protein causes cell cycle arrest and induces apoptosis of colon cancer cells in vitro and in vivo
    Edi Levi
    Veterans Affairs Medical Center, Pathology and Laboratory Medicine Service, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Anticancer Res 24:2885-91. 2004
    ..However, the mechanisms by which ERRP exerts its anti-tumor properties are poorly understood The current investigation was undertaken to delineate the inhibitory mechanisms that are triggered by ERRP...
  40. ncbi request reprint Reduced expression of epidermal growth factor receptor-related protein in hepatocellular carcinoma: implications for cancer growth
    Woo Sung Moon
    Department of Medicine, VA Medical Center, Long Beach and The University of California, Irvine, CA 90822 5201, USA
    Digestion 69:219-24. 2004
    ..The recently cloned EGFR-related protein (ERRP) has been proposed to be a negative regulator of EGFR. The expression of ERRP in non-malignant liver cells and in HCC, and its relation to cell proliferation, have not been examined...
  41. ncbi request reprint Epidermal growth factor receptor-related protein: a potential therapeutic agent for colorectal cancer
    Dorota J Marciniak
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
    Gastroenterology 124:1337-47. 2003
    ..We also studied whether epidermal growth factor receptor-related protein expression is altered in colorectal cancer...