K Maiese

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Group I metabotropic receptors down-regulate nitric oxide induced caspase-3 activity in rat hippocampal neurons
    K Maiese
    Department of Neurology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurosci Lett 264:17-20. 1999
  2. pmc Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus
    Kenneth Maiese
    Department of Neurology, 8C 1 UHC, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Curr Neurovasc Res 4:63-71. 2007
  3. pmc New strategies for Alzheimer's disease and cognitive impairment
    Kenneth Maiese
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Oxid Med Cell Longev 2:279-89. 2009
  4. pmc A fork in the path: Developing therapeutic inroads with FoxO proteins
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Oxid Med Cell Longev 2:119-29. 2009
  5. pmc Therapeutic promise and principles: metabotropic glutamate receptors
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Oxid Med Cell Longev 1:1-14. 2008
  6. pmc Driving cellular plasticity and survival through the signal transduction pathways of metabotropic glutamate receptors
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, 8C 1 UHC, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Curr Neurovasc Res 2:425-46. 2005
  7. pmc Novel avenues of drug discovery and biomarkers for diabetes mellitus
    Kenneth Maiese
    Department of Neurology, 8C 1 UHC, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    J Clin Pharmacol 51:128-52. 2011
  8. ncbi request reprint Insights into oxidative stress and potential novel therapeutic targets for Alzheimer disease
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Restor Neurol Neurosci 22:87-104. 2004
  9. pmc The vitamin nicotinamide: translating nutrition into clinical care
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Molecules 14:3446-85. 2009
  10. pmc Erythropoietin, forkhead proteins, and oxidative injury: biomarkers and biology
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan, USA
    ScientificWorldJournal 9:1072-104. 2009

Detail Information

Publications86

  1. ncbi request reprint Group I metabotropic receptors down-regulate nitric oxide induced caspase-3 activity in rat hippocampal neurons
    K Maiese
    Department of Neurology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurosci Lett 264:17-20. 1999
    ..Activation of only Group I mGluRs completely ameliorates the induction of CPP32 activity by NO and prevents the induction of PCD...
  2. pmc Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus
    Kenneth Maiese
    Department of Neurology, 8C 1 UHC, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Curr Neurovasc Res 4:63-71. 2007
    ..Through the elucidation of these targets, improvement in current strategies as well as the development of future clinical applications can move forward for both the prevention and treatment of Type 1 and Type 2 DM...
  3. pmc New strategies for Alzheimer's disease and cognitive impairment
    Kenneth Maiese
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Oxid Med Cell Longev 2:279-89. 2009
    ....
  4. pmc A fork in the path: Developing therapeutic inroads with FoxO proteins
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Oxid Med Cell Longev 2:119-29. 2009
    ....
  5. pmc Therapeutic promise and principles: metabotropic glutamate receptors
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Oxid Med Cell Longev 1:1-14. 2008
    ..Here we discuss the potential clinical translation of mGluRs and highlight the role of novel signal transduction pathways in the metabotropic glutamate system that may be vital for the clinical utility of mGluRs...
  6. pmc Driving cellular plasticity and survival through the signal transduction pathways of metabotropic glutamate receptors
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, 8C 1 UHC, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Curr Neurovasc Res 2:425-46. 2005
    ....
  7. pmc Novel avenues of drug discovery and biomarkers for diabetes mellitus
    Kenneth Maiese
    Department of Neurology, 8C 1 UHC, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    J Clin Pharmacol 51:128-52. 2011
    ..Greater understanding of the intricacies of these unique cellular mechanisms will shape future drug discovery for diabetes mellitus to provide focused clinical care with limited or absent long-term complications...
  8. ncbi request reprint Insights into oxidative stress and potential novel therapeutic targets for Alzheimer disease
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Restor Neurol Neurosci 22:87-104. 2004
    ....
  9. pmc The vitamin nicotinamide: translating nutrition into clinical care
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Molecules 14:3446-85. 2009
    ....
  10. pmc Erythropoietin, forkhead proteins, and oxidative injury: biomarkers and biology
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan, USA
    ScientificWorldJournal 9:1072-104. 2009
    ....
  11. pmc Oxidative stress: Biomarkers and novel therapeutic pathways
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Exp Gerontol 45:217-34. 2010
    ....
  12. pmc The "O" class: crafting clinical care with FoxO transcription factors
    Kenneth Maiese
    Department of Neurology and Anatomy and Cell Biology, Barbara Ann Karmanos Cancer Institute, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Adv Exp Med Biol 665:242-60. 2009
    ....
  13. pmc Diabetes mellitus: channeling care through cellular discovery
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Curr Neurovasc Res 7:59-64. 2010
    ....
  14. ncbi request reprint Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University, School of Medicine Detroit, St Antoine, MI 48201, USA
    Trends Pharmacol Sci 24:228-32. 2003
    ..As both a therapeutic agent and an investigational tool, nicotinamide offers new therapeutic strategies for degenerative disorders of the CNS...
  15. pmc Mechanistic insights into diabetes mellitus and oxidative stress
    Kenneth Maiese
    Department of Neurology, 8C 1 UHC, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Curr Med Chem 14:1729-38. 2007
    ..Further knowledge acquired in understanding the complexity of DM and its ability to impair cellular systems throughout the body will foster new strategies for the treatment of DM and its complications...
  16. ncbi request reprint Membrane asymmetry and DNA degradation: functionally distinct determinants of neuronal programmed cell death
    K Maiese
    Departments of Neurology and Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Neurosci Res 59:568-80. 2000
    ..In addition, neuronal injury is fluid and reversible in nature, suggesting a "window of opportunity" for the repair and reversal of neurons yet to be committed to PCD...
  17. ncbi request reprint Metabotropic glutamate receptor subtypes independently modulate neuronal intracellular calcium
    K Maiese
    Laboratory of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci Res 55:472-85. 1999
    ..Further characterization of the cellular calcium pools modulated by the mGluR subtypes may provide greater insight into the mechanisms that mediate neuronal function...
  18. ncbi request reprint Critical temporal modulation of neuronal programmed cell injury
    K Maiese
    Department of Neurology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cell Mol Neurobiol 20:383-400. 2000
    ..4. Further investigation into the neuroprotective pathways that alter PCD may provide greater insight into the molecular mechanisms that ultimately determine neuronal injury...
  19. ncbi request reprint The dynamics of cellular injury: transformation into neuronal and vascular protection
    K Maiese
    Department of Neurology, Center for Cellular and Molecular Toxicology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Histol Histopathol 16:633-44. 2001
    ..Employing the knowledge gained from investigations into these pathways will hopefully further efforts to successfully develop effective treatments against central nervous system disorders...
  20. pmc Clever cancer strategies with FoxO transcription factors
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cell Cycle 7:3829-39. 2008
    ..Further elucidation of FoxO protein function during neoplastic growth should continue to lay the foundation for the successful translation of these transcription factors into novel and robust clinical therapies for cancer...
  21. pmc A "FOXO" in sight: targeting Foxo proteins from conception to cancer
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Med Res Rev 29:395-418. 2009
    ..As our knowledge continues to develop for this novel family of proteins, potential clinical applications for the FoxO family should heighten our ability to limit disease progression without clinical compromise...
  22. pmc Rogue proliferation versus restorative protection: where do we draw the line for Wnt and forkhead signaling?
    Kenneth Maiese
    Wayne State University School of Medicine, Department of Neurology, 8C 1 UHC, 4201 Street, Antoine, Detroit, MI 48201, USA
    Expert Opin Ther Targets 12:905-16. 2008
    ..Disease entities such as diabetes, neurodegeneration and cardiovascular disorders affect a significant portion of the world's population...
  23. pmc OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Trends Mol Med 14:219-27. 2008
    ....
  24. pmc "Sly as a FOXO": new paths with Forkhead signaling in the brain
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Curr Neurovasc Res 4:295-302. 2007
    ....
  25. pmc FoxO proteins: cunning concepts and considerations for the cardiovascular system
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Clin Sci (Lond) 116:191-203. 2009
    ..Current knowledge of FoxO protein function combined with future studies should continue to lay the foundation for the successful translation of these transcription factors into novel and robust clinical therapies...
  26. ncbi request reprint The metabotropic glutamate receptor system protects against ischemic free radical programmed cell death in rat brain endothelial cells
    S H Lin
    Laboratory of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cereb Blood Flow Metab 21:262-75. 2001
    ..Further investigation into the ability of the mGluR system to prevent PCD in ECs may open new therapeutic avenues for the treatment of cerebrovascular injury...
  27. pmc Targeting WNT, protein kinase B, and mitochondrial membrane integrity to foster cellular survival in the nervous system
    Z Z Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan, USA
    Histol Histopathol 19:495-504. 2004
    ....
  28. ncbi request reprint Group I metabotropic glutamate receptors prevent endothelial programmed cell death independent from MAP kinase p38 activation in rat
    S H Lin
    Laboratory of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurosci Lett 298:207-11. 2001
    ..We provide initial evidence for Group I mGluRs to prevent NO-induced vascular injury and offer new directions for vascular disease treatment...
  29. ncbi request reprint Group I and group III metabotropic glutamate receptor subtypes provide enhanced neuroprotection
    K Maiese
    Laboratory of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci Res 62:257-72. 2000
    ..Our work elucidates the independent nature of the mGluR subtypes to not only provide discrete levels of protection against neuronal PCD, but also offer robust therapeutic strategies for neurodegenerative disease...
  30. ncbi request reprint The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Center for Molecular Medicine and Genetics, Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cereb Blood Flow Metab 24:728-43. 2004
    ..Their work elucidates some of the unique neuro-protective pathways used by the essential cellular nutrient nicotinamide that may direct future therapeutic approaches for neurodegenerative disorders...
  31. pmc Winding through the WNT pathway during cellular development and demise
    F Li
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Histol Histopathol 21:103-24. 2006
    ....
  32. pmc Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury
    Z Z Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Histol Histopathol 20:299-315. 2005
    ..With further levels of progress in defining the cellular role of Akt, the attractiveness of Akt as a vital and broad cytoprotectant for both neuronal and vascular cell populations should continue to escalate...
  33. ncbi request reprint Cell cycle induction in post-mitotic neurons proceeds in concert with the initial phase of programmed cell death in rat
    S H Lin
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurosci Lett 310:173-7. 2001
    ..We therefore offer an attractive molecular target to prevent or reverse neuronal PCD by elucidating a novel mechanism through which the majority of neurons meet their demise by attempting to enter a latent cell cycle...
  34. pmc Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, United States
    Cell Signal 19:1150-62. 2007
    ....
  35. pmc Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-catenin during oxidative stress
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Neurovasc Res 3:107-17. 2006
    ..Further insight into the cellular mechanisms that determine neuronal protection by the metabotropic glutamate system will foster the successful therapeutic development of mGluRs for neurodegenerative disorders...
  36. pmc Erythropoietin involves the phosphatidylinositol 3-kinase pathway, 14-3-3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity
    Z Z Chong
    Division of Cellular and Molecular Cerebral Ischemia, Center for Molecular Medicine and Genetics, Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Br J Pharmacol 150:839-50. 2007
    ....
  37. ncbi request reprint Metabotropic glutamate receptors promote neuronal and vascular plasticity through novel intracellular pathways
    Z Z Chong
    Division of Cellular and Molecular Cerebral Ischemia, Center for Molecular Medicine and Genetics, Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Histol Histopathol 18:173-89. 2003
    ..Further understanding of the intricate pathways that determine the protective nature of the mGluR system will provide new therapeutic avenues for the treatment of neurodegenerative disorders...
  38. pmc Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, MI 48201, U S A
    Br J Pharmacol 138:1107-18. 2003
    ..6. Elucidating the intrinsic and extrinsic protective pathways of EPO that mediate both neuronal integrity and inflammatory microglial activation may enhance the development of future therapies directed against acute neuronal injury...
  39. ncbi request reprint Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Neurosci Res 71:659-69. 2003
    ..Elucidating some of the novel neuroprotective pathways employed by EPO may further the development of new therapeutic strategies for neurodegenerative disorders...
  40. ncbi request reprint Essential cellular regulatory elements of oxidative stress in early and late phases of apoptosis in the central nervous system
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Center for Molecular Medicine and Genetics, and Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Antioxid Redox Signal 6:277-87. 2004
    ....
  41. pmc Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB
    Faqi Li
    Division of Cellular and Molecular Ischemia, Wayne State University School of Medicine, Michigan 48201, USA
    Curr Neurovasc Res 3:187-201. 2006
    ..Further work that continues to elucidate the ability of EPO to target the intricate pathways that determine inflammatory cell function and integrity may lay the ground work for new therapeutic avenues for neurodegenerative disease...
  42. ncbi request reprint Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide
    Faqi Li
    Division of Cellular and Molecular Cerebral Ischemia, Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Front Biosci 9:2500-20. 2004
    ..cytoprotective agents as nicotinamide in conjunction with the elucidation of the cellular mechanisms responsible for cell survival will continue to solidify the development of therapeutic strategies against neurodegenerative diseases..
  43. pmc The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated "anti-apoptotic" pathways
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebal Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Neurovasc Res 2:271-85. 2005
    ....
  44. pmc The Wnt signaling pathway: aging gracefully as a protectionist?
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Pharmacol Ther 118:58-81. 2008
    ....
  45. pmc Triple play: promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Biomed Pharmacother 62:218-32. 2008
    ..In this way, new avenues of investigation can hopefully bypass toxic complications, or at the very least, avoid contraindications that may limit care and offer both safe and robust clinical treatment for patients...
  46. pmc Raves and risks for erythropoietin
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Center for Molecular Medicine and Genetics, Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cytokine Growth Factor Rev 19:145-55. 2008
    ..Here we present recent advances that have elucidated a number of novel cellular pathways governed by EPO to open new therapeutic avenues for this agent and avert its potential deleterious effects...
  47. pmc Wnt1, FoxO3a, and NF-kappaB oversee microglial integrity and activation during oxidant stress
    Yan Chen Shang
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Cell Signal 22:1317-29. 2010
    ..Our work highlights Wnt1 and the control of novel downstream transcriptional pathways as critical components for the oversight of nervous system microglial cells...
  48. pmc Erythropoietin and oxidative stress
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Curr Neurovasc Res 5:125-42. 2008
    ....
  49. pmc Erythropoietin: elucidating new cellular targets that broaden therapeutic strategies
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Prog Neurobiol 85:194-213. 2008
    ..Obtaining greater insight into the role of EPO in the nervous system and elucidating its unique cellular pathways may provide greater cellular viability not only in the nervous system but also throughout the body...
  50. pmc New avenues of exploration for erythropoietin
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    JAMA 293:90-5. 2005
    ....
  51. ncbi request reprint Erythropoietin in the brain: can the promise to protect be fulfilled?
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Trends Pharmacol Sci 25:577-83. 2004
    ..Further understanding of the cellular pathways that are susceptible to modulation by EPO will be crucial to foster the development of this agent as a robust and efficacious therapy for the brain...
  52. pmc The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury
    Z Z Chong
    Division of Cellular and Molecular Cerebral Ischemia, Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Histol Histopathol 22:1251-67. 2007
    ..Our progressive understanding of the impact of SHP-1 and SHP-2 upon multiple cellular environments and organ systems should continue to facilitate the targeted development of treatments for a variety of disease entities...
  53. pmc Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathways
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine Detroit, Michigan 48201, USA
    Curr Neurovasc Res 5:159-70. 2008
    ....
  54. pmc Life span extension and neuronal cell protection by Drosophila nicotinamidase
    Vitaly Balan
    Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    J Biol Chem 283:27810-9. 2008
    ..Together, our findings establish a life span extending the ability of nicotinamidase in flies and offer a role for nicotinamide-modulating genes in oxidative stress regulated pathways influencing longevity and neuronal cell survival...
  55. ncbi request reprint Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    Circulation 106:2973-9. 2002
    ..Erythropoietin (EPO) is a critical regulator for the proliferation of immature erythroid precursors, but its role as a potential cytoprotectant in the cerebrovasculature system has not been defined...
  56. ncbi request reprint Nicotinamide modulates mitochondrial membrane potential and cysteine protease activity during cerebral vascular endothelial cell injury
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    J Vasc Res 39:131-47. 2002
    ..The work begins to identify therapeutic strategies for the protection of the cerebral vasculature during both acute and chronic degenerative disorders...
  57. ncbi request reprint Hematopoietic factor erythropoietin fosters neuroprotection through novel signal transduction cascades
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 4201 St Antoine Street, Detroit, MI 48201, U S A
    J Cereb Blood Flow Metab 22:503-14. 2002
    ..New knowledge of the cellular pathways regulated by erythropoietin in neuronal environments will potentially solidify the development and initiation of therapeutic strategies against nervous system disorders...
  58. ncbi request reprint Erythropoietin: cytoprotection in vascular and neuronal cells
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Curr Drug Targets Cardiovasc Haematol Disord 3:141-54. 2003
    ..Further understanding of the cellular pathways that modulate EPO cytoprotection in the nervous system will be crucial for the development of therapeutic strategies against neurodegenerative diseases...
  59. pmc The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Int J Mol Med 19:263-72. 2007
    ..Elucidating the underlying pathways that can afford endogenous protection and maintain functional integrity of microglia should offer new prospects for the treatment of a broad range of nervous system disorders...
  60. pmc Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity
    Zhao Zhong Chong
    Department of Neurology, 8C 1 UHC, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Curr Neurovasc Res 2:387-99. 2005
    ....
  61. pmc The forkhead transcription factor FOXO3a controls microglial inflammatory activation and eventual apoptotic injury through caspase 3
    Yan Chen Shang
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Curr Neurovasc Res 6:20-31. 2009
    ..One apoptotic program in particular appears to involve the activation of caspase 3, since loss of FoxO3a through gene silencing prevents the induction of caspase 3 activity by Abeta(1-42)...
  62. pmc FoxO3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis
    Yan Chen Shang
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Curr Neurovasc Res 6:223-38. 2009
    ....
  63. pmc Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation
    Jinling Hou
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Curr Neurovasc Res 7:95-112. 2010
    ....
  64. ncbi request reprint Akt1 protects against inflammatory microglial activation through maintenance of membrane asymmetry and modulation of cysteine protease activity
    Jing Qiong Kang
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci Res 74:37-51. 2003
    ..Removal of Akt1 activity abolished neuronal protection, suggesting that Akt1 functions as a critical pathway for the maintenance of cellular integrity and the prevention of phagocytic cellular removal during neurodegenerative insults...
  65. ncbi request reprint Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Prog Neurobiol 75:207-46. 2005
    ....
  66. ncbi request reprint Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 42801, USA
    J Cereb Blood Flow Metab 23:320-30. 2003
    ..Identification of novel cytoprotective pathways used by EPO may serve as therapeutic targets for cerebral vascular disease...
  67. pmc FOXO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling
    Jinling Hou
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Cell Endocrinol 321:194-206. 2010
    ..Our work identifies Akt1, FoxO3a and closely aligned pathways as key therapeutic targets during impaired glucose tolerance and DM...
  68. pmc mGluRI targets microglial activation and selectively prevents neuronal cell engulfment through Akt and caspase dependent pathways
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, 4201 St Antoine, Detroit, Michigan 48201, USA
    Curr Neurovasc Res 2:197-211. 2005
    ..Our work defines a significant role of mGluRIs for the modulation of cellular survival and inflammation in the nervous system during oxidative stress...
  69. ncbi request reprint Erythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways
    Faqi Li
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    Neurosignals 13:265-89. 2004
    ..As we continue to gain new insight into these pathways, EPO should emerge as a critical agent for the development, maturation, and survival of cells throughout the body...
  70. pmc Wnt1 neuroprotection translates into improved neurological function during oxidant stress and cerebral ischemia through AKT1 and mitochondrial apoptotic pathways
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan, USA
    Oxid Med Cell Longev 3:153-65. 2010
    ..Our work identifies Wnt1 and its downstream signaling as cellular targets with high clinical potential for novel treatment strategies for multiple disorders precipitated by oxidative stress...
  71. ncbi request reprint Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation
    Jing Qiong Kang
    Department of Neurology, 8C 1 UHC, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Mol Pharmacol 64:557-69. 2003
    ..Our work elucidates a novel capacity for Akt1 to maintain cellular integrity through a series of cysteine protease pathways and to uniquely regulate microglial activation through the modulation of membrane PS residue externalization...
  72. ncbi request reprint Angiogenesis and plasticity: role of erythropoietin in vascular systems
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Hematother Stem Cell Res 11:863-71. 2002
    ..Recognition of the multipotential attributes of EPO for vascular systems may further the progress of the development of therapeutic strategies to delay the onset of degenerative diseases...
  73. pmc Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Brain Res Brain Res Rev 49:1-21. 2005
    ....
  74. pmc Attempted cell cycle induction in post-mitotic neurons occurs in early and late apoptotic programs through Rb, E2F1, and caspase 3
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Curr Neurovasc Res 3:25-39. 2006
    ....
  75. pmc Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better?
    Zhao Zhong Chong
    Department of Neurology, 8C 1 UHC, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Curr Neurovasc Res 2:55-72. 2005
    ....
  76. pmc Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Curr Neurovasc Res 4:194-204. 2007
    ....
  77. pmc Cell Life versus cell longevity: the mysteries surrounding the NAD+ precursor nicotinamide
    Faqi Li
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Curr Med Chem 13:883-95. 2006
    ....
  78. ncbi request reprint From the editor's perspective: unlocking the secrets to cell survival and longevity
    Kenneth Maiese
    Curr Neurovasc Res 2:269-70. 2005
  79. ncbi request reprint Inflammatory glial cells of the nervous system: assistants or assassins?
    Kenneth Maiese
    Curr Neurovasc Res 2:187-8. 2005
  80. pmc Diabetic stress: new triumphs and challenges to maintain vascular longevity
    Kenneth Maiese
    Expert Rev Cardiovasc Ther 6:281-4. 2008
  81. ncbi request reprint The tyrosine phosphatase SHP2 modulates MAP kinase p38 and caspase 1 and 3 to foster neuronal survival
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cell Mol Neurobiol 23:561-78. 2003
    ..4. Our work supports the premise that the tyrosine phosphatase SHP2 plays a dominant role during NO-induced PCD and may offer a potential molecular "checkpoint" against neurodegenerative disease...
  82. ncbi request reprint AKT1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-xL and caspase 1, 3, and 9
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Exp Cell Res 296:196-207. 2004
    ..Our work elucidates the critical role of Akt1 during cellular inflammation and identifies new downstream targets of Akt1 that may offer therapeutic potential against vascular disease...
  83. pmc Vital elements of the Wnt-Frizzled signaling pathway in the nervous system
    Faqi Li
    Department of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Neurovasc Res 2:331-40. 2005
    ..Elucidation of the vital elements that shape and control the Wnt-Frizzled signaling pathway may provide significant prospects for the treatment of disorders of the nervous system...

Research Grants1

  1. Impacting Oxidative Stress and Cell Injury through Novel Pathways of the Wnt Gene
    Kenneth Maiese; Fiscal Year: 2007
    ..Through these investigations, we seek to offer innovative avenues to advance therapeutics for diseases of the CNS. ..