Robert P Lisak

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc B-cell-activating factor and autoimmune myasthenia gravis
    Samia Ragheb
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Autoimmune Dis 2011:939520. 2011
  2. doi request reprint The role of B cell-activating factor in autoimmune myasthenia gravis
    Robert P Lisak
    Departments of Neurology, and Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Ann N Y Acad Sci 1274:60-7. 2012
  3. doi request reprint Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro
    Robert P Lisak
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    J Neuroimmunol 246:85-95. 2012
  4. ncbi request reprint Secretory products of central nervous system glial cells induce Schwann cell proliferation and protect from cytokine-mediated death
    Robert P Lisak
    Departments of Neurology and Immunology and Microbiology, Wayne State University Schoolof Medicine, Detroit, Michigan, USA
    J Neurosci Res 83:1425-31. 2006
  5. doi request reprint Cytokines regulate neuronal gene expression: differential effects of Th1, Th2 and monocyte/macrophage cytokines
    Robert P Lisak
    Department of Neurology, Wayne State University, MI 48201, USA
    J Neuroimmunol 238:19-33. 2011
  6. pmc Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures
    Robert P Lisak
    Department of Neurology, 8D University Health Center, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI, 48210, USA
    J Neuroinflammation 6:4. 2009
  7. ncbi request reprint Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures
    R P Lisak
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    Mult Scler 12:149-68. 2006
  8. pmc Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for glial and neural-related molecules in central nervous system mixed glial cell cultures: neurotrophins, growth factors and structural proteins
    Robert P Lisak
    Department of Neurology, 8D University Health Center, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48210, USA
    J Neuroinflammation 4:30. 2007
  9. ncbi request reprint Neurodegeneration in multiple sclerosis: defining the problem
    Robert P Lisak
    Division of Neuroimmunology, Department of Neurology, Wayne State University School of Medicine and the Detroit Medical Center, Detroit, Michigan 48201, USA
    Neurology 68:S5-12; discussion S43-54. 2007
  10. doi request reprint Cytokines decrease expression of interleukin-6 signal transducer and leptin receptor in central nervous system glia
    Jason J Rose
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci Res 87:3098-106. 2009

Collaborators

Detail Information

Publications38

  1. pmc B-cell-activating factor and autoimmune myasthenia gravis
    Samia Ragheb
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Autoimmune Dis 2011:939520. 2011
    ..BAFF may play an important role in the pathogenesis of MG. BAFF antagonists may well provide new treatment options for MG patients, particularly those patients with thymic lymphoid follicular hyperplasia...
  2. doi request reprint The role of B cell-activating factor in autoimmune myasthenia gravis
    Robert P Lisak
    Departments of Neurology, and Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Ann N Y Acad Sci 1274:60-7. 2012
    ..While the exact role of BAFF in the pathogenesis of myasthenia gravis is not clear, BAFF and its receptors may provide potential targets for therapy in patients with myasthenia gravis...
  3. doi request reprint Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro
    Robert P Lisak
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    J Neuroimmunol 246:85-95. 2012
    ..It is possible that such factors produced by peripheral blood B cells when within the CNS could contribute to demyelination in MS patients...
  4. ncbi request reprint Secretory products of central nervous system glial cells induce Schwann cell proliferation and protect from cytokine-mediated death
    Robert P Lisak
    Departments of Neurology and Immunology and Microbiology, Wayne State University Schoolof Medicine, Detroit, Michigan, USA
    J Neurosci Res 83:1425-31. 2006
    ....
  5. doi request reprint Cytokines regulate neuronal gene expression: differential effects of Th1, Th2 and monocyte/macrophage cytokines
    Robert P Lisak
    Department of Neurology, Wayne State University, MI 48201, USA
    J Neuroimmunol 238:19-33. 2011
    ....
  6. pmc Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures
    Robert P Lisak
    Department of Neurology, 8D University Health Center, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI, 48210, USA
    J Neuroinflammation 6:4. 2009
    ..Cytokines secreted by immune cells and activated glia play central roles in both the pathogenesis of and protection from damage to the central nervous system (CNS) in multiple sclerosis (MS)...
  7. ncbi request reprint Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures
    R P Lisak
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    Mult Scler 12:149-68. 2006
    ....
  8. pmc Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for glial and neural-related molecules in central nervous system mixed glial cell cultures: neurotrophins, growth factors and structural proteins
    Robert P Lisak
    Department of Neurology, 8D University Health Center, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48210, USA
    J Neuroinflammation 4:30. 2007
    ..We propose that cytokine mixtures typical of Th1 or Th2 lymphocytes, or monocyte/macrophages each induce unique molecular changes in glial cells...
  9. ncbi request reprint Neurodegeneration in multiple sclerosis: defining the problem
    Robert P Lisak
    Division of Neuroimmunology, Department of Neurology, Wayne State University School of Medicine and the Detroit Medical Center, Detroit, Michigan 48201, USA
    Neurology 68:S5-12; discussion S43-54. 2007
    ..Some of the complexities involved in cellular interactions in the normal-appearing and obviously affected CNS are reviewed here as a starting point for the consideration of approaches to neuroprotective strategies...
  10. doi request reprint Cytokines decrease expression of interleukin-6 signal transducer and leptin receptor in central nervous system glia
    Jason J Rose
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci Res 87:3098-106. 2009
    ....
  11. doi request reprint ACTH protects mature oligodendroglia from excitotoxic and inflammation-related damage in vitro
    Joyce A Benjamins
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Glia 61:1206-17. 2013
    ..In summary, ACTH 1-39 protects OL in vitro from several excitotoxic and inflammation-related insults. ACTH may be activating melanocortin receptors on OL or alternately on AS or MG to prevent OL death...
  12. ncbi request reprint Myasthenia gravis patients, but not healthy subjects, recognize epitopes that are unique to the epsilon-subunit of the acetylcholine receptor
    Samia Ragheb
    Department of Neurology and Immunology, Wayne State University School of Medicine, 3128 Elliman Building, 421 East Canfield Ave, Detroit, Michigan 42801, USA
    J Neuroimmunol 159:137-45. 2005
    ..Differences between the epsilon- and gamma-chains may be important in the development of MG, because only MG patients respond to epitopes that are unique to the epsilon-subunit...
  13. ncbi request reprint Cytokines reduce toxic effects of ethanol on oligodendroglia
    Joyce A Benjamins
    Department of Neurology, Wayne State University School of Medicine, 1228 Elliman Building, 421 E Canfield Ave, Detroit, MI 48201, USA
    Neurochem Res 36:1677-86. 2011
    ..We conclude that cytokines can act either directly on OL or indirectly through effects on astroglia or microglia to protect OL from ethanol toxicity...
  14. doi request reprint Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis
    Bin Zhang
    Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, 1120 15th St, Augusta, GA 30912, USA
    Arch Neurol 69:445-51. 2012
    ....
  15. ncbi request reprint A prospective, open-label treatment trial to compare the effect of IFNbeta-1a (Avonex), IFNbeta-1b (Betaseron), and glatiramer acetate (Copaxone) on the relapse rate in relapsing--remitting multiple sclerosis: results after 18 months of therapy
    O A Khan
    Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Mult Scler 7:349-53. 2001
    ..106) who did not show a significant reduction. Despite limitations of the study design, the results provide helpful clinical information regarding the relative efficacy of each therapy in mildly affected treatment naive RRMS patients...
  16. ncbi request reprint A mouse embryonic stem cell model of Schwann cell differentiation for studies of the role of neurofibromatosis type 1 in Schwann cell development and tumor formation
    Therese M Roth
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Glia 55:1123-33. 2007
    ....
  17. ncbi request reprint Distinct immune regulation of the response to H-2b restricted epitope of MOG causes relapsing-remitting EAE in H-2b/s mice
    Dusanka S Skundric
    Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, 421 E Canfield, 3141 Elliman Building, Detroit, MI 48201, USA
    J Neuroimmunol 136:34-45. 2003
    ..Distinct patterns of inflammation and demyelination, MOG(35-55) memory T cell response and regulation of MCP-1 are associated with relapsing H-2(b/s) phenotype...
  18. ncbi request reprint Activation of IL-1 signaling pathway in Schwann cells during diabetic neuropathy
    Dusanka S Skundric
    Division of Neuroimmunology, Department of Neurology, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA
    Ann N Y Acad Sci 958:393-8. 2002
    ..Our results show activation of the IL-1 signaling pathway in Schwann cells (SC), prior to and during early stages of diabetic neuropathy, thus suggesting its role in the initiation of SC-axonal miscommunication...
  19. ncbi request reprint Multiple sclerosis: therapeutic update
    A C Tselis
    Department of Neurology, Wayne State University School of Medicine, Detroit Medical Center, Mich, USA
    Arch Neurol 56:277-80. 1999
    ..Although much is known about the pathogenesis, there is no cure and the disease must be managed long-term. Recently, there have been a number of advances in the treatment of MS...
  20. pmc Expression of urokinase plasminogen activator receptor on monocytes from patients with relapsing-remitting multiple sclerosis: effect of glatiramer acetate (copolymer 1)
    R Balabanov
    Multiple Sclerosis Clinical Research Center, Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, Michigan 48201, USA
    Clin Diagn Lab Immunol 8:1196-203. 2001
    ..Results indicate that monocyte activation is impatient in MS and that glatiramer acetate may have a significant effect on monocyte activation in patients with RRMS...
  21. ncbi request reprint Schwann cell-specific regulation of IL-1 and IL-1Ra during EAN: possible relevance for immune regulation at paranodal regions
    D S Skundric
    Department of Neurology, Division of Neuroimmunology, School of Medicine, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA
    J Neuroimmunol 116:74-82. 2001
    ..Paranodes are also primary sites where activated macrophages make contact with SC, prior to infiltration.SC-specific autoregulation of IL-1 and IL-1Ra is suggestive of its relevance for immune regulation at paranodes during EAN...
  22. ncbi request reprint A prospective, open-label treatment trial to compare the effect of IFN beta-1a (Avonex), IFNbeta-1b (Betaseron), and glatiramer acetate (Copaxone) on the relapse rate in relapsing-remitting multiple sclerosis
    O A Khan
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    Eur J Neurol 8:141-8. 2001
    ..Despite some limitations of the study design, the results provide helpful clinical information regarding the relative efficacy of each therapy in mildly affected treatment-naïve RRMS patients...
  23. pmc Mechanisms of action of adrenocorticotropic hormone and other melanocortins relevant to the clinical management of patients with multiple sclerosis
    Barry G Arnason
    Department of Neurology, University of Chicago Medical Center, IL, USA
    Mult Scler 19:130-6. 2013
    ..The likelihood that adrenocorticotropic hormone promotes microglial quiescence and counteracts glucocorticoid-mediated bone resorption is discussed...
  24. pmc Role of neuropoietic cytokines in development and progression of diabetic polyneuropathy: from glucose metabolism to neurodegeneration
    Dusanka S Skundric
    Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, Detroit Medical Centre, Detroit, Michigan 48201, USA
    Exp Diabesity Res 4:303-12. 2003
    ..Moreover, their regulatory roles in nerve degeneration and regeneration may potentially be utilized for the prevention and/or therapy of diabetic neuropathy...
  25. pmc Paraneoplastic neuromyelitis optica spectrum disorder associated with metastatic carcinoid expressing aquaporin-4
    Michelle Figueroa
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan
    JAMA Neurol 71:495-8. 2014
    ..Reports of neuromyelitis optica spectrum disorder (NMOSD) occurring in the setting of neoplasia suggest that aquaporin-4 autoimmunity may in some cases have a paraneoplastic basis...
  26. doi request reprint Effects of dextromethorphan on glial cell function: proliferation, maturation, and protection from cytotoxic molecules
    Robert P Lisak
    Department of Neurology, Wayne State University School of Medicine, Detroit, Missouri Department of Immunology Microbiology, Wayne State University School of Medicine, Detroit, Missouri
    Glia 62:751-62. 2014
    ..These agents and DM were not toxic to AS or MG at the concentrations used. Thus, DM stimulates proliferation of OPC, and protects both OL and OPC against excitotoxic and inflammatory insults...
  27. doi request reprint Approaches to neuroprotective strategies in multiple sclerosis
    Alex Tselis
    Wayne State University, Division of Neuroimmunology, Department of Neurology, Detroit, MI 48201, USA
    Expert Opin Pharmacother 11:2869-78. 2010
    ..Multiple sclerosis (MS) is a neurologic disease that is the most common nontraumatic cause of serious disability in young adults...
  28. ncbi request reprint Other demyelinating diseases
    Alex C Tselis
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Adv Neurol 98:335-49. 2006
  29. pmc Complexity of trophic factor signaling in experimental autoimmune encephalomyelitis: differential expression of neurotrophic and gliotrophic factors
    Fei Song
    Department of Neurology, Wayne State University, Detroit, MI 48201, United States The Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, United States Department of Immunology and Microbiology, Wayne State University, Detroit, MI 48201, United States Electronic address
    J Neuroimmunol 262:11-8. 2013
    ..While complex, these studies begin to define underlying axoglial trophic activities that are likely involved in both disease pathogenesis and repair...
  30. ncbi request reprint Differences between the epsilon and gamma subunits of the acetylcholine receptor (AChR) may be significant in autoimmune myasthenia gravis
    Samia Ragheb
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Ann N Y Acad Sci 998:336-8. 2003
  31. ncbi request reprint Myasthenic crisis: guidelines for prevention and treatment
    Agnes Jani-Acsadi
    Department of Neurology, Wayne State University, Detroit, MI, USA
    J Neurol Sci 261:127-33. 2007
    ..Every effort should be done to prevent myasthenic exacerbation/crisis and to develop a maintenance management that leads to effective prevention...
  32. ncbi request reprint Adoptive transfer of myelin basic protein-induced experimental autoimmune encephalomyelitis between SJL and B10.S mice: correlation of priming milieus with susceptibility and resistance phenotypes
    Fei Chen
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Neuroimmunol 173:146-54. 2006
    ..S)F1 recipients failed to induce EAE. These results are consistent with the notion that the priming milieus in the donor mice affect the expression of susceptible and resistant phenotypes...
  33. ncbi request reprint Myasthenia gravis
    Agnes Jani-Acsadi
    Department of Neurology, Neuromuscular Division, Wayne State University, School of Medicine, 8A University Health Center, 4201 St Antoine, Detroit, MI, 48201, USA
    Curr Treat Options Neurol 12:231-43. 2010
    ..Acute management of myasthenic crisis requires intensive monitoring of the patient and institution of an efficient and safe treatment such as plasma exchange. Patient education is essential to a comprehensive long-term treatment plan...
  34. ncbi request reprint Interferon-gamma, tumor necrosis factor-alpha, and transforming growth factor-beta inhibit cyclic AMP-induced Schwann cell differentiation
    R P Lisak
    Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Glia 36:354-63. 2001
    ..The other cytokines had no effects on Gal or NGFRp75 expression. Thus, these three cytokines, which are present in inflammatory lesions in the peripheral nervous system, are capable of inhibiting Schwann cell differentiation...
  35. ncbi request reprint Predictors of well-being among significant others of persons with multiple sclerosis
    T E Sherman
    Department of Rehabilitation Psychology and Neuropsychology, Rehabilitation Institute of Michigan, Detroit, MI 48201, USA
    Mult Scler 13:238-49. 2007
    ..To examine patient and significant other characteristics as predictors of significant other well-being...
  36. ncbi request reprint Effect of monthly intravenous cyclophosphamide in rapidly deteriorating multiple sclerosis patients resistant to conventional therapy
    O A Khan
    Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, USA
    Mult Scler 7:185-8. 2001
    ..Therapy with CTX was well tolerated. CTX may be of benefit in MS patients who experience rapid clinical worsening and are resistant to conventional therapy...
  37. ncbi request reprint Intercaudate nucleus ratio as a linear measure of brain atrophy in multiple sclerosis
    C Caon
    Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Neurology 60:323-5. 2003
    ..67; p = 0.0001) and disease duration (r = 0.32; p < 0.01). Intercaudate ratio appears to be a reliable and reproducible linear measure of brain atrophy and correlates with disability and disease duration in MS...
  38. ncbi request reprint "Rebooting" the immune system with cyclophosphamide: taking risks for a "cure"?
    Richard A Lewis
    Ann Neurol 53:7-9. 2003