Maha Hussain

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs
    Aamir Ahmad
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Hematol Oncol 6:77. 2013
  2. ncbi request reprint Targeting CSCs in tumor microenvironment: the potential role of ROS-associated miRNAs in tumor aggressiveness
    Bin Bao
    Departments of Pathology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, 740 HWCRC, 4100 John R Street, Detroit, MI 48201, USA
    Curr Stem Cell Res Ther 9:22-35. 2014
  3. ncbi request reprint Regulating miRNA by natural agents as a new strategy for cancer treatment
    Sajiv Sethi
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Drug Targets 14:1167-74. 2013
  4. ncbi request reprint Deregulation of PI3K/Akt/mTOR signaling pathways by isoflavones and its implication in cancer treatment
    Aamir Ahmad
    Department of Pathology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Anticancer Agents Med Chem 13:1014-24. 2013
  5. ncbi request reprint Targeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapy
    Aamir Ahmad
    Department of Pathology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Anticancer Agents Med Chem 13:1002-13. 2013
  6. pmc Clinical advances in molecular biomarkers for cancer diagnosis and therapy
    Seema Sethi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Mol Sci 14:14771-84. 2013
  7. pmc Network insights into the genes regulated by hepatocyte nuclear factor 4 in response to drug induced perturbations: a review
    Asfar S Azmi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Drug Discov Technol 10:147-54. 2013
  8. pmc Perspectives on new synthetic curcumin analogs and their potential anticancer properties
    Alok Vyas
    ISTRA, Department of Chemistry, Abeda Inamdar College, University of Pune, Pune 411001, India
    Curr Pharm Des 19:2047-69. 2013
  9. pmc Targeting CSC-related miRNAs for cancer therapy by natural agents
    Bin Bao
    Departments of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Curr Drug Targets 13:1858-68. 2012
  10. ncbi request reprint From body art to anticancer activities: perspectives on medicinal properties of henna
    Rohan Pradhan
    ISTRA, Department of Chemistry, Abeda Inamdar S nior College, University of Pune, Pune 411001 India
    Curr Drug Targets 13:1777-98. 2012

Detail Information

Publications159 found, 100 shown here

  1. pmc Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs
    Aamir Ahmad
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Hematol Oncol 6:77. 2013
    ..Here, we investigated the role of Hh signaling in erlotinib resistance of TGF-β1-induced NSCLC cells that are reminiscent of EMT cells...
  2. ncbi request reprint Targeting CSCs in tumor microenvironment: the potential role of ROS-associated miRNAs in tumor aggressiveness
    Bin Bao
    Departments of Pathology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, 740 HWCRC, 4100 John R Street, Detroit, MI 48201, USA
    Curr Stem Cell Res Ther 9:22-35. 2014
    ..Finally, we will discuss the role of genistein, as a potent anti-tumor agent in the regulation of ROS production during tumorigenesis and tumor development. ..
  3. ncbi request reprint Regulating miRNA by natural agents as a new strategy for cancer treatment
    Sajiv Sethi
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Drug Targets 14:1167-74. 2013
    ....
  4. ncbi request reprint Deregulation of PI3K/Akt/mTOR signaling pathways by isoflavones and its implication in cancer treatment
    Aamir Ahmad
    Department of Pathology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Anticancer Agents Med Chem 13:1014-24. 2013
    ..In this review article, we discuss our current understanding of the regulation of PI3K/Akt/mTOR signaling pathways by isoflavones, which could be responsible for their observed in vitro and in vivo activity against human cancers. ..
  5. ncbi request reprint Targeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapy
    Aamir Ahmad
    Department of Pathology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Anticancer Agents Med Chem 13:1002-13. 2013
    ..Here we will review the available literature on the modulation of PI3K/Akt/mTOR/NF-κB signaling by both parental I3C and DIM, as well as their analogs/derivatives, in an attempt to catalog their anticancer activity. ..
  6. pmc Clinical advances in molecular biomarkers for cancer diagnosis and therapy
    Seema Sethi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Mol Sci 14:14771-84. 2013
    ..Overall, the novel cancer diagnostic tools have extended their application as prognostic risk factors and can be used as targets for personalized medicine. ..
  7. pmc Network insights into the genes regulated by hepatocyte nuclear factor 4 in response to drug induced perturbations: a review
    Asfar S Azmi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Drug Discov Technol 10:147-54. 2013
    ..This article reviews how network pharmacology can help in the identification of druggable avenues in TFs and also allow the selection of drugs and their synergistic pairs against HNFs for cancer therapy...
  8. pmc Perspectives on new synthetic curcumin analogs and their potential anticancer properties
    Alok Vyas
    ISTRA, Department of Chemistry, Abeda Inamdar College, University of Pune, Pune 411001, India
    Curr Pharm Des 19:2047-69. 2013
    ..In this review we provide a summarized account of novel synthetic curcumin formulations and analogs, and the recent progress in the field of cancer prevention and treatment...
  9. pmc Targeting CSC-related miRNAs for cancer therapy by natural agents
    Bin Bao
    Departments of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Curr Drug Targets 13:1858-68. 2012
    ..We will also discuss the potential role of naturally occurring agents (nutraceuticals) as potent anti-tumor agents that are believed to function by targeting CSC-related miRNAs...
  10. ncbi request reprint From body art to anticancer activities: perspectives on medicinal properties of henna
    Rohan Pradhan
    ISTRA, Department of Chemistry, Abeda Inamdar S nior College, University of Pune, Pune 411001 India
    Curr Drug Targets 13:1777-98. 2012
    ....
  11. pmc The Role of MicroRNAs in Breast Cancer Migration, Invasion and Metastasis
    Joy Tang
    Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI 48201, USA
    Int J Mol Sci 13:13414-37. 2012
    ..Therefore, better understanding of the gene networks orchestrated by these miRNAs may help exploit the full potential of miRNAs in regards to cancer diagnosis, treatment, and therapeutics...
  12. pmc The complexities of epidemiology and prevention of gastrointestinal cancers
    Saba Haq
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Mol Sci 13:12556-72. 2012
    ..Additionally, some of the well-known and evolving aspects of epidemiology of colorectal and pancreatic cancer along with current and new prevention strategies will also be reviewed...
  13. pmc Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells
    Aamir Ahmad
    Department of Pathology, Karmanos Cancer Institute, 740 HWCRC Bldg, 4100 John R Street, Detroit, MI 48201, USA
    Mol Cancer Ther 11:2193-201. 2012
    ....
  14. ncbi request reprint Perspectives on medicinal properties of mangiferin
    A Vyas
    Dr D Y Patil University, Pune, India
    Mini Rev Med Chem 12:412-25. 2012
    ....
  15. pmc Recent updates on the role of microRNAs in prostate cancer
    Oudai Hassan
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    J Hematol Oncol 5:9. 2012
    ....
  16. pmc Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells
    Bin Bao
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, 4100 John R Street, Detroit, MI 48201, USA
    Cancer Prev Res (Phila) 5:355-64. 2012
    ....
  17. pmc Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs
    Subhash Padhye
    Department of Pathology, Barbara Ann Karmanos Cancer Center and Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Hematol Oncol 2:38. 2009
    ....
  18. pmc Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest
    Julian J Raffoul
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    BMC Cancer 6:107. 2006
    ..In this study, we investigated the cellular and molecular interaction between genistein and radiation using PC-3 human prostate cancer cells...
  19. pmc Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    BMC Cancer 7:4. 2007
    ....
  20. pmc Implication of microRNAs in drug resistance for designing novel cancer therapy
    Fazlul H Sarkar
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Drug Resist Updat 13:57-66. 2010
    ..These emerging results suggest that specific targeting of miRNAs by different approaches could open new avenues for cancer treatment through overcoming drug resistance and thereby improve the outcome of cancer therapy...
  21. pmc Pancreatic cancer: pathogenesis, prevention and treatment
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, 110 E Warren, Detroit, MI 48201, USA
    Toxicol Appl Pharmacol 224:326-36. 2007
    ..In this brief review, we will summarize the current knowledge regarding the pathogenesis, prevention, and treatment of pancreatic cancer...
  22. ncbi request reprint Indole-3-carbinol and prostate cancer
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, 48201, USA
    J Nutr 134:3493S-3498S. 2004
    ..In conclusion, the results from our laboratory and from others provide ample evidence for the benefit of I3C and DIM for the prevention and the treatment of prostate cancer...
  23. ncbi request reprint The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mini Rev Med Chem 6:401-7. 2006
    ..These results suggest that genistein and synthetic structurally-modified derivatives of isoflavone may be promising agents for cancer chemoprevention and therapy either alone or in combination with existing chemotherapeutic agents...
  24. ncbi request reprint Using chemopreventive agents to enhance the efficacy of cancer therapy
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, 110 East Warren, Detroit, MI 48201, USA
    Cancer Res 66:3347-50. 2006
    ..In this article, we summarize the findings of recent investigations of chemopreventive agents in combination with cancer treatment regimens...
  25. ncbi request reprint Back to the future: COX-2 inhibitors for chemoprevention and cancer therapy
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, Detroit, MI 48201, USA
    Mini Rev Med Chem 7:599-608. 2007
    ..In addition, we provide further evidence regarding the state of our knowledge toward the development of novel COX-2 targeting agents for the prevention and/or treatment of human cancers especially pancreatic cancer...
  26. ncbi request reprint Targeting multiple signal pathways by chemopreventive agents for cancer prevention and therapy
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Acta Pharmacol Sin 28:1305-15. 2007
    ..Here, we have briefly reviewed the role of chemopreventive agents in cancer prevention, but most importantly, we have reviewed how they could be useful for cancer therapy in combination with conventional therapies...
  27. ncbi request reprint NF-kappaB: a potential target for cancer chemoprevention and therapy
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Front Biosci 13:2950-9. 2008
    ..In this brief review article, we will summarize the state of our knowledge for the role of NF-kappaB in relation to cancer prevention and therapy...
  28. doi request reprint NF-kappaB signaling pathway and its therapeutic implications in human diseases
    Fazlul H Sarkar
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Int Rev Immunol 27:293-319. 2008
    ..Therefore, targeting of NF-kappaB signaling pathway could be a potent strategy for the prevention and/or treatment of human cancers and inflammatory diseases...
  29. pmc Cellular signaling perturbation by natural products
    Fazlul H Sarkar
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, 4100 John R, Detroit, MI 48201, USA
    Cell Signal 21:1541-7. 2009
    ..Therefore, non-toxic "natural agents" harvested from the bounties of nature could be useful either alone or in combination with conventional therapeutics for the prevention of tumor progression and/or treatment of human malignancies...
  30. pmc Pancreatic cancer stem cells and EMT in drug resistance and metastasis
    F H Sarkar
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Minerva Chir 64:489-500. 2009
    ....
  31. pmc Lesson learned from nature for the development of novel anti-cancer agents: implication of isoflavone, curcumin, and their synthetic analogs
    Fazlul H Sarkar
    Department of Pathology Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Pharm Des 16:1801-12. 2010
    ....
  32. pmc Novel targets for prostate cancer chemoprevention
    Fazlul H Sarkar
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R Street, Detroit, MI 48201, USA
    Endocr Relat Cancer 17:R195-212. 2010
    ....
  33. pmc The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer
    Fazlul H Sarkar
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 740 HWCRC, 4100 John R Street, Detroit, MI 48201, USA
    Cancer Metastasis Rev 29:383-94. 2010
    ....
  34. doi request reprint Targeting the Hedgehog signaling pathway for cancer therapy
    Yiwei Li
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Expert Opin Ther Targets 16:49-66. 2012
    ..Since CSCs and EMT are important biological factors responsible for cancer cell invasion, metastasis, drug resistance and tumor recurrence, the Hh signaling pathway is believed to be an important target for cancer therapy...
  35. ncbi request reprint The role of isoflavones in cancer chemoprevention
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Front Biosci 9:2714-24. 2004
    ..However, further in depth experimental investigations along with clinical trials are needed to fully evaluate the value of isoflavones in human cancer prevention and/or treatment...
  36. ncbi request reprint Soy isoflavones and cancer prevention
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 715 Hudson Webber Cancer Center, 110 E Warren, Detroit, MI 48201, USA
    Cancer Invest 21:744-57. 2003
    ..In this article, we attempt to provide evidence for these effects of genistein in a succinct manner to provide comprehensive state-of-the-art knowledge of the biological and molecular effects of the isoflavone genistein in cancer cells...
  37. ncbi request reprint Relationship of p21(WAF1) expression with disease-free survival and biochemical recurrence in prostate adenocarcinomas (PCa)
    F H Sarkar
    Department of Pathology, Karmanos Cancer Institute at Wayne State University School of Medicine, Detroit, Michigan, USA
    Prostate 40:256-60. 1999
    ..Its level of expression has been shown to correlate with pathologic stage and Gleason score in prostatic cancer. However, its relationship to clinical outcome is not yet well-characterized...
  38. ncbi request reprint Molecular analysis of p53 and K-ras in lung carcinomas of coal miners
    F H Sarkar
    Department of Pathology, Wayne State University School of Medicine, 540 E Canfield Avenue, Detroit, MI 48201, USA
    Int J Mol Med 8:453-9. 2001
    ..These limited preliminary studies provide insight into the possibility of accurately measuring changes in etiologic markers to unravel the uncertainties of cancer in coal miners...
  39. ncbi request reprint Bax translocation to mitochondria is an important event in inducing apoptotic cell death by indole-3-carbinol (I3C) treatment of breast cancer cells
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Nutr 133:2434S-2439S. 2003
    ....
  40. ncbi request reprint Cell signaling pathways altered by natural chemopreventive agents
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 715 Hudson Webber Cancer Research Center, 110 E Warren, Detroit, MI 48201, USA
    Mutat Res 555:53-64. 2004
    ....
  41. ncbi request reprint Mechanisms of cancer chemoprevention by soy isoflavone genistein
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Metastasis Rev 21:265-80. 2002
    ..Hence, significant advances have been made, both by in vitro and in vivo studies showing that genistein is a promising agent for cancer chemoprevention and/or treatment...
  42. ncbi request reprint Gene expression profiling revealed novel molecular targets of docetaxel and estramustine combination treatment in prostate cancer cells
    Yiwei Li
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 715 Hudson Webber Cancer Research Center, 110 East Warren, Detroit, MI 48201, USA
    Mol Cancer Ther 4:389-98. 2005
    ..This information could be utilized for further mechanistic research and for devising optimized therapeutic strategies against prostate cancer...
  43. ncbi request reprint Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line
    Hector Biliran
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 11:6075-86. 2005
    ..Because pancreatic cancer is invariably resistant to chemotherapy, the goal of this study was to examine whether the drug resistance of pancreatic cancer cells is in part attributed to cyclin D1 overexpression...
  44. ncbi request reprint Lycopene and soy isoflavones in the treatment of prostate cancer
    Ulka Vaishampayan
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Nutr Cancer 59:1-7. 2007
    ..Future studies are warranted to further investigate the efficacy of lycopene and soy isoflavones in prostate cancer as well as the mechanism of potential negative interaction between them...
  45. pmc Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line
    David A Davis
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    BMC Cancer 6:22. 2006
    ....
  46. ncbi request reprint In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancer
    Sanjeev Banerjee
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, 4160 John R Street, Detroit, MI 48201, USA
    Cancer Res 67:3818-26. 2007
    ..Most importantly, the antitumor activity was associated with the down-regulation of molecular markers in tumor tissues that were similar to those observed in vitro...
  47. ncbi request reprint Soy isoflavones in the treatment of prostate cancer
    Maha Hussain
    Division of Hematology and Oncology, Wayne State University, Detroit, MI 48201, USA
    Nutr Cancer 47:111-7. 2003
    ..00002) and from 0.11 to 0.51 microM (P = 0.00001), respectively. No significant changes were observed in serum levels of testosterone, IGF-1, IGFBP-3, or 5-OHmdU. These data suggest that soy isoflavones may benefit some patients with Pca...
  48. pmc Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer
    Shadan Ali
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Mol Cancer Ther 7:1708-19. 2008
    ..These results suggest that the utilization of B-DIM could be a useful strategy for achieving better treatment outcome in patients with activated status of EGFR and NF-kappaB in their tumors...
  49. ncbi request reprint Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signaling
    Zhiwei Wang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, 9374 Scott Hall, 540 East Canfield, Detroit, MI 48201, USA
    Cancer Res 67:11377-85. 2007
    ..e., MMP-9 and VEGF), resulting in the inhibition of invasion and angiogenesis...
  50. pmc Concurrent inhibition of NF-kappaB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer
    Shadan Ali
    Division of Hematology Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Cell Biochem 110:171-81. 2010
    ..Based on our preclinical in vitro and in vivo results, we conclude that this multi-targeted combination could be developed for the treatment of PC patients whose tumors express high levels of COX-2, EGFR, and NF-kappaB...
  51. pmc Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
    Zhiwei Wang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA
    Cancer Res 69:2400-7. 2009
    ....
  52. ncbi request reprint Molecular mechanism(s) of actinomycin-D induced sensitization of pancreatic cancer cells to CD95 mediated apoptosis
    Alexey L Glazyrin
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Oncol 20:201-5. 2002
    ..Thus, our results indicate that modulation of NF-kappaB activity rather then Akt may provide a useful tool to sensitize pancreatic cancer cells to CD95 mediated apoptosis...
  53. pmc miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells
    Dejuan Kong
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Stem Cells 27:1712-21. 2009
    ....
  54. ncbi request reprint Suppression of human prostate cancer cell growth by ciprofloxacin is associated with cell cycle arrest and apoptosis
    Olivia Aranha
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Int J Oncol 22:787-94. 2003
    ..Based on our in vitro results, further in-depth in vivo animal or human investigations are warranted...
  55. ncbi request reprint Neoadjuvant docetaxel and estramustine chemotherapy in high-risk/locallyadvanced prostate cancer
    Maha Hussain
    Division of Hematology Oncology, Wayne State University and Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA
    Urology 61:774-80. 2003
    ..To evaluate the efficacy and safety of neoadjuvant docetaxel and estramustine in patients with high-risk, newly diagnosed, prostate cancer...
  56. doi request reprint Update in systemic therapy of prostate cancer: improvement in quality and duration of life
    Ulka Vaishampayan
    4 HWCRC, 4100 John R Road, Detroit, MI 48201, USA
    Expert Rev Anticancer Ther 8:269-81. 2008
    ..This review attempts to summarize the risk profiling strategy in prostate cancer and the existing therapies in high-risk prostate cancer, including some of the novel agents under investigation...
  57. pmc Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF
    Shadan Ali
    Division of Hematology Oncology, Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 70:3606-17. 2010
    ..These results prompt further interest in CDF as a drug modality to improve treatment outcome of patients diagnosed with PC as a result of its greater bioavailability in pancreatic tissue...
  58. ncbi request reprint Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway
    Yiwei Li
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 8:2369-77. 2002
    ....
  59. pmc TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and invasion in pancreatic cancer
    Zhiwei Wang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Int J Cancer 123:958-66. 2008
    ..We also suggest that TW-37 could be further developed as a potential therapeutic agent for the treatment of pancreatic cancer...
  60. pmc Reactivation of p53 by novel MDM2 inhibitors: implications for pancreatic cancer therapy
    Asfar S Azmi
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Cancer Drug Targets 10:319-31. 2010
    ..No tumor inhibition was found in mut-p53 BxPC-3 xenografts. In light of our results, the inhibitors of MDM2 warrant clinical investigation as new agents for PC treatment...
  61. ncbi request reprint Ciprofloxacin inhibits cell growth and synergises the effect of etoposide in hormone resistant prostate cancer cells
    Basil F El-Rayes
    Department of Hematology Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Oncol 21:207-11. 2002
    ....
  62. ncbi request reprint Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells
    K M Wahidur Rahman
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Nutr Cancer 45:101-12. 2003
    ..From these results, we conclude that I3C selectively induces apoptosis in breast cancer cells, but not in nontumorigenic breast epithelial cells, suggesting the potential therapeutic benefit of I3C against breast cancer...
  63. ncbi request reprint Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/MMP-9 signaling in prostate cancer
    Yiwei Li
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 66:4816-25. 2006
    ..From these results, we conclude that genistein could be a promising nontoxic agent to improve the treatment outcome of metastatic prostate cancer with docetaxel...
  64. doi request reprint A phase II trial of neoadjuvant nab-paclitaxel, carboplatin, and gemcitabine (ACaG) in patients with locally advanced carcinoma of the bladder
    Petros D Grivas
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Urology 82:111-7. 2013
    ..To assess the activity of neoadjuvant nab-paclitaxel, carboplatin, gemcitabine (ACaG) followed by cystectomy in patients with muscle-invasive urothelial carcinoma of the bladder...
  65. pmc Phase II trial of paclitaxel, carboplatin and gemcitabine in patients with locally advanced carcinoma of the bladder
    David C Smith
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan School of Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Urol 180:2384-8; discussion 2388. 2008
    ..This 2-arm phase II multicenter trial was designed to assess the efficacy and toxicity of neoadjuvant paclitaxel, gemcitabine and carboplatin in patients with invasive bladder cancer...
  66. ncbi request reprint Gene expression profiling reveals novel targets of estramustine phosphate in prostate cancer cells
    Xin Hong
    Department of Pathology, Wayne State University School of Medicine, 9374 Scott Hall, 540 East Canfield, Detroit, MI 48201, USA
    Cancer Lett 209:187-95. 2004
    ..EMP-induced regulation of these genes may be further exploited for devising therapeutic strategies for prostate cancer...
  67. pmc A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer
    Elisabeth I Heath
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Clin Cancer Res 14:7940-6. 2008
    ..A two-stage phase II study was conducted to assess the activity and toxicity profile of 17-AAG administered to patients with metastatic, hormone-refractory prostate cancer...
  68. ncbi request reprint Pathogenesis of colloid (pure mucinous) carcinoma of exocrine organs: Coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of collo
    N Volkan Adsay
    Department of Pathology, Karamanos Cancer Institute and Wayne State University, Detroit, Michigan 48201, USA
    Am J Surg Pathol 27:571-8. 2003
    ..This distinctive mucin, accumulated in the stroma surrounding the CC cells, may act as a containing factor, slackening the spread of the cells...
  69. pmc Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells
    Archana Thakur
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
    Clin Cancer Res 14:4427-36. 2008
    ..In this study, we further investigated whether RSK4 inhibits or promotes breast tumor growth and progression...
  70. pmc Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells
    Sanjeev Banerjee
    Division of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Pancreas 39:323-31. 2010
    ..The present study was designed to test our hypothesis whether inactivation of Bcl-2 family of proteins using ApoG2 could sensitize pancreatic cancer cells to the cytotoxic effect of gemcitabine...
  71. ncbi request reprint Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells
    Lijie Gong
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Oncogene 22:4702-9. 2003
    ....
  72. ncbi request reprint Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells
    Sreenivasa R Chinni
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 8:1228-36. 2002
    ..However, further in-depth investigation is needed to establish a cause-and-effect relationship between Akt pathway and I3C effect...
  73. pmc ErbB-inhibitory protein: a modified ectodomain of epidermal growth factor receptor synergizes with dasatinib to inhibit growth of breast cancer cells
    Jyoti Nautiyal
    Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
    Mol Cancer Ther 9:1503-14. 2010
    ..The latter could be attributed to induction of apoptosis. We conclude that combining dasatinib and EBIP could be an effective therapeutic strategy for breast cancer by targeting EGFRs and Src signaling...
  74. pmc Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells
    Dejuan Kong
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
    PLoS ONE 5:e12445. 2010
    ..Increasing evidence suggests that EMT-type cells share many biological characteristics with cancer stem-like cells...
  75. ncbi request reprint Down-regulation of invasion and angiogenesis-related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein
    Yiwei Li
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Lett 186:157-64. 2002
    ..Thus, genistein-induced alternations of gene expressions may be exploited for devising chemopreventive or therapeutic strategies, particularly for chemosensitization of metastatic prostate cancer to existing chemotherapeutic agents...
  76. ncbi request reprint Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells
    Yiwei Li
    Department of Pathology and Internal Medicine, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 65:6934-42. 2005
    ..Theses results warrant carefully designed clinical studies investigating the combination of soy isoflavones and commonly used chemotherapeutic agents for the treatment of human cancers...
  77. ncbi request reprint In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer
    Sanjeev Banerjee
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Cancer 120:906-17. 2007
    ....
  78. ncbi request reprint Loss of heterozygosity and microsatellite instability at the Xq28 and the A/G heterozygosity of the QM gene are associated with ovarian cancer
    Xing jun Shen
    Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Cancer Biol Ther 5:523-8. 2006
    ..6% vs 21.7%, p < 0.01). These results suggest that high frequencies of LOH and MSI at the Xq28 and of the A/G heterozygosity at the 605th nt of the QM gene may be associated with ovarian cancer...
  79. ncbi request reprint Cisplatin-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenografts
    Ramzi M Mohammad
    Division of Hematology and Oncology, Department of Internal Medicine, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer 106:1260-8. 2006
    ....
  80. ncbi request reprint Phase II trial of estramustine and etoposide in androgen-sensitive metastatic prostate carcinoma
    Ulka Vaishampayan
    Division of Hematology Oncology, Barbara Ann Karmanos Cancer Institute and Wayne State University, Detroit, Michiga, USA
    Am J Clin Oncol 27:550-4. 2004
    ..Hence, a phase II trial was conducted to evaluate the efficacy and toxicity of estramustine and etoposide in hormone-sensitive metastatic prostate cancer...
  81. pmc Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): trial results and interleukin-6 analysis: a study by the Department of Defense Prostate Cancer Clinical Trial Consortium and Universi
    Deborah Bradley
    Department of Medicine and Urology, University of Michigan, Ann Arbor, Michigan, USA
    Cancer 115:5541-9. 2009
    ..This phase 2 trial was designed to evaluate the efficacy of vorinostat in chemotherapy-pretreated patients with metastatic castration-resistant prostate cancer...
  82. ncbi request reprint DeltaNp63 expression in pancreas and pancreatic neoplasia
    Olca Basturk
    Department of Pathology, Harper University Hospital, Karmanos Cancer Institute and Wayne State University, Detroit, MI 48201, USA
    Mod Pathol 18:1193-8. 2005
    ..IV) No p63-expressing 'stem' cells are present in the pancreas...
  83. pmc Sensitization of squamous cell carcinoma to cisplatin induced killing by natural agents
    Shadan Ali
    Division of Hematology Oncology, Karmanos Cancer Center, Wayne State University, Detroit, MI, USA
    Cancer Lett 278:201-9. 2009
    ....
  84. pmc Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis
    Asfar Sohail Azmi
    Department of Pathology, Division of Hematology Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, 732 HWCRC, 4100 John R Street, Detroit, MI 48201, USA
    Mol Cancer Ther 7:2884-93. 2008
    ..To our knowledge, this is the first study reporting SMI-mediated apoptosis involving PAR-4 in pancreatic cancer...
  85. pmc Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells
    Dejuan Kong
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Res 68:1927-34. 2008
    ..Our results suggest that B-DIM could serve as a novel and efficient chemopreventive and/or therapeutic agent by inactivation of both mTOR and Akt activity in PDGF-D-overexpressing prostate cancer...
  86. pmc TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway
    Zhiwei Wang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 69:2757-65. 2009
    ..Our data suggest that the observed antitumor activity of TW-37 is mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1...
  87. pmc miR-146a suppresses invasion of pancreatic cancer cells
    Yiwei Li
    Departments of Pathology and Internal Medicine, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 70:1486-95. 2010
    ..Our findings reveal DIM and isoflavone as nontoxic activators of a miRNA that can block pancreatic cancer cell invasion and metastasis, offering starting points to design novel anticancer agents...
  88. ncbi request reprint Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
    Zhiwei Wang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer 106:2503-13. 2006
    ....
  89. ncbi request reprint Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer
    Sanjeev Banerjee
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 65:9064-72. 2005
    ....
  90. doi request reprint Daidzein effect on hormone refractory prostate cancer in vitro and in vivo compared to genistein and soy extract: potentiation of radiotherapy
    Vinita Singh-Gupta
    Department of Radiation Oncology, Wayne State University School of Medicine, 515 Hudson Webber Cancer Research Center, 4100 John R Road, Detroit, Michigan 48201, USA
    Pharm Res 27:1115-27. 2010
    ..A mixture of soy isoflavones (genistein, daidzein, glycitein) did not cause increased metastasis, but potentiated radiotherapy. We tested whether daidzein could negate genistein-induced metastasis...
  91. pmc Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
    Yiwei Li
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 69:6704-12. 2009
    ....
  92. ncbi request reprint Absolute prostate-specific antigen value after androgen deprivation is a strong independent predictor of survival in new metastatic prostate cancer: data from Southwest Oncology Group Trial 9346 (INT-0162)
    Maha Hussain
    University of Michigan, Ann Arbor, MI, USA
    J Clin Oncol 24:3984-90. 2006
    ..To establish whether absolute prostate-specific antigen (PSA) value after androgen deprivation (AD) is prognostic in metastatic (D2) prostate cancer (PCa)...
  93. pmc Gene expression profiling revealed novel mechanism of action of Taxotere and Furtulon in prostate cancer cells
    Yiwei Li
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    BMC Cancer 5:7. 2005
    ..However, the molecular mechanisms of action of Taxotere and Capecitabine have not been fully elucidated in prostate cancer...
  94. ncbi request reprint Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
    Zhiwei Wang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 9374 Scott Hall, 540 East Canfield, Detroit, MI 48201, USA
    Mol Cancer Ther 5:483-93. 2006
    ..These findings suggest that Notch-1 down-regulation, especially by genistein, could be a novel therapeutic approach for the treatment of pancreatic cancer...
  95. pmc Critical need for clinical trials: an example of a pilot human intervention trial of a mixture of natural agents protecting lymphocytes against TNF-alpha induced activation of NF-kappaB
    Kristin Dominiak
    Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pharm Res 27:1061-5. 2010
    ....
  96. pmc Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells
    Aamir Ahmad
    Department of Pathology, Barbara Ann Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Biochem 108:916-25. 2009
    ....
  97. doi request reprint Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer
    Sanjeev Banerjee
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
    Cancer Res 69:5575-83. 2009
    ....
  98. ncbi request reprint Epidermal growth factor receptor (EGFR)-related protein inhibits multiple members of the EGFR family in colon and breast cancer cells
    Hu Xu
    John D Dingell Veterans Affairs Medical Center, 4646 John R, Room B 4238, Detroit, MI 48201, USA
    Mol Cancer Ther 4:435-42. 2005
    ..Our results suggest that ERRP is an effective pan-erbB inhibitor and, thus, may be a potential therapeutic agent for a wide variety of epithelial cancers expressing different levels and subclasses of EGFRs...
  99. ncbi request reprint Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells
    Mohammad M R Bhuiyan
    Departments of Pathology and Internal Medicine, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 66:10064-72. 2006
    ....
  100. ncbi request reprint Down-regulation of Forkhead Box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells
    Zhiwei Wang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Cancer Res 67:8293-300. 2007
    ..These findings suggest that FoxM1 down-regulation could be a novel approach for the inhibition of pancreatic tumor progression...
  101. ncbi request reprint Mechanisms of curcumin- and EGF-receptor related protein (ERRP)-dependent growth inhibition of colon cancer cells
    Sudha Reddy
    Veterans Affairs Medical Center, Karmanos Cancer Institute, Department of Internal Medicine, Michigan 48201, USA
    Nutr Cancer 55:185-94. 2006
    ..The superior effects of the combinatorial treatment could partly be attributed to inhibition of constitutive activation of EGFRs and IGF-1R signaling pathways...

Research Grants24

  1. Molecular Mechanism of Genistein (Isoflavone) in Prostate Cancer
    Fazlul Sarkar; Fiscal Year: 2007
    ....
  2. FoxM1: A molecular target in pancreatic cancer
    Fazlul H Sarkar; Fiscal Year: 2010
    ..We will test our hypothesis by three specific aims using molecular approaches in vitro and by using animal models in vivo (both orthotopic mouse model and transgenic mouse models of PC). ..
  3. Novel Targets of Indoles in Prostate Cancer
    Fazlul H Sarkar; Fiscal Year: 2010
    ..The results of our study will help to design mechanism-based clinical trials for assessing the role of B-DIM in the prevention and/or treatment of PCa. ..
  4. RO1: A novel and targeted approach to inhibit invasion and angiogenesis
    Fazlul H Sarkar; Fiscal Year: 2010
    ..We will test our hypothesis by three specific aims using molecular approaches and animal model studies. ..
  5. Molecular Mechanism of Genistein (Isoflavone) in Prostate Cancer
    Fazlul H Sarkar; Fiscal Year: 2010
    ....
  6. Novel Targets of Indoles in Prostate Cancer
    Fazlul Sarkar; Fiscal Year: 2007
    ..abstract_text> ..
  7. Targeting Akt/NF-kappa beta for Pancreatic Cancer Therapy
    Fazlul Sarkar; Fiscal Year: 2007
    ..These results will provide mechanistic as well as pre-clinical data in support of our hypotheses and may open new and novel avenues for the treatment of human pancreatic cancer. ..
  8. Molecular Mechanism of Genistein in Prostate Cancer
    Fazlul Sarkar; Fiscal Year: 2004
    ..In addition, we also propose to test the anti-tumor activity of genistein in prostate cancer animal models and investigate whether the molecular alterations in animal tumors are similar to those observed in vitro. ..
  9. RO1: A novel and targeted approach to inhibit invasion and angiogenesis
    Fazlul Sarkar; Fiscal Year: 2009
    ..We will test our hypothesis by three specific aims using molecular approaches and animal model studies. ..