Chris-Ellyn Johanson

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. doi request reprint Diversion and abuse of buprenorphine: findings from national surveys of treatment patients and physicians
    Chris Ellyn Johanson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 2761 E Jefferson Ave, Detroit, MI 48207, USA
    Drug Alcohol Depend 120:190-5. 2012
  2. ncbi request reprint Discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans trained to discriminate among d-amphetamine, meta-chlorophenylpiperazine and placebo
    Chris Ellyn Johanson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Drug Abuse Research Division, 2761 East Jefferson, Detroit, MI 48207, USA
    Drug Alcohol Depend 81:27-36. 2006
  3. ncbi request reprint Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers
    Chris Ellyn Johanson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48207, USA
    Psychopharmacology (Berl) 185:327-38. 2006
  4. ncbi request reprint Intravenous cocaine discrimination in humans
    Chris Ellyn Johanson
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48207, USA
    Exp Clin Psychopharmacol 14:99-108. 2006
  5. ncbi request reprint Effects of oral cocaine on intravenous cocaine discrimination in humans
    Chris Ellyn Johanson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, MI, USA
    Exp Clin Psychopharmacol 15:219-27. 2007
  6. pmc Risk management and post-marketing surveillance for the abuse of medications acting on the central nervous system: expert panel report
    Chris Ellyn Johanson
    Psychiatry and Behavioral Sciences, Wayne State University, CRS Associates, LLC, Chicago, IL 60616, USA
    Drug Alcohol Depend 105:S65-71. 2009
  7. ncbi request reprint The influence of an instruction on the stimulus effects of drugs in humans
    C E Johanson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48207, USA
    Exp Clin Psychopharmacol 6:427-32. 1998
  8. ncbi request reprint The effects of fluoxetine on the subjective and physiological effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans
    Manuel Tancer
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 2761 E Jefferson St, Detroit, MI 48207, USA
    Psychopharmacology (Berl) 189:565-73. 2007
  9. ncbi request reprint Effects of buprenorphine maintenance dose on mu-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteers
    Mark K Greenwald
    Department of Psychiatry and Behavioral Neurosciences and Addiction Research Institute, Wayne State University, Detroit, MI 48207, USA
    Neuropsychopharmacology 28:2000-9. 2003
  10. ncbi request reprint Double-blind placebo-controlled trial of methylphenidate in the treatment of adult ADHD patients with comorbid cocaine dependence
    Howard Schubiner
    Department of Internal Medicine, Wayne State University, USA
    Exp Clin Psychopharmacol 10:286-94. 2002

Research Grants

  1. Brain Imaging of Tobacco Craving Using fMRI
    Chris Ellyn Johanson; Fiscal Year: 2003
  2. Intravenous Cocaine Discrimination in Humans
    Chris Ellyn Johanson; Fiscal Year: 2004
  3. Kappa Opioid Antagonist for Cocaine Addiction
    Chris Ellyn Johanson; Fiscal Year: 2005

Detail Information

Publications27

  1. doi request reprint Diversion and abuse of buprenorphine: findings from national surveys of treatment patients and physicians
    Chris Ellyn Johanson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 2761 E Jefferson Ave, Detroit, MI 48207, USA
    Drug Alcohol Depend 120:190-5. 2012
    ..Since 2003, buprenorphine has been approved for the treatment of opioid dependence in office-based practice. Diversion and abuse can be a threat to its continued approval under these conditions...
  2. ncbi request reprint Discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans trained to discriminate among d-amphetamine, meta-chlorophenylpiperazine and placebo
    Chris Ellyn Johanson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Drug Abuse Research Division, 2761 East Jefferson, Detroit, MI 48207, USA
    Drug Alcohol Depend 81:27-36. 2006
    ..The subjective effects of all three drugs overlapped, although the effects of MDMA appeared more amphetamine-like...
  3. ncbi request reprint Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers
    Chris Ellyn Johanson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48207, USA
    Psychopharmacology (Berl) 185:327-38. 2006
    ..The present study was designed to further our understanding of changes in brain function in humans that might result from chronic high dose use of MA after at least 3 months of abstinence...
  4. ncbi request reprint Intravenous cocaine discrimination in humans
    Chris Ellyn Johanson
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48207, USA
    Exp Clin Psychopharmacol 14:99-108. 2006
    ..This failure to demonstrate pharmacological selectivity may be related to participants' learning a drug-vs.-no-drug discrimination, and thus it may be necessary to alter training procedures in future studies...
  5. ncbi request reprint Effects of oral cocaine on intravenous cocaine discrimination in humans
    Chris Ellyn Johanson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, MI, USA
    Exp Clin Psychopharmacol 15:219-27. 2007
    ..Thus, although oral cocaine given acutely likely is not a viable treatment medication for cocaine dependence, the usefulness of the drug discrimination model in the evaluation of agonist treatment medications remains unclear...
  6. pmc Risk management and post-marketing surveillance for the abuse of medications acting on the central nervous system: expert panel report
    Chris Ellyn Johanson
    Psychiatry and Behavioral Sciences, Wayne State University, CRS Associates, LLC, Chicago, IL 60616, USA
    Drug Alcohol Depend 105:S65-71. 2009
    ..It is also important that the unintended consequences of increased regulation and the imposition of risk management plans be minimized...
  7. ncbi request reprint The influence of an instruction on the stimulus effects of drugs in humans
    C E Johanson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48207, USA
    Exp Clin Psychopharmacol 6:427-32. 1998
    ..Thus, instructions designed to give expectations had no effect on discrimination and only a few changes in subjective effects. When asked to name the drug that they believed they received, labels reflected instructional set...
  8. ncbi request reprint The effects of fluoxetine on the subjective and physiological effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans
    Manuel Tancer
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 2761 E Jefferson St, Detroit, MI 48207, USA
    Psychopharmacology (Berl) 189:565-73. 2007
    ..The purpose of this study was to investigate the role of serotonin (5-HT) in the effects of oral 3,4-methylenedioxymethamphetamine (MDMA) in humans...
  9. ncbi request reprint Effects of buprenorphine maintenance dose on mu-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteers
    Mark K Greenwald
    Department of Psychiatry and Behavioral Neurosciences and Addiction Research Institute, Wayne State University, Detroit, MI 48207, USA
    Neuropsychopharmacology 28:2000-9. 2003
    ....
  10. ncbi request reprint Double-blind placebo-controlled trial of methylphenidate in the treatment of adult ADHD patients with comorbid cocaine dependence
    Howard Schubiner
    Department of Internal Medicine, Wayne State University, USA
    Exp Clin Psychopharmacol 10:286-94. 2002
    ..Because of the relatively small sample size, the results are preliminary. However, we found that MTP improved subjective reports of ADHD symptoms and did not worsen cocaine use while participants were in treatment...
  11. ncbi request reprint Reinforcing, subjective, and physiological effects of MDMA in humans: a comparison with d-amphetamine and mCPP
    Manuel Tancer
    Department of Psychiatry and Behavioral Neurosciences, Substance Abuse Research Division, Addiction Research Institute, Wayne State University, 2761 E Jefferson, Detroit, MI 48207, USA
    Drug Alcohol Depend 72:33-44. 2003
    ..In contrast, only the dopaminergic agents, d-amphetamine and MDMA, had reinforcing effects...
  12. ncbi request reprint Major depression: the relative contribution of gender, MDMA, and cannabis use
    Heather Durdle
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48207, USA
    Depress Anxiety 25:241-7. 2008
    ....
  13. ncbi request reprint Buprenorphine duration of action: mu-opioid receptor availability and pharmacokinetic and behavioral indices
    Mark Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences Wayne State University, Detroit, Michigan 48207, USA
    Biol Psychiatry 61:101-10. 2007
    ..This study examined the duration of action of BUP at microORs and correlations with pharmacokinetic and pharmacodynamic outcomes in 10 heroin-dependent volunteers...
  14. ncbi request reprint Postmarketing surveillance of abuse liability of sibutramine
    Cynthia L Arfken
    Department of Psychiatry and Behavioral Neurosciences, Addiction Research Institute, Wayne State University, 2761 E Jefferson, Detroit, MI 48207, USA
    Drug Alcohol Depend 69:169-73. 2003
    ..This approach is only one indicator in a surveillance framework but appears promising and validates findings from laboratory-based abuse liability studies that also indicate low abuse liability for sibutramine...
  15. ncbi request reprint Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans
    Robert R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Psychopharmacology (Berl) 183:248-56. 2005
    ..In rats, MDMA causes hyperthermia at warm ambient temperatures but hypothermia at cold ones...
  16. ncbi request reprint Reinforcing effects of diazepam under anxiogenic conditions in individuals with social anxiety
    Todd C Helmus
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detrioit, MI, USA
    Exp Clin Psychopharmacol 13:348-56. 2005
    ..These results suggest that DZ reinforcement may occur under conditions of heightened anxiety by bestowing therapeutic efficacy...
  17. ncbi request reprint Pharmacokinetic comparison of the buprenorphine sublingual liquid and tablet
    K J Schuh
    Wayne State University School of Medicine, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI 48207, USA
    Drug Alcohol Depend 56:55-60. 1999
    ..Thus, the buprenorphine tablet dose might have to be adjusted to produce plasma concentrations equivalent to those of the liquid...
  18. ncbi request reprint Opioid reinforcement in heroin-dependent volunteers during outpatient buprenorphine maintenance
    M K Greenwald
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48207, USA
    Drug Alcohol Depend 56:191-203. 1999
    ..In summary, BUP effects on opioid reinforcement were consistent from outpatient setting (heroin abstinence) to laboratory setting (decreased HYD reinforcement), supporting the validity of this laboratory model...
  19. ncbi request reprint Discrimination of intranasal cocaine
    K J Schuh
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48207, USA
    Behav Pharmacol 11:511-5. 2000
    ..g. taste) that are not affected by anaesthesia of the nasal passage, and that the intranasal route of cocaine administration is unlikely to be feasible with a drug discrimination paradigm...
  20. ncbi request reprint Behavioral measurement of thermal pain sensitivity in humans: effects of stimulus intensity and instructions
    M K Greenwald
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detriot, Michigan 48207, USA
    Exp Clin Psychopharmacol 9:209-14. 2001
    ..Instruction set differences were significantly larger at higher stimulus intensities. This technique may be useful in human psychopharmacological research...
  21. ncbi request reprint The subjective effects of MDMA and mCPP in moderate MDMA users
    M E Tancer
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48207, USA
    Drug Alcohol Depend 65:97-101. 2001
    ..g. increases on POMS Elation, VAS High and Stimulated), as well as hallucinogenic effects (four of the six scales of the Hallucinogenic Rating Scale), which has not been observed in previous studies...
  22. ncbi request reprint The discriminative stimulus effects of tripelennamine in humans
    C E Johanson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48207, USA
    Psychopharmacology (Berl) 126:140-6. 1996
    ..These results indicate that tripelennamine can function as a discriminative stimulus, but with little evidence of pharmacological specificity...
  23. ncbi request reprint Establishment of a diazepam preference in human volunteers following a differential-conditioning history of placebo versus diazepam choice
    Sheila M Alessi
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, USA
    Exp Clin Psychopharmacol 10:77-83; discussion 101-3. 2002
    ..Preference was reassessed during the last 5 sessions of Phase 2. Five of the participants preferred placebo in Phase 1 but diazepam in Phase 2. Subjective responses to the drugs also changed across the 2 phases...
  24. ncbi request reprint Effects of buprenorphine sublingual tablet maintenance on opioid drug-seeking behavior by humans
    Mark K Greenwald
    Addiction Research Institute, Wayne State University School of Medicine, 2761 E Jefferson, Detroit, MI 48207, USA
    Psychopharmacology (Berl) 160:344-52. 2002
    ..e. motivational measures) among outpatient volunteers using clinically relevant dosing schedules has not been extensively studied...
  25. ncbi request reprint Cocaine-dependence and cocaine-induced paranoia and mid-latency auditory evoked responses and sensory gating
    Nash N Boutros
    Wayne State University, Department of Psychiatry and Behavioral Neurosciences, USA
    Psychiatry Res 145:147-54. 2006
    ..The data also suggest that prolonged latency of the evoked potentials may be a correlate of cocaine-induced psychosis. Finally, the data suggest that some recovery of amplitude and gating occurs with abstinence...
  26. ncbi request reprint Marian W. Fischman: 1939-2001
    Chris Ellyn Johanson
    Department of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI 48207, USA
    Psychopharmacology (Berl) 160:337-8. 2002
  27. ncbi request reprint Impact of formulation on the abuse liability, safety and regulation of medications: the expert panel report
    Charles Grudzinskas
    NDA Partners LLC, 720 Riverview Terrace, Annapolis, MD 21401, USA
    Drug Alcohol Depend 83:S77-82. 2006
    ..Finally, knowledge and experience are needed to translate scientific work into a predictable, transparent and reliable regulatory process...

Research Grants8

  1. Brain Imaging of Tobacco Craving Using fMRI
    Chris Ellyn Johanson; Fiscal Year: 2003
    ..Finally, because nicotine dependence is a prototypic addiction, this research should provide a model for similar research with other drug dependencies. ..
  2. Intravenous Cocaine Discrimination in Humans
    Chris Ellyn Johanson; Fiscal Year: 2004
    ..If successful, this will be an efficient paradigm for examining the ability of compounds to attenuate the effects of cocaine in humans and may lead to a successful pharmacological treatment for cocaine abuse/dependence. ..
  3. Kappa Opioid Antagonist for Cocaine Addiction
    Chris Ellyn Johanson; Fiscal Year: 2005
    ..abstract_text> ..