Csaba Juhasz

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Quantitative PET imaging of tryptophan accumulation in gliomas and remote cortex: correlation with tumor proliferative activity
    Csaba Juhasz
    PET Center and Translational Imaging Laboratory, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Clin Nucl Med 37:838-42. 2012
  2. pmc Tryptophan metabolism in breast cancers: molecular imaging and immunohistochemistry studies
    Csaba Juhasz
    PET Center and Translational Imaging Laboratory, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Nucl Med Biol 39:926-32. 2012
  3. doi request reprint The impact of positron emission tomography imaging on the clinical management of patients with epilepsy
    Csaba Juhasz
    Department of Pediatrics, Wayne State University School of Medicine, PET Center, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Expert Rev Neurother 12:719-32. 2012
  4. pmc Differential kinetics of α-[¹¹C]methyl-L-tryptophan on PET in low-grade brain tumors
    Csaba Juhasz
    PET Center, Children s Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    J Neurooncol 102:409-15. 2011
  5. ncbi request reprint In vivo uptake and metabolism of alpha-[11C]methyl-L-tryptophan in human brain tumors
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, 48201, USA
    J Cereb Blood Flow Metab 26:345-57. 2006
  6. pmc Evolution of cortical metabolic abnormalities and their clinical correlates in Sturge-Weber syndrome
    C Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI, USA
    Eur J Paediatr Neurol 11:277-84. 2007
  7. ncbi request reprint An almost missed leptomeningeal angioma in Sturge-Weber syndrome
    Csaba Juhasz
    Division of Pediatric Neurology PET Center, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Neurology 68:243. 2007
  8. ncbi request reprint Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome
    C Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    AJNR Am J Neuroradiol 28:900-6. 2007
  9. ncbi request reprint Imaging the epileptic brain with positron emission tomography
    Csaba Juhasz
    Division of Pediatric Neurology, Wayne State University School of Medicine, Positron Emission Tomography Center, Children s Hospital of Michigan, Detroit, MI, USA
    Neuroimaging Clin N Am 13:705-16, viii. 2003
  10. ncbi request reprint White matter volume as a major predictor of cognitive function in Sturge-Weber syndrome
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Arch Neurol 64:1169-74. 2007

Research Grants

Collaborators

Detail Information

Publications90

  1. pmc Quantitative PET imaging of tryptophan accumulation in gliomas and remote cortex: correlation with tumor proliferative activity
    Csaba Juhasz
    PET Center and Translational Imaging Laboratory, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Clin Nucl Med 37:838-42. 2012
    ..We evaluated if kinetic parameters (K-complex, VD') of AMT, measured by PET, can predict the proliferative activity of glioma, and if these AMT parameters are altered in the remote cortex...
  2. pmc Tryptophan metabolism in breast cancers: molecular imaging and immunohistochemistry studies
    Csaba Juhasz
    PET Center and Translational Imaging Laboratory, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Nucl Med Biol 39:926-32. 2012
    ..In this study, we combined quantitative positron emission tomography (PET) with tumor immunohistochemistry to analyze tryptophan transport and metabolism in breast cancer...
  3. doi request reprint The impact of positron emission tomography imaging on the clinical management of patients with epilepsy
    Csaba Juhasz
    Department of Pediatrics, Wayne State University School of Medicine, PET Center, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Expert Rev Neurother 12:719-32. 2012
    ....
  4. pmc Differential kinetics of α-[¹¹C]methyl-L-tryptophan on PET in low-grade brain tumors
    Csaba Juhasz
    PET Center, Children s Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    J Neurooncol 102:409-15. 2011
    ..Kinetic analysis of AMT uptake shows significantly higher tumor/cortex tryptophan metabolic ratios in astrocytomas and oligoastrocytomas in comparison with oligodendrogliomas and DNETs...
  5. ncbi request reprint In vivo uptake and metabolism of alpha-[11C]methyl-L-tryptophan in human brain tumors
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, 48201, USA
    J Cereb Blood Flow Metab 26:345-57. 2006
    ..AMT PET might be a useful molecular imaging method to guide therapeutic approaches aimed at controlling tumor cell proliferation by acting on tryptophan metabolism...
  6. pmc Evolution of cortical metabolic abnormalities and their clinical correlates in Sturge-Weber syndrome
    C Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI, USA
    Eur J Paediatr Neurol 11:277-84. 2007
    ..The natural course of Sturge-Weber syndrome (SWS) is poorly understood, although neurological symptoms are often progressive...
  7. ncbi request reprint An almost missed leptomeningeal angioma in Sturge-Weber syndrome
    Csaba Juhasz
    Division of Pediatric Neurology PET Center, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Neurology 68:243. 2007
  8. ncbi request reprint Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome
    C Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    AJNR Am J Neuroradiol 28:900-6. 2007
    ....
  9. ncbi request reprint Imaging the epileptic brain with positron emission tomography
    Csaba Juhasz
    Division of Pediatric Neurology, Wayne State University School of Medicine, Positron Emission Tomography Center, Children s Hospital of Michigan, Detroit, MI, USA
    Neuroimaging Clin N Am 13:705-16, viii. 2003
    ..Detailed comparisons of PET abnormalities with intracranial electroencephalographic findings also improve our understanding of the pathophysiology of human epilepsy...
  10. ncbi request reprint White matter volume as a major predictor of cognitive function in Sturge-Weber syndrome
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Arch Neurol 64:1169-74. 2007
    ..To assess the role of gray and white matter volume loss vs seizures in cognitive impairment of children with Sturge-Weber syndrome with unilateral involvement...
  11. ncbi request reprint Pathophysiology and functional consequences of human partial epilepsy: lessons from positron emission tomography studies
    Cs Juhász
    Department of Pediatrics, Wayne State University, School of Medicine, Detroit, Michigan, USA
    Acta Physiol Hung 90:281-303. 2003
    ....
  12. pmc Focal decreases of cortical GABAA receptor binding remote from the primary seizure focus: what do they indicate?
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan and Harper University Hospital, Detroit Medical Center, Wayne State University School of Medcine, Detroit, Michigan, USA
    Epilepsia 50:240-50. 2009
    ..To determine the electroclinical significance and histopathological correlates of cortical gamma-aminobutyric acid(A)(GABA(A)) receptor abnormalities detected in and remote from human neocortical epileptic foci...
  13. pmc Quantification of tryptophan transport and metabolism in lung tumors using PET
    Csaba Juhasz
    PET Center, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    J Nucl Med 50:356-63. 2009
    ..The goal of this study was to evaluate the in vivo kinetics of alpha-(11)C-methyl-l-tryptophan (AMT), a PET tracer for tryptophan metabolism, in human lung tumors...
  14. ncbi request reprint Significance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism
    Sreenivasa R Chandana
    Department of Pharmacology, Wayne State University School of Medicine, 3901 Beaubian Blvd, Detroit, MI 48201, USA
    Int J Dev Neurosci 23:171-82. 2005
    ..Global as well as focal abnormally asymmetric development in the serotonergic system could lead to miswiring of the neural circuits specifying hemispheric specialization...
  15. pmc Cortical gamma-oscillations modulated by visuomotor tasks: Intracranial recording in patients with epilepsy
    Tetsuro Nagasawa
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA
    Epilepsy Behav 18:254-61. 2010
    ..The present study has increased our understanding of the physiology of the human visuomotor system...
  16. ncbi request reprint Altered regional brain glucose metabolism in Duchenne muscular dystrophy: a pet study
    Joon Soo Lee
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, Michigan 48201, USA
    Muscle Nerve 26:506-12. 2002
    ....
  17. pmc Origin and propagation of epileptic spasms delineated on electrocorticography
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Street, Detroit, MI 48201, U S A
    Epilepsia 46:1086-97. 2005
    ....
  18. pmc Objective detection of epileptic foci by 18F-FDG PET in children undergoing epilepsy surgery
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Nucl Med 51:1901-7. 2010
    ..The purpose of the present study was to evaluate and optimize the performance (lateralization and lobar localization value of epileptic foci) of objective voxel-based analysis of (18)F-FDG PET scans in a pediatric epilepsy population...
  19. ncbi request reprint Longitudinal changes in cortical glucose hypometabolism in children with intractable epilepsy
    Krisztina Benedek
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Child Neurol 21:26-31. 2006
    ..The findings have implications on how aggressively persistent seizures should be treated in children. (J Child Neurol 2006;21:26-31)...
  20. ncbi request reprint Hippocampal and thalamic diffusion abnormalities in children with temporal lobe epilepsy
    Tomomi Kimiwada
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 47:167-75. 2006
    ....
  21. ncbi request reprint Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L-tryptophan positron emission tomography (PET)
    Kenji Kagawa
    Department of Pediatrics, Pediatric Neurology PET Center, Children s Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201, USA
    J Child Neurol 20:429-38. 2005
    ..AMT PET can provide independent complementary information regarding the localization of epileptogenic regions in tuberous sclerosis complex and enhance the confidence of patient selection for successful epilepsy surgery...
  22. ncbi request reprint Evaluation with alpha-[11C]methyl-L-tryptophan positron emission tomography for reoperation after failed epilepsy surgery
    Csaba Juhasz
    Department of Pediatrics, Children s Hospital of Michigan and Harper University Hospital, Detroit Medical Center, Wayne State University School of Medicine, 48201, USA
    Epilepsia 45:124-30. 2004
    ..This study analyzed whether increased cortical AMT uptake can detect nonresected epileptic foci in patients with previously failed neocortical resection...
  23. ncbi request reprint Quantitative interictal subdural EEG analyses in children with neocortical epilepsy
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Epilepsia 44:425-34. 2003
    ....
  24. pmc Accurate differentiation of recurrent gliomas from radiation injury by kinetic analysis of α-11C-methyl-L-tryptophan PET
    Balint Alkonyi
    PET Center, Children s Hospital of Michigan, Detroit, MI, USA
    J Nucl Med 53:1058-64. 2012
    ..The aim of this study was to evaluate the usefulness of (11)C-AMT PET supplemented by tracer kinetic analysis for distinguishing recurrent gliomas from radiation injury...
  25. pmc Evaluating reverse speech as a control task with language-related gamma activity on electrocorticography
    Erik C Brown
    MD PhD Program, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Neuroimage 60:2335-45. 2012
    ..Superior temporal lobe engagement may indicate increased attention to reverse speech. Reverse speech does not appear to be a suitable task for the control of non-language auditory functions on ECoG...
  26. pmc γ-oscillations modulated by picture naming and word reading: intracranial recording in epileptic patients
    Helen C Wu
    MD PhD Program, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Clin Neurophysiol 122:1929-42. 2011
    ..We measured cortical gamma-oscillations in response to visual-language tasks consisting of picture naming and word reading in an effort to better understand human visual-language pathways...
  27. pmc Increased striatal serotonin synthesis following cortical resection in children with intractable epilepsy
    Harry T Chugani
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
    Epilepsy Res 78:124-30. 2008
    ..In this study we used positron emission tomography (PET) with alpha[11C]methyl-l-tryptophan (AMT) to evaluate serotonergic alterations in subcortical structures following cortical resection in children with intractable epilepsy...
  28. pmc Imaging correlates of differential expression of indoleamine 2,3-dioxygenase in human brain tumors
    Carlos E A Batista
    Carman and Ann Adams Department of Pediatrics, School of Medicine, Wayne State University, Detroit, MI, USA
    Mol Imaging Biol 11:460-6. 2009
    ..In the present study, we investigated whether increased tryptophan metabolism in brain tumors measured by PET is related to expression of IDO in resected brain tumor specimens...
  29. ncbi request reprint Alpha[11C] methyl-L-typtophan positron emission tomography in patients with alternating hemiplegia of childhood
    Zoltan Pfund
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201, USA
    J Child Neurol 17:253-60. 2002
    ..Furthermore, the attack number may have an effect on neurodevelopmental delay, thus supporting the notion that alternating hemiplegia of childhood may be a progressive disorder...
  30. doi request reprint Alpha-methyl-l-tryptophan positron emission tomography in epilepsy with cortical developmental malformations
    Hiroyuki Wakamoto
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pediatr Neurol 39:181-8. 2008
    ..When an alpha-[(11)C]methyl-l-tryptophan focus is detected, it likely represents the epileptogenic region to be resected...
  31. pmc Quantitative visualization of ictal subdural EEG changes in children with neocortical focal seizures
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Clin Neurophysiol 115:2718-27. 2004
    ..To quantify the ictal subdural electroencephalogram (EEG) changes using spectral analysis, and to delineate the quantitatively defined ictal onset zones on high-resolution 3D MR images in children with intractable neocortical epilepsy...
  32. pmc Increased tryptophan transport in epileptogenic dysembryoplastic neuroepithelial tumors
    Balint Alkonyi
    PET Center, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    J Neurooncol 107:365-72. 2012
    ..Increased AMT uptake can extend to extratumoral cortex, and presence of such cortical regions may increase the likelihood of recurrent seizures following surgical excision of DNTs...
  33. pmc Quantitative brain surface mapping of an electrophysiologic/metabolic mismatch in human neocortical epilepsy
    Balint Alkonyi
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    Epilepsy Res 87:77-87. 2009
    ..The clinical utility of FDG PET in guiding subdural electrode placement in neocortical epilepsy could be greatly enhanced by extending grid coverage to at least 2 cm beyond hypometabolic cortex, when feasible...
  34. pmc Somatosensory-related gamma-, beta- and alpha-augmentation precedes alpha- and beta-attenuation in humans
    Miho Fukuda
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA
    Clin Neurophysiol 121:366-75. 2010
    ..In the present study, we addressed a question whether somatosensory-related gamma augmentation 'precedes' or 'co-occurs with' somatosensory-related attenuation of alpha-beta oscillations...
  35. pmc Cortical gamma-oscillations modulated by auditory-motor tasks-intracranial recording in patients with epilepsy
    Tetsuro Nagasawa
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA
    Hum Brain Mapp 31:1627-42. 2010
    ..The superior temporal gyrus in each hemisphere might play a greater pivotal role when the contralateral hand needs to be used for motor responses, compared with when the ipsilateral hand does...
  36. pmc Cortical glucose metabolism positively correlates with gamma-oscillations in nonlesional focal epilepsy
    Masaaki Nishida
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Neuroimage 42:1275-84. 2008
    ....
  37. pmc Short-latency median-nerve somatosensory-evoked potentials and induced gamma-oscillations in humans
    Miho Fukuda
    Department of Pediatrics, Wayne State University, Detroit Medical Center, Detroit, MI, 48201, USA
    Brain 131:1793-805. 2008
    ....
  38. pmc Differentiation of glioblastomas from metastatic brain tumors by tryptophan uptake and kinetic analysis: a positron emission tomographic study with magnetic resonance imaging comparison
    David O Kamson
    PET Center and Translational Imaging Laboratory, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Mol Imaging 12:327-37. 2013
    ..This approach may be particularly useful in patients with a newly diagnosed solitary ring-enhancing mass...
  39. ncbi request reprint Relationship between brain glucose metabolism positron emission tomography (PET) and electroencephalography (EEG) in children with continuous spike-and-wave activity during slow-wave sleep
    Aimee F Luat
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    J Child Neurol 20:682-90. 2005
    ..Resective surgery can be effective in selected patients with uncontrolled seizures associated with continuous spike-and-wave activity during slow-wave sleep provided that there is concordance between focal abnormalities on PET and EEG...
  40. ncbi request reprint Metabolic changes of subcortical structures in intractable focal epilepsy
    Krisztina Benedek
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 45:1100-5. 2004
    ..In the present study, we analyzed alterations of glucose metabolism in subcortical nuclei and hippocampus by using FDG-PET in young patients with intractable epilepsy...
  41. pmc Cortico-cortical evoked potentials and stimulation-elicited gamma activity preferentially propagate from lower- to higher-order visual areas
    Naoyuki Matsuzaki
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA
    Clin Neurophysiol 124:1290-6. 2013
    ....
  42. pmc Is intraoperative electrocorticography reliable in children with intractable neocortical epilepsy?
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Epilepsia 45:1091-9. 2004
    ..To study the relation between the spike frequency during intraoperative electrocorticography (ECoG) under general anesthesia with isoflurane and that during extraoperative ECoG monitoring in children with intractable neocortical epilepsy...
  43. doi request reprint Reorganization of the right arcuate fasciculus following left arcuate fasciculus resection in children with intractable epilepsy
    Dhruman Goradia
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Child Neurol 26:1246-51. 2011
    ..399) in patients. These findings suggest a compensatory reorganization in the right arcuate fasciculus in children with intractable epilepsy following left arcuate fasciculus resection...
  44. pmc Brain damage and IQ in unilateral Sturge-Weber syndrome: support for a "fresh start" hypothesis
    Michael E Behen
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Epilepsy Behav 22:352-7. 2011
    ..Children in whom a very large extent of the hemisphere is severely affected are likely to have relatively preserved cognitive function...
  45. pmc Electrocorticographic correlates of cognitive control in a Stroop task-intracranial recording in epileptic patients
    Shinichiro Koga
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA
    Hum Brain Mapp 32:1580-91. 2011
    ....
  46. pmc The role of the thalamus in neuro-cognitive dysfunction in early unilateral hemispheric injury: a multimodality imaging study of children with Sturge-Weber syndrome
    Balint Alkonyi
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Eur J Paediatr Neurol 14:425-33. 2010
    ..Sturge-Weber syndrome (SWS) with unilateral hemispheric involvement is a clinical model of early onset, chronic, often progressive hemispheric injury, resulting in variable neuro-cognitive impairment...
  47. ncbi request reprint Cerebellar lesions in tuberous sclerosis complex: neurobehavioral and neuroimaging correlates
    Thomas J Eluvathingal
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI 48201, USA
    J Child Neurol 21:846-51. 2006
    ..Further investigation of the potential role of the right cerebellum in autism, particularly with regard to the dentatothalamofrontal circuit, is warranted...
  48. pmc Occipital gamma-oscillations modulated during eye movement tasks: simultaneous eye tracking and electrocorticography recording in epileptic patients
    Tetsuro Nagasawa
    Department of Pediatrics, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA
    Neuroimage 58:1101-9. 2011
    ..In functional studies comparing brain activation between two tasks, eye movement patterns during tasks may need to be considered as confounding factors...
  49. pmc Successful surgical treatment of an inflammatory lesion associated with new-onset refractory status epilepticus
    Csaba Juhasz
    Department of Pediatrics, Wayne State University Detroit, MI 48201, USA
    Neurosurg Focus 34:E5. 2013
    ..Molecular imaging of neuroinflammation can be instrumental in the management of NORSE by guiding placement of intracranial electrodes or assessing the extent and severity of inflammation for antiinflammatory interventions...
  50. pmc Tryptophan PET in pretreatment delineation of newly-diagnosed gliomas: MRI and histopathologic correlates
    David O Kamson
    PET Center and Translational Imaging Laboratory, Children s Hospital of Michigan, Detroit, MI, USA
    J Neurooncol 112:121-32. 2013
    ..While tryptophan uptake is low in peritumoral vasogenic edema, AMT-PET can detect tumor-infiltrated brain outside T2-lesions. Thus, AMT-PET may assist pretreatment delineation of tumor infiltration, particularly in high-grade gliomas...
  51. pmc Surface-based laminar analysis of diffusion abnormalities in cortical and white matter layers in neocortical epilepsy
    Rajkumar Munian Govindan
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Epilepsia 54:667-77. 2013
    ....
  52. pmc Spontaneous and visually driven high-frequency oscillations in the occipital cortex: intracranial recording in epileptic patients
    Tetsuro Nagasawa
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA
    Hum Brain Mapp 33:569-83. 2012
    ..Further studies are warranted to determine whether δ-phase coupling distinguishes physiological from pathological HFOs or simply differs across anatomical locations...
  53. pmc Cortical gamma oscillations modulated by word association tasks: intracranial recording
    Lunliya Thampratankul
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit Medical Center, 3901 Beaubien Street, Detroit, MI 48201, USA
    Epilepsy Behav 18:116-8. 2010
    ..Differential gamma augmentation in the supramarginal gyrus might be attributed to a larger workload required in the food-texture association task compared with the remaining two tasks...
  54. pmc Cortical gamma-oscillations modulated by listening and overt repetition of phonemes
    Miho Fukuda
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Neuroimage 49:2735-45. 2010
    ..Our observations support the hypothesis that positioning of the mouth to articulate phonemes is predominantly driven and/or monitored by the primary sensorimotor area on the left side...
  55. pmc Clinical and histopathologic correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 52:1692-8. 2011
    ..Therefore, in the present study, we evaluated the clinical and histopathologic correlates of AMT-PET abnormalities in children with intractable epilepsy undergoing resective surgery...
  56. pmc Cortical glucose metabolism correlates negatively with delta-slowing and spike-frequency in epilepsy associated with tuberous sclerosis
    Masaaki Nishida
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Hum Brain Mapp 29:1255-64. 2008
    ....
  57. ncbi request reprint Abnormal brain connectivity in children after early severe socioemotional deprivation: a diffusion tensor imaging study
    Thomas J Eluvathingal
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    Pediatrics 117:2093-100. 2006
    ..The present study used diffusion tensor imaging tractography to examine the integrity of white matter tracts that connect these brain regions...
  58. ncbi request reprint Diffusion tensor imaging of the corticospinal tract following cerebral hemispherectomy
    Hiroyuki Wakamoto
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit 48201, USA
    J Child Neurol 21:566-71. 2006
    ....
  59. doi request reprint Multimodality neuroimaging in Tourette syndrome: alpha-[11C] methyl-L-tryptophan positron emission tomography and diffusion tensor imaging studies
    Anita S D Saporta
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
    J Child Neurol 25:336-42. 2010
    ....
  60. pmc Increased L-[1-11 C] leucine uptake in the leptomeningeal angioma of sturge-weber syndrome: a PET study
    Balint Alkonyi
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
    J Neuroimaging 22:177-83. 2012
    ..We used L-[1-(11) C]leucine (LEU) positron emission tomography (PET) to measure amino acid uptake in children with Sturge-Weber syndrome (SWS), and to relate amino acid uptake measures with glucose metabolism...
  61. pmc Application of an objective method for localizing bilateral cortical FDG PET abnormalities to guide the resection of epileptic foci
    Otto Muzik
    Department of Pediatrics and Radiology, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    IEEE Trans Biomed Eng 52:1574-81. 2005
    ..The accuracy of this approach with respect to invasive subdural electroencephalography (EEG) data was assessed in a group of children with neocortical epilepsy...
  62. pmc Statistical mapping of ictal high-frequency oscillations in epileptic spasms
    Hiroki Nariai
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA
    Epilepsia 52:63-74. 2011
    ..We assessed 636 epileptic spasms seen in 11 children (median 44 spasms per child) and determined the spatial and temporal characteristics of ictal high-frequency oscillations (HFOs) in relation to the onset of spasms...
  63. pmc Ictal high-frequency oscillations at 80-200 Hz coupled with delta phase in epileptic spasms
    Hiroki Nariai
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA
    Epilepsia 52:e130-4. 2011
    ..Ictal slow-waves in epileptic spasms may be generated by a mechanism different from what generates interictal HFOs-slow-wave complexes...
  64. pmc Magnetic resonance spectroscopic imaging detects abnormalities in normal-appearing frontal lobe of patients with Sturge-Weber syndrome
    Carlos E A Batista
    Department of Pediatrics, Radiology, Wayne State University, Detroit, Michigan, USA
    J Neuroimaging 18:306-13. 2008
    ..Frontal lobe involvement increases the risk of motor impairment. The goal of this study was to determine whether Magnetic Resonance Spectroscopic Imaging (MRSI) can improve detection of frontal lobe involvement in children with SWS...
  65. pmc Young patients with focal seizures may have the primary motor area for the hand in the postcentral gyrus
    Ateeq Haseeb
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Epilepsy Res 76:131-9. 2007
    ..We determined whether the primary motor hand area was most frequently located in the precentral gyrus in young patients with intractable focal seizures...
  66. pmc Intracranial recording and source localization of auditory brain responses elicited at the 50 ms latency in three children aged from 3 to 16 years
    Oleg Korzyukov
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Brain Topogr 22:166-75. 2009
    ..Moreover, the present source localisation results of auditory response at the 50 ms latency might be useful in paediatric neurosurgery practice...
  67. ncbi request reprint Hypotheses from functional neuroimaging studies
    Csaba Juhasz
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Int Rev Neurobiol 49:37-55. 2002
    ....
  68. ncbi request reprint Quantitative analysis of gray- and white-matter volumes and glucose metabolism in Sturge-Weber syndrome
    Zoltan Pfund
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Child Neurol 18:119-26. 2003
    ..Extensive gray- and white-matter volume loss and hypometabolism ipsilateral to the angioma likely contribute to the frequently observed progressive cognitive dysfunction in these patients, regardless of the extent of the angioma...
  69. pmc Olfactory hallucinations elicited by electrical stimulation via subdural electrodes: effects of direct stimulation of olfactory bulb and tract
    Gogi Kumar
    Department of Pediatrics, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA
    Epilepsy Behav 24:264-8. 2012
    ..We failed to provide evidence that a positive olfactory perception could be elicited by conventional stimulation of secondary olfactory cortex alone...
  70. pmc Independent predictors of neuronal adaptation in human primary visual cortex measured with high-gamma activity
    Naoyuki Matsuzaki
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA
    Neuroimage 59:1639-46. 2012
    ..The local effects of pre-stimulus beta augmentation and delta phase on neuronal adaptation may be modest in primary visual cortex...
  71. pmc A sensitive diffusion tensor imaging quantification method to detect language laterality in children: correlation with the Wada test
    Vijay Narayan Tiwari
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    J Child Neurol 26:1516-21. 2011
    ..003 and .002, respectively). The Laterality Index values were concordant with the Wada test results except for 1 case. Fractional anisotropy also falsely lateralized language in 1 case...
  72. ncbi request reprint Assessment of progression and treatment response of optic pathway glioma with positron emission tomography using alpha-[(11)C]methyl-L-tryptophan
    Fangyu Peng
    The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Imaging Biol 9:106-9. 2007
    ..To report the utility of positron emission tomography (PET) with alpha-[(11)C]methyl-L-tryptophan (AMT) for monitoring progression and response to treatment of an isolated optic pathway glioma (OPG) in a 16-year-old girl...
  73. pmc Differential visually-induced gamma-oscillations in human cerebral cortex
    Eishi Asano
    Division of Pediatric Neurology, Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Neuroimage 45:477-89. 2009
    ..Gamma-attenuation in the anterior-medial occipital cortex during central-field picture-stimuli might be associated with relative inattention to the peripheral visual field during central-field object visualization...
  74. pmc Role of subdural electrocorticography in prediction of long-term seizure outcome in epilepsy surgery
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Street, Detroit, MI 48201, USA
    Brain 132:1038-47. 2009
    ..Yet, the additive clinical impact of interictal spike frequency measures to predict long-term surgical outcome may be modest in the presence of ictal ECoG and neuroimaging data...
  75. pmc In vivo animation of auditory-language-induced gamma-oscillations in children with intractable focal epilepsy
    Erik C Brown
    MD PhD Program, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Neuroimage 41:1120-31. 2008
    ..Further studies are warranted to determine whether recording of language-induced gamma-oscillations can supplement language mapping using neurostimulation in presurgical evaluation of children with focal epilepsy...
  76. pmc Effect of sleep on interictal spikes and distribution of sleep spindles on electrocorticography in children with focal epilepsy
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Clin Neurophysiol 118:1360-8. 2007
    ....
  77. doi request reprint Secondary tics or tourettism associated with a brain tumor
    Aimee F Luat
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    Pediatr Neurol 41:457-60. 2009
    ....
  78. pmc Diffusion tensor analysis of temporal and extra-temporal lobe tracts in temporal lobe epilepsy
    Rajkumar Munian Govindan
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI, USA
    Epilepsy Res 80:30-41. 2008
    ..To determine whether the major temporal lobe white matter tracts in patients with temporal lobe epilepsy manifest abnormal water diffusion properties...
  79. doi request reprint Paradoxical imaging findings in cerebral gliomas
    Marie Atkinson
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    J Neurol Sci 269:180-3. 2008
    ..We conclude preoperative grading of cerebral gliomas may be inaccurate occasionally even in cases with concordant structural and functional imaging findings. This should be considered when counseling patients...
  80. ncbi request reprint Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome
    Michael Behen
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Mov Disord 22:2256-62. 2007
    ..This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS...
  81. ncbi request reprint Autism with facial port-wine stain: a new syndrome?
    Harry T Chugani
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Pediatr Neurol 37:192-9. 2007
    ..Unilateral facial port-wine stain and autism with no intracranial angioma on conventional imaging may represent a rare clinical entity distinct from both infantile autism and previously described variants of Sturge-Weber syndrome...
  82. pmc The corticospinal tract in Sturge-Weber syndrome: a diffusion tensor tractography study
    Lalitha Sivaswamy
    Carman and Ann Adams Department of Pediatrics, Division of Pediatric Neurology, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI 48201, USA
    Brain Dev 30:447-53. 2008
    ..To utilize diffusion tensor tractography and evaluate the integrity of the corticospinal tract in children with unilateral Sturge-Weber syndrome (SWS)...
  83. pmc Focal white matter abnormalities related to neurocognitive dysfunction: an objective diffusion tensor imaging study of children with Sturge-Weber syndrome
    Balint Alkonyi
    Departments of Pediatrics, School of Medicine, Wayne State University, Detroit, Michigan, 48201, USA
    Pediatr Res 69:74-9. 2011
    ..Nevertheless, cognitive and fine motor functions are related to diffusion abnormalities in specific ipsilateral, mostly frontal, WM regions...
  84. ncbi request reprint Transient hypermetabolism of the basal ganglia following perinatal hypoxia
    Carlos E A Batista
    Carman and Ann Adams, Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Neurol 36:330-3. 2007
    ..Thus, positron emission tomography can help predict this form of cerebral palsy in neonates...
  85. pmc Transient focal cortical increase of interictal glucose metabolism in Sturge-Weber syndrome: implications for epileptogenesis
    Balint Alkonyi
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, U S A
    Epilepsia 52:1265-72. 2011
    ..To investigate clinical correlates and longitudinal course of interictal focal cortical glucose hypermetabolism in children with Sturge-Weber syndrome (SWS)...
  86. pmc MR susceptibility weighted imaging (SWI) complements conventional contrast enhanced T1 weighted MRI in characterizing brain abnormalities of Sturge-Weber Syndrome
    Jiani Hu
    Department of Radiology, Wayne State University, Detroit, Michigan 48201, USA
    J Magn Reson Imaging 28:300-7. 2008
    ..To evaluate the efficacy of susceptibility weighted imaging (SWI) in comparison to standard T1 weighted postgadolinium contrast (T1-Gd) MRI in patients with Sturge-Weber Syndrome (SWS)...
  87. pmc Clinical outcomes in bilateral Sturge-Weber syndrome
    Balint Alkonyi
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Pediatr Neurol 44:443-9. 2011
    ..Good seizure control and only mild/moderate developmental impairment can be achieved in about 50% of patients with bilateral Sturge-Weber syndrome, with or without resective surgery...
  88. doi request reprint Isolated intracranial Whipple's disease--report of a rare case and review of the literature
    Wazim Mohamed
    Department of Neurology, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA
    J Neurol Sci 308:1-8. 2011
    ..Myorhythmia is a hallmark of WD. Isolated CNS involvement is very rare...
  89. ncbi request reprint Increased visual cortex glucose metabolism contralateral to angioma in children with Sturge-Weber syndrome
    Carlos E A Batista
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    Dev Med Child Neurol 49:567-73. 2007
    ..012). These findings indicate that early, severe unilateral cortical damage in SWS may induce increased glucose metabolism in the contralateral visual cortex, probably reflecting reorganization...
  90. pmc Diffusion tensor imaging study of the cortical origin and course of the corticospinal tract in healthy children
    A Kumar
    Departments of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    AJNR Am J Neuroradiol 30:1963-70. 2009
    ....

Research Grants11

  1. Longitudinal Neuroimaging in Sturge-Weber Syndrome
    Csaba Juhasz; Fiscal Year: 2010
    ..The results will introduce novel, more accurate diagnostic tests and also identify new therapeutic targets to improve the outcome of this often devastating disease. ..
  2. Longitudinal Neuroimaging in Sturge-Weber Syndrome
    Csaba Juhasz; Fiscal Year: 2003
    ..Further, the findings will help to better understand the effect of early brain lesion on reorganizational processes in the developing brain. ..
  3. Tryptophan Metabolism in Human Brain Tumors
    Csaba Juhasz; Fiscal Year: 2010
    ....
  4. Longitudinal Neuroimaging in Sturge-Weber Syndrome
    Csaba Juhasz; Fiscal Year: 2009
    ..The results will introduce novel, more accurate diagnostic tests and also identify new therapeutic targets to improve the outcome of this often devastating disease. ..
  5. Tryptophan Metabolism in Human Brain Tumors
    Csaba Juhasz; Fiscal Year: 2009
    ....
  6. Longitudinal Neuroimaging in Sturge-Weber Syndrome
    Csaba Juhasz; Fiscal Year: 2006
    ..Further, the findings will help to better understand the effect of early brain lesion on reorganizational processes in the developing brain. ..
  7. Longitudinal Neuroimaging in Sturge-Weber Syndrome
    Csaba Juhasz; Fiscal Year: 2005
    ..Further, the findings will help to better understand the effect of early brain lesion on reorganizational processes in the developing brain. ..
  8. Longitudinal Neuroimaging in Sturge-Weber Syndrome
    Csaba Juhasz; Fiscal Year: 2004
    ..Further, the findings will help to better understand the effect of early brain lesion on reorganizational processes in the developing brain. ..
  9. Tryptophan Metabolism in Human Brain Tumors
    Csaba Juhasz; Fiscal Year: 2011
    ....