Chris-Ellyn Johanson

..Since 2003, buprenorphine has been approved for the treatment of opioid dependence in office-based practice. Diversion and abuse can be a threat to its continued approval under these conditions...

..The subjective effects of all three drugs overlapped, although the effects of MDMA appeared more amphetamine-like...

..The present study was designed to further our understanding of changes in brain function in humans that might result from chronic high dose use of MA after at least 3 months of abstinence...

..This failure to demonstrate pharmacological selectivity may be related to participants' learning a drug-vs.-no-drug discrimination, and thus it may be necessary to alter training procedures in future studies...

..Thus, although oral cocaine given acutely likely is not a viable treatment medication for cocaine dependence, the usefulness of the drug discrimination model in the evaluation of agonist treatment medications remains unclear...

..It is also important that the unintended consequences of increased regulation and the imposition of risk management plans be minimized...

..Thus, instructions designed to give expectations had no effect on discrimination and only a few changes in subjective effects. When asked to name the drug that they believed they received, labels reflected instructional set...

..The purpose of this study was to investigate the role of serotonin (5-HT) in the effects of oral 3,4-methylenedioxymethamphetamine (MDMA) in humans...

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..Because of the relatively small sample size, the results are preliminary. However, we found that MTP improved subjective reports of ADHD symptoms and did not worsen cocaine use while participants were in treatment...

..In contrast, only the dopaminergic agents, d-amphetamine and MDMA, had reinforcing effects...

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..This study examined the duration of action of BUP at microORs and correlations with pharmacokinetic and pharmacodynamic outcomes in 10 heroin-dependent volunteers...

..This approach is only one indicator in a surveillance framework but appears promising and validates findings from laboratory-based abuse liability studies that also indicate low abuse liability for sibutramine...

..In rats, MDMA causes hyperthermia at warm ambient temperatures but hypothermia at cold ones...

..These results suggest that DZ reinforcement may occur under conditions of heightened anxiety by bestowing therapeutic efficacy...

..Thus, the buprenorphine tablet dose might have to be adjusted to produce plasma concentrations equivalent to those of the liquid...

..In summary, BUP effects on opioid reinforcement were consistent from outpatient setting (heroin abstinence) to laboratory setting (decreased HYD reinforcement), supporting the validity of this laboratory model...

..g. taste) that are not affected by anaesthesia of the nasal passage, and that the intranasal route of cocaine administration is unlikely to be feasible with a drug discrimination paradigm...

..Instruction set differences were significantly larger at higher stimulus intensities. This technique may be useful in human psychopharmacological research...

..g. increases on POMS Elation, VAS High and Stimulated), as well as hallucinogenic effects (four of the six scales of the Hallucinogenic Rating Scale), which has not been observed in previous studies...

..These results indicate that tripelennamine can function as a discriminative stimulus, but with little evidence of pharmacological specificity...

..Preference was reassessed during the last 5 sessions of Phase 2. Five of the participants preferred placebo in Phase 1 but diazepam in Phase 2. Subjective responses to the drugs also changed across the 2 phases...

..e. motivational measures) among outpatient volunteers using clinically relevant dosing schedules has not been extensively studied...

..The data also suggest that prolonged latency of the evoked potentials may be a correlate of cocaine-induced psychosis. Finally, the data suggest that some recovery of amplitude and gating occurs with abstinence...

..Finally, knowledge and experience are needed to translate scientific work into a predictable, transparent and reliable regulatory process...

..Finally, because nicotine dependence is a prototypic addiction, this research should provide a model for similar research with other drug dependencies. ..

..If successful, this will be an efficient paradigm for examining the ability of compounds to attenuate the effects of cocaine in humans and may lead to a successful pharmacological treatment for cocaine abuse/dependence. ..

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