Lawrence Lash

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. doi request reprint Renal membrane transport of glutathione in toxicology and disease
    L H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Vet Pathol 48:408-19. 2011
  2. ncbi request reprint The mitochondrial benzodiazepine receptor as a potential target protein for drug development: demonstration of functional significance with cell lines exhibiting differential expression of Bcl-2
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Toxicol Sci 74:1-3. 2003
  3. pmc Metabolism and tissue distribution of orally administered trichloroethylene in male and female rats: identification of glutathione- and cytochrome P-450-derived metabolites in liver, kidney, blood, and urine
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Toxicol Environ Health A 69:1285-309. 2006
  4. ncbi request reprint Role of glutathione transport processes in kidney function
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan 48201, USA
    Toxicol Appl Pharmacol 204:329-42. 2005
  5. ncbi request reprint Molecular markers of trichloroethylene-induced toxicity in human kidney cells
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Toxicol Appl Pharmacol 206:157-68. 2005
  6. pmc Role of organic anion and amino acid carriers in transport of inorganic mercury in rat renal basolateral membrane vesicles: influence of compensatory renal growth
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Toxicol Sci 88:630-44. 2005
  7. pmc Mitochondrial glutathione transport: physiological, pathological and toxicological implications
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Chem Biol Interact 163:54-67. 2006
  8. ncbi request reprint Influence of compensatory renal growth on susceptibility of primary cultures of renal cells to chemically induced injury
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Toxicol Sci 94:417-27. 2006
  9. ncbi request reprint Membrane transport function in primary cultures of human proximal tubular cells
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, United States
    Toxicology 228:200-18. 2006
  10. pmc Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, United States
    Toxicology 235:11-26. 2007

Research Grants

  1. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2005
  2. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 2003
  3. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2001
  4. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 1999
  5. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 1993
  6. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2007

Collaborators

Detail Information

Publications51

  1. doi request reprint Renal membrane transport of glutathione in toxicology and disease
    L H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Vet Pathol 48:408-19. 2011
    ....
  2. ncbi request reprint The mitochondrial benzodiazepine receptor as a potential target protein for drug development: demonstration of functional significance with cell lines exhibiting differential expression of Bcl-2
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Toxicol Sci 74:1-3. 2003
    ..66-73). The following brief review summarizes their findings, highlights the novel biological model and experimental approach used, and explores potential mechanistic and therapeutic implications of these findings...
  3. pmc Metabolism and tissue distribution of orally administered trichloroethylene in male and female rats: identification of glutathione- and cytochrome P-450-derived metabolites in liver, kidney, blood, and urine
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Toxicol Environ Health A 69:1285-309. 2006
    ..The relationship between gender-dependent differences in distribution and metabolism of TRI and susceptibility to TRI-induced toxicity is discussed...
  4. ncbi request reprint Role of glutathione transport processes in kidney function
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan 48201, USA
    Toxicol Appl Pharmacol 204:329-42. 2005
    ..Hence, membrane transport processes are critical to regulation of renal cellular and subcellular GSH pools and are determinants of susceptibility to cytotoxicity induced by oxidants and electrophiles...
  5. ncbi request reprint Molecular markers of trichloroethylene-induced toxicity in human kidney cells
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Toxicol Appl Pharmacol 206:157-68. 2005
    ..The precise pattern of expression of these and other proteins can thus serve as molecular markers for TRI exposure and effect in human kidney...
  6. pmc Role of organic anion and amino acid carriers in transport of inorganic mercury in rat renal basolateral membrane vesicles: influence of compensatory renal growth
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Toxicol Sci 88:630-44. 2005
    ..These results support the hypothesis that compensatory renal growth is associated with increased uptake of Hg(2+) in proximal tubular cells and we have identified specific transporters involved in the process...
  7. pmc Mitochondrial glutathione transport: physiological, pathological and toxicological implications
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Chem Biol Interact 163:54-67. 2006
    ..Several conditions, such as alcoholic liver disease, cirrhosis or other chronic biliary obstructive diseases, and diabetic nephropathy, are associated with depletion or oxidation of the mitochondrial GSH pool in liver or kidney...
  8. ncbi request reprint Influence of compensatory renal growth on susceptibility of primary cultures of renal cells to chemically induced injury
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Toxicol Sci 94:417-27. 2006
    ..This is the first report validating the use of a mammalian renal cell culture model to study the toxicological effects of compensatory renal cellular hypertrophy...
  9. ncbi request reprint Membrane transport function in primary cultures of human proximal tubular cells
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, United States
    Toxicology 228:200-18. 2006
    ....
  10. pmc Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, United States
    Toxicology 235:11-26. 2007
    ....
  11. pmc Interactive toxicity of inorganic mercury and trichloroethylene in rat and human proximal tubules: effects on apoptosis, necrosis, and glutathione status
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Toxicol Appl Pharmacol 221:349-62. 2007
    ..These results demonstrate that by altering processes related to GSH status, susceptibilities of rPT and hPT cells to acute injury from Hg(2+), TRI, or DCVC are markedly altered by prior exposures...
  12. pmc Role of rat organic anion transporter 3 (Oat3) in the renal basolateral transport of glutathione
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, United States
    Chem Biol Interact 170:124-34. 2007
    ..We conclude that Oat3 can function in GSH uptake and that NRK-52E cells possess a low background rate of GSH uptake, making these cells a good model for overexpression of specific, putative GSH carriers...
  13. ncbi request reprint Mitochondrial GSH transport and intestinal cell injury: a commentary on "Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis"
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Free Radic Biol Med 44:765-7. 2008
  14. pmc Drug metabolism enzyme expression and activity in primary cultures of human proximal tubular cells
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, United States
    Toxicology 244:56-65. 2008
    ..These results indicate that primary cultures of hPT cells possess significant capacity to metabolize many classes of drugs, and can be used as an effective model to study drug metabolism...
  15. doi request reprint Renal glutathione transport: Identification of carriers, physiological functions, and controversies
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biofactors 35:500-8. 2009
    ....
  16. ncbi request reprint Roles of necrosis, Apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Ave, Detroit, MI 48201, USA
    J Pharmacol Exp Ther 305:1163-72. 2003
    ....
  17. ncbi request reprint Genetics and susceptibility to toxic chemicals: do you (or should you) know your genetic profile?
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan 48201, USA
    J Pharmacol Exp Ther 305:403-9. 2003
    ..Finally, ethical and legal concerns with the application of this knowledge and methodology to human health will be discussed...
  18. ncbi request reprint Biochemical and functional characteristics of cultured renal epithelial cells from uninephrectomized rats: factors influencing nephrotoxicity
    L H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Pharmacol Exp Ther 296:243-51. 2001
    ..These findings also suggest that these cell cultures may be useful for the study of biochemical processes associated with compensatory renal cellular hypertrophy...
  19. pmc Modes of action of trichloroethylene for kidney tumorigenesis
    L H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Environ Health Perspect 108:225-40. 2000
    ..Finally, the status of risk assessment for TCE based on the kidneys as a target organ and remaining questions and research needs are discussed...
  20. pmc Metabolism of trichloroethylene
    L H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Environ Health Perspect 108:177-200. 2000
    ..italic)Key words(/italic): conjugate beta-lyase, cysteine glutathione, cytochrome P450, glutathione (italic)S(/italic)-transferases, metabolism, sex dependence, species dependence, tissue dependence, trichloroethylene...
  21. ncbi request reprint Hepatic and renal toxicities associated with perchloroethylene
    L H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201 1928, USA
    Pharmacol Rev 53:177-208. 2001
    ..Finally, the epidemiological and experimental data are assessed and use of toxicity information in the development of a reference dose and a reference concentration for human Perc exposure are presented...
  22. ncbi request reprint Influence of exogenous thiols on inorganic mercury-induced injury in renal proximal and distal tubular cells from normal and uninephrectomized rats
    L H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201 1928, USA
    J Pharmacol Exp Ther 291:492-502. 1999
    ..Thus, renal cells from NPX rats are more susceptible to Hg(2+)-induced injury, PT and DT cells respond differently to exposure to Hg(2+), and thiols can significantly modulate the toxic response to Hg(2+)...
  23. ncbi request reprint Renal cellular transport of exogenous glutathione: heterogeneity at physiological and pharmacological concentrations
    L H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Biochem Pharmacol 58:897-907. 1999
    ....
  24. ncbi request reprint Glutathione conjugation of trichloroethylene in human liver and kidney: kinetics and individual variation
    L H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Drug Metab Dispos 27:351-9. 1999
    ....
  25. ncbi request reprint Renal toxicity of perchloroethylene and S-(1,2,2-trichlorovinyl)glutathione in rats and mice: sex- and species-dependent differences
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Toxicol Appl Pharmacol 179:163-71. 2002
    ..Thus, many of the species-, sex-, and tissue-dependent differences in toxicity of Perc and TCVG that are observed in vivo are also observed in these in vitro models...
  26. ncbi request reprint Identification of S-(1,2-dichlorovinyl)glutathione in the blood of human volunteers exposed to trichloroethylene
    L H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201 1928, USA
    J Toxicol Environ Health A 56:1-21. 1999
    ....
  27. ncbi request reprint Cellular and subcellular heterogeneity of glutathione metabolism and transport in rat kidney cells
    L H Lash
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Toxicology 130:1-15. 1998
    ....
  28. ncbi request reprint Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter
    Lawrence H Lash
    Department of Pharmacology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    J Pharmacol Exp Ther 303:476-86. 2002
    ....
  29. ncbi request reprint Cellular energetics and glutathione status in NRK-52E cells: toxicological implications
    Lawrence H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Biochem Pharmacol 64:1533-46. 2002
    ..In most respects, however, NRK-52E cells exhibited functions similar to those of the rat renal proximal tubule in vivo...
  30. ncbi request reprint Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences
    L H Lash
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Ave, Detroit, MI 48201, USA
    J Pharmacol Exp Ther 297:155-64. 2001
    ..Thus, many of the species-, sex-, and tissue-dependent differences in toxicity observed in vivo are also observed in vitro...
  31. pmc Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells
    Feng Xu
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Biochem Pharmacol 76:552-67. 2008
    ..These results support the conclusion that mitochondrial dysfunction is an early and obligatory step in DCVC-induced cytotoxicity in hPT cells...
  32. doi request reprint Diabetes increases susceptibility of primary cultures of rat proximal tubular cells to chemically induced injury
    Qing Zhong
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Toxicol Appl Pharmacol 241:1-13. 2009
    ..These results support the hypothesis that primary cultures of PT cells from diabetic rats are a valid model in which to study renal cellular function in the diabetic state...
  33. doi request reprint Influence of renal compensatory hypertrophy on mitochondrial energetics and redox status
    Bavneet Benipal
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, United States
    Biochem Pharmacol 81:295-303. 2011
    ..These studies provide additional insight into the molecular changes that occur in compensatory renal hypertrophy and should help in the development of novel therapeutic approaches for patients with reduced renal mass...
  34. pmc Hepatic mitochondrial transport of glutathione: studies in isolated rat liver mitochondria and H4IIE rat hepatoma cells
    Qing Zhong
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201 1928, USA
    Arch Biochem Biophys 474:119-27. 2008
    ....
  35. pmc Overexpression of Bcl-2 as a proxy redox stimulus to enhance activity of non-viral redox-responsive delivery vectors
    Devika S Manickam
    Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48202, USA
    Biomaterials 29:2680-8. 2008
    ..This study shows that Bcl-2 overexpression can serve as a proxy redox stimulus to enhance the activity of all major classes of potential nucleic acid therapeutics, when delivered using redox-sensitive vectors...
  36. pmc Effect of innate glutathione levels on activity of redox-responsive gene delivery vectors
    Devika S Manickam
    Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48202, USA
    J Control Release 141:77-84. 2010
    ..Results demonstrate that increased GSH levels are associated with improved transfection of mRNA polyplexes but no clear trend is observed for pDNA, AON and siRNA polyplexes...
  37. pmc Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis
    Feng Xu
    Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Ave, Detroit, MI 48201, USA
    J Pharmacol Exp Ther 316:1175-86. 2006
    ..These results provide further evidence that genetic manipulation of mitochondrial GSH transporter expression alters mitochondrial and cellular GSH status, resulting in markedly altered susceptibility to chemically induced apoptosis...
  38. ncbi request reprint Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, Greensboro, NC 27402 6170, USA
    Toxicol Sci 97:459-66. 2007
    ..g., GSH was increased in the frontal cortex and decreased in the caudate despite two- to threefold increases in Mn concentrations in these regions)...
  39. ncbi request reprint Airborne manganese exposure differentially affects end points of oxidative stress in an age- and sex-dependent manner
    Keith M Erikson
    Department of Physiology and Pharmacology and Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Biol Trace Elem Res 100:49-62. 2004
    ..1-mg/m3 manganese phosphate exposure. These results demonstrate that age and sex are variables that must be considered when assessing the neurotoxicity of manganese...
  40. ncbi request reprint Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, Greensboro, NC 27402 6170, USA
    Biol Trace Elem Res 104:151-63. 2005
    ....
  41. ncbi request reprint Metabolism and toxicity of trichloroethylene in epididymis and testis
    Poh Gek Forkert
    Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario, Canada, K7L 3N6
    Toxicol Appl Pharmacol 182:244-54. 2002
    ..These results indicated that TCE is metabolized in the male reproductive tract, leading to adverse effects that are more severe in the epididymis than in the testis...
  42. ncbi request reprint Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1
    Poh Gek Forkert
    Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Drug Metab Dispos 33:1429-37. 2005
    ..Moreover, the rates of CH production were substantially higher in murine than in human lung...
  43. ncbi request reprint Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity
    Renee J Krause
    Department of Comparative Biosciences and Center for Molecular and Environmental Toxicology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Pharmacol Exp Ther 304:185-91. 2003
    ....
  44. doi request reprint Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, Greensboro, NC 27402 6170, USA
    Neurotoxicology 29:377-85. 2008
    ..Overall, the nonhuman primate brain responds to airborne Mn in a heterogeneous manner and most alterations in these biomarkers of neurotoxicity are reversible upon cessation of Mn exposure...
  45. doi request reprint Epidermal growth factor receptor ligands and renal epithelial cell proliferation
    Lawrence H Lash
    Am J Physiol Renal Physiol 294:F457-8. 2008
  46. ncbi request reprint Pulmonary bronchiolar cytotoxicity and formation of dichloroacetyl lysine protein adducts in mice treated with trichloroethylene
    Poh Gek Forkert
    Department of Anatomy and Cell Biology, Queen s University, Kingston, ON, Canada
    J Pharmacol Exp Ther 316:520-9. 2006
    ..These findings supported the contention that TCE bioactivation within the Clara cells, predominantly involving CYP2F2, correlated with bronchiolar cytotoxicity in mice...
  47. ncbi request reprint Manganese-induced cytotoxicity in dopamine-producing cells
    Denise L Stredrick
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 25:543-53. 2004
    ..In conclusion, DA content was not responsible for the enhanced sensitivity of CATH.a cells to Mn toxicity, but oxidative stress was implicated as a probable mechanism of cytotoxicity...
  48. ncbi request reprint Cystine alters the renal and hepatic disposition of inorganic mercury and plasma thiol status
    Rudolfs K Zalups
    Division of Basic Medical Sciences, Mercer University School of Medicine, 1550 College Street, Macon, GA 31207, USA
    Toxicol Appl Pharmacol 214:88-97. 2006
    ..Additionally, the present findings indicate that thiol status is an important determinant of renal and hepatic disposition, and urinary and fecal excretion, of inorganic mercury...
  49. ncbi request reprint Effects of manganese (Mn) on the developing rat brain: oxidative-stress related endpoints
    Sarah Weber
    Department of Physiology and Pharmacology, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 23:169-75. 2002
    ..05) total cerebrocortical GSH without accompanying changes in any of the other measured parameters. Therefore, it is unlikely that high dose Mn exposure is associated with oxidative stress in this experimental paradigm...
  50. ncbi request reprint Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese
    Keith M Erikson
    Department of Nutrition, University of North Carolina Greensboro, NC, USA
    Biol Trace Elem Res 111:199-215. 2006
    ..It is important to note that the doses of Mn utilized represent levels that are a hundred- to a thousand-fold higher than the inhalation reference concentration set by the United States Environmental Protection Agency...
  51. ncbi request reprint Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus
    Ashley N Donahue
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Mech Ageing Dev 127:57-63. 2006
    ..We conclude that the age-related decline in circulating growth hormone and IGF-1 contribute to increased oxidative stress in hippocampus with age...

Research Grants18

  1. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2005
    ..abstract_text> ..
  2. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 2003
    ..This information may have therapeutic applications for prevention of renal cellular injury or for understanding mitochondrial diseases or age-related decreases that occur in mitochondrial function. ..
  3. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2001
    ....
  4. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 1999
    ..These results will ultimately help in development of procedures to maintain or improve kidney function. ..
  5. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 1993
    ..These results will ultimately help in development of procedures to maintain or improve kidney function...
  6. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2007
    ..Achievement of these aims should build on our previous work in human kidney cells and extend it to provide a much more complete understanding of the various and complex ways in which DCVC affects the human kidney ..