Maha Hussain


Affiliation: Wayne State University
Country: USA


  1. request reprint
    Sarkar F, Li Y. Mechanisms of cancer chemoprevention by soy isoflavone genistein. Cancer Metastasis Rev. 2002;21:265-80 pubmed
    ..Hence, significant advances have been made, both by in vitro and in vivo studies showing that genistein is a promising agent for cancer chemoprevention and/or treatment. ..
  2. request reprint
    Sarkar F, Adsule S, Padhye S, Kulkarni S, Li Y. The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy. Mini Rev Med Chem. 2006;6:401-7 pubmed
    ..These results suggest that genistein and synthetic structurally-modified derivatives of isoflavone may be promising agents for cancer chemoprevention and therapy either alone or in combination with existing chemotherapeutic agents. ..
  3. request reprint
    Tang J, Ahmad A, Sarkar F. MicroRNAs in breast cancer therapy. Curr Pharm Des. 2014;20:5268-74 pubmed
    ..Here we provide an update on our current understanding of miRNAs as molecular targets for diagnosis, prognosis and therapy of breast cancers. ..
  4. Ahmad A, Ginnebaugh K, Li Y, Padhye S, Sarkar F. Molecular targets of naturopathy in cancer research: bridge to modern medicine. Nutrients. 2015;7:321-34 pubmed publisher
  5. Suresh R, Ali S, Ahmad A, Philip P, Sarkar F. The Role of Cancer Stem Cells in Recurrent and Drug-Resistant Lung Cancer. Adv Exp Med Biol. 2016;890:57-74 pubmed publisher
    ..g. curcumin, CDF, and BR-DIM is highlighted in overcoming therapeutic resistance, suggesting that the above mentioned agents could be important for better treatment of lung cancer in combination therapy. ..
  6. Michelhaugh S, Guastella A, Varadarajan K, Klinger N, Parajuli P, Ahmad A, et al. Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1. J Transl Med. 2015;13:227 pubmed publisher
    ..high-grade meningioma tumor biology and disease progression as well as to develop novel therapies to improve treatment options for poor prognosis or recurrent meningiomas. ..
  7. Sarkar F, Li Y, Wang Z, Kong D. NF-kappaB signaling pathway and its therapeutic implications in human diseases. Int Rev Immunol. 2008;27:293-319 pubmed publisher
    ..Therefore, targeting of NF-kappaB signaling pathway could be a potent strategy for the prevention and/or treatment of human cancers and inflammatory diseases. ..
  8. Sarkar F, Li Y, Wang Z, Kong D. Pancreatic cancer stem cells and EMT in drug resistance and metastasis. Minerva Chir. 2009;64:489-500 pubmed
  9. Sarkar F, Li Y, Wang Z, Padhye S. Lesson learned from nature for the development of novel anti-cancer agents: implication of isoflavone, curcumin, and their synthetic analogs. Curr Pharm Des. 2010;16:1801-12 pubmed

More Information


  1. Azmi A, Bao G, Gao J, Mohammad R, Sarkar F. Network insights into the genes regulated by hepatocyte nuclear factor 4 in response to drug induced perturbations: a review. Curr Drug Discov Technol. 2013;10:147-54 pubmed
    ..This article reviews how network pharmacology can help in the identification of druggable avenues in TFs and also allow the selection of drugs and their synergistic pairs against HNFs for cancer therapy. ..
  2. Ahmad A, Ginnebaugh K, Yin S, Bollig Fischer A, Reddy K, Sarkar F. Functional role of miR-10b in tamoxifen resistance of ER-positive breast cancer cells through down-regulation of HDAC4. BMC Cancer. 2015;15:540 pubmed publisher
    ..We propose miR-10b-HDAC4 nexus as one of the molecular mechanism of tamoxifen resistance which can potentially be expolited as a novel targeted therapeutic approach for the clinical management of tamoxifen-resistant breast cancers. ..
  3. Sarkar F, Li Y. Indole-3-carbinol and prostate cancer. J Nutr. 2004;134:3493S-3498S pubmed publisher
    ..In conclusion, the results from our laboratory and from others provide ample evidence for the benefit of I3C and DIM for the prevention and the treatment of prostate cancer. ..
  4. Bao B, Azmi A, Aboukameel A, Ahmad A, Bolling Fischer A, Sethi S, et al. Pancreatic cancer stem-like cells display aggressive behavior mediated via activation of FoxQ1. J Biol Chem. 2014;289:14520-33 pubmed publisher
  5. Ali S, Ahmad A, Aboukameel A, Ahmed A, Bao B, Banerjee S, et al. Deregulation of miR-146a expression in a mouse model of pancreatic cancer affecting EGFR signaling. Cancer Lett. 2014;351:134-42 pubmed publisher