Research Topics
| Maha HussainSummaryAffiliation: Wayne State University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
From body art to anticancer activities: perspectives on medicinal properties of hennaRohan Pradhan
ISTRA, Department of Chemistry, Abeda Inamdar S nior College, University of Pune, Pune 411001 India
Curr Drug Targets 13:1777-98. 2012....- Targeting CSC-related miRNAs for cancer therapy by natural agentsBin Bao
Departments of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
Curr Drug Targets 13:1858-68. 2012..We will also discuss the potential role of naturally occurring agents (nutraceuticals) as potent anti-tumor agents that are believed to function by targeting CSC-related miRNAs... 
The Role of MicroRNAs in Breast Cancer Migration, Invasion and MetastasisJoy Tang
Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI 48201, USA
Int J Mol Sci 13:13414-37. 2012..Therefore, better understanding of the gene networks orchestrated by these miRNAs may help exploit the full potential of miRNAs in regards to cancer diagnosis, treatment, and therapeutics...- The complexities of epidemiology and prevention of gastrointestinal cancersSaba Haq
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Int J Mol Sci 13:12556-72. 2012..Additionally, some of the well-known and evolving aspects of epidemiology of colorectal and pancreatic cancer along with current and new prevention strategies will also be reviewed... 
Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cellsAamir Ahmad
Department of Pathology, Karmanos Cancer Institute, 740 HWCRC Bldg, 4100 John R Street, Detroit, MI 48201, USA
Mol Cancer Ther 11:2193-201. 2012....- Perspectives on medicinal properties of mangiferinA Vyas
Dr D Y Patil University, Pune, India
Mini Rev Med Chem 12:412-25. 2012.... - Recent updates on the role of microRNAs in prostate cancerOudai Hassan
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
J Hematol Oncol 5:9. 2012.... - Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cellsBin Bao
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, 4100 John R Street, Detroit, MI 48201, USA
Cancer Prev Res (Phila) 5:355-64. 2012.... - Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogsSubhash Padhye
Department of Pathology, Barbara Ann Karmanos Cancer Center and Wayne State University School of Medicine, Detroit, MI 48201, USA
J Hematol Oncol 2:38. 2009.... 
Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrestJulian J Raffoul
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
BMC Cancer 6:107. 2006..In this study, we investigated the cellular and molecular interaction between genistein and radiation using PC-3 human prostate cancer cells...- Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic modelGilda G Hillman
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
BMC Cancer 7:4. 2007.... - Cell signaling pathways altered by natural chemopreventive agentsFazlul H Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 715 Hudson Webber Cancer Research Center, 110 E Warren, Detroit, MI 48201, USA
Mutat Res 555:53-64. 2004.... - The role of isoflavones in cancer chemopreventionFazlul H Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Front Biosci 9:2714-24. 2004..However, further in depth experimental investigations along with clinical trials are needed to fully evaluate the value of isoflavones in human cancer prevention and/or treatment... - NF-kappaB signaling pathway and its therapeutic implications in human diseasesFazlul H Sarkar
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Int Rev Immunol 27:293-319. 2008..Therefore, targeting of NF-kappaB signaling pathway could be a potent strategy for the prevention and/or treatment of human cancers and inflammatory diseases... - Implication of microRNAs in drug resistance for designing novel cancer therapyFazlul H Sarkar
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Drug Resist Updat 13:57-66. 2010..These emerging results suggest that specific targeting of miRNAs by different approaches could open new avenues for cancer treatment through overcoming drug resistance and thereby improve the outcome of cancer therapy... - Targeting multiple signal pathways by chemopreventive agents for cancer prevention and therapyFazlul H Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Acta Pharmacol Sin 28:1305-15. 2007..Here, we have briefly reviewed the role of chemopreventive agents in cancer prevention, but most importantly, we have reviewed how they could be useful for cancer therapy in combination with conventional therapies... - Lesson learned from nature for the development of novel anti-cancer agents: implication of isoflavone, curcumin, and their synthetic analogsFazlul H Sarkar
Department of Pathology Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Curr Pharm Des 16:1801-12. 2010.... - Indole-3-carbinol and prostate cancerFazlul H Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, 48201, USA
J Nutr 134:3493S-3498S. 2004..In conclusion, the results from our laboratory and from others provide ample evidence for the benefit of I3C and DIM for the prevention and the treatment of prostate cancer... - Pancreatic cancer stem cells and EMT in drug resistance and metastasisF H Sarkar
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
Minerva Chir 64:489-500. 2009.... - NF-kappaB: a potential target for cancer chemoprevention and therapyFazlul H Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Front Biosci 13:2950-9. 2008..In this brief review article, we will summarize the state of our knowledge for the role of NF-kappaB in relation to cancer prevention and therapy... - Using chemopreventive agents to enhance the efficacy of cancer therapyFazlul H Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, 110 East Warren, Detroit, MI 48201, USA
Cancer Res 66:3347-50. 2006..In this article, we summarize the findings of recent investigations of chemopreventive agents in combination with cancer treatment regimens... - Back to the future: COX-2 inhibitors for chemoprevention and cancer therapyFazlul H Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, Detroit, MI 48201, USA
Mini Rev Med Chem 7:599-608. 2007..In addition, we provide further evidence regarding the state of our knowledge toward the development of novel COX-2 targeting agents for the prevention and/or treatment of human cancers especially pancreatic cancer... - The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapyFazlul H Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Mini Rev Med Chem 6:401-7. 2006..These results suggest that genistein and synthetic structurally-modified derivatives of isoflavone may be promising agents for cancer chemoprevention and therapy either alone or in combination with existing chemotherapeutic agents... - Cellular signaling perturbation by natural productsFazlul H Sarkar
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, 4100 John R, Detroit, MI 48201, USA
Cell Signal 21:1541-7. 2009.... - Pancreatic cancer: pathogenesis, prevention and treatmentFazlul H Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, 110 E Warren, Detroit, MI 48201, USA
Toxicol Appl Pharmacol 224:326-36. 2007..In this brief review, we will summarize the current knowledge regarding the pathogenesis, prevention, and treatment of pancreatic cancer... - Soy isoflavones and cancer preventionFazlul H Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 715 Hudson Webber Cancer Center, 110 E Warren, Detroit, MI 48201, USA
Cancer Invest 21:744-57. 2003..In this article, we attempt to provide evidence for these effects of genistein in a succinct manner to provide comprehensive state-of-the-art knowledge of the biological and molecular effects of the isoflavone genistein in cancer cells... - Novel targets for prostate cancer chemopreventionFazlul H Sarkar
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R Street, Detroit, MI 48201, USA
Endocr Relat Cancer 17:R195-212. 2010.... - Mechanisms of cancer chemoprevention by soy isoflavone genisteinFazlul H Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Cancer Metastasis Rev 21:265-80. 2002..Hence, significant advances have been made, both by in vitro and in vivo studies showing that genistein is a promising agent for cancer chemoprevention and/or treatment... - Relationship of p21(WAF1) expression with disease-free survival and biochemical recurrence in prostate adenocarcinomas (PCa)F H Sarkar
Department of Pathology, Karmanos Cancer Institute at Wayne State University School of Medicine, Detroit, Michigan, USA
Prostate 40:256-60. 1999..Its level of expression has been shown to correlate with pathologic stage and Gleason score in prostatic cancer. However, its relationship to clinical outcome is not yet well-characterized... - The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancerFazlul H Sarkar
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 740 HWCRC, 4100 John R Street, Detroit, MI 48201, USA
Cancer Metastasis Rev 29:383-94. 2010.... - Molecular analysis of p53 and K-ras in lung carcinomas of coal minersF H Sarkar
Department of Pathology, Wayne State University School of Medicine, 540 E Canfield Avenue, Detroit, MI 48201, USA
Int J Mol Med 8:453-9. 2001..These limited preliminary studies provide insight into the possibility of accurately measuring changes in etiologic markers to unravel the uncertainties of cancer in coal miners... - Targeting the Hedgehog signaling pathway for cancer therapyYiwei Li
Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Expert Opin Ther Targets 16:49-66. 2012.... - Bax translocation to mitochondria is an important event in inducing apoptotic cell death by indole-3-carbinol (I3C) treatment of breast cancer cellsFazlul H Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Nutr 133:2434S-2439S. 2003.... - Gene expression profiling revealed novel molecular targets of docetaxel and estramustine combination treatment in prostate cancer cellsYiwei Li
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 715 Hudson Webber Cancer Research Center, 110 East Warren, Detroit, MI 48201, USA
Mol Cancer Ther 4:389-98. 2005..This information could be utilized for further mechanistic research and for devising optimized therapeutic strategies against prostate cancer... - Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell lineHector Biliran
Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Clin Cancer Res 11:6075-86. 2005.... - Lycopene and soy isoflavones in the treatment of prostate cancerUlka Vaishampayan
Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
Nutr Cancer 59:1-7. 2007..Future studies are warranted to further investigate the efficacy of lycopene and soy isoflavones in prostate cancer as well as the mechanism of potential negative interaction between them... - Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell lineDavid A Davis
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
BMC Cancer 6:22. 2006.... - In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancerSanjeev Banerjee
Department of Pathology, Barbara Ann Karmanos Cancer Institute, 4160 John R Street, Detroit, MI 48201, USA
Cancer Res 67:3818-26. 2007..Most importantly, the antitumor activity was associated with the down-regulation of molecular markers in tumor tissues that were similar to those observed in vitro... - Soy isoflavones in the treatment of prostate cancerMaha Hussain
Division of Hematology and Oncology, Wayne State University, Detroit, MI 48201, USA
Nutr Cancer 47:111-7. 2003..00002) and from 0.11 to 0.51 microM (P = 0.00001), respectively. No significant changes were observed in serum levels of testosterone, IGF-1, IGFBP-3, or 5-OHmdU. These data suggest that soy isoflavones may benefit some patients with Pca... - Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancerShadan Ali
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
Mol Cancer Ther 7:1708-19. 2008..These results suggest that the utilization of B-DIM could be a useful strategy for achieving better treatment outcome in patients with activated status of EGFR and NF-kappaB in their tumors... - Concurrent inhibition of NF-kappaB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancerShadan Ali
Division of Hematology Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
J Cell Biochem 110:171-81. 2010..Based on our preclinical in vitro and in vivo results, we conclude that this multi-targeted combination could be developed for the treatment of PC patients whose tumors express high levels of COX-2, EGFR, and NF-kappaB... - Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signalingZhiwei Wang
Department of Pathology, Karmanos Cancer Institute, Wayne State University, 9374 Scott Hall, 540 East Canfield, Detroit, MI 48201, USA
Cancer Res 67:11377-85. 2007..e., MMP-9 and VEGF), resulting in the inhibition of invasion and angiogenesis... - Molecular mechanism(s) of actinomycin-D induced sensitization of pancreatic cancer cells to CD95 mediated apoptosisAlexey L Glazyrin
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Int J Oncol 20:201-5. 2002..Thus, our results indicate that modulation of NF-kappaB activity rather then Akt may provide a useful tool to sensitize pancreatic cancer cells to CD95 mediated apoptosis... - miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cellsDejuan Kong
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Stem Cells 27:1712-21. 2009.... - Suppression of human prostate cancer cell growth by ciprofloxacin is associated with cell cycle arrest and apoptosisOlivia Aranha
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
Int J Oncol 22:787-94. 2003..Based on our in vitro results, further in-depth in vivo animal or human investigations are warranted... - Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathwayZhiwei Wang
Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA
Cancer Res 69:2400-7. 2009.... - Neoadjuvant docetaxel and estramustine chemotherapy in high-risk/locallyadvanced prostate cancerMaha Hussain
Division of Hematology/Oncology, Wayne State University and Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA
Urology 61:774-80. 2003..This combination is active; however, its efficacy relative to hormonal therapy will require a controlled randomized trial... - Update in systemic therapy of prostate cancer: improvement in quality and duration of lifeUlka Vaishampayan
4 HWCRC, 4100 John R Road, Detroit, MI 48201, USA
Expert Rev Anticancer Ther 8:269-81. 2008..This review attempts to summarize the risk profiling strategy in prostate cancer and the existing therapies in high-risk prostate cancer, including some of the novel agents under investigation... - Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/MMP-9 signaling in prostate cancerYiwei Li
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 66:4816-25. 2006..From these results, we conclude that genistein could be a promising nontoxic agent to improve the treatment outcome of metastatic prostate cancer with docetaxel... - TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and invasion in pancreatic cancerZhiwei Wang
Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
Int J Cancer 123:958-66. 2008..We also suggest that TW-37 could be further developed as a potential therapeutic agent for the treatment of pancreatic cancer... - Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathwayYiwei Li
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Clin Cancer Res 8:2369-77. 2002.... - Ciprofloxacin inhibits cell growth and synergises the effect of etoposide in hormone resistant prostate cancer cellsBasil F El-Rayes
Department of Hematology/Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Int J Oncol 21:207-11. 2002.... - Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cellsK M Wahidur Rahman
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Nutr Cancer 45:101-12. 2003..From these results, we conclude that I3C selectively induces apoptosis in breast cancer cells, but not in nontumorigenic breast epithelial cells, suggesting the potential therapeutic benefit of I3C against breast cancer... - Reactivation of p53 by novel MDM2 inhibitors: implications for pancreatic cancer therapyAsfar S Azmi
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Curr Cancer Drug Targets 10:319-31. 2010..No tumor inhibition was found in mut-p53 BxPC-3 xenografts. In light of our results, the inhibitors of MDM2 warrant clinical investigation as new agents for PC treatment... - Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDFShadan Ali
Division of Hematology Oncology, Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
Cancer Res 70:3606-17. 2010..These results prompt further interest in CDF as a drug modality to improve treatment outcome of patients diagnosed with PC as a result of its greater bioavailability in pancreatic tissue... - Phase II trial of paclitaxel, carboplatin and gemcitabine in patients with locally advanced carcinoma of the bladderDavid C Smith
Department of Internal Medicine, Division of Hematology Oncology, University of Michigan School of Medicine, University of Michigan, Ann Arbor, Michigan, USA
J Urol 180:2384-8; discussion 2388. 2008..This 2-arm phase II multicenter trial was designed to assess the efficacy and toxicity of neoadjuvant paclitaxel, gemcitabine and carboplatin in patients with invasive bladder cancer... - Gene expression profiling reveals novel targets of estramustine phosphate in prostate cancer cellsXin Hong
Department of Pathology, Wayne State University School of Medicine, 9374 Scott Hall, 540 East Canfield, Detroit, MI 48201, USA
Cancer Lett 209:187-95. 2004..EMP-induced regulation of these genes may be further exploited for devising therapeutic strategies for prostate cancer... - Pathogenesis of colloid (pure mucinous) carcinoma of exocrine organs: Coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of colloN Volkan Adsay
Department of Pathology, Karamanos Cancer Institute and Wayne State University, Detroit, Michigan 48201, USA
Am J Surg Pathol 27:571-8. 2003..This distinctive mucin, accumulated in the stroma surrounding the CC cells, may act as a containing factor, slackening the spread of the cells... - A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancerElisabeth I Heath
Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
Clin Cancer Res 14:7940-6. 2008..A two-stage phase II study was conducted to assess the activity and toxicity profile of 17-AAG administered to patients with metastatic, hormone-refractory prostate cancer... - Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cellsArchana Thakur
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
Clin Cancer Res 14:4427-36. 2008..In this study, we further investigated whether RSK4 inhibits or promotes breast tumor growth and progression... - Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cellsDejuan Kong
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
PLoS ONE 5:e12445. 2010..Increasing evidence suggests that EMT-type cells share many biological characteristics with cancer stem-like cells... - Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cellsLijie Gong
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
Oncogene 22:4702-9. 2003.... - Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cellsSreenivasa R Chinni
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Clin Cancer Res 8:1228-36. 2002..However, further in-depth investigation is needed to establish a cause-and-effect relationship between Akt pathway and I3C effect... - ErbB-inhibitory protein: a modified ectodomain of epidermal growth factor receptor synergizes with dasatinib to inhibit growth of breast cancer cellsJyoti Nautiyal
Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
Mol Cancer Ther 9:1503-14. 2010..The latter could be attributed to induction of apoptosis. We conclude that combining dasatinib and EBIP could be an effective therapeutic strategy for breast cancer by targeting EGFRs and Src signaling... - In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancerSanjeev Banerjee
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Int J Cancer 120:906-17. 2007.... - Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cellsSanjeev Banerjee
Division of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Pancreas 39:323-31. 2010..The present study was designed to test our hypothesis whether inactivation of Bcl-2 family of proteins using ApoG2 could sensitize pancreatic cancer cells to the cytotoxic effect of gemcitabine... - Cisplatin-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenograftsRamzi M Mohammad
Division of Hematology and Oncology, Department of Internal Medicine, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Cancer 106:1260-8. 2006.... - Down-regulation of invasion and angiogenesis-related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genisteinYiwei Li
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Cancer Lett 186:157-64. 2002..Thus, genistein-induced alternations of gene expressions may be exploited for devising chemopreventive or therapeutic strategies, particularly for chemosensitization of metastatic prostate cancer to existing chemotherapeutic agents... - Loss of heterozygosity and microsatellite instability at the Xq28 and the A/G heterozygosity of the QM gene are associated with ovarian cancerXing jun Shen
Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan 48201, USA
Cancer Biol Ther 5:523-8. 2006..6% vs 21.7%, p < 0.01). These results suggest that high frequencies of LOH and MSI at the Xq28 and of the A/G heterozygosity at the 605th nt of the QM gene may be associated with ovarian cancer... - Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cellsYiwei Li
Department of Pathology and Internal Medicine, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 65:6934-42. 2005..Theses results warrant carefully designed clinical studies investigating the combination of soy isoflavones and commonly used chemotherapeutic agents for the treatment of human cancers... - Phase II trial of estramustine and etoposide in androgen-sensitive metastatic prostate carcinomaUlka Vaishampayan
Division of Hematology/Oncology, Barbara Ann Karmanos Cancer Institute and Wayne State University, Detroit, Michiga, USA
Am J Clin Oncol 27:550-4. 2004..Median survival has not yet been reached. CONCLUSION: The combination of estramustine and etoposide is well tolerated, and has promising activity in newly diagnosed metastatic prostate cancer... - Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): trial results and interleukin-6 analysis: a study by the Department of Defense Prostate Cancer Clinical Trial Consortium and UniversiDeborah Bradley
Department of Medicine and Urology, University of Michigan, Ann Arbor, Michigan, USA
Cancer 115:5541-9. 2009..This phase 2 trial was designed to evaluate the efficacy of vorinostat in chemotherapy-pretreated patients with metastatic castration-resistant prostate cancer... - DeltaNp63 expression in pancreas and pancreatic neoplasiaOlca Basturk
Department of Pathology, Harper University Hospital, Karmanos Cancer Institute and Wayne State University, Detroit, MI 48201, USA
Mod Pathol 18:1193-8. 2005..IV) No p63-expressing 'stem' cells are present in the pancreas... - Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cellsDejuan Kong
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Cancer Res 68:1927-34. 2008..Our results suggest that B-DIM could serve as a novel and efficient chemopreventive and/or therapeutic agent by inactivation of both mTOR and Akt activity in PDGF-D-overexpressing prostate cancer... - Daidzein effect on hormone refractory prostate cancer in vitro and in vivo compared to genistein and soy extract: potentiation of radiotherapyVinita Singh-Gupta
Department of Radiation Oncology, Wayne State University School of Medicine, 515 Hudson Webber Cancer Research Center, 4100 John R Road, Detroit, Michigan 48201, USA
Pharm Res 27:1115-27. 2010..A mixture of soy isoflavones (genistein, daidzein, glycitein) did not cause increased metastasis, but potentiated radiotherapy. We tested whether daidzein could negate genistein-induced metastasis... - Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cellsYiwei Li
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 69:6704-12. 2009.... - TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathwayZhiwei Wang
Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
Cancer Res 69:2757-65. 2009..Our data suggest that the observed antitumor activity of TW-37 is mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1... - Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancerSanjeev Banerjee
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 65:9064-72. 2005.... - Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cellsZhiwei Wang
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer 106:2503-13. 2006..These results suggest that the down-regulation of Notch signaling by curcumin may be a novel strategy for the treatment of patients with pancreatic cancer... - miR-146a suppresses invasion of pancreatic cancer cellsYiwei Li
Departments of Pathology and Internal Medicine, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 70:1486-95. 2010..Our findings reveal DIM and isoflavone as nontoxic activators of a miRNA that can block pancreatic cancer cell invasion and metastasis, offering starting points to design novel anticancer agents... - Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosisAsfar Sohail Azmi
Department of Pathology, Division of Hematology Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, 732 HWCRC, 4100 John R Street, Detroit, MI 48201, USA
Mol Cancer Ther 7:2884-93. 2008..To our knowledge, this is the first study reporting SMI-mediated apoptosis involving PAR-4 in pancreatic cancer... - Sensitization of squamous cell carcinoma to cisplatin induced killing by natural agentsShadan Ali
Division of Hematology Oncology, Karmanos Cancer Center, Wayne State University, Detroit, MI, USA
Cancer Lett 278:201-9. 2009.... - Gene expression profiling revealed novel mechanism of action of Taxotere and Furtulon in prostate cancer cellsYiwei Li
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
BMC Cancer 5:7. 2005..However, the molecular mechanisms of action of Taxotere and Capecitabine have not been fully elucidated in prostate cancer... - Absolute prostate-specific antigen value after androgen deprivation is a strong independent predictor of survival in new metastatic prostate cancer: data from Southwest Oncology Group Trial 9346 (INT-0162)Maha Hussain
University of Michigan, Ann Arbor, MI, USA
J Clin Oncol 24:3984-90. 2006..2 ng/mL or less. CONCLUSION: A PSA of 4 ng/mL or less after 7 months of AD is a strong predictor of survival. This data should be used to tailor future trial design for D2 prostate cancer... - Critical need for clinical trials: an example of a pilot human intervention trial of a mixture of natural agents protecting lymphocytes against TNF-alpha induced activation of NF-kappaBKristin Dominiak
Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
Pharm Res 27:1061-5. 2010.... - Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancerSanjeev Banerjee
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
Cancer Res 69:5575-83. 2009.... - Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cellsDejuan Kong
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Stem Cells 26:1425-35. 2008..Disclosure of potential conflicts of interest is found at the end of this article... - Synergistic effects of multiple natural products in pancreatic cancer cellsZhiwei Wang
Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States
Life Sci 83:293-300. 2008..The superior effects of the combinatorial treatment could partly be attributed to the inhibition of constitutive activation of Notch-1 and NF-kappaB signaling pathways... - Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cellsAamir Ahmad
Department of Pathology, Barbara Ann Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
J Cell Biochem 108:916-25. 2009.... - Down-regulation of Forkhead Box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cellsZhiwei Wang
Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
Cancer Res 67:8293-300. 2007..These findings suggest that FoxM1 down-regulation could be a novel approach for the inhibition of pancreatic tumor progression... - Regulation of microtubule, apoptosis, and cell cycle-related genes by taxotere in prostate cancer cells analyzed by microarrayYiwei Li
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Neoplasia 6:158-67. 2004..Nevertheless, our results could be further exploited for devising strategies to optimize therapeutic effects of Taxotere for the treatment of prostate cancer... - Epidermal growth factor receptor (EGFR)-related protein inhibits multiple members of the EGFR family in colon and breast cancer cellsHu Xu
John D Dingell Veterans Affairs Medical Center, 4646 John R, Room B 4238, Detroit, MI 48201, USA
Mol Cancer Ther 4:435-42. 2005..Our results suggest that ERRP is an effective pan-erbB inhibitor and, thus, may be a potential therapeutic agent for a wide variety of epithelial cancers expressing different levels and subclasses of EGFRs... - Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cellsZhiwei Wang
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 9374 Scott Hall, 540 East Canfield, Detroit, MI 48201, USA
Mol Cancer Ther 5:483-93. 2006..These findings suggest that Notch-1 down-regulation, especially by genistein, could be a novel therapeutic approach for the treatment of pancreatic cancer... - Mechanisms of curcumin- and EGF-receptor related protein (ERRP)-dependent growth inhibition of colon cancer cellsSudha Reddy
Veterans Affairs Medical Center, Karmanos Cancer Institute, Department of Internal Medicine, Michigan 48201, USA
Nutr Cancer 55:185-94. 2006..The superior effects of the combinatorial treatment could partly be attributed to inhibition of constitutive activation of EGFRs and IGF-1R signaling pathways... - Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cellsMohammad M R Bhuiyan
Departments of Pathology and Internal Medicine, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 66:10064-72. 2006.... - A novel copper complex of 3-benzoyl-alpha methyl benzene acetic acid with antitumor activity mediated via cyclooxygenase pathwayFakhara Ahmed
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Int J Cancer 120:734-42. 2007..These results suggest that FPA-306 is an effective and potent agent in inhibiting the growth of PC cells... - Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancerDejuan Kong
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
Cancer Res 67:3310-9. 2007.... - Gene expression profiles of genistein-treated PC3 prostate cancer cellsYiwei Li
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
J Nutr 132:3623-31. 2002..Genistein-induced regulation of these genes may be further exploited for devising chemopreventive and/or therapeutic strategies for prostate cancer... - Combination of 5-deoxy-5-fluorouridine and tamoxifen show cell-type specific antagonistic and cooperative effects on cytotoxicity in human mammary carcinoma cellsAliccia Bollig
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Oncol Rep 14:177-83. 2005..This has clinical relevance in that it suggests that patients undergoing chemo-endocrine therapy with orally administered 5-FU precursor drugs may benefit from lower treatment dosages relative to other adjuvant therapies... - Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysisYiwei Li
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Nutr 133:1011-9. 2003.... - Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cellsZhiwei Wang
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 66:2778-84. 2006....
Research Grants
- Molecular Mechanism of Genistein (Isoflavone) in Prostate CancerFazlul Sarkar; Fiscal Year: 2007....
- FoxM1: A molecular target in pancreatic cancerFazlul H Sarkar; Fiscal Year: 2010..We will test our hypothesis by three specific aims using molecular approaches in vitro and by using animal models in vivo (both orthotopic mouse model and transgenic mouse models of PC). ..
- Novel Targets of Indoles in Prostate CancerFazlul H Sarkar; Fiscal Year: 2010..The results of our study will help to design mechanism-based clinical trials for assessing the role of B-DIM in the prevention and/or treatment of PCa. ..
- RO1: A novel and targeted approach to inhibit invasion and angiogenesisFazlul H Sarkar; Fiscal Year: 2010..We will test our hypothesis by three specific aims using molecular approaches and animal model studies. ..
- Molecular Mechanism of Genistein (Isoflavone) in Prostate CancerFazlul H Sarkar; Fiscal Year: 2010....
- Novel Targets of Indoles in Prostate CancerFazlul Sarkar; Fiscal Year: 2007..abstract_text> ..
- Targeting Akt/NF-kappa beta for Pancreatic Cancer TherapyFazlul Sarkar; Fiscal Year: 2007..These results will provide mechanistic as well as pre-clinical data in support of our hypotheses and may open new and novel avenues for the treatment of human pancreatic cancer. ..
- Molecular Mechanism of Genistein in Prostate CancerFazlul Sarkar; Fiscal Year: 2004..In addition, we also propose to test the anti-tumor activity of genistein in prostate cancer animal models and investigate whether the molecular alterations in animal tumors are similar to those observed in vitro. ..
- RO1: A novel and targeted approach to inhibit invasion and angiogenesisFazlul Sarkar; Fiscal Year: 2009..We will test our hypothesis by three specific aims using molecular approaches and animal model studies. ..