O Kucuk

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. doi request reprint Lycopene in cancer prevention and treatment
    Soley Seren
    Department of Internal Medicine, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Am J Ther 15:66-81. 2008
  2. pmc Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest
    Julian J Raffoul
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    BMC Cancer 6:107. 2006
  3. pmc Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    BMC Cancer 7:4. 2007
  4. ncbi request reprint Phase II study of cisplatin and 5-fluorouracil in previously treated metastatic breast cancer: an Eastern Cooperative Oncology Group study (PA 185)
    O Kucuk
    Karmanos Cancer Institute, Wayne State University Detroit, Michigan, USA
    Breast Cancer Res Treat 57:201-6. 1999
  5. ncbi request reprint Cancer chemoprevention
    Omer Kucuk
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Cancer Metastasis Rev 21:189-97. 2002
  6. ncbi request reprint Chemoprevention of prostate cancer
    Omer Kucuk
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Metastasis Rev 21:111-24. 2002
  7. ncbi request reprint New opportunities in chemoprevention research
    Omer Kucuk
    Barbara Ann Karmanos Cancer Institute, Wayne State University, 3990 John R, 5 Hudson, Detroit, MI 48201, USA
    Cancer Invest 20:237-45. 2002
  8. ncbi request reprint Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy
    O Kucuk
    Division of Hematology and Oncology, Wayne State University, and Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
    Cancer Epidemiol Biomarkers Prev 10:861-8. 2001
  9. ncbi request reprint Effects of lycopene supplementation in patients with localized prostate cancer
    Omer Kucuk
    Division of Hematology and Oncology, 3990 John R, Barbara Ann Karmanos Cancer Institute, Wayne State University, 5 Hudson, Detroit, MI 48201, USA
    Exp Biol Med (Maywood) 227:881-5. 2002
  10. ncbi request reprint Phase II trail of didemnin B in previously treated non-Hodgkin's lymphoma: an Eastern Cooperative Oncology Group (ECOG) Study
    O Kucuk
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Am J Clin Oncol 23:273-7. 2000

Collaborators

Detail Information

Publications50

  1. doi request reprint Lycopene in cancer prevention and treatment
    Soley Seren
    Department of Internal Medicine, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Am J Ther 15:66-81. 2008
    ..Further mechanistic studies and randomized controlled clinical intervention trials with lycopene involving cancer patients are warranted...
  2. pmc Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest
    Julian J Raffoul
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    BMC Cancer 6:107. 2006
    ..In this study, we investigated the cellular and molecular interaction between genistein and radiation using PC-3 human prostate cancer cells...
  3. pmc Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    BMC Cancer 7:4. 2007
    ....
  4. ncbi request reprint Phase II study of cisplatin and 5-fluorouracil in previously treated metastatic breast cancer: an Eastern Cooperative Oncology Group study (PA 185)
    O Kucuk
    Karmanos Cancer Institute, Wayne State University Detroit, Michigan, USA
    Breast Cancer Res Treat 57:201-6. 1999
    ..The present study was conducted to investigate the efficacy and toxicity of a cisplatin and 5-fluorouracil (5-FU) combination in previously treated advanced breast cancer...
  5. ncbi request reprint Cancer chemoprevention
    Omer Kucuk
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Cancer Metastasis Rev 21:189-97. 2002
    ..Current challenge is to build on this success and identify non-toxic chemopreventive agents. A promising area of research is clinical studies with botanicals, cancer preventive compounds in fruits, vegetables and other plants...
  6. ncbi request reprint Chemoprevention of prostate cancer
    Omer Kucuk
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Metastasis Rev 21:111-24. 2002
    ..Inclusion of appropriate biomarkers in clinical trials will help elucidate the mechanisms by which genetic and epigenetic pathways of carcinogenesis are modulated by nutrients and phytochemicals...
  7. ncbi request reprint New opportunities in chemoprevention research
    Omer Kucuk
    Barbara Ann Karmanos Cancer Institute, Wayne State University, 3990 John R, 5 Hudson, Detroit, MI 48201, USA
    Cancer Invest 20:237-45. 2002
    ..In addition, administration of chemopreventive agents prior to surgery provides an opportunity to investigate the modulation of genetic and epigenetic pathways by putative cancer preventive compounds and nutrients...
  8. ncbi request reprint Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy
    O Kucuk
    Division of Hematology and Oncology, Wayne State University, and Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
    Cancer Epidemiol Biomarkers Prev 10:861-8. 2001
    ..0002 and P = 0.0003, respectively). The results suggest that lycopene supplementation may decrease the growth of prostate cancer. However, no firm conclusions can be drawn at this time because of the small sample size...
  9. ncbi request reprint Effects of lycopene supplementation in patients with localized prostate cancer
    Omer Kucuk
    Division of Hematology and Oncology, 3990 John R, Barbara Ann Karmanos Cancer Institute, Wayne State University, 5 Hudson, Detroit, MI 48201, USA
    Exp Biol Med (Maywood) 227:881-5. 2002
    ..This pilot study suggests that lycopene may have beneficial effects in prostate cancer. Larger clinical trials are warranted to investigate the potential preventive and/or therapeutic role of lycopene in prostate cancer...
  10. ncbi request reprint Phase II trail of didemnin B in previously treated non-Hodgkin's lymphoma: an Eastern Cooperative Oncology Group (ECOG) Study
    O Kucuk
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Am J Clin Oncol 23:273-7. 2000
    ..7 years. There were five grade V, 12 grade IV, and 57 grade III toxicities. Didemnin B appears to have modest activity in low grade NHL. However, the drug has considerable toxicity in this population of patients...
  11. ncbi request reprint Phase II trial of menogaril in patients with previously treated multiple myeloma or chronic lymphocytic leukemia
    O Kucuk
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Am J Clin Oncol 23:379-83. 2000
    ..Five grade 4 hematologic toxicities were observed. There was one fatal neutropenic sepsis. Menogaril, as administered in this study, does not appear to have significant activity in patients with previously treated MM or CLL...
  12. ncbi request reprint Phase II trial of cisplatin, etoposide, and 5-fluorouracil in advanced non-small-cell lung cancer: an Eastern Cooperative Oncology Group Study (PB586)
    O Kucuk
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Am J Clin Oncol 23:371-5. 2000
    ..The combination of cisplatin, 5-FU, and etoposide as administered in this study appears to have considerable toxicity and does not appear to be superior to other cisplatin-containing regimens used for the treatment of advanced NSCLC...
  13. ncbi request reprint Effect of soy isoflavone supplementation on markers of oxidative stress in men and women
    Z Djuric
    Barbara Ann Karmanos Cancer Institute, 110 East Warren, Detroit, MI 48201, USA
    Cancer Lett 172:1-6. 2001
    ..These pilot results suggest that soy isoflavone supplementation decreases levels of oxidative DNA damage in humans, and this may be a mechanism behind the cancer-preventive effects of soy isoflavones...
  14. ncbi request reprint Genistein potentiates the radiation effect on prostate carcinoma cells
    G G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, and Harper Hospital, Detroit, Michigan 48201, USA
    Clin Cancer Res 7:382-90. 2001
    ..These studies suggest a potential of combining genistein with radiation for the treatment of localized prostate carcinoma...
  15. ncbi request reprint Phase II trial of bicalutamide in patients with advanced prostate cancer in whom conventional hormonal therapy failed: a Southwest Oncology Group study (SWOG 9235)
    O Kucuk
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA
    Urology 58:53-8. 2001
    ..CONCLUSIONS: These data suggest that bicalutamide decreases pain and improves symptom status in patients with prostate cancer in whom first-line hormonal therapy failed...
  16. ncbi request reprint Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes
    J N Davis
    Department of Cancer Biology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48202, USA
    Free Radic Biol Med 30:1293-302. 2001
    ..This preliminary study demonstrates that soy isoflavone supplementation may protect cells from oxidative stress-inducing agents by inhibiting NF-kappa B activation and decreasing DNA adduct levels...
  17. ncbi request reprint Cisplatin-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenografts
    Ramzi M Mohammad
    Division of Hematology and Oncology, Department of Internal Medicine, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer 106:1260-8. 2006
    ....
  18. ncbi request reprint Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells
    Yiwei Li
    Department of Pathology and Internal Medicine, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 65:6934-42. 2005
    ..Theses results warrant carefully designed clinical studies investigating the combination of soy isoflavones and commonly used chemotherapeutic agents for the treatment of human cancers...
  19. ncbi request reprint Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/MMP-9 signaling in prostate cancer
    Yiwei Li
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 66:4816-25. 2006
    ..From these results, we conclude that genistein could be a promising nontoxic agent to improve the treatment outcome of metastatic prostate cancer with docetaxel...
  20. ncbi request reprint Prostate cancer treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model
    Yu Wang
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA
    Radiat Res 166:73-80. 2006
    ....
  21. ncbi request reprint An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels
    Mark Messina
    Loma Linda University, School of Public Health, Department of Nutrition, Loma Linda, CA 92350, USA
    J AOAC Int 89:1121-34. 2006
    ....
  22. ncbi request reprint Pilot study of intraoperative chemotherapy with cisplatin and 5-fluorouracil in patients with advanced squamous cell carcinoma of the head and neck
    Ozlem E Tulunay
    Department of Otolaryngology Head and Neck Surgery, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan, USA
    Head Neck 29:267-71. 2007
    ....
  23. ncbi request reprint Soy isoflavones enhance radiotherapy in a metastatic prostate cancer model
    Julian J Raffoul
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Cancer 120:2491-8. 2007
    ..Our studies demonstrate the safety and potential role of soy isoflavones for enhancing the therapeutic effect of radiotherapy in prostate cancer...
  24. ncbi request reprint Mature results of a phase II trial of gemcitabine/paclitaxel given every 2 weeks in patients with advanced non-small-cell lung cancer
    Antoinette J Wozniak
    Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Clin Lung Cancer 8:313-8. 2007
    ..Treatment with 1 previous chemotherapy regimen was allowed. Patients received gemcitabine 3000 mg/m(2) intravenously over 30 minutes and paclitaxel 150 mg/m(2) over 3 hours every 2 weeks...
  25. ncbi request reprint Effects of high fruit-vegetable and/or low-fat intervention on breast nipple aspirate fluid micronutrient levels
    Zora Djuric
    Department of Family Medicine, University of Michigan, Room 2150 Cancer and Geriatrics Center, Ann Arbor, MI 48109 0930, USA
    Cancer Epidemiol Biomarkers Prev 16:1393-9. 2007
    ..A change in diet is known to affect micronutrient levels in blood but to what extent diet can affect micronutrient levels in the breast is not yet well established...
  26. ncbi request reprint Lycopene and soy isoflavones in the treatment of prostate cancer
    Ulka Vaishampayan
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Nutr Cancer 59:1-7. 2007
    ..Future studies are warranted to further investigate the efficacy of lycopene and soy isoflavones in prostate cancer as well as the mechanism of potential negative interaction between them...
  27. doi request reprint Effect of docetaxel on the surgical tumor microenvironment of head and neck cancer in murine models
    George H Yoo
    Department of Otolaryngology Head and Neck Surgery, Wayne State University, 5E University Health Center, 4201 St Antoine, Detroit, MI 48201, USA
    Arch Otolaryngol Head Neck Surg 134:735-42. 2008
    ..To identify the antitumor activity and wound-healing effect of docetaxel delivered in the surgical tumor microenvironment of head and neck squamous cell carcinoma (HNSCC)...
  28. ncbi request reprint Lycopene supplementation prevents the development of spontaneous smooth muscle tumors of the oviduct in Japanese quail
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Nutr Cancer 50:181-9. 2004
    ..Clinical trials should be conducted to investigate the efficacy of lycopene supplementation in the prevention and treatment of uterine leiomyoma in humans...
  29. ncbi request reprint Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper University Hospital, Detroit, MI 48201, USA
    Mol Cancer Ther 3:1271-9. 2004
    ..We tested this approach in vivo using an orthotopic prostate carcinoma model of PC-3 cells in nude mice...
  30. ncbi request reprint Re: Response of hormone refractory prostate cancer to lycopene
    Omer Kucuk
    J Urol 167:651. 2002
  31. ncbi request reprint Genistein sensitizes diffuse large cell lymphoma to CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy
    Ramzi M Mohammad
    Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Cancer Ther 2:1361-8. 2003
    ..Because soy isoflavone genistein is a widely available nutritional supplement, its use in combination with CHOP chemotherapy should be further explored in a clinical trial in patients with NHL...
  32. ncbi request reprint Methods to increase fruit and vegetable intake with and without a decrease in fat intake: compliance and effects on body weight in the nutrition and breast health study
    Zora Djuric
    Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
    Nutr Cancer 43:141-51. 2002
    ..Maintenance of energy intake, therefore, did not appear to be attained intrinsically when individuals were counseled to make changes in the composition of their diets...
  33. ncbi request reprint Epidermal growth factor receptor (EGFR)-related protein inhibits multiple members of the EGFR family in colon and breast cancer cells
    Hu Xu
    John D Dingell Veterans Affairs Medical Center, 4646 John R, Room B 4238, Detroit, MI 48201, USA
    Mol Cancer Ther 4:435-42. 2005
    ..Our results suggest that ERRP is an effective pan-erbB inhibitor and, thus, may be a potential therapeutic agent for a wide variety of epithelial cancers expressing different levels and subclasses of EGFRs...
  34. ncbi request reprint Soy isoflavones in the treatment of prostate cancer
    Maha Hussain
    Division of Hematology and Oncology, Wayne State University, Detroit, MI 48201, USA
    Nutr Cancer 47:111-7. 2003
    ..00002) and from 0.11 to 0.51 microM (P = 0.00001), respectively. No significant changes were observed in serum levels of testosterone, IGF-1, IGFBP-3, or 5-OHmdU. These data suggest that soy isoflavones may benefit some patients with Pca...
  35. ncbi request reprint Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappaB in BxPC-3 pancreatic cancer cell line
    Yiwei Li
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Pancreas 28:e90-5. 2004
    ....
  36. pmc Regulation of gene expression and inhibition of experimental prostate cancer bone metastasis by dietary genistein
    Yiwei Li
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neoplasia 6:354-63. 2004
    ..Genistein may thus be a promising agent for the prevention and/or treatment of prostate cancer...
  37. ncbi request reprint Antioxidant effect of zinc in humans
    Ananda S Prasad
    Department of Medicine, Division of Hematology Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Free Radic Biol Med 37:1182-90. 2004
    ..Zinc administration to human subjects with conditions associated with increased oxidative stress should be explored...
  38. ncbi request reprint Dietary tomato powder supplementation in the prevention of leiomyoma of the oviduct in the Japanese quail
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Nutr Cancer 59:70-5. 2007
    ..Clinical trials should be conducted to investigate the efficacy of tomato powder supplementation in the prevention and treatment of uterine leiomyoma in humans...
  39. ncbi request reprint Zinc in cancer prevention
    Ananda S Prasad
    Department of Medicine Division of Hematology Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine Detroit, MI 48201, USA
    Cancer Metastasis Rev 21:291-5. 2002
    ..Preclinical and clinical studies need to investigate modulation of genetic and epigenetic pathways of carcinogenesis by zinc...
  40. ncbi request reprint Expression of prostate-specific antigen is transcriptionally regulated by genistein in prostate cancer cells
    Joanne N Davis
    Department of Urology, University of Michigan Medical Center, Ann Arbor, USA
    Mol Carcinog 34:91-101. 2002
    ..These results suggest that ligand-dependent differences in the ability to activate PSA expression may contribute to the agonistic/antagonistic responses observed with genistein in prostate cancer cells...
  41. ncbi request reprint Oral preneoplasia and chemoprevention of squamous cell carcinoma of the head and neck
    Omer Kucuk
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA
    Cancer Treat Res 114:61-83. 2003
  42. doi request reprint Supplementation with organic or inorganic selenium in heat-distressed quail
    Nurhan Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, 23119, Elazig, Turkey
    Biol Trace Elem Res 122:229-37. 2008
    ..Results of the present study suggest that supplementation with Se-Met can be considered to be more protective than Na2SeO3 by reducing the negative effects of oxidative stress induced by heat stress in quail...
  43. ncbi request reprint Folic acid mediated attenuation of loss of heterozygosity of DCC tumor suppressor gene in the colonic mucosa of patients with colorectal adenomas
    Kiran K Nagothu
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Detect Prev 27:297-304. 2003
    ..Taken together, our data suggest that one of the ways folate may exert its chemopreventive effect is by stabilizing certain tumor suppressor gene(s) and preventing further increases in proliferation...
  44. ncbi request reprint Benefit of postoperative chemoradiotherapy for patients with unknown primary squamous cell carcinoma of the head and neck
    Nasfat J Shehadeh
    Division of Hematology Oncology and Transplantation HOT, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    Head Neck 28:1090-8. 2006
    ..The optimal treatment of unknown primary squamous cell cancer of the head and neck (SCCHN) continues to be controversial, since major randomized studies excluded those patients...
  45. ncbi request reprint Differential expression of hZnT-4 in human prostate tissues
    Frances W J Beck
    Department of Internal Medicine, Division of Hematology Oncology and Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Prostate 58:374-81. 2004
    ..It is not known whether loss of zinc, necessary to restrain aggressive growth, results from loss of a single specific or multiple zinc transporters...
  46. ncbi request reprint Folic acid reduces nuclear translocation of beta-catenin in rectal mucosal crypts of patients with colorectal adenomas
    Richard Jaszewski
    Division of Gastroenterology, and Department of Internal Medicine, Veterans Affairs Medical Center, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Lett 206:27-33. 2004
    ..05) and cellular expression of pGSK3beta (P < 0.01) when compared to placebo. Folic acid may exert its chemopreventive effect, at least in part, through inhibition of nuclear translocation of beta-catenin...
  47. ncbi request reprint Effects of dietary genistein on nutrient use and mineral status in heat-stressed quails
    Nurhan Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Exp Anim 55:75-82. 2006
    ..In conclusion, genistein supplementation to the basal diet improved digestibility of CP, DM and ash and levels of Ca and P and bone mineralization in quails reared under heat stress conditions...
  48. ncbi request reprint Folic acid-mediated inhibition of serum-induced activation of EGFR promoter in colon cancer cells
    Kiran K Nagothu
    Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
    Am J Physiol Gastrointest Liver Physiol 287:G541-6. 2004
    ..This could partly be responsible for FA-mediated inhibition of growth-related processes in colorectal neoplasia...
  49. ncbi request reprint Zinc supplementation alleviates heat stress in laying Japanese quail
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig Turkey
    J Nutr 133:2808-11. 2003
    ..No significant differences in any values were observed in the TN groups (P > 0.05). Results of the present study suggest that supplementation with 60 mg zinc/kg diet protects quail by reducing the negative effects of heat stress...
  50. ncbi request reprint EGF-receptor related protein causes cell cycle arrest and induces apoptosis of colon cancer cells in vitro and in vivo
    Edi Levi
    Veterans Affairs Medical Center, Pathology and Laboratory Medicine Service, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Anticancer Res 24:2885-91. 2004
    ..However, the mechanisms by which ERRP exerts its anti-tumor properties are poorly understood The current investigation was undertaken to delineate the inhibitory mechanisms that are triggered by ERRP...