R D MacArthur
Affiliation: Wayne State University
- Abacavir/lamivudine combination in the treatment of HIV: a reviewGeetha Sivasubramanian
Division of Infectious Diseases, Wayne State University, Detroit, MI, USA
Ther Clin Risk Manag 6:83-94. 2010..This review will focus on the pharmacokinetics, activity, side effects, and resistance profile of both abacavir and lamivudine, including a thorough review of all of the recent studies relevant to both drugs...
- Profile of etravirine for the treatment of HIV infectionAlice Tseng
Toronto General Hospital, Toronto, ON, Canada
Ther Clin Risk Manag 6:49-58. 2010..Etravirine offers a potent sequencing option after the development of resistance to first-line NNRTIs, and is a welcome addition to this established drug class...
- Etiology and pharmacologic management of noninfectious diarrhea in HIV-infected individuals in the highly active antiretroviral therapy eraRodger D MacArthur
Division of Infectious Diseases, Wayne State University, Detroit, Michigan 48201, USA
Clin Infect Dis 55:860-7. 2012..New therapies targeting the pathogenic mechanisms of noninfectious diarrheas are needed...
- Understanding HIV phenotypic resistance testing: usefulness in managing treatment-experienced patientsRodger D MacArthur
Wayne State University School of Medicine, Division of Infectious Diseases, Detroit, Michigan 48201, USA
AIDS Rev 11:223-30. 2009..An understanding of the basic principles of phenotypic resistance testing is crucial for providing optimal care, particularly for antiretroviral-experienced patients...
- Reviews of anti-infective agents: maraviroc: the first of a new class of antiretroviral agentsRodger D MacArthur
Wayne State University, Detroit, Michigan, USA
Clin Infect Dis 47:236-41. 2008..HIV-1 mechanisms of resistance to maraviroc, assays to determine viral coreceptor use (tropism), drug safety, and clinical use of maraviroc are discussed at length...
- Darunavir: promising initial resultsRodger D MacArthur
Wayne State University, Detroit, MI 48201, USA
Lancet 369:1143-4. 2007
- Comparison of prognostic importance of latest CD4+ cell count and HIV RNA levels in patients with advanced HIV infection on highly active antiretroviral therapyRodger D MacArthur
Wayne State University, University Health Center, Detroit, Michigan 48201, USA
HIV Clin Trials 6:127-35. 2005..The comparative prognostic importance of latest plasma HIV RNA levels (viral loads) and CD4+ cell counts among patients prescribed highly active antiretroviral therapy (HAART) has not been well characterized...
- Efficacy and safety of abacavir plus lamivudine versus didanosine plus stavudine when combined with a protease inhibitor, a nonnucleoside reverse transcriptase inhibitor, or both in HIV-1 positive antiretroviral-naive personsR D MacArthur
Department of Medicine, Division of Infectious Diseases, Wayne State University, Detroit, Michigan 48201, USA
HIV Clin Trials 5:361-70. 2004....
- Adequacy of early empiric antibiotic treatment and survival in severe sepsis: experience from the MONARCS trialRodger D MacArthur
Wayne State University, Detroit, Michigan 48201, USA
Clin Infect Dis 38:284-8. 2004..001). We conclude that adequate antibiotic therapy results in a significant decrease in the crude mortality rate among patients suspected of sepsis...
- The rationale and design of the CPCRA (Terry Beirn Community Programs for Clinical Research on AIDS) 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) trialR D MacArthur
University Health Center, Wayne State University, 4201 St Antoine, UHC 7 D, Detroit, MI 48201, USA
Control Clin Trials 22:176-90. 2001..This article presents the study design, discusses the challenges we have faced in implementing the trial, and describes our preliminary experiences. Control Clin Trials 2001;22:176-190..
- An updated guide to genotype interpretationRodger D MacArthur
Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan, USA
AIDS Read 14:256-8, 261-4, 266. 2004..This report gives an update about important new developments in the area of antiretroviral resistance and provides a guide to interpreting genotype reports...
- The effects of massage therapy alone and in combination with other complementary therapies on immune system measures and quality of life in human immunodeficiency virusT J Birk
Department of Physical Therapy, College of Pharmacy and Allied Health, Wayne State University and Rehabilitation Institute of Michigan, Detroit 48207, USA
J Altern Complement Med 6:405-14. 2000....
- A self-learning fuzzy discrete event system for HIV/AIDS treatment regimen selectionHao Ying
Department of Electrical and Computer Engineering, Wayne State University, Detroit, MI 48202, USA
IEEE Trans Syst Man Cybern B Cybern 37:966-79. 2007..This learning and prediction approach, as well as our original FDESs theory, is general purpose and can be applied to other medical or nonmedical problems...
- Mild-to-moderate symptoms during the first year of antiretroviral therapy worsen quality of life in HIV-infected individualsSharon B Mannheimer
Division of Infectious Diseases, Harlem Hospital Center, New York, New York, USA
Clin Infect Dis 46:941-5. 2008..Quality of life was inversely related to the number of symptoms and in the change in the number of symptoms from baseline...
- A fuzzy discrete event system approach to determining optimal HIV/AIDS treatment regimensHao Ying
Department of Electrical and Computer Engineering, Wayne State University, Detroit, MI 48202, USA
IEEE Trans Inf Technol Biomed 10:663-76. 2006..These are practically important features to medical applications in general, and HIV/AIDS treatment in particular, as national HIV/AIDS treatment guidelines are modified several times per year...
- Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levelsEdward A Panacek
Department of Medicine, University of California Davis Medical Center, Sacramento, CA, USA
Crit Care Med 32:2173-82. 2004..To evaluate whether administration of afelimomab, an anti-tumor necrosis factor F(ab')2 monoclonal antibody fragment, would reduce 28-day all-cause mortality in patients with severe sepsis and elevated serum levels of IL-6...
- A comparison of three highly active antiretroviral treatment strategies consisting of non-nucleoside reverse transcriptase inhibitors, protease inhibitors, or both in the presence of nucleoside reverse transcriptase inhibitors as initial therapy (CPCRA 05Rodger D MacArthur
Wayne State University, Detroit, MI, USA
Lancet 368:2125-35. 2006..Here, we report results from the FIRST trial, which compared initial treatment strategies for clinical, immunological, and virological outcomes...
- Effects of Mycobacterium avium complex-infection treatment on cytokine expression in human immunodeficiency virus-infected persons: results of AIDS clinical trials group protocol 853R D MacArthur
Wayne State University, Department of Medicine, Division of Infectious Diseases, Detroit, MI 48201, USA
J Infect Dis 181:1486-90. 2000..Nonsignificant decreases in plasma levels of TNF-alpha, IL-1beta, IL-6, and HIV RNA were also seen in those individuals who remained on stable antiretroviral therapy throughout the 8 weeks of the study...
- Discordance between viral loads determined by Roche COBAS AMPLICOR human immunodeficiency virus type 1 monitor (version 1.5) Standard and ultrasensitive assays caused by freezing patient plasma in centrifuged becton-dickinson vacutainer brand plasma prepaHossein Salimnia
Department of Pathology, Detroit, MI 48201, USA
J Clin Microbiol 43:4635-9. 2005..If the plasma was transferred from the centrifuged plasma preparation tubes before freezing, standard and ultrasensitive results were concordant with each other and with values determined on plasma from lavender-topped EDTA tubes...
- Aerobic exercise training fails to lower hypertriglyceridemia levels in persons with advanced HIV-1 infectionThomas J Birk
Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA
J Assoc Nurses AIDS Care 13:20-4. 2002..The results suggest that long-term exercise training cannot correct lipid profile abnormality, particularly hypertriglyceridemia, common to individuals with advanced HIV-1 infection...
- Multicenter evaluation of a human monoclonal antibody to Enterobacteriaceae common antigen in patients with Gram-negative sepsisTimothy E Albertson
Department of Medicine, University of California, Davis, Sacramento, USA
Crit Care Med 31:419-27. 2003....
- Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivityWilliam M O'Neil
Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48202, USA
J Clin Pharmacol 42:613-9. 2002....
- Repair type I aortic dissection in a patient with human immunodeficiency virus infectionFrank A Baciewicz
Department of Cardiothoracic Surgery, Harper University Hospital, Wayne State University, Detroit, Michigan 48201, USA
Ann Thorac Surg 76:917-9. 2003..The thoracic and abdominal aorta diameters have remained stable. Select patients with type I aortic dissection and HIV infection are candidates for surgical repair...
- Prevalence and impact of HIV-1 protease codon 33 mutations and polymorphisms in treatment-naive and treatment-experienced patientsMichael J Kozal
Yale University Et VA CT Healthcare System, New Haven, CT, USA
Antivir Ther 11:457-63. 2006..Little is known about the difference in prevalence of codon 33 mutations and polymorphisms between treatment-naive and treatment-experienced patients, and the effect of codon 33F on PI phenotypic resistance patterns...
- A randomized clinical trial comparing nelfinavir and ritonavir in patients with advanced HIV disease (CPCRA 042/CTN 102)George Perez
North Jersey Community Research Initiative, Newark, NJ 07103, USA
HIV Clin Trials 5:7-18. 2004..To compare the long-term clinical efficacy and toxicity of initial strategies of nelfinavir (NFV) or ritonavir (RTV) in patients with CD4+ cells below 200/mm3...
- Prevalence of antiretroviral drug resistance mutations in chronically HIV-infected, treatment-naive patients: implications for routine resistance screening before initiation of antiretroviral therapyRichard M Novak
University of Illinois, Chicago, IL 60612, USA
Clin Infect Dis 40:468-74. 2005..However, it is unclear to what extent these mutations persist in chronically infected, treatment-naive patients...
- Episodic antiretroviral therapy increases HIV transmission risk compared with continuous therapy: results of a randomized controlled trialWilliam Burman
Denver Public Health, 605 Bannock Street, Denver, CO 80204, USA
J Acquir Immune Defic Syndr 49:142-50. 2008..To compare the HIV transmission risk among patients randomized to episodic versus continuous antiretroviral therapy...
- Poor initial CD4+ recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseasesJason V Baker
Department of Biostatistics, University of Minnesota, Minneapolis, MN, USA
J Acquir Immune Defic Syndr 48:541-6. 2008..Low CD4+ increases risk for both AIDS- and non-AIDS-related morbidity and mortality. The magnitude of CD4+ recovery early after initial antiretroviral therapy (ART) is important in the ultimate duration of immune depletion...
- CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infectionJason V Baker
University of Minnesota, Minneapolis, USA
AIDS 22:841-8. 2008..Reductions in AIDS-related morbidity and mortality following the advent of combination antiretroviral therapy have coincided with relative increases in chronic non-AIDS end-organ diseases among HIV+ patients...
- Differential adherence to combination antiretroviral therapy is associated with virological failure with resistanceEdward M Gardner
Denver Public Health, Denver, Colorado 80204, USA
AIDS 22:75-82. 2008..To investigate the occurrence of differential adherence to components of combination antiretroviral therapy and assess its predictors and association with virological failure and antiretroviral medication resistance...
- The Incidence of HIV drug resistance and its impact on progression of HIV disease among antiretroviral-naïve participants started on three different antiretroviral therapy strategiesMichael J Kozal
Yale University School of Medicine and VA CT Healthcare System, New Haven, Connecticut 06510, USA
HIV Clin Trials 8:357-70. 2007..The strategies were compared for drug resistance at first virologic failure (VF; HIV RNA >1000 copies/mL). The impact of resistance on AIDS or death was determined...
- Beta-glucuronidase activity in patients infected with HIVWilliam M O'Neil
AIDS 17:269-70. 2003
- Antibody to enterobacterial common antigen and gram-negative sepsisPaul Bayardelle
Crit Care Med 32:617-8. 2004