Jun Li

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Major myelin protein gene (P0) mutation causes a novel form of axonal degeneration
    Jun Li
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Comp Neurol 498:252-65. 2006
  2. doi request reprint Hypothesis of double polarization
    Jun Li
    Department of Neurology, John D Dingell VA Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurol Sci 275:33-6. 2008
  3. ncbi request reprint Skin biopsies in myelin-related neuropathies: bringing molecular pathology to the bedside
    Jun Li
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Brain 128:1168-77. 2005
  4. ncbi request reprint Stoichiometric alteration of PMP22 protein determines the phenotype of hereditary neuropathy with liability to pressure palsies
    Jun Li
    Department of Neurology, Wayne State University, 4201 St Antoine St, UHC 8D, Detroit, MI 48201, USA
    Arch Neurol 64:974-8. 2007
  5. ncbi request reprint Loss-of-function phenotype of hereditary neuropathy with liability to pressure palsies
    Jun Li
    Department of Neurology, Wayne State University School of Medicine, 4201 St Antoine, UHC 8D, Detroit, Michigan 48201, USA
    Muscle Nerve 29:205-10. 2004
  6. ncbi request reprint Asymmetric flaccid paralysis: a neuromuscular presentation of West Nile virus infection
    Jun Li
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Ann Neurol 53:703-10. 2003
  7. ncbi request reprint Electromyography of sternocleidomastoid muscle in ALS: a prospective study
    Jun Li
    Department of Neurology, University of Utah, Salt Lake City, Utah, USA
    Muscle Nerve 25:725-8. 2002
  8. ncbi request reprint Hereditary neuropathy with liability to pressure palsy: the electrophysiology fits the name
    Jun Li
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurology 58:1769-73. 2002
  9. pmc PMP22 expression in dermal nerve myelin from patients with CMT1A
    Istvan Katona
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Brain 132:1734-40. 2009
  10. doi request reprint Trauma does not accelerate neuronal degeneration in Fig4 insufficient mice
    Qing Yan
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Neurol Sci 312:102-7. 2012

Research Grants

Detail Information

Publications79

  1. ncbi request reprint Major myelin protein gene (P0) mutation causes a novel form of axonal degeneration
    Jun Li
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Comp Neurol 498:252-65. 2006
    ..This report represents the first study in which the molecular basis of axonal degeneration in the late-onset CMT1B has been explored in human tissue...
  2. doi request reprint Hypothesis of double polarization
    Jun Li
    Department of Neurology, John D Dingell VA Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurol Sci 275:33-6. 2008
    ..Thus, vulnerability of the nervous system may derive from additive impairments not only in axonal transport, but also in glial transport and neuronal-glial interactions...
  3. ncbi request reprint Skin biopsies in myelin-related neuropathies: bringing molecular pathology to the bedside
    Jun Li
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Brain 128:1168-77. 2005
    ..Taken together, our data suggest that skin biopsy may in certain circumstances replace the more invasive sural nerve biopsy in the morphological and molecular evaluation of inherited and other demyelinating neuropathies...
  4. ncbi request reprint Stoichiometric alteration of PMP22 protein determines the phenotype of hereditary neuropathy with liability to pressure palsies
    Jun Li
    Department of Neurology, Wayne State University, 4201 St Antoine St, UHC 8D, Detroit, MI 48201, USA
    Arch Neurol 64:974-8. 2007
    ..Whether any mutation within the coding region of the PMP22 gene ultimately causes HNPP by reducing the amount of peripheral myelin protein 22 (PMP22) expressed in myelin is also unknown...
  5. ncbi request reprint Loss-of-function phenotype of hereditary neuropathy with liability to pressure palsies
    Jun Li
    Department of Neurology, Wayne State University School of Medicine, 4201 St Antoine, UHC 8D, Detroit, Michigan 48201, USA
    Muscle Nerve 29:205-10. 2004
    ..These studies suggest that the function of PMP22, at least in part, is to stabilize myelin so that it will be protected from injuries resulting from repetitive, minor trauma...
  6. ncbi request reprint Asymmetric flaccid paralysis: a neuromuscular presentation of West Nile virus infection
    Jun Li
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Ann Neurol 53:703-10. 2003
    ..It will be important for physicians to consider WNV infection in patients with acute asymmetric paralysis with or without encephalitic symptoms...
  7. ncbi request reprint Electromyography of sternocleidomastoid muscle in ALS: a prospective study
    Jun Li
    Department of Neurology, University of Utah, Salt Lake City, Utah, USA
    Muscle Nerve 25:725-8. 2002
    ..SCM innervation includes the rostral cervical cord and brainstem, and EMG abnormalities in this muscle support a diffuse involvement, which is unique to ALS...
  8. ncbi request reprint Hereditary neuropathy with liability to pressure palsy: the electrophysiology fits the name
    Jun Li
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurology 58:1769-73. 2002
    ....
  9. pmc PMP22 expression in dermal nerve myelin from patients with CMT1A
    Istvan Katona
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Brain 132:1734-40. 2009
    ..The extra copy of PMP22 in CMT1A results in disruption of the tightly regulated expression of PMP22. Thus, variability of PMP22 levels, rather than absolute level of PMP22, may play an important role in the pathogenesis of CMT1A...
  10. doi request reprint Trauma does not accelerate neuronal degeneration in Fig4 insufficient mice
    Qing Yan
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Neurol Sci 312:102-7. 2012
    ..Taken together, our results demonstrate that haploinsufficiency of fig4 does not impose risks in rodents to develop neuronal degeneration in either naïve or traumatic conditions...
  11. pmc Shortened internodal length of dermal myelinated nerve fibres in Charcot-Marie-Tooth disease type 1A
    Mario A Saporta
    Department of Neurology, Wayne State University, Detroit 48201, USA
    Brain 132:3263-73. 2009
    ..Intra-axonal accumulation of mitochondria provides new insights into the pathogenesis of axonal degeneration in Charcot-Marie-Tooth disease type 1A...
  12. pmc Conduction block in PMP22 deficiency
    Yunhong Bai
    Department of Neurology, Wayne State University, Detroit, Michigan, USA
    J Neurosci 30:600-8. 2010
    ..Together, these results demonstrate that a function of Pmp22 is to protect the nerve from mechanical injury...
  13. ncbi request reprint Recovery and prognosticators of paralysis in West Nile virus infection
    Nancy Jingyang Cao
    Department of Neurology, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    J Neurol Sci 236:73-80. 2005
    ....
  14. doi request reprint Distinct pathogenic processes between Fig4-deficient motor and sensory neurons
    Istvan Katona
    Department of Neurology, Wayne State University, Detroit, MI, USA
    Eur J Neurosci 33:1401-10. 2011
    ..These two distinct pathological changes may contribute to neuronal degeneration...
  15. ncbi request reprint Phenotypic clustering in MPZ mutations
    Michael E Shy
    Department of Neurology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Brain 127:371-84. 2004
    ..In contrast, late onset neuropathy is caused by mutations that more subtly alter myelin structure and which probably disrupt Schwann cell-axonal interactions...
  16. pmc Evaluation of dermal myelinated nerve fibers in diabetes mellitus
    Amanda C Peltier
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
    J Peripher Nerv Syst 18:162-7. 2013
    ..This study supports the utilization of skin biopsy to quantitatively evaluate axonal loss of myelinated nerve fibers in patients with DPN...
  17. ncbi request reprint T118M PMP22 mutation causes partial loss of function and HNPP-like neuropathy
    Michael E Shy
    Department of Neurology and Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA
    Ann Neurol 59:358-64. 2006
    ..To determine the clinical consequences of the PMP22 point mutation, T118M, which has been previously considered to either cause an autosomal recessive form of Charcot-Marie-Tooth (CMT) disease or be a benign polymorphism...
  18. pmc Neuropathy in a human without the PMP22 gene
    Mario Andre Saporta
    Department of Neurology, Wayne State University, Detroit, Michigan, USA
    Arch Neurol 68:814-21. 2011
    ..However, the biological functions of the PMP22 protein in humans have largely been unexplored owing to the absence of patients with PMP22-null mutations...
  19. ncbi request reprint Effect of an R69C mutation in the myelin protein zero gene on myelination and ion channel subtypes
    Yunhong Bai
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Arch Neurol 63:1787-94. 2006
    ..Axonal degeneration in the late-onset H10P mutation may be caused by the disruption of axoglial interaction...
  20. doi request reprint Fig4 expression in the rodent nervous system and its potential role in preventing abnormal lysosomal accumulation
    Jiasong Guo
    Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA
    J Neuropathol Exp Neurol 71:28-39. 2012
    ..We speculate that adequate levels of Fig4 may be required to prevent neurons and glia from excessive lysosomal accumulation after injury and in neurodegeneration...
  21. ncbi request reprint Motor unit number estimate of distal and proximal muscles in Charcot-Marie-Tooth disease
    Richard A Lewis
    Department of Neurology, Wayne State University School of Medicine, 4201 St Antoine, Detroit, Michigan 48201, USA
    Muscle Nerve 28:161-7. 2003
    ..This study suggests that MUNE can assess motor unit loss in CMT and may better reflect axonal loss than CMAP amplitude. The STA technique of MUNE may be useful in longitudinal studies of proximal and distal motor unit changes in CMT...
  22. pmc Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration
    Xuebao Zhang
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Brain 131:1990-2001. 2008
    ..This study represents the first documentation of the natural history of CMT4J. Physical obstruction of organelle trafficking by vacuoles is a potential novel cellular mechanism of neurodegeneration...
  23. pmc Sex differences in minocycline-induced neuroprotection after experimental stroke
    Jun Li
    Department of Neurology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Cereb Blood Flow Metab 29:670-4. 2009
    ..Clinical trials must consider possible sex differences in the response to neuroprotective agents, if we hope to translate promising therapies to stroke patients of both sexes...
  24. pmc Effects of metformin in experimental stroke
    Jun Li
    Department of Neurology, Farmington, CT 06030, USA
    Stroke 41:2645-52. 2010
    ..Metformin is a known AMPK activator but reduces stroke incidence in clinical populations. We investigated the effect of acute and chronic metformin treatment on infarct volume and AMPK activation in experimental stroke...
  25. pmc Inhibition of calcium/calmodulin-dependent protein kinase kinase β and calcium/calmodulin-dependent protein kinase IV is detrimental in cerebral ischemia
    Louise D McCullough
    Department of Neurology, University of Connecticut Health Center, Farmington, CT, USA
    Stroke 44:2559-66. 2013
    ..Compelling evidence has suggested that CaMKK and its downstream kinase CaMK IV are critical in neuronal survival when cells are under ischemic stress. We examined the functional role of CaMKK/CaMK IV signaling in stroke...
  26. pmc Deletion of macrophage migration inhibitory factor worsens stroke outcome in female mice
    L Christine Turtzo
    Department of Neurology, University of Connecticut Health Center, Farmington, CT, USA
    Neurobiol Dis 54:421-31. 2013
    ..This response is sex-specific, and is in part independent of physiological serum levels of estrogen...
  27. pmc Evaluating dermal myelinated nerve fibers in skin biopsy
    M Iliza Myers
    Department of Neurology, A 0118 Medical Center North, 1161 21st Avenue South, Vanderbilt University, Nashville, Tennessee, 37232, USA
    Muscle Nerve 47:1-11. 2013
    ..The clinical relevance of a better understanding of the role of dermal myelinated nerve terminations in peripheral neuropathy will be addressed in light of recent publications in the growing field of skin biopsy...
  28. pmc Functional recovery in aging mice after experimental stroke
    Bharti Manwani
    Department of Neurology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Brain Behav Immun 25:1689-700. 2011
    ..Reactive gliosis, formation of glial scar, and an enhanced innate immune response was seen in the aging brain and may contribute to the delayed behavioral recovery seen in the aging animals...
  29. pmc Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke
    Jun Li
    Department of Neurology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Stroke 38:2992-9. 2007
    ..In this study, we examined the effects of AMPK inhibition using both pharmacological and genetic approaches in an in vivo stroke model...
  30. ncbi request reprint Significant differences in proton trimethyl ammonium signals between human gastrocnemius and soleus muscle
    Jiani Hu
    Department of Radiology, Wayne State University, Detroit, Michigan, USA
    J Magn Reson Imaging 19:617-22. 2004
    ....
  31. ncbi request reprint A case of Hashimoto's encephalopathy: association with sensory ganglionopathy
    Nancy J Cao
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    J Neurol Sci 238:105-7. 2005
    ..Sensory ganglionopathy seems to be another aspect of the broad clinical syndrome labeled Hashimoto's encephalopathy...
  32. pmc Inherited neuropathies
    Jun Li
    Department of Neurology, Center for Molecular Neuroscience, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Semin Neurol 32:204-14. 2012
    ..Several cases are presented to illustrate the diagnostic processes...
  33. ncbi request reprint Association of attention-deficit/hyperactivity disorder with serotonin 4 receptor gene polymorphisms in Han Chinese subjects
    Jun Li
    Institute of Mental Health, Peking University Peking University sixth hospital, Beijing 100083, People s Republic of China
    Neurosci Lett 401:6-9. 2006
    ..003) and the C/G/C haplotype of these and the -36 C>T polymorphism (chi(2)=5.762, P=0.016) were under-transmitted to probands with ADHD. These results suggest that the HTR4 gene may play a role in the genetic predisposition to ADHD...
  34. ncbi request reprint Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology
    Joshua W Knowles
    Falk Cardiovascular Research Building, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305 5406, USA
    Arterioscler Thromb Vasc Biol 27:2068-78. 2007
    ..We discuss the advantages and limitations of genetic studies and highlight the need for collaborative networks of PAD investigators for shedding light on this dark corner of vascular biology...
  35. ncbi request reprint Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism
    Qiujin Qian
    Institute of Mental Health, Peking University, Beijing 100083, People s Republic of China
    Am J Med Genet B Neuropsychiatr Genet 118:103-9. 2003
    ..Although these results suggest the COMT gene exerts some influence on the risk for ADHD in the Han Chinese population, given the potential for Type I error, these findings require replication before drawing definitive conclusions...
  36. ncbi request reprint Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli
    Donald A Simone
    Department of Oral Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurophysiol 91:213-22. 2004
    ..We conclude that the STT neurons in our sample are more likely to contribute to pain, allodynia, and hyperalgesia than to itch and alloknesis...
  37. ncbi request reprint Association of HLA-B alleles with human immunodeficiency virus type 1 infection in the Yi ethnic group in Sichuan province
    Ming Yan Xu
    National Centerfor STD AIDS Control and Prevention, Beijing 100050, China
    Biomed Environ Sci 17:203-8. 2004
    ..To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection...
  38. pmc SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing
    Jun Li
    Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, 4304 CCGC, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0936, USA
    Neoplasia 7:312-23. 2005
    ..Thus, SAK repression by p53 is likely mediated through the recruitment of HDAC repressors, and SAK repression contributes to p53-induced apoptosis...
  39. ncbi request reprint An association study between the transthyretin (TTR) gene and mental retardation
    Jun Li
    Bio X Center, Shanghai Jiao Tong University, Shanghai 200030, China
    Eur Arch Psychiatry Clin Neurosci 256:230-5. 2006
    ....
  40. ncbi request reprint Cloning and characterization of a second form of the rice adenine phosphoribosyl transferase gene (OsAPT2) and its association with TGMS
    Chun Jiang Zhou
    State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China
    Plant Mol Biol 60:365-76. 2006
    ..These data suggest that OsAPT2 is likely to be involved in TGMS in the rice line 'Annong S-1'...
  41. ncbi request reprint Brain-derived neurotrophic factor polymorphisms and smoking in schizophrenia
    Zhi Ren Wang
    Schizophr Res 97:299-301. 2007
  42. pmc Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes
    Eleonora Olivotto
    Istituti Ortopedici Rizzoli, Bologna, Italy
    Arthritis Rheum 58:227-39. 2008
    ..This study was undertaken to investigate the differential roles of each IKK in chondrocyte differentiation and hypertrophy...
  43. ncbi request reprint Expression and clinical significance of epidermal growth factor receptor and type 1 insulin-like growth factor receptor in nasopharyngeal carcinoma
    Yulin Yuan
    Department of Anatomy, Wuhan University School of Medicine, Hubei, People s Republic of China
    Ann Otol Rhinol Laryngol 117:192-200. 2008
    ..They were separately found to be associated with prognosis in patients with NPC. To date, their expression correlation and clinicopathologic significance have never been specifically addressed in NPC...
  44. doi request reprint 1H and 13C NMR assignments of three nitrogen containing compounds from the mangrove endophytic fungus (ZZF08)
    Yiwen Tao
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou, 510275, PR China
    Magn Reson Chem 46:501-5. 2008
    ..0 microg ml(-1) and KBv200 cells with IC(50) at 16.8 microg ml(-1), and compound 2 exhibited strong cytotoxicity toward KB cells and KBv200 cells with IC(50) less than 1.25 microg ml(-1)...
  45. doi request reprint 1H and 13C NMR assignments for two lignans from the heartwood of Streblus asper
    Jun Li
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou 510275, China
    Magn Reson Chem 46:497-500. 2008
    ..Primary bioassays showed that magnolignan A-2-O-beta-D-glucopyranoside and strebluslignanol have medium cytotoxic activity against HEp-2 and HepG2 cells, with IC(50) of 13.3 microM, 46.4 microM and 10.1 microM, 21.7 microM, respectively...
  46. doi request reprint High sensitivity of the sheep pulmonary vein antrum to acetylcholine stimulation
    Lei Liang
    Department of Cardiology, Tongji Hospital, Tongji University, Shanghai, China
    J Appl Physiol (1985) 105:293-8. 2008
    ..Such an acetylcholine-induced ERP heterogeneity is possibly a substrate for atrial fibrillation and hence one of the potential electrophysiological bases for the isolation therapy...
  47. pmc Effects of antiviral agents and HBV genotypes on intrahepatic covalently closed circular DNA in HBeAg-positive chronic hepatitis B patients
    Hai Ying Lu
    Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China
    World J Gastroenterol 14:1268-73. 2008
    ..To evaluate the effects of antiviral agents and HBV genotypes on intrahepatic covalently closed circular DNA (ccc DNA) in HBeAg-positive chronic hepatitis B patients...
  48. pmc Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD
    Joshua W Knowles
    Division of Cardiovascular Medicine, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
    BMC Med Genet 9:23. 2008
    ..We tested whether single nucleotide polymorphisms (SNPs) in OLR1 are associated with clinically significant CAD in the Atherosclerotic Disease, VAscular FuNction, & Geneti C Epidemiology (ADVANCE) study...
  49. doi request reprint Single gene contributions: genetic variants of peroxisome proliferator-activated receptor (isoforms alpha, beta/delta and gamma) and mechanisms of dyslipidemias
    Eu Leong Yong
    Department of Obstetrics and Gynecology, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore
    Curr Opin Lipidol 19:106-12. 2008
    ..Polymorphisms in peroxisome proliferator-activated receptor isoforms may be among the most important single-gene contributors to dyslipidemias, insulin resistance, and maturity-onset diabetes...
  50. pmc Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study
    Themistocles L Assimes
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
    Hum Mol Genet 17:2320-8. 2008
    ..Further investigations in other populations are needed to confirm or refute our findings...
  51. ncbi request reprint Lack of association between HoxA1 and HoxB1 gene variants and autism in 110 multiplex families
    Jun Li
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
    Am J Med Genet 114:24-30. 2002
    ..None of these subsets revealed significant deviation from the null expectation. Our interpretation of these findings is that it is unlikely that HoxA1 and HoxB1 play a significant role in the genetic predisposition to autism...
  52. ncbi request reprint BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuropsychopharmacology 33:2200-5. 2008
    ..Our results suggest that variation in the BDNF gene may be a risk factor for weight gain in male patients with schizophrenia on long-term antipsychotic treatment, and decreased BDNF levels may be associated with weight gain in females...
  53. ncbi request reprint The monoamine oxidase B gene exhibits significant association to ADHD
    Jun Li
    Institute of Mental Health, Peking University Peking University sixth hospital, China
    Am J Med Genet B Neuropsychiatr Genet 147:370-4. 2008
    ..20E-6) and haplotype-based TDT analyses also found distorted transmission. In conclusion, this study provides the strongest evidence for the involvement of MAOB gene in the etiology of ADHD to date, at least in Han Chinese population...
  54. ncbi request reprint Contribution of 5-HT2A receptor gene -1438A>G polymorphism to outcome of attention-deficit/hyperactivity disorder in adolescents
    Jun Li
    Institute of Mental Health, Peking University Peking University sixth hospital, Beijing, People s Republic of China
    Am J Med Genet B Neuropsychiatr Genet 141:473-6. 2006
    ..029). Due to potential phenotypic and etiologic heterogeneity in ADHD, the results of this study must be replicated in additional samples before they can be generalized to other populations...
  55. ncbi request reprint [Detection of MSH2 gene mutation by PCR]
    Duo Zheng
    School of Biologic Science and Technology, Central South University, Changsha, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:200-3. 2006
    ..To establish a genetic diagnosis method for a novel MSH2 mutation...
  56. ncbi request reprint [Dihydroartemisinin inhibits the expression of vascular endothelial growth factor in K562 cells]
    Jun Li
    Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China
    Yao Xue Xue Bao 40:1041-5. 2005
    ..To study the effect of dihydroartemisinin (DHA) on vascular endothelial growth factor (VEGF) expression in K562 cells and assess the effect of DHA on leukemic angiogenesis induced by K562 cells...
  57. ncbi request reprint Genetical genomics: combining genetics with gene expression analysis
    Jun Li
    Stanford Human Genome Center, Stanford University, Palo Alto, CA, USA
    Hum Mol Genet 14:R163-9. 2005
    ....
  58. ncbi request reprint Poly(ester urethane)s consisting of poly[(R)-3-hydroxybutyrate] and poly(ethylene glycol) as candidate biomaterials: characterization and mechanical property study
    Xu Li
    Institute of Materials Research and Engineering IMRE, National University of Singapore, 3 Research Link, Singapore 117602
    Biomacromolecules 6:2740-7. 2005
    ..Young's modulus and the stress at break increased with increasing PHB segment length or PEG segment length, whereas the strain at break increased with increasing PEG segment length or decreasing PHB segment length...
  59. ncbi request reprint Adenosine A1 receptors modulate the discharge activities of inspiratory and biphasic expiratory neurons in the medial region of Nucleus Retrofacialis of neonatal rat in vitro
    Jian Li Wang
    Department of Physiology, Southern Medical University, Guangzhou 510515, PR China
    Neurosci Lett 379:27-31. 2005
    ..Activation of adenosine A1 receptors may modulate the inhibitory synaptic inputs from I neurons to biphasic E neurons...
  60. ncbi request reprint [Association studies of G352A polymorphism of dopamine transporter gene in Han Chinese attention deficit hyperactivity disorder patients]
    Qiu jin Qian
    Peking University Institute of Mental Health, Beijing 100083, China
    Beijing Da Xue Xue Bao 36:626-9. 2004
    ..To investigate association of the new polymorphism G352A in the dopamine transporter gene (DAT1) exon 15 with attention deficit hyperactivity disorder (ADHD) in Han Chinese children...
  61. ncbi request reprint Association of norepinephrine transporter gene with methylphenidate response
    Li Yang
    Institute of Mental Health, Peking University, China
    J Am Acad Child Adolesc Psychiatry 43:1154-8. 2004
    ..This study aimed to explore the association between alleles of the norepinephrine transporter gene and the methylphenidate response...
  62. ncbi request reprint [Association between serotonin 2C gene polymorphisms and attention deficit hyperactivity disorder comorbid or not comorbid with learning disorder]
    Jun Li
    Institute of Mental Health, Peking University, Beijing 10083, China
    Beijing Da Xue Xue Bao 36:366-9. 2004
    ..To investigate the relationship between two HTR2C gene polymorphisms, that is C-759T and G-697C polymorphisms, and attention deficit hyperactivity disorder (ADHD) comorbid or not comorbid learning disorder (LD)...
  63. ncbi request reprint Lack of evidence for an association between WNT2 and RELN polymorphisms and autism
    Jun Li
    Department of Genetics M344, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Am J Med Genet B Neuropsychiatr Genet 126:51-7. 2004
    ..Our interpretation of these findings is that it is unlikely that DNA variations in RELN and WNT2 play a significant role in the genetic predisposition to autism...
  64. ncbi request reprint [Association between AvaII exon 13 polymorphism at the LDL receptor gene different and serum lipid levels in normotensives and essential hypertensives in Shanghai]
    Ai Ping Liu
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100083, China
    Zhonghua Liu Xing Bing Xue Za Zhi 24:542-6. 2003
    ..To investigate the AvaII polymorphism of low density lipoprotein receptor gene in both health and essential hypertension populations, and to evaluate the association of AvaII polymorphism with level of blood lipid...
  65. ncbi request reprint Association between polymorphisms in serotonin transporter gene and attention deficit hyperactivity disorder in Chinese Han subjects
    Jun Li
    Institute of Mental Health, Peking University, Peking University Sixth Hospital, Beijing, PR China
    Am J Med Genet B Neuropsychiatr Genet 144:14-9. 2007
    ..751, P = 0.016) to probands with ADHD. Haplotype analysis found the L/10 haplotype was over-transmitted (chi(2) = 6.172, P = 0.013), while L/12 was under-transmitted to probands with ADHD (chi(2) = 4.866, P = 0.027)...
  66. ncbi request reprint Innervation of the trapezius muscle: is cervical contribution important to its function?
    Wen Zhao
    Department of Oral and Maxillofacial Surgery, The Ninth People s Hospital of Shanghai, School of Stomatology, Shanghai Jiaotong University, Shanghai, PR, China
    Otolaryngol Head Neck Surg 135:758-64. 2006
    ..To study the effect of the cervical plexus and the accessory nerve to the function of the trapezius muscle...
  67. ncbi request reprint Correlation between plasma glucagon-like peptide 2 levels and proliferative makers in small intestinal injury in rats induced by methotrexate administration
    Yoshihiko Hirotani
    Laboratory of Clinical Pharmaceutics, Faculty of Pharmacy, Osaka Ohatani University, Tondabayashi, Japan
    Biol Pharm Bull 29:2327-30. 2006
    ..Correlations were found between plasma GLP-2 levels and mucosal weight, DNA and protein content. We concluded that plasma GLP-2 levels reflect the degree of intestinal injury following MTX administration in this preclinical model...
  68. ncbi request reprint Cloning, characterization, and transformation of the phosphoethanolamine N-methyltransferase gene (ZmPEAMT1) in maize (Zea mays L.)
    Suowei Wu
    The State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China
    Mol Biotechnol 36:102-12. 2007
    ..These data indicated that ZmPEAMT1 maybe involved in maize root development and stress resistance, and maybe having a potential application in maize genetic engineering...
  69. ncbi request reprint Correlation between TIMP-1 expression and liver fibrosis in two rat liver fibrosis models
    Qing He Nie
    Chinese PLA Centre of Diagnosis and Treatment for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, Shaanxi Province, China
    World J Gastroenterol 12:3044-9. 2006
    ..To evaluate serum TIMP-1 level and the correlation between TIMP-1 expression and liver fibrosis in immune-induced and CCL4-induced liver fibrosis models in rats...
  70. ncbi request reprint Sequential histopathology of pancreatic tissues in aly/aly mice
    Yoichi Nakamura
    Department of Anatomy, Tokyo Medical University, Tokyo, Japan
    Cells Tissues Organs 186:204-9. 2007
    ....
  71. pmc Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J
    Clement Y Chow
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 448:68-72. 2007
    ..This novel form of autosomal recessive Charcot-Marie-Tooth disorder is designated CMT4J...
  72. ncbi request reprint Vertically aligned carbon nanofiber architecture as a multifunctional 3-D neural electrical interface
    T D Barbara Nguyen-Vu
    NASA Ames Research Center, Moffett Field, CA 94035, USA
    IEEE Trans Biomed Eng 54:1121-8. 2007
    ..Further development of this technology may potentially result in a highly multiplex closed-loop system with multifunctions for neuromodulation and neuroprostheses...
  73. pmc The beta2 adrenergic receptor regulates morphine tolerance and physical dependence
    De Yong Liang
    Veterans Affairs Palo Alto Health Care System, Stanford University, Department of Anesthesiology, 3801 Miranda Ave, Palo Alto, CA 94304, USA
    Behav Brain Res 181:118-26. 2007
    ..Therefore, beta2-AR antagonists show some promise as agents to enhance chronic opioid analgesic therapy...
  74. ncbi request reprint Endothelial nitric oxide synthase gene intron 4, 27 bp repeat polymorphism and essential hypertension in the Kazakh Chinese population
    Fengmei Deng
    West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610044, China
    Acta Biochim Biophys Sin (Shanghai) 39:311-6. 2007
    ..However, a positive association between plasma eNOS activity and essential hypertension has been revealed...
  75. ncbi request reprint [Molecular detection and haematological analysis of heterozygotes in beta-thalassemia combining deletional alpha-thalassemia]
    Yong Lin Cai
    Central Laboratory, Wuzhou Red Cross Hospital, Wuzhou 543002, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:195-7. 2007
    ..It is more useful for genetic counselling and prenatal diagnosis of this disease...
  76. ncbi request reprint West Nile virus
    Laura D Kramer
    Wadsworth Center, New York State Department of Health, Albany, New York 12208, USA
    Lancet Neurol 6:171-81. 2007
    ..The goal of this Review is to highlight recent advances in our understanding of West Nile virus virology, ecology, clinical disease, diagnosis, and development of potential vaccines and antiviral therapies...
  77. ncbi request reprint Vertically aligned carbon nanofiber arrays: an advance toward electrical-neural interfaces
    T D Barbara Nguyen-Vu
    NASA Ames Research Center, Center for Nanotechnology, Moffett Field, CA 94035, USA
    Small 2:89-94. 2006
  78. ncbi request reprint The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects
    Jun Li
    Institute of Mental Health, Peking University Peking University sixth hospital, Beijing 100083, China
    Am J Med Genet B Neuropsychiatr Genet 141:874-6. 2006
    ..815, P = 0.051) and a significant preferential transmission to probands of ADHDC (chi2 = 4.198, P = 0.040). Additional polymorphisms in this gene need to be studied further...
  79. pmc Extensive linkage disequilibrium, a common 16.7-kilobase deletion, and evidence of balancing selection in the human protocadherin alpha cluster
    James P Noonan
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 72:621-35. 2003
    ..This deletion appears in unaffected individuals from multiple populations, suggesting that a reduction in protocadherin gene number is not obviously deleterious...

Research Grants2

  1. The Pathophysiology of Conduction Block in HNPP
    Jun Li; Fiscal Year: 2007
    ..Aim 3: Test the hypothesis that increasing age or multiple injuries predispose CB in pmp22 +/- and wild type mice. ..