Sujatha Kannan

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Anti-inflammatory and anti-oxidant activity of anionic dendrimer-N-acetyl cysteine conjugates in activated microglial cells
    Bing Wang
    Department of Pediatrics Critical Care Medicine, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Int J Pharm 377:159-68. 2009
  2. ncbi Microglial activation in perinatal rabbit brain induced by intrauterine inflammation: detection with 11C-(R)-PK11195 and small-animal PET
    Sujatha Kannan
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
    J Nucl Med 48:946-54. 2007
  3. pmc Positron emission tomography imaging of neuroinflammation
    Sujatha Kannan
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Child Neurol 24:1190-9. 2009
  4. pmc Decreased cortical serotonin in neonatal rabbits exposed to endotoxin in utero
    Sujatha Kannan
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cereb Blood Flow Metab 31:738-49. 2011
  5. pmc Magnitude of [(11)C]PK11195 binding is related to severity of motor deficits in a rabbit model of cerebral palsy induced by intrauterine endotoxin exposure
    Sujatha Kannan
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Dev Neurosci 33:231-40. 2011
  6. pmc Stimuli-responsive star poly(ethylene glycol) drug conjugates for improved intracellular delivery of the drug in neuroinflammation
    Raghavendra S Navath
    Department of Chemical Engineering and Material Science, and Biomedical Engineering, Wayne State University, Detroit, MI 48202, USA
    J Control Release 142:447-56. 2010
  7. pmc Amino acid-functionalized dendrimers with heterobifunctional chemoselective peripheral groups for drug delivery applications
    Raghavendra S Navath
    Department of Chemical Engineering and Material Science, Wayne State University, Detroit, Michigan 48202, USA
    Biomacromolecules 11:1544-63. 2010
  8. pmc Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model
    Sujatha Kannan
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Detroit, MI 48201, USA
    Sci Transl Med 4:130ra46. 2012
  9. pmc Intrauterine administration of endotoxin leads to motor deficits in a rabbit model: a link between prenatal infection and cerebral palsy
    Fadoua Saadani-Makki
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    Am J Obstet Gynecol 199:651.e1-7. 2008
  10. pmc Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers
    Bing Wang
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, United States
    Int J Pharm 395:298-308. 2010

Collaborators

Detail Information

Publications23

  1. pmc Anti-inflammatory and anti-oxidant activity of anionic dendrimer-N-acetyl cysteine conjugates in activated microglial cells
    Bing Wang
    Department of Pediatrics Critical Care Medicine, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Int J Pharm 377:159-68. 2009
    ..The improved efficacy of the conjugate, when combined with the intrinsic neuroinflammation-targeting ability of the PAMAM dendrimers, may provide new opportunities for in vivo applications...
  2. ncbi Microglial activation in perinatal rabbit brain induced by intrauterine inflammation: detection with 11C-(R)-PK11195 and small-animal PET
    Sujatha Kannan
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
    J Nucl Med 48:946-54. 2007
    ....
  3. pmc Positron emission tomography imaging of neuroinflammation
    Sujatha Kannan
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Child Neurol 24:1190-9. 2009
    ....
  4. pmc Decreased cortical serotonin in neonatal rabbits exposed to endotoxin in utero
    Sujatha Kannan
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cereb Blood Flow Metab 31:738-49. 2011
    ..This may be a common link in neurodevelopmental disorders resulting in impairment of the somatosensory system, such as cerebral palsy and autism...
  5. pmc Magnitude of [(11)C]PK11195 binding is related to severity of motor deficits in a rabbit model of cerebral palsy induced by intrauterine endotoxin exposure
    Sujatha Kannan
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Dev Neurosci 33:231-40. 2011
    ..Molecular imaging of ongoing neuroinflammation in the neonatal period may be helpful as a screening biomarker for detecting patients at risk of developing cerebral palsy due to a perinatal insult...
  6. pmc Stimuli-responsive star poly(ethylene glycol) drug conjugates for improved intracellular delivery of the drug in neuroinflammation
    Raghavendra S Navath
    Department of Chemical Engineering and Material Science, and Biomedical Engineering, Wayne State University, Detroit, MI 48202, USA
    J Control Release 142:447-56. 2010
    ....
  7. pmc Amino acid-functionalized dendrimers with heterobifunctional chemoselective peripheral groups for drug delivery applications
    Raghavendra S Navath
    Department of Chemical Engineering and Material Science, Wayne State University, Detroit, Michigan 48202, USA
    Biomacromolecules 11:1544-63. 2010
    ..With this study, we demonstrate the development of biocompatible dendrimers bearing multiple orthogonal surface groups, enabling the attachment of drugs, imaging agents, and gel formation using minimal synthetic steps...
  8. pmc Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model
    Sujatha Kannan
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Detroit, MI 48201, USA
    Sci Transl Med 4:130ra46. 2012
    ..The effectiveness of the dendrimer-NAC treatment, administered in the postnatal period for a prenatal insult, suggests a window of opportunity for treatment of CP in humans after birth...
  9. pmc Intrauterine administration of endotoxin leads to motor deficits in a rabbit model: a link between prenatal infection and cerebral palsy
    Fadoua Saadani-Makki
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    Am J Obstet Gynecol 199:651.e1-7. 2008
    ..This study was undertaken to determine whether maternal intrauterine endotoxin administration leads to neurobehavioral deficits in newborn rabbits...
  10. pmc Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers
    Bing Wang
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, United States
    Int J Pharm 395:298-308. 2010
    ..coli membrane and the G(3.5)-PAMAM-COOH acts as a polyanion, chelating the divalent ions in outer cell membrane of E. coli. This is the first study which shows that G(4)-PAMAM-OH dendrimer acts as an antibacterial agent...
  11. pmc Intrauterine endotoxin administration leads to white matter diffusivity changes in newborn rabbits
    Fadoua Saadani-Makki
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Child Neurol 24:1179-89. 2009
    ..Diffusion tensor imaging may be a clinically useful tool for detecting neuroinflammation induced by maternal infection in neonatal white matter...
  12. pmc Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery
    Yunus E Kurtoglu
    Department of Chemical Engineering, Wayne State University, Detroit, MI 48202, USA
    Biomaterials 30:2112-21. 2009
    ..When combined with intrinsic and ligand-based targeting with dendrimers, these types of GSH sensitive nanodevices can lead to improved drug release profiles and in vivo efficacy...
  13. pmc Concurrent quantification of tryptophan and its major metabolites
    Wojciech G Lesniak
    Department of Chemical Engineering and Material Science, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48202, USA The Center for Nanomedicine, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Perinatology Research Branch, National Institute of Child Health and Human Development, NIH, DHHS, Detroit, MI 48201, USA Perinatology Research Branch, National Institute of Child Health and Human Development, NIH, DHHS, Bethesda, MD 20892, USA
    Anal Biochem 443:222-31. 2013
    ....
  14. pmc Injectable PAMAM dendrimer-PEG hydrogels for the treatment of genital infections: formulation and in vitro and in vivo evaluation
    Raghavendra S Navath
    Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, Michigan 48202, USA
    Mol Pharm 8:1209-23. 2011
    ....
  15. pmc Intrinsic targeting of inflammatory cells in the brain by polyamidoamine dendrimers upon subarachnoid administration
    Hui Dai
    Department of Pediatrics Critical Care Medicine, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Nanomedicine (Lond) 5:1317-29. 2010
    ..This article explores the unusual neuroinflammation targeting of dendrimers (with no targeting ligands) in the brain, with significant consequences for nanoscale materials in medicine...
  16. pmc Effects of branching architecture and linker on the activity of hyperbranched polymer-drug conjugates
    Omathanu Perumal
    Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Bioconjug Chem 20:842-6. 2009
    ..This has key implications in the eventual in vivo efficacy of these nanodevices...
  17. pmc Transport and biodistribution of dendrimers across human fetal membranes: implications for intravaginal administration of dendrimer-drug conjugates
    Anupa R Menjoge
    Department of Chemical Engineering and Material Science, Wayne State University, Detroit, MI 48202, USA
    Biomaterials 31:5007-21. 2010
    ....
  18. ncbi Predictors of red cell transfusion in children and adolescents undergoing spinal fusion surgery
    Kathleen L Meert
    Departments of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Spine (Phila Pa 1976) 27:2137-42. 2002
    ..A retrospective review was performed...
  19. doi Drug release characteristics of PAMAM dendrimer-drug conjugates with different linkers
    Yunus E Kurtoglu
    Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI 48202, USA
    Int J Pharm 384:189-94. 2010
    ..Understanding these structural and steric effects on their drug release characteristics is crucial for the design of dendrimer conjugates with high efficacy...
  20. ncbi The effect of surface functionality on cellular trafficking of dendrimers
    Omathanu P Perumal
    Critical Care Medicine, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Biomaterials 29:3469-76. 2008
    ..These findings open up new possibilities of targeting therapeutic agents to specific cell organelles based on surface charge...
  21. pmc Applications of positron emission tomography in the newborn nursery
    Sujatha Kannan
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Semin Perinatol 34:39-45. 2010
    ....
  22. pmc Augmented annotation and orthologue analysis for Oryctolagus cuniculus: Better Bunny
    Douglas B Craig
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    BMC Bioinformatics 13:84. 2012
    ..We developed a web-based application that provides augmented annotation and orthologue analysis for rabbit genes. Importantly, the application allows comprehensive functional analysis through the use of orthologous relationships...
  23. pmc Dendrimer-drug conjugates for tailored intracellular drug release based on glutathione levels
    Raghavendra S Navath
    Department of Chemical Engineering and Material Science, and Biomedical Engineering, Wayne State University, Detroit, Michigan 48202, USA
    Bioconjug Chem 19:2446-55. 2008
    ..The results indicate that PAMAM dendrimer conjugates produce higher local NAC concentration inside the cells, with GSH-sensitive disulfide linker enabling efficient and rapid cellular release of the drug...