Ajay Kumar

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Wayne State University PET Center, Children s Hospital of Michigan, Detroit Medical Center, Detroit, Michigan 48201, USA
    J Nucl Med 51:139-44. 2010
  2. ncbi Alterations in frontal lobe tracts and corpus callosum in young children with autism spectrum disorder
    Ajay Kumar
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Cereb Cortex 20:2103-13. 2010
  3. ncbi Objective detection of epileptic foci by 18F-FDG PET in children undergoing epilepsy surgery
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Nucl Med 51:1901-7. 2010
  4. ncbi Can diffusion tensor imaging (DTI) identify epileptogenic tubers in tuberous sclerosis complex? Correlation with α-[11C]methyl-L-tryptophan ([11C] AMT) positron emission tomography (PET)
    Vijay Narayan Tiwari
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    J Child Neurol 27:598-603. 2012
  5. ncbi Abnormal brain protein synthesis in language areas of children with pervasive developmental disorder: a L-[1-11C]-leucine PET study
    Varun Shandal
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Child Neurol 26:1347-54. 2011
  6. ncbi Diffusion tensor imaging of frontal lobe in autism spectrum disorder
    Senthil K Sundaram
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Cereb Cortex 18:2659-65. 2008
  7. ncbi Clinical and histopathologic correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 52:1692-8. 2011
  8. ncbi Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI, USA
    J Neuroinflammation 9:232. 2012
  9. ncbi Sensitive diffusion tensor imaging quantification method to identify language pathway abnormalities in children with developmental delay
    Sai Prasad Gopal
    Department of Pediatrics and Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    J Pediatr 160:147-51. 2012
  10. ncbi α-[¹¹C]-methyl-L-tryptophan PET for tracer localization of epileptogenic brain regions: clinical studies
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI, USA
    Biomark Med 5:577-84. 2011

Collaborators

Detail Information

Publications16

  1. ncbi PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Wayne State University PET Center, Children s Hospital of Michigan, Detroit Medical Center, Detroit, Michigan 48201, USA
    J Nucl Med 51:139-44. 2010
    ..The objective of this study was to derive the biodistribution and in vivo radiation dose estimates of PK in children studied for brain inflammatory conditions and in healthy adults...
  2. ncbi Alterations in frontal lobe tracts and corpus callosum in young children with autism spectrum disorder
    Ajay Kumar
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Cereb Cortex 20:2103-13. 2010
    ..Volume of bilateral UF and right AF and fiber density of left UF were positively associated with autistic features...
  3. ncbi Objective detection of epileptic foci by 18F-FDG PET in children undergoing epilepsy surgery
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Nucl Med 51:1901-7. 2010
    ..The purpose of the present study was to evaluate and optimize the performance (lateralization and lobar localization value of epileptic foci) of objective voxel-based analysis of (18)F-FDG PET scans in a pediatric epilepsy population...
  4. ncbi Can diffusion tensor imaging (DTI) identify epileptogenic tubers in tuberous sclerosis complex? Correlation with α-[11C]methyl-L-tryptophan ([11C] AMT) positron emission tomography (PET)
    Vijay Narayan Tiwari
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    J Child Neurol 27:598-603. 2012
    ..45; P = .003). Tubers with higher AMT-PET uptake ratios corresponded well with lower FA values in tuberous sclerosis complex patients...
  5. ncbi Abnormal brain protein synthesis in language areas of children with pervasive developmental disorder: a L-[1-11C]-leucine PET study
    Varun Shandal
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Child Neurol 26:1347-54. 2011
    ..03 and P = .04, respectively). In conclusion, abnormal language area protein synthesis in developmentally delayed children may be related to pervasive symptoms...
  6. ncbi Diffusion tensor imaging of frontal lobe in autism spectrum disorder
    Senthil K Sundaram
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Cereb Cortex 18:2659-65. 2008
    ..Abnormal frontal FA and ADC may be due to white matter organization abnormalities in ASD. Lack of evidence for excessive short range connectivity in ASD in this study may need to be re-examined with future advances in DTI technology...
  7. ncbi Clinical and histopathologic correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 52:1692-8. 2011
    ..Therefore, in the present study, we evaluated the clinical and histopathologic correlates of AMT-PET abnormalities in children with intractable epilepsy undergoing resective surgery...
  8. ncbi Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI, USA
    J Neuroinflammation 9:232. 2012
    ..We studied the distribution and expression of translocator protein in the human brain using (11)C-[R]-PK-11195 positron emission tomography (PK11195 PET) and evaluated age-related changes...
  9. ncbi Sensitive diffusion tensor imaging quantification method to identify language pathway abnormalities in children with developmental delay
    Sai Prasad Gopal
    Department of Pediatrics and Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    J Pediatr 160:147-51. 2012
    ..To investigate whether abnormal regional white matter architecture in the perisylvian region could be used as an easy and sensitive quantitative method to demonstrate language pathway abnormalities in children with developmental delay (DD)...
  10. ncbi α-[¹¹C]-methyl-L-tryptophan PET for tracer localization of epileptogenic brain regions: clinical studies
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI, USA
    Biomark Med 5:577-84. 2011
    ..Therefore, there is a need for more clinical studies from other centers and this can be greatly facilitated if AMT can be labeled with (18)F, a PET radionuclide widely available with a half-life of 110 min...
  11. ncbi A diffusion tensor imaging study of the cerebellar pathways in children with autism spectrum disorder
    Lalitha Sivaswamy
    Department of Pediatrics and Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Child Neurol 25:1223-31. 2010
    ..This study reiterates the underconnectivity between the cerebellum and neocortex, using diffusion tensor imaging...
  12. ncbi Arcuate fasciculus and speech in congenital bilateral perisylvian syndrome
    Anita S D Saporta
    Department of Neurology, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
    Pediatr Neurol 44:270-4. 2011
    ..In this small series, the absence of arcuate fasciculi on diffusion tensor imaging correlated with a more severe phenotype, which cannot be appreciated via structural magnetic resonance imaging alone...
  13. ncbi Epilepsy surgery in a case of encephalitis: use of 11C-PK11195 positron emission tomography
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    Pediatr Neurol 38:439-42. 2008
    ..In such cases, (11)C-PK11195 positron emission tomography may highlight the region of maximal inflammation for palliative surgical treatment...
  14. ncbi Evaluation of neuroinflammation in X-linked adrenoleukodystrophy
    Ajay Kumar
    Department of Pediatrics and Neurology, Wayne State University School of Medicine, Children s Hospital of Michigan, Detroit Medical Center, Detroit, Michigan 48201, USA
    Pediatr Neurol 44:143-6. 2011
    ..This technique may be particularly useful for evaluating treatment response, which is not easy with other imaging modalities, after white matter is significantly and extensively damaged...
  15. ncbi Niemann-Pick disease type C: unique 2-deoxy-2[¹⁸F] fluoro-D-glucose PET abnormality
    Ajay Kumar
    Department of Pediatrics and Neurology, Wayne State University School of Medicine, Children s Hospital of Michigan, Detroit Medical Center, Detroit, Michigan, USA
    Pediatr Neurol 44:57-60. 2011
    ....
  16. ncbi Epilepsy diagnosis: positron emission tomography
    Ajay Kumar
    Departments of Pediatrics and Neurology, School of Medicine, Wayne State University, Children s Hospital of Michigan, Detroit, MI, USA
    Handb Clin Neurol 107:409-24. 2012
    ..Other tracers such as 5HT(1A) receptor ligands, have an important research role...