G G Hillman

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi Soy isoflavones enhance radiotherapy in a metastatic prostate cancer model
    Julian J Raffoul
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Cancer 120:2491-8. 2007
  2. ncbi Soy isoflavones radiosensitize lung cancer while mitigating normal tissue injury
    Gilda G Hillman
    Department of Radiation Oncology, Wayne State University School of Medicine, 4100 John R Road, Detroit, MI 48201, USA
    Radiother Oncol 101:329-36. 2011
  3. ncbi Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest
    Julian J Raffoul
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    BMC Cancer 6:107. 2006
  4. ncbi Genistein potentiates the radiation effect on prostate carcinoma cells
    G G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, and Harper Hospital, Detroit, Michigan 48201, USA
    Clin Cancer Res 7:382-90. 2001
  5. ncbi Soy isoflavones sensitize cancer cells to radiotherapy
    Gilda G Hillman
    Barbara Ann Karmanos Cancer Institute, Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Free Radic Biol Med 51:289-98. 2011
  6. ncbi Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neoplasia 11:910-20. 2009
  7. ncbi Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    BMC Cancer 7:4. 2007
  8. ncbi Tumor irradiation followed by intratumoral cytokine gene therapy for murine renal adenocarcinoma
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper Hospital, Detroit, Michigan 48201, USA
    Cancer Gene Ther 11:61-72. 2004
  9. ncbi Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper University Hospital, Detroit, MI 48201, USA
    Mol Cancer Ther 3:1271-9. 2004
  10. ncbi Neutron or photon irradiation for prostate tumors: enhancement of cytokine therapy in a metastatic tumor model
    G G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine Detroit, Michigan 48201, USA
    Clin Cancer Res 7:136-44. 2001

Detail Information

Publications25

  1. ncbi Soy isoflavones enhance radiotherapy in a metastatic prostate cancer model
    Julian J Raffoul
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Cancer 120:2491-8. 2007
    ..Our studies demonstrate the safety and potential role of soy isoflavones for enhancing the therapeutic effect of radiotherapy in prostate cancer...
  2. ncbi Soy isoflavones radiosensitize lung cancer while mitigating normal tissue injury
    Gilda G Hillman
    Department of Radiation Oncology, Wayne State University School of Medicine, 4100 John R Road, Detroit, MI 48201, USA
    Radiother Oncol 101:329-36. 2011
    ..We have now investigated the combination of soy with RT in lung cancer (NSCLC), for which RT is limited by radiation-induced pneumonitis...
  3. ncbi Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest
    Julian J Raffoul
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    BMC Cancer 6:107. 2006
    ..In this study, we investigated the cellular and molecular interaction between genistein and radiation using PC-3 human prostate cancer cells...
  4. ncbi Genistein potentiates the radiation effect on prostate carcinoma cells
    G G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, and Harper Hospital, Detroit, Michigan 48201, USA
    Clin Cancer Res 7:382-90. 2001
    ..These studies suggest a potential of combining genistein with radiation for the treatment of localized prostate carcinoma...
  5. ncbi Soy isoflavones sensitize cancer cells to radiotherapy
    Gilda G Hillman
    Barbara Ann Karmanos Cancer Institute, Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Free Radic Biol Med 51:289-98. 2011
    ..These observations open new avenues for exploiting soy isoflavones as supplements to conventional therapies...
  6. ncbi Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neoplasia 11:910-20. 2009
    ..These studies emphasize the clinical potential of DCE-MRI in selecting the dose and schedule of antiangiogenic compounds...
  7. ncbi Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    BMC Cancer 7:4. 2007
    ....
  8. ncbi Tumor irradiation followed by intratumoral cytokine gene therapy for murine renal adenocarcinoma
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper Hospital, Detroit, Michigan 48201, USA
    Cancer Gene Ther 11:61-72. 2004
    ..These findings demonstrate that tumor irradiation improves the efficacy of Ad-IL-2 gene therapy for induction of antitumor immune response...
  9. ncbi Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper University Hospital, Detroit, MI 48201, USA
    Mol Cancer Ther 3:1271-9. 2004
    ..We tested this approach in vivo using an orthotopic prostate carcinoma model of PC-3 cells in nude mice...
  10. ncbi Neutron or photon irradiation for prostate tumors: enhancement of cytokine therapy in a metastatic tumor model
    G G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine Detroit, Michigan 48201, USA
    Clin Cancer Res 7:136-44. 2001
    ..This combined modality induced an antitumor response that controlled the growth of prostate tumors and their metastases...
  11. ncbi Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer
    O Greco
    Department of Radiation Oncology, Wayne State University and Karmanos Cancer Institute, Hudson Webber CRC, Detroit, MI, USA
    Gene Ther 13:206-15. 2006
    ..In conclusion, hypoxia- and radiation-activated 'molecular switch' vectors represent a promising strategy for both targeted and effective gene therapy of solid tumors...
  12. ncbi Curative antitumor immune response is optimal with tumor irradiation followed by genetic induction of major histocompatibility complex class I and class II molecules and suppression of Ii protein
    Yu Wang
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine and Harper Hospital, Detroit, MI 48201, USA
    Hum Gene Ther 16:187-99. 2005
    ..The radiation contributes to the gene therapy by causing tumor debulking and increasing the permeability of tumors to infiltration of inflammatory cells...
  13. ncbi Generating MHC Class II+/Ii- phenotype after adenoviral delivery of both an expressible gene for MHC Class II inducer and an antisense Ii-RNA construct in tumor cells
    G G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine, Detroit, MI, USA
    Gene Ther 10:1512-8. 2003
    ..The methods are adaptable for producing enhanced genetic vaccines, attenuated virus vaccines (eg, vaccinia), and ex vivo cell-based vaccines (dendritic and tumor cells)...
  14. ncbi Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo
    Julian J Raffoul
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Res 67:2141-9. 2007
    ....
  15. ncbi Radiation improves intratumoral gene therapy for induction of cancer vaccine in murine prostate carcinoma
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine and Harper Hospital, Detroit, MI 48201, USA
    Hum Gene Ther 14:763-75. 2003
    ..Administering radiation before this novel gene therapy approach, that creates an in situ tumor vaccine, holds promise for the treatment of human prostate carcinoma...
  16. ncbi Daidzein effect on hormone refractory prostate cancer in vitro and in vivo compared to genistein and soy extract: potentiation of radiotherapy
    Vinita Singh-Gupta
    Department of Radiation Oncology, Wayne State University School of Medicine, 515 Hudson Webber Cancer Research Center, 4100 John R Road, Detroit, Michigan 48201, USA
    Pharm Res 27:1115-27. 2010
    ..A mixture of soy isoflavones (genistein, daidzein, glycitein) did not cause increased metastasis, but potentiated radiotherapy. We tested whether daidzein could negate genistein-induced metastasis...
  17. ncbi Prostate cancer treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model
    Yu Wang
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA
    Radiat Res 166:73-80. 2006
    ....
  18. ncbi Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase
    Daotai Nie
    Department of Radiation Oncology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan 48202, USA
    Clin Exp Metastasis 20:657-63. 2003
    ..Taken together, our data suggest that an increase in 12-LOX expression enhances the metastatic potential of human prostate cancer cells...
  19. ncbi Responsiveness of experimental prostate carcinoma bone tumors to neutron or photon radiation combined with cytokine therapy
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine and Harper Hospital, Detroit, MI 48201, USA
    Int J Radiat Oncol Biol Phys 56:1426-37. 2003
    ..To improve the outcome of radiotherapy for prostate carcinoma bone tumors, we investigated bone tumor irradiation with photons or neutrons followed by interleukin 2 (IL-2) therapy in a tumor model...
  20. ncbi Turning tumor cells in situ into T-helper cell-stimulating, MHC class II tumor epitope-presenters: immuno-curing and immuno-consolidation
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine, 4100 John R, Detroit, MI 48201, USA
    Cancer Treat Rev 30:281-90. 2004
    ..We review our findings, and analyze remaining issues for preclinical study and the design of clinical trials...
  21. ncbi Radiation-induced HIF-1alpha cell survival pathway is inhibited by soy isoflavones in prostate cancer cells
    Vinita Singh-Gupta
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI
    Int J Cancer 124:1675-84. 2009
    ....
  22. ncbi Radiosensitization of prostate cancer by soy isoflavones
    Julian J Raffoul
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Cancer Drug Targets 7:759-65. 2007
    ..We will discuss molecular pathways regulated by soy isoflavones that inhibit survival pathways activated by radiation and ultimately drive the cells to cell death both in vitro and in vivo in pre-clinical models...
  23. ncbi Tumor immunotherapy by converting tumor cells to MHC class II-positive, Ii protein-negative phenotype
    Xueqing Lu
    Antigen Express, 100 Barber Avenue, Worcester, MA 01606, USA
    Cancer Immunol Immunother 52:592-8. 2003
    ..Our method provides an effective immunotherapy warranting further development for human cancers...
  24. ncbi Forcing tumor cells to present their own tumor antigens to the immune system: a necessary design for an efficient tumor immunotherapy
    Robert E Humphreys
    Antigen Express, Inc, Worcester, MA 01606, USA
    Cell Mol Immunol 1:180-5. 2004
    ..MHC class II+/Ii- tumor cells are potent tumor cell vaccines and also cure a significant number of animals with renal and prostate tumors. We have developed analogous human gene vectors that are suitable for most patients and cancers...
  25. ncbi Immunotherapy of cancer by antisense inhibition of Ii protein, an immunoregulator of antigen selection by MHC class II molecules
    Minzhen Xu
    Antigen Express Inc, 100 Barber Avenue, Worcester, MA 01606, USA
    Curr Opin Mol Ther 6:160-5. 2004
    ..The systemic antitumor immune response generated subsequently eradicates both directly treated cells and distant tumor deposits. The drugs and mechanisms of this therapy are considered, in addition to practical developmental questions...