Ajay Kumar

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI, USA
    J Neuroinflammation 9:232. 2012
  2. doi request reprint PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Wayne State University PET Center, Children s Hospital of Michigan, Detroit Medical Center, Detroit, Michigan 48201, USA
    J Nucl Med 51:139-44. 2010
  3. doi request reprint Alterations in frontal lobe tracts and corpus callosum in young children with autism spectrum disorder
    Ajay Kumar
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Cereb Cortex 20:2103-13. 2010
  4. pmc Objective detection of epileptic foci by 18F-FDG PET in children undergoing epilepsy surgery
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Nucl Med 51:1901-7. 2010
  5. doi request reprint Abnormal brain protein synthesis in language areas of children with pervasive developmental disorder: a L-[1-11C]-leucine PET study
    Varun Shandal
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Child Neurol 26:1347-54. 2011
  6. pmc Clinical and histopathologic correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 52:1692-8. 2011
  7. doi request reprint Can diffusion tensor imaging (DTI) identify epileptogenic tubers in tuberous sclerosis complex? Correlation with α-[11C]methyl-L-tryptophan ([11C] AMT) positron emission tomography (PET)
    Vijay Narayan Tiwari
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    J Child Neurol 27:598-603. 2012
  8. pmc Diffusion tensor imaging of frontal lobe in autism spectrum disorder
    Senthil K Sundaram
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Cereb Cortex 18:2659-65. 2008
  9. pmc α-[11C]-Methyl-L-tryptophan--PET in 191 patients with tuberous sclerosis complex
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI, USA
    Neurology 81:674-80. 2013
  10. pmc Sensitive diffusion tensor imaging quantification method to identify language pathway abnormalities in children with developmental delay
    Sai Prasad Gopal
    Department of Pediatrics and Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    J Pediatr 160:147-51. 2012

Detail Information

Publications23

  1. pmc Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI, USA
    J Neuroinflammation 9:232. 2012
    ..We studied the distribution and expression of translocator protein in the human brain using (11)C-[R]-PK-11195 positron emission tomography (PK11195 PET) and evaluated age-related changes...
  2. doi request reprint PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Wayne State University PET Center, Children s Hospital of Michigan, Detroit Medical Center, Detroit, Michigan 48201, USA
    J Nucl Med 51:139-44. 2010
    ..The objective of this study was to derive the biodistribution and in vivo radiation dose estimates of PK in children studied for brain inflammatory conditions and in healthy adults...
  3. doi request reprint Alterations in frontal lobe tracts and corpus callosum in young children with autism spectrum disorder
    Ajay Kumar
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Cereb Cortex 20:2103-13. 2010
    ..Volume of bilateral UF and right AF and fiber density of left UF were positively associated with autistic features...
  4. pmc Objective detection of epileptic foci by 18F-FDG PET in children undergoing epilepsy surgery
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Nucl Med 51:1901-7. 2010
    ..The purpose of the present study was to evaluate and optimize the performance (lateralization and lobar localization value of epileptic foci) of objective voxel-based analysis of (18)F-FDG PET scans in a pediatric epilepsy population...
  5. doi request reprint Abnormal brain protein synthesis in language areas of children with pervasive developmental disorder: a L-[1-11C]-leucine PET study
    Varun Shandal
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Child Neurol 26:1347-54. 2011
    ..03 and P = .04, respectively). In conclusion, abnormal language area protein synthesis in developmentally delayed children may be related to pervasive symptoms...
  6. pmc Clinical and histopathologic correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 52:1692-8. 2011
    ..Therefore, in the present study, we evaluated the clinical and histopathologic correlates of AMT-PET abnormalities in children with intractable epilepsy undergoing resective surgery...
  7. doi request reprint Can diffusion tensor imaging (DTI) identify epileptogenic tubers in tuberous sclerosis complex? Correlation with α-[11C]methyl-L-tryptophan ([11C] AMT) positron emission tomography (PET)
    Vijay Narayan Tiwari
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    J Child Neurol 27:598-603. 2012
    ..45; P = .003). Tubers with higher AMT-PET uptake ratios corresponded well with lower FA values in tuberous sclerosis complex patients...
  8. pmc Diffusion tensor imaging of frontal lobe in autism spectrum disorder
    Senthil K Sundaram
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Cereb Cortex 18:2659-65. 2008
    ..Abnormal frontal FA and ADC may be due to white matter organization abnormalities in ASD. Lack of evidence for excessive short range connectivity in ASD in this study may need to be re-examined with future advances in DTI technology...
  9. pmc α-[11C]-Methyl-L-tryptophan--PET in 191 patients with tuberous sclerosis complex
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI, USA
    Neurology 81:674-80. 2013
    ....
  10. pmc Sensitive diffusion tensor imaging quantification method to identify language pathway abnormalities in children with developmental delay
    Sai Prasad Gopal
    Department of Pediatrics and Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    J Pediatr 160:147-51. 2012
    ..To investigate whether abnormal regional white matter architecture in the perisylvian region could be used as an easy and sensitive quantitative method to demonstrate language pathway abnormalities in children with developmental delay (DD)...
  11. doi request reprint Epilepsy surgery in a case of encephalitis: use of 11C-PK11195 positron emission tomography
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    Pediatr Neurol 38:439-42. 2008
    ..In such cases, (11)C-PK11195 positron emission tomography may highlight the region of maximal inflammation for palliative surgical treatment...
  12. pmc α-[¹¹C]-methyl-L-tryptophan PET for tracer localization of epileptogenic brain regions: clinical studies
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI, USA
    Biomark Med 5:577-84. 2011
    ..Therefore, there is a need for more clinical studies from other centers and this can be greatly facilitated if AMT can be labeled with (18)F, a PET radionuclide widely available with a half-life of 110 min...
  13. doi request reprint Arcuate fasciculus and speech in congenital bilateral perisylvian syndrome
    Anita S D Saporta
    Department of Neurology, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
    Pediatr Neurol 44:270-4. 2011
    ..In this small series, the absence of arcuate fasciculi on diffusion tensor imaging correlated with a more severe phenotype, which cannot be appreciated via structural magnetic resonance imaging alone...
  14. doi request reprint A diffusion tensor imaging study of the cerebellar pathways in children with autism spectrum disorder
    Lalitha Sivaswamy
    Department of Pediatrics and Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Child Neurol 25:1223-31. 2010
    ..This study reiterates the underconnectivity between the cerebellum and neocortex, using diffusion tensor imaging...
  15. doi request reprint Microstructural abnormalities in language and limbic pathways in orphanage-reared children: a diffusion tensor imaging study
    Ajay Kumar
    1Carmen and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI, USA
    J Child Neurol 29:318-25. 2014
    ..Our findings suggest that white matter pathways, connecting limbic and paralimbic brain regions is abnormal in children with histories of early deprivation, with some pathways appearing more susceptible to early deprivation than others. ..
  16. doi request reprint GABA(A) receptor imaging with positron emission tomography in the human newborn: a unique binding pattern
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Neurol 48:459-62. 2013
    ....
  17. doi request reprint The role of radionuclide imaging in epilepsy, part 2: epilepsy syndromes
    Ajay Kumar
    PET Center, Department of Pediatrics, Neurology, and Radiology, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan
    J Nucl Med 54:1924-30. 2013
    ..Longitudinal PET and SPECT studies may increase our understanding of the etiopathogenesis of epilepsy syndromes and provide a clearer picture of the natural history of neurologic progression. ..
  18. pmc 15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat
    Otto Muzik
    Department of Pediatrics, Wayne State University, Detroit, MI 48201, USA
    J Nucl Med 54:523-31. 2013
    ..The objective of this study was to determine to what extent BAT thermogenesis is activated in adults during cold stress and to establish the relationship between BAT oxidative metabolism and (18)F-FDG tracer uptake...
  19. doi request reprint Functional imaging: PET
    Ajay Kumar
    Departments of Pediatrics and Neurology, School of Medicine, Wayne State University, and PET Center, Children s Hospital of Michigan, Detroit, MI, USA
    Handb Clin Neurol 111:767-76. 2013
    ..Finally, PET can also be used to evaluate various cognitive processes and their underlying neurological substrates and can help in addressing the issue of brain plasticity and reorganization, related to epilepsy...
  20. doi request reprint Niemann-Pick disease type C: unique 2-deoxy-2[¹⁸F] fluoro-D-glucose PET abnormality
    Ajay Kumar
    Department of Pediatrics and Neurology, Wayne State University School of Medicine, Children s Hospital of Michigan, Detroit Medical Center, Detroit, Michigan, USA
    Pediatr Neurol 44:57-60. 2011
    ....
  21. doi request reprint Evaluation of neuroinflammation in X-linked adrenoleukodystrophy
    Ajay Kumar
    Department of Pediatrics and Neurology, Wayne State University School of Medicine, Children s Hospital of Michigan, Detroit Medical Center, Detroit, Michigan 48201, USA
    Pediatr Neurol 44:143-6. 2011
    ..This technique may be particularly useful for evaluating treatment response, which is not easy with other imaging modalities, after white matter is significantly and extensively damaged...
  22. doi request reprint The role of radionuclide imaging in epilepsy, Part 1: Sporadic temporal and extratemporal lobe epilepsy
    Ajay Kumar
    PET Center, Department of Pediatrics, Neurology, and Radiology, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan
    J Nucl Med 54:1775-81. 2013
    ....
  23. ncbi request reprint Epilepsy diagnosis: positron emission tomography
    Ajay Kumar
    Departments of Pediatrics and Neurology, School of Medicine, Wayne State University, Children s Hospital of Michigan, Detroit, MI, USA
    Handb Clin Neurol 107:409-24. 2012
    ..Other tracers such as 5HT(1A) receptor ligands, have an important research role...