Matcheri Keshavan

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Pituitary volume in neuroleptic-naïve schizophrenia: a structural MRI study
    Ameet R Upadhyaya
    Brain Research and Imaging Neuroscience, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48201, USA
    Schizophr Res 90:266-73. 2007
  2. ncbi request reprint Guidelines for clinical treatment of early course schizophrenia
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 4201 St Antoine, University Health Center, 9B, Detroit, MI 48201, USA
    Curr Psychiatry Rep 8:329-34. 2006
  3. doi request reprint Schizophrenia, "just the facts": what we know in 2008 Part 3: neurobiology
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201 St Antoine Blvd, UHC 9B, Detroit, Michigan 48202, United States
    Schizophr Res 106:89-107. 2008
  4. ncbi request reprint Early intervention in schizophrenia: current and future perspectives
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48201, USA
    Curr Psychiatry Rep 9:325-8. 2007
  5. pmc Psychopathology among offspring of parents with schizophrenia: relationship to premorbid impairments
    Matcheri Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201, St Antoine Blvd, Detroit, MI 48201, USA
    Schizophr Res 103:114-20. 2008
  6. ncbi request reprint Are brain structural abnormalities useful as endophenotypes in schizophrenia?
    Matcheri S Keshavan
    Department of Psychiatry, Wayne State University School of Medicine, 4201 St Antoine Boulevard, Detroit, MA 48201, USA
    Int Rev Psychiatry 19:397-406. 2007
  7. ncbi request reprint Neurobiology of early psychosis
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, UCH 9B, 4201 St Antoine Boulevard, Detroit, MI, USA
    Br J Psychiatry Suppl 48:s8-18. 2005
  8. ncbi request reprint Premorbid indicators and risk for schizophrenia: a selective review and update
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201 St Antoine, Suite 9B, Detroit, MI 48201, USA
    Schizophr Res 79:45-57. 2005
  9. ncbi request reprint A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus
    Larry J Seidman
    Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Bull 29:803-30. 2003
  10. pmc fMRI BOLD response to the eyes task in offspring from multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Alcohol Clin Exp Res 31:2028-35. 2007

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Pituitary volume in neuroleptic-naïve schizophrenia: a structural MRI study
    Ameet R Upadhyaya
    Brain Research and Imaging Neuroscience, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48201, USA
    Schizophr Res 90:266-73. 2007
    ..Similar volume reductions have been seen in other neuropsychiatric populations and may cut across diagnostic boundaries...
  2. ncbi request reprint Guidelines for clinical treatment of early course schizophrenia
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 4201 St Antoine, University Health Center, 9B, Detroit, MI 48201, USA
    Curr Psychiatry Rep 8:329-34. 2006
    ..Although evidence-based interventions have generated new optimism among those with the illness, more efforts are needed to increase access to care in community settings...
  3. doi request reprint Schizophrenia, "just the facts": what we know in 2008 Part 3: neurobiology
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201 St Antoine Blvd, UHC 9B, Detroit, Michigan 48202, United States
    Schizophr Res 106:89-107. 2008
    ..The accumulating fact-base on the neurobiology of schizophrenia calls for novel integrative model(s) that may generate new, testable predictions...
  4. ncbi request reprint Early intervention in schizophrenia: current and future perspectives
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48201, USA
    Curr Psychiatry Rep 9:325-8. 2007
    ..More evidence-based data are needed to place the EI models in schizophrenia on firm footing in order to effectively implement them in the resource-strapped community mental health service settings...
  5. pmc Psychopathology among offspring of parents with schizophrenia: relationship to premorbid impairments
    Matcheri Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201, St Antoine Blvd, Detroit, MI 48201, USA
    Schizophr Res 103:114-20. 2008
    ..We examined the prevalence and correlates of psychopathology in an ongoing study of offspring genetically at risk for schizophrenia...
  6. ncbi request reprint Are brain structural abnormalities useful as endophenotypes in schizophrenia?
    Matcheri S Keshavan
    Department of Psychiatry, Wayne State University School of Medicine, 4201 St Antoine Boulevard, Detroit, MA 48201, USA
    Int Rev Psychiatry 19:397-406. 2007
    ..Further work is needed to examine how specific genes and their interactions with the environment may produce alterations in brain structure and function that accompany psychotic disorders...
  7. ncbi request reprint Neurobiology of early psychosis
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, UCH 9B, 4201 St Antoine Boulevard, Detroit, MI, USA
    Br J Psychiatry Suppl 48:s8-18. 2005
    ..Neurobiological studies of the early course of psychoses, such as schizophrenia, allow investigation of pathophysiology without the confounds of illness chronicity and treatment...
  8. ncbi request reprint Premorbid indicators and risk for schizophrenia: a selective review and update
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201 St Antoine, Suite 9B, Detroit, MI 48201, USA
    Schizophr Res 79:45-57. 2005
    ..Collectively, such data may help us to predict the eventual emergence of schizophrenia, and schizophrenia spectrum or non-spectrum psychopathology...
  9. ncbi request reprint A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus
    Larry J Seidman
    Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Bull 29:803-30. 2003
    ..Implications of genetic risk studies for prodromal research are discussed...
  10. pmc fMRI BOLD response to the eyes task in offspring from multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Alcohol Clin Exp Res 31:2028-35. 2007
    ..These characteristics may be related to inherited differences in the neuroanatomical network that comprises the social brain...
  11. doi request reprint Use of aripiprazole in tardive dyskinesia: an open label study of six cases
    Rajaprabhakaran Rajarethinam
    Wayne State University School of Medicine, Detroit, MI, USA
    World J Biol Psychiatry 10:416-9. 2009
    ..The results need to be viewed with caution and not considered as indicative of a viable treatment option for TD as this is an open label study, and a small sample size...
  12. doi request reprint Reduced activation of superior temporal gyrus during auditory comprehension in young offspring of patients with schizophrenia
    Rajaprabhakaran Rajarethinam
    Wayne State University, Detroit Michigan, USA
    Schizophr Res 130:101-5. 2011
    ..In this study, we examined the brain activation for auditory comprehension using fMRI in a group of young offspring of schizophrenia patients (HR) with a hypothesis that HR subjects will not activate STG as well as comparison subjects...
  13. pmc Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia
    Hader A Mansour
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:701-10. 2009
    ..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders...
  14. doi request reprint Grey matter volume reductions in the emotion network of patients with depression and coronary artery disease
    Alison M Gilbert
    University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychiatry Res 181:9-14. 2010
    ..Our results support that the network of brain regions involved in emotion regulation may be relevant to the relationship between CAD and MDD...
  15. ncbi request reprint Caudate volume in offspring of patients with schizophrenia
    Rajaprabhakaran Rajarethinam
    Department of Psychiatry, Wayne State University School of Medicine, 4201 St Antoine Street UHC 9B, Detroit, Michigan 48201, USA
    Br J Psychiatry 191:258-9. 2007
    ..1% respectively in 50 offspring without psychosis of patients with schizophrenia compared with 53 age- and gender-matched controls, providing new evidence that caudate volume reduction may be a trait-related abnormality in schizophrenia...
  16. doi request reprint Differential processing of metacognitive evaluation and the neural circuitry of the self and others in schizophrenia: a pilot study
    Eric R Murphy
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit Michigan, USA
    Schizophr Res 116:252-8. 2010
    ....
  17. ncbi request reprint Adverse effects of risperidone on spatial working memory in first-episode schizophrenia
    James L Reilly
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, IL 60612, USA
    Arch Gen Psychiatry 63:1189-97. 2006
    ..The oculomotor delayed response task is a translational spatial working memory paradigm used to characterize the neurophysiologic and neurochemical aspects of working memory in the primate brain...
  18. ncbi request reprint Neuropsychological dysfunction in antipsychotic-naive first-episode unipolar psychotic depression
    S Kristian Hill
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Psychiatry 161:996-1003. 2004
    ....
  19. ncbi request reprint Regionally specific alterations in membrane phospholipids in children with ADHD: An in vivo 31P spectroscopy study
    Jeffrey A Stanley
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, University Health Center 9B 28, 4201 St Antoine Street, Detroit, MI 48201, USA
    Psychiatry Res 148:217-21. 2006
    ..No differences were noted in the ST. These deficits in membrane phospholipid (MPL) precursor levels suggest reduced mass of cellular MPLs due to a possible underdevelopment of neuronal processes and synapses in ADHD...
  20. ncbi request reprint Anatomic evaluation of the orbitofrontal cortex in major depressive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Biol Psychiatry 55:353-8. 2004
    ..This study examined the OFC and its subdivisions in patients with MDD and matched healthy control subjects...
  21. ncbi request reprint Proceedings and data from The Schizophrenia Summit: a critical appraisal to improve the management of Schizophrenia
    Henry A Nasrallah
    Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson St, Suite 3224, Cincinnati, OH 45267 0559, USA
    J Clin Psychiatry 70:4-46. 2009
    ..Summit faculty member opinion is compared with field survey results, and recommendations are made for future research...
  22. pmc Cognitive enhancement therapy for early-course schizophrenia: effects of a two-year randomized controlled trial
    Shaun M Eack
    School of Social Work, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Psychiatr Serv 60:1468-76. 2009
    ..This study examined the two-year effects of an integrated neurocognitive and social-cognitive rehabilitation program, cognitive enhancement therapy (CET), on cognitive and functional outcomes in early-course schizophrenia...
  23. ncbi request reprint Prolonged untreated illness duration from prodromal onset predicts outcome in first episode psychoses
    Matcheri S Keshavan
    University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Schizophr Bull 29:757-69. 2003
    ..The latter, if true, would strongly support therapeutic intervention efforts in the prodromal and early psychotic phases of schizophrenia...
  24. ncbi request reprint Effect of antipsychotics on pituitary gland volume in treatment-naïve first-episode schizophrenia: a pilot study
    Frank P MacMaster
    Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Schizophr Res 92:207-10. 2007
    ..This appeared to be specific to the prolactin-elevating drugs. In controls, pituitary volume did not change significantly (3% decrease). Pituitary volume may be a useful biomarker for treatments that affect neuroendocrine function...
  25. ncbi request reprint Pathways to care for African Americans with early psychosis
    Orlena B Merritt-Davis
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 2751 East Jefferson, Detroit, Michigan 48207, USA
    Psychiatr Serv 57:1043-4. 2006
    ..Further research is necessary to evaluate the role of ethnicity in treatment delays among patients with recent-onset psychotic illnesses...
  26. ncbi request reprint Genetically predisposed offspring with schizotypal features: an ultra high-risk group for schizophrenia?
    Vaibhav A Diwadkar
    Depatment of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:230-8. 2006
    ..We propose that schizotypy may define a hyper vulnerable sub-sample among individuals genetically predisposed to schizophrenia and that future studies that attempt to assess risk may benefit from such a convergent approach...
  27. ncbi request reprint Pituitary volume in pediatric obsessive-compulsive disorder
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48201, USA
    Biol Psychiatry 59:252-7. 2006
    ..Abnormalities in the limbic-hypothalamic-pituitary-adrenal (LHPA) axis have been implicated in the pathogenesis of obsessive-compulsive disorder (OCD). To our knowledge, however, no prior study has measured pituitary gland volume in OCD...
  28. pmc Do inter-regional gray-matter volumetric correlations reflect altered functional connectivity in high-risk offspring of schizophrenia patients?
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 118:62-8. 2010
    ..Gray-matter volumetric alterations may be related to these functional connectivity deficits. Also, gray-matter volume inter-regional correlations may reflect altered inter-regional functional connectivity...
  29. pmc Reduced N-acetyl-aspartate levels in schizophrenia patients with a younger onset age: a single-voxel 1H spectroscopy study
    Jeffrey A Stanley
    Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, United States
    Schizophr Res 93:23-32. 2007
    ....
  30. doi request reprint No difference in the prevalence of cavum septum pellucidum (CSP) between first-episode schizophrenia patients, offspring of schizophrenia patients and healthy controls
    Rajaprabhakaran Rajarethinam
    Brain Research and Imaging Neuroscience, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201, St Antoine street, Detroit, MI 48201, USA
    Schizophr Res 103:22-5. 2008
    ..We also did not find any influence of the sex or age in the presence or size of CSP. Our data cast doubt on the significance of CSP as markers of neurodevelopmental pathology in schizophrenia...
  31. ncbi request reprint Increased frontal cortical folding in autism: a preliminary MRI study
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 131:263-8. 2004
    ..These preliminary findings suggest that the gyrification patterns in autism may be abnormal, which could be related to the various cortical anomalies observed in this disorder...
  32. pmc Gray matter differences between pediatric obsessive-compulsive disorder patients and high-risk siblings: a preliminary voxel-based morphometry study
    Andrew R Gilbert
    Department of Psychiatry, University of Pittsburgh School of Medicine, Psychiatry 9B, 4201 St Antoine Boulevard, Pittsburgh, PA, United States
    Neurosci Lett 435:45-50. 2008
    ....
  33. doi request reprint Evidence of developmental alterations in cortical and subcortical regions of children with attention-deficit/hyperactivity disorder: a multivoxel in vivo phosphorus 31 spectroscopy study
    Jeffrey A Stanley
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
    Arch Gen Psychiatry 65:1419-28. 2008
    ..In vivo phosphorus 31 magnetic resonance spectroscopy ((31)P MRS) is a noninvasive neuroimaging approach that is sensitive in assessing developmental changes of overproducing/pruning of synapses...
  34. ncbi request reprint Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychoses
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic and University of Pittsburgh School of Medicine, Pittsburg, PA 15213, USA
    Am J Psychiatry 160:1298-304. 2003
    ..quot; This study examined the neuroanatomical correlates and diagnostic specificity of abnormal findings on the neurological examination in first-episode schizophrenia and other psychotic disorders...
  35. ncbi request reprint Grief and mourning in schizophrenia
    Daniela Wittmann
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, USA
    Psychiatry 70:154-66. 2007
    ....
  36. pmc Sensory-gating deficit of the N100 mid-latency auditory evoked potential in medicated schizophrenia patients
    Nash N Boutros
    Wayne State University, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI, USA
    Schizophr Res 113:339-46. 2009
    ..Data also suggest that improving the signal to noise ratio (MOAD data) increases the sensitivity for detecting gating abnormalities and assessing their clinical correlates...
  37. ncbi request reprint A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Room 984, University of Pittsburgh School of Medicine, 3811 0 Hara Street, Pittsburgh, PA 15213, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:1143-9. 2002
    ..These abnormalities need to be prospectively investigated in nonpsychotic individuals at risk for schizophrenia in order to determine their predictive value for eventual emergence of schizophrenia or related disorders...
  38. ncbi request reprint Prefrontal subregions and dimensions of insight in first-episode schizophrenia--a pilot study
    Mujeeb U Shad
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX 75235, USA
    Psychiatry Res 146:35-42. 2006
    ..DLPFC deficits may have resulted in illness unawareness by interfering with self-monitoring, while OFC abnormalities may have mediated symptom misattribution by conferring aberrant salience to perceived symptomatology...
  39. ncbi request reprint Insight and prefrontal cortex in first-episode Schizophrenia
    Mujeeb U Shad
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroimage 22:1315-20. 2004
    ....
  40. ncbi request reprint 1H MRS study of dorsolateral prefrontal cortex in healthy individuals before and after lithium administration
    Paolo Brambilla
    Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Neuropsychopharmacology 29:1918-24. 2004
    ....
  41. ncbi request reprint Parahippocampal gyrus in first episode psychotic disorders: a structural magnetic resonance imaging study
    Konasale M R Prasad
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, PA 15213, USA
    Prog Neuropsychopharmacol Biol Psychiatry 28:651-8. 2004
    ..Significant association of PHG volume with psychotic symptoms suggests that PHG pathology plays an important role in the etiopathology of psychosis and its symptoms...
  42. ncbi request reprint Correlates of insight in first episode psychosis
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Schizophr Res 70:187-94. 2004
    ..These observations suggest that deficits in insight may be related to a generalized dysfunction of neural networks involved in memory, learning, and executive functions...
  43. pmc Longitudinal alterations of executive function in non-psychotic adolescents at familial risk for schizophrenia
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:469-74. 2010
    ..Our results suggest an altered maturational trajectory of executive function during adolescence in individuals at familial risk for schizophrenia...
  44. pmc Response suppression deficits in treatment-naïve first-episode patients with schizophrenia, psychotic bipolar disorder and psychotic major depression
    Margret S H Harris
    Department of Psychiatry, University of Illinois, Chicago, IL, USA
    Psychiatry Res 170:150-6. 2009
    ..However, the distinct pattern of dysfunction in schizophrenia across oculomotor paradigms suggests possible unique causes of their observed oculomotor performance deficits...
  45. ncbi request reprint 1H magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in bipolar disorder patients
    Paolo Brambilla
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Affect Disord 86:61-7. 2005
    ..Furthermore, recent MRS reports suggested possible lithium-induced increase in NAA levels in bipolar patients. We examined with in vivo (1)H MRS NAA levels in the DLPFC of adult bipolar patients...
  46. pmc Effects of risperidone on procedural learning in antipsychotic-naive first-episode schizophrenia
    Margret S H Harris
    Department of Psychiatry, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 34:468-76. 2009
    ....
  47. ncbi request reprint Blunted serotonergic responsivity in neuroleptic-naïve patients at first-episode of schizophrenia
    Ravinder Reddy
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Schizophr Res 90:81-5. 2007
    ..To determine whether serotonergic responsivity, as assessed in platelets, is blunted in treatment-naïve patients with first episode psychosis, similar to observations in chronic schizophrenia...
  48. pmc Cerebellar volume in offspring from multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 61:41-7. 2007
    ..Additionally, developmental changes in cerebellar volume during adolescence have been reported...
  49. pmc Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Biol Psychiatry 65:129-36. 2009
    ..The role of the orbitofrontal cortex (OFC) in regulating emotional processing is increasingly being recognized along with its association with impulsive behavior...
  50. ncbi request reprint Pituitary volume in treatment-naïve pediatric major depressive disorder
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, and Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Biol Psychiatry 60:862-6. 2006
    ..In this independent sample, we focus on gender differences in pituitary volume in a larger sample of pediatric patients with MDD...
  51. doi request reprint Schizophrenia, "just the facts" 5. Treatment and prevention. Past, present, and future
    Rajiv Tandon
    University of Florida, Department of Psychiatry, FL, USA
    Schizophr Res 122:1-23. 2010
    ..We evaluate the potential contribution of pharmacogenomics and other biological markers in optimizing individual treatment and outcome in the future...
  52. ncbi request reprint Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder
    Simerjit Kaur
    Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Psychiatry 162:1637-43. 2005
    ..This anatomical magnetic resonance imaging study examined the cingulate cortex in children and adolescents with bipolar disorder and matched healthy comparison subjects...
  53. ncbi request reprint Personality dimensions in first-episode psychoses
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Psychiatry 162:102-9. 2005
    ..The authors compared the patterns and specificity of premorbid personality dimensions in first-episode schizophrenia patients with those in patients with first-episode nonschizophrenia psychoses and healthy comparison subjects...
  54. ncbi request reprint 1H Magnetic resonance spectroscopy study of dorsolateral prefrontal cortex in unipolar mood disorder patients
    Paolo Brambilla
    Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA
    Psychiatry Res 138:131-9. 2005
    ..Future 1H MRS investigations should longitudinally examine the role of illness chronicity on DLPFC abnormalities and their relationship with the symptoms of unipolar disorder...
  55. ncbi request reprint Decreased nonlinear complexity and chaos during sleep in first episode schizophrenia: a preliminary report
    Matcheri S Keshavan
    Department of Psychiatry, University of Pittsburgh School of Medicine, UPMC Health System Western Psychiatric Institute and Clinic, Room 441, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Schizophr Res 71:263-72. 2004
    ..Diminished complexity of EEG time series during awake and REM sleep in patients with schizophrenia may underlie the impaired ability to process information in psychotic disorders such as schizophrenia...
  56. ncbi request reprint Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder
    Barbara K Chen
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Biol Psychiatry 56:399-405. 2004
    ....
  57. ncbi request reprint Psychosis proneness and ADHD in young relatives of schizophrenia patients
    Matcheri S Keshavan
    Department of Psychiatry, UPMC Health System Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Room 984, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Schizophr Res 59:85-92. 2003
    ..Longitudinal studies can clarify whether an "ADHD subgroup" within HR subjects predict an increased risk for future emergence of schizophrenia...
  58. ncbi request reprint Negative symptom resolution and improvements in specific cognitive deficits after acute treatment in first-episode schizophrenia
    Daniel Schuepbach
    Neurobehavioral Studies Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Schizophr Res 53:249-61. 2002
    ..Reduction in positive symptoms was not associated with change in cognitive abilities. These findings suggest a linkage between early, treatment-induced improvements in negative symptoms and reductions in distinct cognitive deficits...
  59. ncbi request reprint Neuropsychological performance and regional cerebral blood flow in obsessive-compulsive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Room 984, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:657-65. 2003
    ..They also extend the existing research, showing associations between deficits in cortical-subcortical circuitry and performance on neuropsychological tests of controlled attention and visuospatial functions...
  60. doi request reprint Longitudinal treatment outcome of African American and Caucasian patients with first episode psychosis
    Huijun Li
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, United States Department of Psychology, Florida Agricultural and Mechanical University, United States
    Asian J Psychiatr 4:266-71. 2011
    ..While both groups of patients have experienced significant improvement during the one-year treatment, that of the African American patients was less optimal...
  61. ncbi request reprint Reduced plasma antioxidants in first-episode patients with schizophrenia
    Ravinder Reddy
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Schizophr Res 62:205-12. 2003
    ..The present data suggest that a defect in the antioxidant defense system (AODS), which may lead to oxidative damage, occurs early in the course of illness and is independent of treatment effects...
  62. pmc Dorsolateral prefrontal cortex magnetic resonance imaging measurements and cognitive performance in autism
    Jessica Griebling
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Child Neurol 25:856-63. 2010
    ..The absence of correlations suggests that executive dysfunction is not the result of focal brain alterations but, rather, is the result of a distributed neural network dysfunction...
  63. ncbi request reprint Decreased left amygdala and hippocampal volumes in young offspring at risk for schizophrenia
    Matcheri S Keshavan
    Department of Psychiatry, UPMC Health System Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room 984, Pittsburgh, PA 15213, USA
    Schizophr Res 58:173-83. 2002
    ..Follow-up studies are needed to examine the predictive value of these measures for future emergence of schizophrenia in at-risk individuals...
  64. ncbi request reprint Risperidone in first-episode psychosis: a longitudinal, exploratory voxel-based morphometric study
    Ragy R Girgis
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Schizophr Res 82:89-94. 2006
    ..No areas of change were found in controls. The results of this exploratory investigation support the possibility that risperidone has short-term effects on brain parenchyma in individuals with first-episode psychosis...
  65. ncbi request reprint Anatomical MRI study of borderline personality disorder patients
    Paolo Brambilla
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Psychiatry Res 131:125-33. 2004
    ..Early traumatic experiences may play a role in hippocampal atrophy, whereas substance use disorders may contribute to putamen enlargement...
  66. ncbi request reprint Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging study
    Hua Hsua Chen
    Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Neurosci Lett 363:65-8. 2004
    ..Decreased white matter connections may be the core of abnormalities in STG, which is an important region for speech, language and communication, and could possibly underlie neurocognitive deficits present in bipolar patients...
  67. pmc Untreated illness duration correlates with gray matter loss in first-episode psychoses
    Srihari S Bangalore
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Neuroreport 20:729-34. 2009
    ..The observed inverse relationship between DUI and temporal gray matter density is consistent with a progressive process during the early course of schizophrenia...
  68. doi request reprint Effects of word frequency on semantic memory in schizophrenia: electrophysiological evidence for a deficit in linguistic access
    Ruth Condray
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Psychophysiol 75:141-56. 2010
    ..g., cholinergic system). Electrophysiological responding may be informative regarding the storage-access distinction for schizophrenia...
  69. ncbi request reprint Measurement of the orbitofrontal cortex: a validation study of a new method
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroimage 19:665-73. 2003
    ..996 and 0.998. This method appears to be a valid method for measuring the OFC with excellent reliability. This uncomplicated approach is easy to apply and has the potential to be a valuable alternative to the previously published methods...
  70. doi request reprint Verbal fluency deficits and altered lateralization of language brain areas in individuals genetically predisposed to schizophrenia
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 115:202-8. 2009
    ..Volumetric deficits and altered asymmetry in inferior parietal and Heschl's gyrii may accompany genetic liability to schizophrenia...
  71. ncbi request reprint Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging study
    Marsal Sanches
    Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Curl Drive, San Antonio, TX 87229, USA
    Psychiatry Res 138:43-9. 2005
    ..55 +/- 73.67 mm(3), respectively. There were no statistically significant differences between groups regarding right or left SGPFC volumes. We found no evidence of volumetric abnormalities in the SGPFC of bipolar children and adolescents...
  72. ncbi request reprint Brief report: abnormal association between the thalamus and brain size in Asperger's disorder
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Autism Dev Disord 38:390-4. 2008
    ....
  73. pmc Reduced platelet serotonergic responsivity as assessed by dense granule secretion in first-episode psychosis
    Ravinder D Reddy
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Clin Biochem 40:1081-3. 2007
    ..To determine whether blunted serotonergic responsivity, indicated by decreased platelet dense granule secretion (DGS), occurs in neuroleptic-naïve patients with schizophrenia, as observed previously in chronic schizophrenia...
  74. ncbi request reprint Decreased coherence in higher frequency ranges (beta and gamma) between central and frontal EEG in patients with schizophrenia: A preliminary report
    Vikram Kumar Yeragani
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Psychiatry Res 141:53-60. 2006
    ..These results have been discussed further in relation to wake and sleep stages...
  75. pmc Deconstructing psychosis with human brain imaging
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania 10 Gates, 3400 Spruce Philadelphia, PA 19104, USA
    Schizophr Bull 33:921-31. 2007
    ....
  76. pmc Development and sexual dimorphism of the pituitary gland
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, and Children s Hospital of Michigan, Detroit, MI 48201, USA
    Life Sci 80:940-4. 2007
    ....
  77. ncbi request reprint Dorsolateral prefrontal cortex morphology and short-term outcome in first-episode schizophrenia
    Konasale M R Prasad
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Psychiatry Res 140:147-55. 2005
    ..Volume of the left DLPFC at baseline predicted functional outcome in schizophrenia at 1 but not at 2 years. Specific cognitive functions regulated by the left DLPFC may be critical for functional outcome...
  78. ncbi request reprint Emotional words induce enhanced brain activity in schizophrenic patients with auditory hallucinations
    Julio Sanjuan
    Psychiatric Unit, University of Valencia School of Medicine, Valencia, Spain
    Psychiatry Res 154:21-9. 2007
    ..Our findings are consistent with other studies suggesting a relevant role for emotional response in the pathogenesis and treatment of auditory hallucinations...
  79. ncbi request reprint Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, 90095, USA
    Schizophr Bull 29:653-69. 2003
    ....
  80. ncbi request reprint Early treatment-induced improvement of negative symptoms predicts cognitive functioning in treatment-naive first episode schizophrenia: a 2-year followup
    Daniel Schuepbach
    Psychiatric University Hospital Zurich, PO Box 68, CH 8029 Zurich, Switzerland
    Schizophr Bull 30:837-48. 2004
    ..These findings suggest an important relationship between treatment efficacy of antipsychotic medication and the longer term course of cognitive deficits in schizophrenia...
  81. ncbi request reprint Investigation of corpus callosum in schizophrenia with diffusion imaging
    Paolo Brambilla
    Department of Pathology and Clinical and Experimental Medicine, Section of Psychiatry, University of Udine, Udine, Italy
    Schizophr Res 79:201-10. 2005
    ..We here further investigated CC organization with diffusion imaging (DWI) in a sample of schizophrenia patients recruited from the epidemiologically defined catchment area of South Verona, Italy...
  82. pmc Cognitive enhancement therapy improves emotional intelligence in early course schizophrenia: preliminary effects
    Shaun M Eack
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, United States
    Schizophr Res 89:308-11. 2007
    ..These findings lend preliminary support to the previously documented benefits of CET on social cognition in schizophrenia, and suggest that such benefits can be extended to patients in the early course of the illness...
  83. ncbi request reprint Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients
    Roberto B Sassi
    Division of Mood and Anxiety Disorders, Associate Professor of Psychiatry and Radiology, Krus Endowed Chair in Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Am J Psychiatry 162:2109-15. 2005
    ..In order to examine whether such abnormalities would also be found in younger patients, a 1H spectroscopy study was conducted that focused on the dorsolateral prefrontal cortex of children and adolescents with bipolar disorder...
  84. doi request reprint Cannabis use and brain structural alterations in first episode schizophrenia--a region of interest, voxel based morphometric study
    Srihari S Bangalore
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213 USA
    Schizophr Res 99:1-6. 2008
    ..The results suggest that cannabis use may be associated with altered brain structure, in particular regions rich in CB1 receptors. These findings need to be confirmed by larger, prospective studies...
  85. ncbi request reprint Longitudinal studies of antisaccades in antipsychotic-naive first-episode schizophrenia
    Margret S H Harris
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Psychol Med 36:485-94. 2006
    ..Some data suggest that treatment with antipsychotic medications may ameliorate these deficits...
  86. ncbi request reprint Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites
    Jeffrey K Yao
    Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Building 13, 7180 Highland Drive, Pittsburgh, PA 15206, USA
    Biol Psychiatry 52:823-30. 2002
    ..To address this question we examined the relations between red blood cell polyunsaturated fatty acids and brain phospholipid metabolites from different regions of interest in schizophrenia and healthy subjects...
  87. ncbi request reprint Superior temporal gyrus volumes in pediatric generalized anxiety disorder
    Michael D De Bellis
    University of Pittsburgh Medical Center, Developmental Traumatology Program Developmental Family Health Clinic and Neuroimaging Laboratory, Western Psychiatric Institute and Clinic, Rm 392, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Biol Psychiatry 51:553-62. 2002
    ..Larger amygdala volumes were previously reported in pediatric GAD; however, the brain regions involved in social intelligence were not examined in this pilot study...
  88. ncbi request reprint Superior temporal gyrus volumes in maltreated children and adolescents with PTSD
    Michael D De Bellis
    University of Pittsburgh Medical Center, Developmental Traumatology Program Developmental Family Health Clinic and Neuroimaging Laboratory, Western Psychiatric Institute and Clinic, Rm 392, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Biol Psychiatry 51:544-52. 2002
    ..Event-related potential abnormalities were previously reported in PTSD, implicating the existence of dysfunction in the primary auditory cortex and adjacent anterior auditory cortex of the STG in adult PTSD...
  89. ncbi request reprint Developmental reflexes and 31P Magnetic Resonance Spectroscopy of basal ganglia in antipsychotic-naive schizophrenia
    Bangalore N Gangadhar
    Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, India
    Prog Neuropsychopharmacol Biol Psychiatry 30:910-3. 2006
    ..These patients had younger age-at-onset of psychosis. Together, this suggests neurodevelopmental etiopathogenesis in schizophrenia...
  90. ncbi request reprint Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naïve patients with schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, Department of Psychiatry M C 913, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
    Schizophr Res 68:49-63. 2004
    ..Relatively static and generalized neuropsychological dysfunction, evident from illness onset, is consistent with neurodevelopmental rather than neurodegenerative models of schizophrenia...
  91. ncbi request reprint Abnormalities of the corpus callosum in nonpsychotic children with chromosome 22q11 deletion syndrome
    Vandana Shashi
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neuroimage 21:1399-406. 2004
    ..Further longitudinal studies on these children will help determine which of these structural abnormalities is/are pertinent to the development of psychosis...
  92. ncbi request reprint Impairment of verbal memory and learning in antipsychotic-naïve patients with first-episode schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
    Schizophr Res 68:127-36. 2004
    ..The goal of this study was to characterize the nature of verbal memory impairments in antipsychotic-naïve schizophrenic patients early in the course of illness...
  93. ncbi request reprint Confirmatory factor analysis of the Neurological Evaluation Scale in unmedicated schizophrenia
    Richard D Sanders
    Dayton VA Hospital, 4100 W Third Street, Dayton, OH 45428, USA
    Psychiatry Res 133:65-71. 2005
    ..The current results contribute to the development of empirical subscales for neurological assessment procedures to be used in psychiatric conditions...
  94. ncbi request reprint Abnormalities in visually guided saccades suggest corticofugal dysregulation in never-treated schizophrenia
    James L Reilly
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Biol Psychiatry 57:145-54. 2005
    ..Previous studies have reported intact visually guided saccades in schizophrenia, but these are limited by potential acute and long-term pharmacological treatment effects, small sample sizes, and a failure to follow patients over time...
  95. ncbi request reprint Relationships between cognitive and neurological performance in neuroleptic-naïve psychosis
    Richard D Sanders
    Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 16:480-7. 2004
    ..Customarily, frontal neuropsychological tasks also relate more strongly to CogPer than to RepMot. Approximately one-half of the variability in these cognitive and neurological assessments is shared...
  96. pmc Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia
    James L Reilly
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Biol Psychiatry 63:776-83. 2008
    ..This suggests that dysregulation of automatic attentional processes may contribute to disturbances in prefrontally mediated control of voluntary behavior...
  97. ncbi request reprint Sex difference in cognitive response to antipsychotic treatment in first episode schizophrenia
    Leah H Rubin
    Department of Psychiatry and Psychology, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 33:290-7. 2008
    ..Future studies of the neurocognitive effects of antipsychotic treatment may need to take potential sex differences in cognitive response into account...
  98. ncbi request reprint The effects of antipsychotic medication on factor and cluster structure of neurologic examination abnormalities in schizophrenia
    Gerald Goldstein
    VA Pittsburgh HCS, 7180 Highland Drive, Pittsburgh, PA 15206, USA
    Schizophr Res 75:55-64. 2005
    ..As is the case with other domains of symptoms and performance in schizophrenia, relationships among neurologic exam variables are altered by the presence of antipsychotic medication...
  99. pmc Foresight in schizophrenia: a potentially unique and relevant factor to functional disability
    Shaun M Eack
    School of Social Work, University of Pittsburgh, USA
    Psychiatr Serv 59:256-60. 2008
    ..This research sought to further elucidate the factors that conspire against functional recovery from schizophrenia by introducing the concept of foresight and exploring its unique contribution to functional outcome...
  100. ncbi request reprint Antipsychotic drugs exacerbate impairment on a working memory task in first-episode schizophrenia
    James L Reilly
    Center for Cognitive Medicine, University of Illinois at Chicago, Illinois 60612, USA
    Biol Psychiatry 62:818-21. 2007
    ....
  101. pmc Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?
    Konasale M Prasad
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Schizophr Bull 34:774-90. 2008
    ..Further work is needed to examine how specific genes and their interactions with the environment may produce alterations in brain structure and function that accompany psychotic disorders...

Research Grants15

  1. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Matcheri Keshavan; Fiscal Year: 2009
    ....
  2. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Matcheri Keshavan; Fiscal Year: 2007
    ....
  3. BRAIN MATURATION AND VULNERABILITY TO SCHIZOPHRENIA
    Matcheri Keshavan; Fiscal Year: 2004
    ..This professional enhancement plan and the research project are likely to help the candidate realize his full potential and contribute to our further understanding of the pathogenesis of schizophrenia. ..
  4. BRAIN MATURATION AND VULNERABILITY TO SCHIZOPHRENIA
    Matcheri Keshavan; Fiscal Year: 2006
    ..These studies will establish a cohort of high-risk subjects for further follow-up studies of developmental vulnerability to schizophrenia. ..
  5. Rehabilitation, Brain Function and Early Schizophrenia
    Matcheri Keshavan; Fiscal Year: 2005
    ..An understanding of the cerebral correlates of improvement (or lack thereof) in cognition and behavior might guide development of future cognitive rehabilitation strategies for schizophrenia. ..
  6. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Matcheri S Keshavan; Fiscal Year: 2010
    ....