Robert P Lisak

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi The role of B cell-activating factor in autoimmune myasthenia gravis
    Robert P Lisak
    Departments of Neurology, and Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Ann N Y Acad Sci 1274:60-7. 2012
  2. ncbi Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro
    Robert P Lisak
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    J Neuroimmunol 246:85-95. 2012
  3. ncbi Cytokines regulate neuronal gene expression: differential effects of Th1, Th2 and monocyte/macrophage cytokines
    Robert P Lisak
    Department of Neurology, Wayne State University, MI 48201, USA
    J Neuroimmunol 238:19-33. 2011
  4. ncbi Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures
    Robert P Lisak
    Department of Neurology, 8D University Health Center, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI, 48210, USA
    J Neuroinflammation 6:4. 2009
  5. ncbi Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for glial and neural-related molecules in central nervous system mixed glial cell cultures: neurotrophins, growth factors and structural proteins
    Robert P Lisak
    Department of Neurology, 8D University Health Center, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48210, USA
    J Neuroinflammation 4:30. 2007
  6. ncbi Neurodegeneration in multiple sclerosis: defining the problem
    Robert P Lisak
    Division of Neuroimmunology, Department of Neurology, Wayne State University School of Medicine and the Detroit Medical Center, Detroit, Michigan 48201, USA
    Neurology 68:S5-12; discussion S43-54. 2007
  7. ncbi Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures
    R P Lisak
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    Mult Scler 12:149-68. 2006
  8. ncbi Secretory products of central nervous system glial cells induce Schwann cell proliferation and protect from cytokine-mediated death
    Robert P Lisak
    Departments of Neurology and Immunology and Microbiology, Wayne State University Schoolof Medicine, Detroit, Michigan, USA
    J Neurosci Res 83:1425-31. 2006
  9. ncbi Cytokines decrease expression of interleukin-6 signal transducer and leptin receptor in central nervous system glia
    Jason J Rose
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci Res 87:3098-106. 2009
  10. ncbi Myasthenia gravis patients, but not healthy subjects, recognize epitopes that are unique to the epsilon-subunit of the acetylcholine receptor
    Samia Ragheb
    Department of Neurology and Immunology, Wayne State University School of Medicine, 3128 Elliman Building, 421 East Canfield Ave, Detroit, Michigan 42801, USA
    J Neuroimmunol 159:137-45. 2005

Collaborators

Detail Information

Publications33

  1. ncbi The role of B cell-activating factor in autoimmune myasthenia gravis
    Robert P Lisak
    Departments of Neurology, and Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Ann N Y Acad Sci 1274:60-7. 2012
    ..While the exact role of BAFF in the pathogenesis of myasthenia gravis is not clear, BAFF and its receptors may provide potential targets for therapy in patients with myasthenia gravis...
  2. ncbi Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro
    Robert P Lisak
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    J Neuroimmunol 246:85-95. 2012
    ..It is possible that such factors produced by peripheral blood B cells when within the CNS could contribute to demyelination in MS patients...
  3. ncbi Cytokines regulate neuronal gene expression: differential effects of Th1, Th2 and monocyte/macrophage cytokines
    Robert P Lisak
    Department of Neurology, Wayne State University, MI 48201, USA
    J Neuroimmunol 238:19-33. 2011
    ....
  4. ncbi Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures
    Robert P Lisak
    Department of Neurology, 8D University Health Center, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI, 48210, USA
    J Neuroinflammation 6:4. 2009
    ..Cytokines secreted by immune cells and activated glia play central roles in both the pathogenesis of and protection from damage to the central nervous system (CNS) in multiple sclerosis (MS)...
  5. ncbi Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for glial and neural-related molecules in central nervous system mixed glial cell cultures: neurotrophins, growth factors and structural proteins
    Robert P Lisak
    Department of Neurology, 8D University Health Center, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48210, USA
    J Neuroinflammation 4:30. 2007
    ..We propose that cytokine mixtures typical of Th1 or Th2 lymphocytes, or monocyte/macrophages each induce unique molecular changes in glial cells...
  6. ncbi Neurodegeneration in multiple sclerosis: defining the problem
    Robert P Lisak
    Division of Neuroimmunology, Department of Neurology, Wayne State University School of Medicine and the Detroit Medical Center, Detroit, Michigan 48201, USA
    Neurology 68:S5-12; discussion S43-54. 2007
    ..Some of the complexities involved in cellular interactions in the normal-appearing and obviously affected CNS are reviewed here as a starting point for the consideration of approaches to neuroprotective strategies...
  7. ncbi Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures
    R P Lisak
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    Mult Scler 12:149-68. 2006
    ....
  8. ncbi Secretory products of central nervous system glial cells induce Schwann cell proliferation and protect from cytokine-mediated death
    Robert P Lisak
    Departments of Neurology and Immunology and Microbiology, Wayne State University Schoolof Medicine, Detroit, Michigan, USA
    J Neurosci Res 83:1425-31. 2006
    ....
  9. ncbi Cytokines decrease expression of interleukin-6 signal transducer and leptin receptor in central nervous system glia
    Jason J Rose
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci Res 87:3098-106. 2009
    ....
  10. ncbi Myasthenia gravis patients, but not healthy subjects, recognize epitopes that are unique to the epsilon-subunit of the acetylcholine receptor
    Samia Ragheb
    Department of Neurology and Immunology, Wayne State University School of Medicine, 3128 Elliman Building, 421 East Canfield Ave, Detroit, Michigan 42801, USA
    J Neuroimmunol 159:137-45. 2005
    ..Differences between the epsilon- and gamma-chains may be important in the development of MG, because only MG patients respond to epitopes that are unique to the epsilon-subunit...
  11. ncbi Cytokines reduce toxic effects of ethanol on oligodendroglia
    Joyce A Benjamins
    Department of Neurology, Wayne State University School of Medicine, 1228 Elliman Building, 421 E Canfield Ave, Detroit, MI 48201, USA
    Neurochem Res 36:1677-86. 2011
    ..We conclude that cytokines can act either directly on OL or indirectly through effects on astroglia or microglia to protect OL from ethanol toxicity...
  12. ncbi Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis
    Bin Zhang
    Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, 1120 15th St, Augusta, GA 30912, USA
    Arch Neurol 69:445-51. 2012
    ....
  13. ncbi A prospective, open-label treatment trial to compare the effect of IFNbeta-1a (Avonex), IFNbeta-1b (Betaseron), and glatiramer acetate (Copaxone) on the relapse rate in relapsing--remitting multiple sclerosis: results after 18 months of therapy
    O A Khan
    Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Mult Scler 7:349-53. 2001
    ..106) who did not show a significant reduction. Despite limitations of the study design, the results provide helpful clinical information regarding the relative efficacy of each therapy in mildly affected treatment naive RRMS patients...
  14. ncbi A mouse embryonic stem cell model of Schwann cell differentiation for studies of the role of neurofibromatosis type 1 in Schwann cell development and tumor formation
    Therese M Roth
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Glia 55:1123-33. 2007
    ....
  15. ncbi Distinct immune regulation of the response to H-2b restricted epitope of MOG causes relapsing-remitting EAE in H-2b/s mice
    Dusanka S Skundric
    Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, 421 E Canfield, 3141 Elliman Building, Detroit, MI 48201, USA
    J Neuroimmunol 136:34-45. 2003
    ..Distinct patterns of inflammation and demyelination, MOG(35-55) memory T cell response and regulation of MCP-1 are associated with relapsing H-2(b/s) phenotype...
  16. ncbi Activation of IL-1 signaling pathway in Schwann cells during diabetic neuropathy
    Dusanka S Skundric
    Division of Neuroimmunology, Department of Neurology, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA
    Ann N Y Acad Sci 958:393-8. 2002
    ..Our results show activation of the IL-1 signaling pathway in Schwann cells (SC), prior to and during early stages of diabetic neuropathy, thus suggesting its role in the initiation of SC-axonal miscommunication...
  17. ncbi Schwann cell-specific regulation of IL-1 and IL-1Ra during EAN: possible relevance for immune regulation at paranodal regions
    D S Skundric
    Department of Neurology, Division of Neuroimmunology, School of Medicine, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA
    J Neuroimmunol 116:74-82. 2001
    ..Paranodes are also primary sites where activated macrophages make contact with SC, prior to infiltration.SC-specific autoregulation of IL-1 and IL-1Ra is suggestive of its relevance for immune regulation at paranodes during EAN...
  18. ncbi Expression of urokinase plasminogen activator receptor on monocytes from patients with relapsing-remitting multiple sclerosis: effect of glatiramer acetate (copolymer 1)
    R Balabanov
    Multiple Sclerosis Clinical Research Center, Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, Michigan 48201, USA
    Clin Diagn Lab Immunol 8:1196-203. 2001
    ..Results indicate that monocyte activation is impatient in MS and that glatiramer acetate may have a significant effect on monocyte activation in patients with RRMS...
  19. ncbi Multiple sclerosis: therapeutic update
    A C Tselis
    Department of Neurology, Wayne State University School of Medicine, Detroit Medical Center, Mich, USA
    Arch Neurol 56:277-80. 1999
    ..Although much is known about the pathogenesis, there is no cure and the disease must be managed long-term. Recently, there have been a number of advances in the treatment of MS...
  20. ncbi A prospective, open-label treatment trial to compare the effect of IFN beta-1a (Avonex), IFNbeta-1b (Betaseron), and glatiramer acetate (Copaxone) on the relapse rate in relapsing-remitting multiple sclerosis
    O A Khan
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    Eur J Neurol 8:141-8. 2001
    ..Despite some limitations of the study design, the results provide helpful clinical information regarding the relative efficacy of each therapy in mildly affected treatment-naïve RRMS patients...
  21. ncbi Role of neuropoietic cytokines in development and progression of diabetic polyneuropathy: from glucose metabolism to neurodegeneration
    Dusanka S Skundric
    Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, Detroit Medical Centre, Detroit, Michigan 48201, USA
    Exp Diabesity Res 4:303-12. 2003
    ..Moreover, their regulatory roles in nerve degeneration and regeneration may potentially be utilized for the prevention and/or therapy of diabetic neuropathy...
  22. ncbi Approaches to neuroprotective strategies in multiple sclerosis
    Alex Tselis
    Wayne State University, Division of Neuroimmunology, Department of Neurology, Detroit, MI 48201, USA
    Expert Opin Pharmacother 11:2869-78. 2010
    ..Multiple sclerosis (MS) is a neurologic disease that is the most common nontraumatic cause of serious disability in young adults...
  23. ncbi Other demyelinating diseases
    Alex C Tselis
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Adv Neurol 98:335-49. 2006
  24. ncbi Differences between the epsilon and gamma subunits of the acetylcholine receptor (AChR) may be significant in autoimmune myasthenia gravis
    Samia Ragheb
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Ann N Y Acad Sci 998:336-8. 2003
  25. ncbi Myasthenic crisis: guidelines for prevention and treatment
    Agnes Jani Acsadi
    Department of Neurology, Wayne State University, Detroit, MI, USA
    J Neurol Sci 261:127-33. 2007
    ..Every effort should be done to prevent myasthenic exacerbation/crisis and to develop a maintenance management that leads to effective prevention...
  26. ncbi Adoptive transfer of myelin basic protein-induced experimental autoimmune encephalomyelitis between SJL and B10.S mice: correlation of priming milieus with susceptibility and resistance phenotypes
    Fei Chen
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Neuroimmunol 173:146-54. 2006
    ..S)F1 recipients failed to induce EAE. These results are consistent with the notion that the priming milieus in the donor mice affect the expression of susceptible and resistant phenotypes...
  27. ncbi Myasthenia gravis
    Agnes Jani-Acsadi
    Department of Neurology, Neuromuscular Division, Wayne State University, School of Medicine, 8A University Health Center, 4201 St Antoine, Detroit, MI, 48201, USA
    Curr Treat Options Neurol 12:231-43. 2010
    ..Acute management of myasthenic crisis requires intensive monitoring of the patient and institution of an efficient and safe treatment such as plasma exchange. Patient education is essential to a comprehensive long-term treatment plan...
  28. ncbi B-cell-activating factor and autoimmune myasthenia gravis
    Samia Ragheb
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Autoimmune Dis 2011:939520. 2011
    ..BAFF may play an important role in the pathogenesis of MG. BAFF antagonists may well provide new treatment options for MG patients, particularly those patients with thymic lymphoid follicular hyperplasia...
  29. ncbi Effect of monthly intravenous cyclophosphamide in rapidly deteriorating multiple sclerosis patients resistant to conventional therapy
    O A Khan
    Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, USA
    Mult Scler 7:185-8. 2001
    ..Therapy with CTX was well tolerated. CTX may be of benefit in MS patients who experience rapid clinical worsening and are resistant to conventional therapy...
  30. ncbi Interferon-gamma, tumor necrosis factor-alpha, and transforming growth factor-beta inhibit cyclic AMP-induced Schwann cell differentiation
    R P Lisak
    Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Glia 36:354-63. 2001
    ..The other cytokines had no effects on Gal or NGFRp75 expression. Thus, these three cytokines, which are present in inflammatory lesions in the peripheral nervous system, are capable of inhibiting Schwann cell differentiation...
  31. ncbi Predictors of well-being among significant others of persons with multiple sclerosis
    T E Sherman
    Department of Rehabilitation Psychology and Neuropsychology, Rehabilitation Institute of Michigan, Detroit, MI 48201, USA
    Mult Scler 13:238-49. 2007
    ..To examine patient and significant other characteristics as predictors of significant other well-being...
  32. ncbi Intercaudate nucleus ratio as a linear measure of brain atrophy in multiple sclerosis
    C Caon
    Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Neurology 60:323-5. 2003
    ..67; p = 0.0001) and disease duration (r = 0.32; p < 0.01). Intercaudate ratio appears to be a reliable and reproducible linear measure of brain atrophy and correlates with disability and disease duration in MS...
  33. ncbi "Rebooting" the immune system with cyclophosphamide: taking risks for a "cure"?
    Richard A Lewis
    Ann Neurol 53:7-9. 2003