Research Topics
Genomes and GenesSpecies | Matcheri KeshavanSummaryAffiliation: Wayne State University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Pituitary volume in neuroleptic-naïve schizophrenia: a structural MRI studyAmeet R Upadhyaya
Brain Research and Imaging Neuroscience, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48201, USA
Schizophr Res 90:266-73. 2007..Similar volume reductions have been seen in other neuropsychiatric populations and may cut across diagnostic boundaries...- Guidelines for clinical treatment of early course schizophreniaMatcheri S Keshavan
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 4201 St Antoine, University Health Center, 9B, Detroit, MI 48201, USA
Curr Psychiatry Rep 8:329-34. 2006..Although evidence-based interventions have generated new optimism among those with the illness, more efforts are needed to increase access to care in community settings... 
Schizophrenia, "just the facts": what we know in 2008 Part 3: neurobiologyMatcheri S Keshavan
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201 St Antoine Blvd, UHC 9B, Detroit, Michigan 48202, United States
Schizophr Res 106:89-107. 2008..The accumulating fact-base on the neurobiology of schizophrenia calls for novel integrative model(s) that may generate new, testable predictions...- Early intervention in schizophrenia: current and future perspectivesMatcheri S Keshavan
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48201, USA
Curr Psychiatry Rep 9:325-8. 2007..More evidence-based data are needed to place the EI models in schizophrenia on firm footing in order to effectively implement them in the resource-strapped community mental health service settings... 
Psychopathology among offspring of parents with schizophrenia: relationship to premorbid impairmentsMatcheri Keshavan
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201, St Antoine Blvd, Detroit, MI 48201, USA
Schizophr Res 103:114-20. 2008..We examined the prevalence and correlates of psychopathology in an ongoing study of offspring genetically at risk for schizophrenia...- Are brain structural abnormalities useful as endophenotypes in schizophrenia?Matcheri S Keshavan
Department of Psychiatry, Wayne State University School of Medicine, 4201 St Antoine Boulevard, Detroit, MA 48201, USA
Int Rev Psychiatry 19:397-406. 2007..Further work is needed to examine how specific genes and their interactions with the environment may produce alterations in brain structure and function that accompany psychotic disorders... - Neurobiology of early psychosisMatcheri S Keshavan
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, UCH 9B, 4201 St Antoine Boulevard, Detroit, MI, USA
Br J Psychiatry Suppl 48:s8-18. 2005..Neurobiological studies of the early course of psychoses, such as schizophrenia, allow investigation of pathophysiology without the confounds of illness chronicity and treatment... - Premorbid indicators and risk for schizophrenia: a selective review and updateMatcheri S Keshavan
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201 St Antoine, Suite 9B, Detroit, MI 48201, USA
Schizophr Res 79:45-57. 2005..Collectively, such data may help us to predict the eventual emergence of schizophrenia, and schizophrenia spectrum or non-spectrum psychopathology... - A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrusLarry J Seidman
Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
Schizophr Bull 29:803-30. 2003..Implications of genetic risk studies for prodromal research are discussed... - fMRI BOLD response to the eyes task in offspring from multiplex alcohol dependence familiesShirley Y Hill
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Alcohol Clin Exp Res 31:2028-35. 2007..These characteristics may be related to inherited differences in the neuroanatomical network that comprises the social brain... - Use of aripiprazole in tardive dyskinesia: an open label study of six casesRajaprabhakaran Rajarethinam
Wayne State University School of Medicine, Detroit, MI, USA
World J Biol Psychiatry 10:416-9. 2009..The results need to be viewed with caution and not considered as indicative of a viable treatment option for TD as this is an open label study, and a small sample size... - Reduced activation of superior temporal gyrus during auditory comprehension in young offspring of patients with schizophreniaRajaprabhakaran Rajarethinam
Wayne State University, Detroit Michigan, USA
Schizophr Res 130:101-5. 2011..In this study, we examined the brain activation for auditory comprehension using fMRI in a group of young offspring of schizophrenia patients (HR) with a hypothesis that HR subjects will not activate STG as well as comparison subjects... - Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophreniaHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 11:701-10. 2009..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders... - Grey matter volume reductions in the emotion network of patients with depression and coronary artery diseaseAlison M Gilbert
University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychiatry Res 181:9-14. 2010..Our results support that the network of brain regions involved in emotion regulation may be relevant to the relationship between CAD and MDD... - Caudate volume in offspring of patients with schizophreniaRajaprabhakaran Rajarethinam
Department of Psychiatry, Wayne State University School of Medicine, 4201 St Antoine Street UHC 9B, Detroit, Michigan 48201, USA
Br J Psychiatry 191:258-9. 2007..1% respectively in 50 offspring without psychosis of patients with schizophrenia compared with 53 age- and gender-matched controls, providing new evidence that caudate volume reduction may be a trait-related abnormality in schizophrenia... - Differential processing of metacognitive evaluation and the neural circuitry of the self and others in schizophrenia: a pilot studyEric R Murphy
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit Michigan, USA
Schizophr Res 116:252-8. 2010.... - Adverse effects of risperidone on spatial working memory in first-episode schizophreniaJames L Reilly
Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, IL 60612, USA
Arch Gen Psychiatry 63:1189-97. 2006..Studies with nonhuman primates performing oculomotor delayed response tasks suggest that the apparent adverse effect of risperidone might result from treatment-related changes in modulatory functions of prefrontal D1 receptor systems... - Neuropsychological dysfunction in antipsychotic-naive first-episode unipolar psychotic depressionS Kristian Hill
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
Am J Psychiatry 161:996-1003. 2004.... - Regionally specific alterations in membrane phospholipids in children with ADHD: An in vivo 31P spectroscopy studyJeffrey A Stanley
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, University Health Center 9B-28, 4201 St. Antoine Street, Detroit, MI 48201, USA
Psychiatry Res 148:217-21. 2006..No differences were noted in the ST. These deficits in membrane phospholipid (MPL) precursor levels suggest reduced mass of cellular MPLs due to a possible underdevelopment of neuronal processes and synapses in ADHD... - Anatomic evaluation of the orbitofrontal cortex in major depressive disorderAcioly L T Lacerda
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Biol Psychiatry 55:353-8. 2004..Future studies examining the relationship between specific symptomatic dimensions of MDD and OFC volumes could be especially informative... - Proceedings and data from The Schizophrenia Summit: a critical appraisal to improve the management of SchizophreniaHenry A Nasrallah
Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson St, Suite 3224, Cincinnati, OH 45267 0559, USA
J Clin Psychiatry 70:4-46. 2009..Summit faculty member opinion is compared with field survey results, and recommendations are made for future research... - Cognitive enhancement therapy for early-course schizophrenia: effects of a two-year randomized controlled trialShaun M Eack
School of Social Work, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Psychiatr Serv 60:1468-76. 2009..This study examined the two-year effects of an integrated neurocognitive and social-cognitive rehabilitation program, cognitive enhancement therapy (CET), on cognitive and functional outcomes in early-course schizophrenia... - Prolonged untreated illness duration from prodromal onset predicts outcome in first episode psychosesMatcheri S Keshavan
University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Schizophr Bull 29:757-69. 2003..The latter, if true, would strongly support therapeutic intervention efforts in the prodromal and early psychotic phases of schizophrenia... - Effect of antipsychotics on pituitary gland volume in treatment-naïve first-episode schizophrenia: a pilot studyFrank P MacMaster
Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
Schizophr Res 92:207-10. 2007..This appeared to be specific to the prolactin-elevating drugs. In controls, pituitary volume did not change significantly (3% decrease). Pituitary volume may be a useful biomarker for treatments that affect neuroendocrine function... - Pathways to care for African Americans with early psychosisOrlena B Merritt-Davis
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 2751 East Jefferson, Detroit, Michigan 48207, USA
Psychiatr Serv 57:1043-4. 2006..Further research is necessary to evaluate the role of ethnicity in treatment delays among patients with recent-onset psychotic illnesses... - Genetically predisposed offspring with schizotypal features: an ultra high-risk group for schizophrenia?Vaibhav A Diwadkar
Depatment of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI 48201, USA
Prog Neuropsychopharmacol Biol Psychiatry 30:230-8. 2006..We propose that schizotypy may define a hyper vulnerable sub-sample among individuals genetically predisposed to schizophrenia and that future studies that attempt to assess risk may benefit from such a convergent approach... - Pituitary volume in pediatric obsessive-compulsive disorderFrank P MacMaster
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48201, USA
Biol Psychiatry 59:252-7. 2006..Abnormalities in the limbic-hypothalamic-pituitary-adrenal (LHPA) axis have been implicated in the pathogenesis of obsessive-compulsive disorder (OCD). To our knowledge, however, no prior study has measured pituitary gland volume in OCD... - Do inter-regional gray-matter volumetric correlations reflect altered functional connectivity in high-risk offspring of schizophrenia patients?Tejas S Bhojraj
Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center Harvard Medical School, Boston, MA 02215, USA
Schizophr Res 118:62-8. 2010..Gray-matter volumetric alterations may be related to these functional connectivity deficits. Also, gray-matter volume inter-regional correlations may reflect altered inter-regional functional connectivity... - Reduced N-acetyl-aspartate levels in schizophrenia patients with a younger onset age: a single-voxel 1H spectroscopy studyJeffrey A Stanley
Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, United States
Schizophr Res 93:23-32. 2007.... - No difference in the prevalence of cavum septum pellucidum (CSP) between first-episode schizophrenia patients, offspring of schizophrenia patients and healthy controlsRajaprabhakaran Rajarethinam
Brain Research and Imaging Neuroscience, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201, St Antoine street, Detroit, MI 48201, USA
Schizophr Res 103:22-5. 2008..We also did not find any influence of the sex or age in the presence or size of CSP. Our data cast doubt on the significance of CSP as markers of neurodevelopmental pathology in schizophrenia... - Increased frontal cortical folding in autism: a preliminary MRI studyAntonio Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Psychiatry Res 131:263-8. 2004..These preliminary findings suggest that the gyrification patterns in autism may be abnormal, which could be related to the various cortical anomalies observed in this disorder... - Gray matter differences between pediatric obsessive-compulsive disorder patients and high-risk siblings: a preliminary voxel-based morphometry studyAndrew R Gilbert
Department of Psychiatry, University of Pittsburgh School of Medicine, Psychiatry 9B, 4201 St Antoine Boulevard, Pittsburgh, PA, United States
Neurosci Lett 435:45-50. 2008.... - Evidence of developmental alterations in cortical and subcortical regions of children with attention-deficit/hyperactivity disorder: a multivoxel in vivo phosphorus 31 spectroscopy studyJeffrey A Stanley
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
Arch Gen Psychiatry 65:1419-28. 2008..In vivo phosphorus 31 magnetic resonance spectroscopy ((31)P MRS) is a noninvasive neuroimaging approach that is sensitive in assessing developmental changes of overproducing/pruning of synapses... - Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychosesMatcheri S Keshavan
Department of Psychiatry, Western Psychiatric Institute and Clinic and University of Pittsburgh School of Medicine, Pittsburg, PA 15213, USA
Am J Psychiatry 160:1298-304. 2003..quot; This study examined the neuroanatomical correlates and diagnostic specificity of abnormal findings on the neurological examination in first-episode schizophrenia and other psychotic disorders... - Grief and mourning in schizophreniaDaniela Wittmann
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, USA
Psychiatry 70:154-66. 2007.... - Sensory-gating deficit of the N100 mid-latency auditory evoked potential in medicated schizophrenia patientsNash N Boutros
Wayne State University, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI, USA
Schizophr Res 113:339-46. 2009..Data also suggest that improving the signal to noise ratio (MOAD data) increases the sensitivity for detecting gating abnormalities and assessing their clinical correlates... - A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parentsMatcheri S Keshavan
Department of Psychiatry, Western Psychiatric Institute and Clinic, Room 984, University of Pittsburgh School of Medicine, 3811 0 Hara Street, Pittsburgh, PA 15213, USA
Prog Neuropsychopharmacol Biol Psychiatry 26:1143-9. 2002..These abnormalities need to be prospectively investigated in nonpsychotic individuals at risk for schizophrenia in order to determine their predictive value for eventual emergence of schizophrenia or related disorders... - Prefrontal subregions and dimensions of insight in first-episode schizophrenia--a pilot studyMujeeb U Shad
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX 75235, USA
Psychiatry Res 146:35-42. 2006..DLPFC deficits may have resulted in illness unawareness by interfering with self-monitoring, while OFC abnormalities may have mediated symptom misattribution by conferring aberrant salience to perceived symptomatology... - Insight and prefrontal cortex in first-episode SchizophreniaMujeeb U Shad
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Neuroimage 22:1315-20. 2004.... - 1H MRS study of dorsolateral prefrontal cortex in healthy individuals before and after lithium administrationPaolo Brambilla
Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Neuropsychopharmacology 29:1918-24. 2004.... - Parahippocampal gyrus in first episode psychotic disorders: a structural magnetic resonance imaging studyKonasale M R Prasad
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, PA 15213, USA
Prog Neuropsychopharmacol Biol Psychiatry 28:651-8. 2004..Significant association of PHG volume with psychotic symptoms suggests that PHG pathology plays an important role in the etiopathology of psychosis and its symptoms... - Correlates of insight in first episode psychosisMatcheri S Keshavan
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Schizophr Res 70:187-94. 2004..These observations suggest that deficits in insight may be related to a generalized dysfunction of neural networks involved in memory, learning, and executive functions... - Longitudinal alterations of executive function in non-psychotic adolescents at familial risk for schizophreniaTejas S Bhojraj
Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts, USA
Prog Neuropsychopharmacol Biol Psychiatry 34:469-74. 2010..Our results suggest an altered maturational trajectory of executive function during adolescence in individuals at familial risk for schizophrenia... - Response suppression deficits in treatment-naïve first-episode patients with schizophrenia, psychotic bipolar disorder and psychotic major depressionMargret S H Harris
Department of Psychiatry, University of Illinois, Chicago, IL, USA
Psychiatry Res 170:150-6. 2009..However, the distinct pattern of dysfunction in schizophrenia across oculomotor paradigms suggests possible unique causes of their observed oculomotor performance deficits... - 1H magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in bipolar disorder patientsPaolo Brambilla
Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
J Affect Disord 86:61-7. 2005..Longitudinal 1H MRS studies should further examine NAA levels in prefrontal cortex regions in untreated bipolar patients before and after mood stabilizing treatment... - Effects of risperidone on procedural learning in antipsychotic-naive first-episode schizophreniaMargret S H Harris
Department of Psychiatry, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Neuropsychopharmacology 34:468-76. 2009.... - Blunted serotonergic responsivity in neuroleptic-naïve patients at first-episode of schizophreniaRavinder Reddy
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Schizophr Res 90:81-5. 2007..To determine whether serotonergic responsivity, as assessed in platelets, is blunted in treatment-naïve patients with first episode psychosis, similar to observations in chronic schizophrenia... - Cerebellar volume in offspring from multiplex alcohol dependence familiesShirley Y Hill
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 61:41-7. 2007..Additionally, developmental changes in cerebellar volume during adolescence have been reported... - Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence familiesShirley Y Hill
Department of Psychiatry, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
Biol Psychiatry 65:129-36. 2009..The role of the orbitofrontal cortex (OFC) in regulating emotional processing is increasingly being recognized along with its association with impulsive behavior... - Pituitary volume in treatment-naïve pediatric major depressive disorderFrank P MacMaster
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, and Children's Hospital of Michigan, Detroit, Michigan 48201, USA
Biol Psychiatry 60:862-6. 2006..CONCLUSIONS: These findings provide new evidence of increased pituitary volume in psychotropic-naïve pediatric patients with MDD that seems to be more prominent in male patients with nonfamilial MDD... - Schizophrenia, "just the facts" 5. Treatment and prevention. Past, present, and futureRajiv Tandon
University of Florida, Department of Psychiatry, FL, USA
Schizophr Res 122:1-23. 2010..We evaluate the potential contribution of pharmacogenomics and other biological markers in optimizing individual treatment and outcome in the future... - Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorderSimerjit Kaur
Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
Am J Psychiatry 162:1637-43. 2005..64 cm3 [SD=0.21] versus 2.71 cm3 [SD=0.10]). CONCLUSIONS: The findings indicate smaller cingulate volumes in children and adolescents with bipolar disorder, suggesting that such abnormalities may be present early in the illness course... - Personality dimensions in first-episode psychosesMatcheri S Keshavan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Am J Psychiatry 162:102-9. 2005..The authors compared the patterns and specificity of premorbid personality dimensions in first-episode schizophrenia patients with those in patients with first-episode nonschizophrenia psychoses and healthy comparison subjects... - 1H Magnetic resonance spectroscopy study of dorsolateral prefrontal cortex in unipolar mood disorder patientsPaolo Brambilla
Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA
Psychiatry Res 138:131-9. 2005..Future 1H MRS investigations should longitudinally examine the role of illness chronicity on DLPFC abnormalities and their relationship with the symptoms of unipolar disorder... - Decreased nonlinear complexity and chaos during sleep in first episode schizophrenia: a preliminary reportMatcheri S Keshavan
Department of Psychiatry, University of Pittsburgh School of Medicine, UPMC Health System Western Psychiatric Institute and Clinic, Room 441, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Schizophr Res 71:263-72. 2004..Diminished complexity of EEG time series during awake and REM sleep in patients with schizophrenia may underlie the impaired ability to process information in psychotic disorders such as schizophrenia... - Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorderBarbara K Chen
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
Biol Psychiatry 56:399-405. 2004..48, p = .03). CONCLUSIONS: The direct correlation between left amygdala volumes and age in bipolar patients, not present in healthy control subjects, may reflect abnormal developmental mechanisms in bipolar disorder... - Psychosis proneness and ADHD in young relatives of schizophrenia patientsMatcheri S Keshavan
Department of Psychiatry, UPMC Health System Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Room 984, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Schizophr Res 59:85-92. 2003..Longitudinal studies can clarify whether an "ADHD subgroup" within HR subjects predict an increased risk for future emergence of schizophrenia... - Negative symptom resolution and improvements in specific cognitive deficits after acute treatment in first-episode schizophreniaDaniel Schuepbach
Neurobehavioral Studies Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Schizophr Res 53:249-61. 2002..Reduction in positive symptoms was not associated with change in cognitive abilities. These findings suggest a linkage between early, treatment-induced improvements in negative symptoms and reductions in distinct cognitive deficits... - Neuropsychological performance and regional cerebral blood flow in obsessive-compulsive disorderAcioly L T Lacerda
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Room 984, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Prog Neuropsychopharmacol Biol Psychiatry 27:657-65. 2003..They also extend the existing research, showing associations between deficits in cortical-subcortical circuitry and performance on neuropsychological tests of controlled attention and visuospatial functions... - Longitudinal treatment outcome of African American and Caucasian patients with first episode psychosisHuijun Li
Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, United States Department of Psychology, Florida Agricultural and Mechanical University, United States
Asian J Psychiatr 4:266-71. 2011..While both groups of patients have experienced significant improvement during the one-year treatment, that of the African American patients was less optimal... - Reduced plasma antioxidants in first-episode patients with schizophreniaRavinder Reddy
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Schizophr Res 62:205-12. 2003..The present data suggest that a defect in the antioxidant defense system (AODS), which may lead to oxidative damage, occurs early in the course of illness and is independent of treatment effects... - Dorsolateral prefrontal cortex magnetic resonance imaging measurements and cognitive performance in autismJessica Griebling
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Child Neurol 25:856-63. 2010..The absence of correlations suggests that executive dysfunction is not the result of focal brain alterations but, rather, is the result of a distributed neural network dysfunction... - Decreased left amygdala and hippocampal volumes in young offspring at risk for schizophreniaMatcheri S Keshavan
Department of Psychiatry, UPMC Health System Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room 984, Pittsburgh, PA 15213, USA
Schizophr Res 58:173-83. 2002..Follow-up studies are needed to examine the predictive value of these measures for future emergence of schizophrenia in at-risk individuals... - Risperidone in first-episode psychosis: a longitudinal, exploratory voxel-based morphometric studyRagy R Girgis
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
Schizophr Res 82:89-94. 2006..No areas of change were found in controls. The results of this exploratory investigation support the possibility that risperidone has short-term effects on brain parenchyma in individuals with first-episode psychosis... - Anatomical MRI study of borderline personality disorder patientsPaolo Brambilla
Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Psychiatry Res 131:125-33. 2004..Early traumatic experiences may play a role in hippocampal atrophy, whereas substance use disorders may contribute to putamen enlargement... - Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging studyHua Hsua Chen
Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Neurosci Lett 363:65-8. 2004..Decreased white matter connections may be the core of abnormalities in STG, which is an important region for speech, language and communication, and could possibly underlie neurocognitive deficits present in bipolar patients... - Untreated illness duration correlates with gray matter loss in first-episode psychosesSrihari S Bangalore
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Neuroreport 20:729-34. 2009..The observed inverse relationship between DUI and temporal gray matter density is consistent with a progressive process during the early course of schizophrenia... - Effects of word frequency on semantic memory in schizophrenia: electrophysiological evidence for a deficit in linguistic accessRuth Condray
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Int J Psychophysiol 75:141-56. 2010..g., cholinergic system). Electrophysiological responding may be informative regarding the storage-access distinction for schizophrenia... - Measurement of the orbitofrontal cortex: a validation study of a new methodAcioly L T Lacerda
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Neuroimage 19:665-73. 2003..996 and 0.998. This method appears to be a valid method for measuring the OFC with excellent reliability. This uncomplicated approach is easy to apply and has the potential to be a valuable alternative to the previously published methods... - Verbal fluency deficits and altered lateralization of language brain areas in individuals genetically predisposed to schizophreniaTejas S Bhojraj
Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA 02215, USA
Schizophr Res 115:202-8. 2009..Volumetric deficits and altered asymmetry in inferior parietal and Heschl's gyrii may accompany genetic liability to schizophrenia... - Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging studyMarsal Sanches
Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Curl Drive, San Antonio, TX 87229, USA
Psychiatry Res 138:43-9. 2005..55 +/- 73.67 mm(3), respectively. There were no statistically significant differences between groups regarding right or left SGPFC volumes. We found no evidence of volumetric abnormalities in the SGPFC of bipolar children and adolescents... - Brief report: abnormal association between the thalamus and brain size in Asperger's disorderAntonio Y Hardan
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Autism Dev Disord 38:390-4. 2008.... - Reduced platelet serotonergic responsivity as assessed by dense granule secretion in first-episode psychosisRavinder D Reddy
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Clin Biochem 40:1081-3. 2007..To determine whether blunted serotonergic responsivity, indicated by decreased platelet dense granule secretion (DGS), occurs in neuroleptic-naïve patients with schizophrenia, as observed previously in chronic schizophrenia... - Decreased coherence in higher frequency ranges (beta and gamma) between central and frontal EEG in patients with schizophrenia: A preliminary reportVikram Kumar Yeragani
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
Psychiatry Res 141:53-60. 2006..These results have been discussed further in relation to wake and sleep stages... - Deconstructing psychosis with human brain imagingRaquel E Gur
Department of Psychiatry, University of Pennsylvania 10 Gates, 3400 Spruce Philadelphia, PA 19104, USA
Schizophr Bull 33:921-31. 2007.... - Development and sexual dimorphism of the pituitary glandFrank P MacMaster
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, and Children s Hospital of Michigan, Detroit, MI 48201, USA
Life Sci 80:940-4. 2007.... - Dorsolateral prefrontal cortex morphology and short-term outcome in first-episode schizophreniaKonasale M R Prasad
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Psychiatry Res 140:147-55. 2005..Volume of the left DLPFC at baseline predicted functional outcome in schizophrenia at 1 but not at 2 years. Specific cognitive functions regulated by the left DLPFC may be critical for functional outcome... - Emotional words induce enhanced brain activity in schizophrenic patients with auditory hallucinationsJulio Sanjuan
Psychiatric Unit, University of Valencia School of Medicine, Valencia, Spain
Psychiatry Res 154:21-9. 2007..Our findings are consistent with other studies suggesting a relevant role for emotional response in the pathogenesis and treatment of auditory hallucinations... - Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactionsTyrone D Cannon
Department of Psychology, University of California, Los Angeles, 90095, USA
Schizophr Bull 29:653-69. 2003.... - Early treatment-induced improvement of negative symptoms predicts cognitive functioning in treatment-naive first episode schizophrenia: a 2-year followupDaniel Schuepbach
Psychiatric University Hospital Zurich, PO Box 68, CH 8029 Zurich, Switzerland
Schizophr Bull 30:837-48. 2004..These findings suggest an important relationship between treatment efficacy of antipsychotic medication and the longer term course of cognitive deficits in schizophrenia... - Investigation of corpus callosum in schizophrenia with diffusion imagingPaolo Brambilla
Department of Pathology and Clinical and Experimental Medicine, Section of Psychiatry, University of Udine, Udine, Italy
Schizophr Res 79:201-10. 2005..We here further investigated CC organization with diffusion imaging (DWI) in a sample of schizophrenia patients recruited from the epidemiologically defined catchment area of South Verona, Italy... - Cognitive enhancement therapy improves emotional intelligence in early course schizophrenia: preliminary effectsShaun M Eack
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, United States
Schizophr Res 89:308-11. 2007..These findings lend preliminary support to the previously documented benefits of CET on social cognition in schizophrenia, and suggest that such benefits can be extended to patients in the early course of the illness... - Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patientsRoberto B Sassi
Division of Mood and Anxiety Disorders, Associate Professor of Psychiatry and Radiology, Krus Endowed Chair in Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA
Am J Psychiatry 162:2109-15. 2005..These neuronal abnormalities in the dorsolateral prefrontal cortex of bipolar disorder youth are unlikely to represent long-term degenerative processes, at least in the subgroup of patients where the illness had relatively early onset... - Cannabis use and brain structural alterations in first episode schizophrenia--a region of interest, voxel based morphometric studySrihari S Bangalore
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213 USA
Schizophr Res 99:1-6. 2008..The results suggest that cannabis use may be associated with altered brain structure, in particular regions rich in CB1 receptors. These findings need to be confirmed by larger, prospective studies... - Longitudinal studies of antisaccades in antipsychotic-naive first-episode schizophreniaMargret S H Harris
Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Psychol Med 36:485-94. 2006.... - Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolitesJeffrey K Yao
Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Building 13, 7180 Highland Drive, Pittsburgh, PA 15206, USA
Biol Psychiatry 52:823-30. 2002.... - Superior temporal gyrus volumes in pediatric generalized anxiety disorderMichael D De Bellis
University of Pittsburgh Medical Center, Developmental Traumatology Program (Developmental Family Health Clinic and Neuroimaging Laboratory, Western Psychiatric Institute and Clinic, Rm 392, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Biol Psychiatry 51:553-62. 2002..CONCLUSIONS: These data agree with previous work implicating posterior right-hemispheric regions in anxiety disorders and may suggest developmental alterations in pediatric GAD... - Superior temporal gyrus volumes in maltreated children and adolescents with PTSDMichael D De Bellis
University of Pittsburgh Medical Center, Developmental Traumatology Program (Developmental Family Health Clinic and Neuroimaging Laboratory, Western Psychiatric Institute and Clinic, Rm 392, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Biol Psychiatry 51:544-52. 2002..CONCLUSIONS: These STG findings may suggest developmental alterations in maltreatment-related pediatric PTSD... - Developmental reflexes and 31P Magnetic Resonance Spectroscopy of basal ganglia in antipsychotic-naive schizophreniaBangalore N Gangadhar
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, India
Prog Neuropsychopharmacol Biol Psychiatry 30:910-3. 2006..These patients had younger age-at-onset of psychosis. Together, this suggests neurodevelopmental etiopathogenesis in schizophrenia... - Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naïve patients with schizophreniaS Kristian Hill
Center for Cognitive Medicine, Department of Psychiatry M C 913, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
Schizophr Res 68:49-63. 2004..Relatively static and generalized neuropsychological dysfunction, evident from illness onset, is consistent with neurodevelopmental rather than neurodegenerative models of schizophrenia... - Abnormalities of the corpus callosum in nonpsychotic children with chromosome 22q11 deletion syndromeVandana Shashi
Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Neuroimage 21:1399-406. 2004..Further longitudinal studies on these children will help determine which of these structural abnormalities is/are pertinent to the development of psychosis... - Impairment of verbal memory and learning in antipsychotic-naïve patients with first-episode schizophreniaS Kristian Hill
Center for Cognitive Medicine, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
Schizophr Res 68:127-36. 2004..The goal of this study was to characterize the nature of verbal memory impairments in antipsychotic-naïve schizophrenic patients early in the course of illness... - Confirmatory factor analysis of the Neurological Evaluation Scale in unmedicated schizophreniaRichard D Sanders
Dayton VA Hospital, 4100 W. Third Street, Dayton, OH 45428, USA
Psychiatry Res 133:65-71. 2005..The current results contribute to the development of empirical subscales for neurological assessment procedures to be used in psychiatric conditions... - Abnormalities in visually guided saccades suggest corticofugal dysregulation in never-treated schizophreniaJames L Reilly
Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Biol Psychiatry 57:145-54. 2005..This dysfunction appears to be minimized by the atypical antipsychotic risperidone but at the cost of a subtle reduction in saccade accuracy, possibly mediated via adverse effects on cerebellar vermis function... - Relationships between cognitive and neurological performance in neuroleptic-naïve psychosisRichard D Sanders
Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
J Neuropsychiatry Clin Neurosci 16:480-7. 2004..Customarily, frontal neuropsychological tasks also relate more strongly to CogPer than to RepMot. Approximately one-half of the variability in these cognitive and neurological assessments is shared... - Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophreniaJames L Reilly
Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Biol Psychiatry 63:776-83. 2008..This suggests that dysregulation of automatic attentional processes may contribute to disturbances in prefrontally mediated control of voluntary behavior... - Sex difference in cognitive response to antipsychotic treatment in first episode schizophreniaLeah H Rubin
Department of Psychiatry and Psychology, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Neuropsychopharmacology 33:290-7. 2008..Future studies of the neurocognitive effects of antipsychotic treatment may need to take potential sex differences in cognitive response into account... - The effects of antipsychotic medication on factor and cluster structure of neurologic examination abnormalities in schizophreniaGerald Goldstein
VA Pittsburgh HCS, 7180 Highland Drive, Pittsburgh, PA 15206, USA
Schizophr Res 75:55-64. 2005..As is the case with other domains of symptoms and performance in schizophrenia, relationships among neurologic exam variables are altered by the presence of antipsychotic medication... - Foresight in schizophrenia: a potentially unique and relevant factor to functional disabilityShaun M Eack
School of Social Work, University of Pittsburgh, USA
Psychiatr Serv 59:256-60. 2008..This research sought to further elucidate the factors that conspire against functional recovery from schizophrenia by introducing the concept of foresight and exploring its unique contribution to functional outcome... - Antipsychotic drugs exacerbate impairment on a working memory task in first-episode schizophreniaJames L Reilly
Center for Cognitive Medicine, University of Illinois at Chicago, Illinois 60612, USA
Biol Psychiatry 62:818-21. 2007.... - Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?Konasale M Prasad
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Schizophr Bull 34:774-90. 2008..Further work is needed to examine how specific genes and their interactions with the environment may produce alterations in brain structure and function that accompany psychotic disorders...
Research Grants
- Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesMatcheri Keshavan; Fiscal Year: 2009....
- Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesMatcheri Keshavan; Fiscal Year: 2007....
- BRAIN MATURATION AND VULNERABILITY TO SCHIZOPHRENIAMatcheri Keshavan; Fiscal Year: 2004..This professional enhancement plan and the research project are likely to help the candidate realize his full potential and contribute to our further understanding of the pathogenesis of schizophrenia. ..
- BRAIN MATURATION AND VULNERABILITY TO SCHIZOPHRENIAMatcheri Keshavan; Fiscal Year: 2006..These studies will establish a cohort of high-risk subjects for further follow-up studies of developmental vulnerability to schizophrenia. ..
- Rehabilitation, Brain Function and Early SchizophreniaMatcheri Keshavan; Fiscal Year: 2005..An understanding of the cerebral correlates of improvement (or lack thereof) in cognition and behavior might guide development of future cognitive rehabilitation strategies for schizophrenia. ..
- Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesMatcheri S Keshavan; Fiscal Year: 2010....