Jeffery A Loeb

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi Accuracy of cDNA microarray methods to detect small gene expression changes induced by neuregulin on breast epithelial cells
    Bin Yao
    Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA
    BMC Bioinformatics 5:99. 2004
  2. ncbi Expression patterns of transmembrane and released forms of neuregulin during spinal cord and neuromuscular synapse development
    J A Loeb
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Development 126:781-91. 1999
  3. ncbi A human systems biology approach to discover new drug targets in epilepsy
    Jeffery A Loeb
    Department of Neurology, Wayne State University School of Medicine, Center for Molecular Medicine and Genetics, Detroit, Michigan, USA
    Epilepsia 51:171-7. 2010
  4. ncbi Neuroprotection and repair by neurotrophic and gliotrophic factors in multiple sclerosis
    Jeffrey A Loeb
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurology 68:S38-42; discussion S43-54. 2007
  5. ncbi Brain calcifications induce neurological dysfunction that can be reversed by a bone drug
    Jeffrey A Loeb
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    J Neurol Sci 243:77-81. 2006
  6. ncbi Identifying targets for preventing epilepsy using systems biology
    Jeffrey A Loeb
    Department of Neurology and The Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, United States
    Neurosci Lett 497:205-12. 2011
  7. ncbi Neuregulin expression at neuromuscular synapses is modulated by synaptic activity and neurotrophic factors
    Jeffrey A Loeb
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci 22:2206-14. 2002
  8. ncbi Neuregulin: an activity-dependent synaptic modulator at the neuromuscular junction
    Jeffrey A Loeb
    Department of Neurology and The Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Neurocytol 32:649-64. 2003
  9. ncbi Synergistic effects of neuregulin and agrin on muscle acetylcholine receptor expression
    Qunfang Li
    Department of Neurology and The Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Cell Neurosci 26:558-69. 2004
  10. ncbi Development of an autocrine neuregulin signaling loop with malignant transformation of human breast epithelial cells
    Qunfang Li
    Department of Neurology and Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 64:7078-85. 2004

Research Grants

  1. Activity-Dependent Gene Expression in Human Epilepsy
    JEFFREY LOEB; Fiscal Year: 2003
  2. Activity-Dependent Gene Expression in Human Epilepsy
    JEFFREY LOEB; Fiscal Year: 2006
  3. Electrical, Molecular and Clinical Correlates of Human Interictal Spiking
    Jeffrey A Loeb; Fiscal Year: 2010
  4. Soluble Neuregulins in Neuromuscular and Peripheral Nerve Development
    Jeffrey A Loeb; Fiscal Year: 2010
  5. Activity-Dependent Gene Expression in Human Epilepsy
    Jeffrey A Loeb; Fiscal Year: 2010

Collaborators

Detail Information

Publications21

  1. ncbi Accuracy of cDNA microarray methods to detect small gene expression changes induced by neuregulin on breast epithelial cells
    Bin Yao
    Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA
    BMC Bioinformatics 5:99. 2004
    ....
  2. ncbi Expression patterns of transmembrane and released forms of neuregulin during spinal cord and neuromuscular synapse development
    J A Loeb
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Development 126:781-91. 1999
    ....
  3. ncbi A human systems biology approach to discover new drug targets in epilepsy
    Jeffery A Loeb
    Department of Neurology, Wayne State University School of Medicine, Center for Molecular Medicine and Genetics, Detroit, Michigan, USA
    Epilepsia 51:171-7. 2010
    ....
  4. ncbi Neuroprotection and repair by neurotrophic and gliotrophic factors in multiple sclerosis
    Jeffrey A Loeb
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurology 68:S38-42; discussion S43-54. 2007
    ....
  5. ncbi Brain calcifications induce neurological dysfunction that can be reversed by a bone drug
    Jeffrey A Loeb
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    J Neurol Sci 243:77-81. 2006
    ....
  6. ncbi Identifying targets for preventing epilepsy using systems biology
    Jeffrey A Loeb
    Department of Neurology and The Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, United States
    Neurosci Lett 497:205-12. 2011
    ..Most importantly, epileptogenic targets need to be validated in animal models of epileptogenesis, so that, if successful, these new methods have the potential to identify unbiased, important new therapeutics...
  7. ncbi Neuregulin expression at neuromuscular synapses is modulated by synaptic activity and neurotrophic factors
    Jeffrey A Loeb
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci 22:2206-14. 2002
    ..These findings suggest a local, positive feedback loop between synaptic regulatory factors that translates activity into structural changes at neuromuscular synapses...
  8. ncbi Neuregulin: an activity-dependent synaptic modulator at the neuromuscular junction
    Jeffrey A Loeb
    Department of Neurology and The Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Neurocytol 32:649-64. 2003
    ....
  9. ncbi Synergistic effects of neuregulin and agrin on muscle acetylcholine receptor expression
    Qunfang Li
    Department of Neurology and The Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Cell Neurosci 26:558-69. 2004
    ....
  10. ncbi Development of an autocrine neuregulin signaling loop with malignant transformation of human breast epithelial cells
    Qunfang Li
    Department of Neurology and Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 64:7078-85. 2004
    ....
  11. ncbi Rapid axoglial signaling mediated by neuregulin and neurotrophic factors
    Raymond M Esper
    Department of Neurology, Wayne State University, Detroit, Michigan 48201, USA
    J Neurosci 24:6218-27. 2004
    ....
  12. ncbi Asymmetric flaccid paralysis: a neuromuscular presentation of West Nile virus infection
    Jun Li
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Ann Neurol 53:703-10. 2003
    ..It will be important for physicians to consider WNV infection in patients with acute asymmetric paralysis with or without encephalitic symptoms...
  13. ncbi Neurotrophins induce neuregulin release through protein kinase Cdelta activation
    Raymond M Esper
    Department of Neurology, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 284:26251-60. 2009
    ..These findings implicate this specific PKC isoform as an important factor for the cleavage and neurotrophin-regulated release of soluble NRG1 forms that have important effects in nervous system development and disease...
  14. ncbi Targeting human epidermal growth factor receptor signaling with the neuregulin's heparin-binding domain
    Zhenzhong Ma
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 284:32108-15. 2009
    ..These findings demonstrate the utility of the HBD of NRG in biopharmaceutical targeting and provide a new way to block HER signaling in cancer cells...
  15. ncbi Differential distribution of neuregulin in human brain and spinal fluid
    Mark S Pankonin
    Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA
    Brain Res 1258:1-11. 2009
    ....
  16. ncbi A common pattern of persistent gene activation in human neocortical epileptic foci
    Sanjay N Rakhade
    Center for Molecular Medicine and Genetics, Detroit, MI 48201, USA
    Ann Neurol 58:736-47. 2005
    ....
  17. ncbi Neuregulins: versatile growth and differentiation factors in nervous system development and human disease
    Raymond M Esper
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    Brain Res Rev 51:161-75. 2006
    ..Here, we review the basic biology of neuregulins and relate this to research suggesting their involvement with and potential therapeutic uses for neurological disorders...
  18. ncbi Activity-dependent gene expression correlates with interictal spiking in human neocortical epilepsy
    Sanjay N Rakhade
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 48:86-95. 2007
    ....
  19. ncbi Specific structural features of heparan sulfate proteoglycans potentiate neuregulin-1 signaling
    Mark S Pankonin
    Department of Neurology, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 280:383-8. 2005
    ..These results suggest that the regulation of glycosaminoglycan sulfation is an important biological mechanism that can modulate both the localization and potentiation of neuregulin-1 signaling...
  20. ncbi Neuregulin-1 type III determines the ensheathment fate of axons
    Carla Taveggia
    Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Neuron 47:681-94. 2005
    ..These results indicate that levels of NRG1 type III, independent of axon diameter, provide a key instructive signal that determines the ensheathment fate of axons...
  21. ncbi NT-3 and CNTF exert dose-dependent, pleiotropic effects on cells in the immature dorsal root ganglion: neuregulin-mediated proliferation of progenitor cells and neuronal differentiation
    Sharon J Hapner
    Department of Cell Biology and Neuroscience, Montana State University, Bozeman, MT 59717, USA
    Dev Biol 297:182-97. 2006
    ..Thus, the genesis and differentiation of neurons and glia in the DRG are dependent upon reciprocal interactions among nascent neurons, glia, and mitotically active progenitor cells...

Research Grants10

  1. Activity-Dependent Gene Expression in Human Epilepsy
    JEFFREY LOEB; Fiscal Year: 2003
    ..abstract_text> ..
  2. Activity-Dependent Gene Expression in Human Epilepsy
    JEFFREY LOEB; Fiscal Year: 2006
    ..abstract_text> ..
  3. Electrical, Molecular and Clinical Correlates of Human Interictal Spiking
    Jeffrey A Loeb; Fiscal Year: 2010
    ....
  4. Soluble Neuregulins in Neuromuscular and Peripheral Nerve Development
    Jeffrey A Loeb; Fiscal Year: 2010
    ..Our studies also test a more general 'targeting'system we invented that effectively delivers therapeutics to specific cell types through their unique heparan sulfate composition. ..
  5. Activity-Dependent Gene Expression in Human Epilepsy
    Jeffrey A Loeb; Fiscal Year: 2010
    ..abstract_text> ..