Henry H Q Heng

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Analysis of marker or complex chromosomal rearrangements present in pre- and post-natal karyotypes utilizing a combination of G-banding, spectral karyotyping and fluorescence in situ hybridization
    H H Q Heng
    Center for Molecular Medicine and Genetics, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Clin Genet 63:358-67. 2003
  2. ncbi request reprint Chromatin loops are selectively anchored using scaffold/matrix-attachment regions
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48202, USA
    J Cell Sci 117:999-1008. 2004
  3. doi request reprint Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Physiol 220:538-47. 2009
  4. pmc Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer
    Christine J Ye
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Physiol 219:288-300. 2009
  5. doi request reprint The evolutionary mechanism of cancer
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201
    J Cell Biochem 109:1072-84. 2010
  6. ncbi request reprint Stochastic cancer progression driven by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Cell Physiol 208:461-72. 2006
  7. ncbi request reprint Mitotic cell death by chromosome fragmentation
    Joshua B Stevens
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 67:7686-94. 2007
  8. doi request reprint Why imatinib remains an exception of cancer research
    Steven D Horne
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Cell Physiol 228:665-70. 2013
  9. doi request reprint Decoding the genome beyond sequencing: the new phase of genomic research
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Genomics 98:242-52. 2011
  10. ncbi request reprint Cancer progression by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Biochem 98:1424-35. 2006

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Analysis of marker or complex chromosomal rearrangements present in pre- and post-natal karyotypes utilizing a combination of G-banding, spectral karyotyping and fluorescence in situ hybridization
    H H Q Heng
    Center for Molecular Medicine and Genetics, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Clin Genet 63:358-67. 2003
    ..Our results confirm that an algorithm which selectively uses SKY or M-FISH will provide an efficient and improved method for pre- and post-natal chromosomal analysis...
  2. ncbi request reprint Chromatin loops are selectively anchored using scaffold/matrix-attachment regions
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48202, USA
    J Cell Sci 117:999-1008. 2004
    ..Consequently, S/MAR anchors were necessary but not sufficient for chromatin loops to form. These observations reconcile many seemingly contradictory attributes previously associated with S/MARs...
  3. doi request reprint Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Physiol 220:538-47. 2009
    ..Compared to the degree of heterogeneity, individual molecular pathways will have limited predictability during stochastic cancer evolution where genome dynamics (reflected by karyotypic heterogeneity) will dominate...
  4. pmc Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer
    Christine J Ye
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Physiol 219:288-300. 2009
    ..This study reconciles the difference between evolutionary and molecular mechanisms of cancer and suggests that NCCAs can serve as a biomarker to monitor the probability of cancer progression...
  5. doi request reprint The evolutionary mechanism of cancer
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201
    J Cell Biochem 109:1072-84. 2010
    ..Recognizing the fundamental importance of the underlying basis of the evolutionary mechanism of cancer mandates the development of new strategies in cancer research...
  6. ncbi request reprint Stochastic cancer progression driven by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Cell Physiol 208:461-72. 2006
    ..The dynamic relationship between NCCAs and CCAs provides a mechanism underlying chromosomal based cancer evolution and could have broad clinical applications...
  7. ncbi request reprint Mitotic cell death by chromosome fragmentation
    Joshua B Stevens
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 67:7686-94. 2007
    ..Paradoxically, this process could result in genome aberrations common in cancer. The characterization of chromosome fragmentation may also shine light on the mechanism of chromosomal pulverization...
  8. doi request reprint Why imatinib remains an exception of cancer research
    Steven D Horne
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Cell Physiol 228:665-70. 2013
    ..Changing the focus of cancer research from a gene-based view to a genome-based theory will provide insight into solid tumor evolutionary dynamics...
  9. doi request reprint Decoding the genome beyond sequencing: the new phase of genomic research
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Genomics 98:242-52. 2011
    ..To make this transition for the next phase of genomic research, it is essential to acknowledge the importance of new genome-based biological concepts and to establish new technology platforms to decode the genome beyond sequencing...
  10. ncbi request reprint Cancer progression by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Biochem 98:1424-35. 2006
    ..To further illustrate the involvement of NCCA/CCA cycles in the pattern of cancer evolution, four cancer evolutionary models have been proposed based on the comparative analysis of karyotype patterns of various types of cancer...
  11. doi request reprint Evolutionary mechanisms and diversity in cancer
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, MI, USA
    Adv Cancer Res 112:217-53. 2011
    ..Finally, the potential clinical implications of the evolutionary mechanism of cancer are briefly reviewed...
  12. ncbi request reprint Cancer genome sequencing: the challenges ahead
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Bioessays 29:783-94. 2007
    ..This analysis suggests that cancer is a disease of probability and the most-challenging issue to the TCGA project, as well as the development of general strategies for fighting cancer, lie at the conceptual level...
  13. doi request reprint Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability
    Shanmuganathan Chandrakasan
    Division of Pediatric Hematology Oncology, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan
    Pediatr Blood Cancer 56:1143-5. 2011
    ..In addition, PHA-stimulated peripheral blood lymphocytes showed increased frequency of non-clonal chromosomal aberrations. The potential role of genomic instability in early onset of SM in our patient is discussed...
  14. doi request reprint The conflict between complex systems and reductionism
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 3226 Scott Hall, 540 E Canfield, Detroit, MI 48201, USA
    JAMA 300:1580-1. 2008
  15. pmc Sequential molecular and cellular events during neoplastic progression: a mouse syngeneic ovarian cancer model
    Paul C Roberts
    Department of Immunology Microbiology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Neoplasia 7:944-56. 2005
    ....
  16. doi request reprint The genome-centric concept: resynthesis of evolutionary theory
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Bioessays 31:512-25. 2009
    ....
  17. ncbi request reprint Clonal and non-clonal chromosome aberrations and genome variation and aberration
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Genome 49:195-204. 2006
    ..This study raises challenging questions regarding the concept of cancer evolution driven by stochastic chromosomal aberration mediated genome irregularities that could have repercussions reaching far beyond cancer and organismal genomes...
  18. doi request reprint High-resolution FISH analysis
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Curr Protoc Hum Genet . 2005
    ..The Basic Protocol 2, high-resolution FISH mapping with free chromatin, is a modification of the method used for FISH mapping of interphase nuclei...
  19. ncbi request reprint A mathematical model relating chromosome aberrations to cancer progression
    Julia DiPierdomenico
    Coll of Electr and Comput Eng, Wayne State Univ, Detroit, MI 48202, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2028-31. 2006
    ..Lastly, this novel approach to quantifying and predicting the dynamics of cancer in an in vitro model may be extended to other forms of malignancies...
  20. ncbi request reprint Elimination of altered karyotypes by sexual reproduction preserves species identity
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Karmanos Cancer Institute, Department of Pathology, 3226 Scott Hall, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Genome 50:517-24. 2007
    ..Genetic recombination does contribute to genetic diversity, but it does so secondarily and within the framework of the chromosomally defined genome...
  21. ncbi request reprint The dynamics of cancer chromosomes and genomes
    C J Ye
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA
    Cytogenet Genome Res 118:237-46. 2007
    ..This genome centric concept will have a profound impact on the future of biological and medical research...
  22. pmc Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma
    Tamotsu Takeuchi
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Am J Pathol 163:1395-404. 2003
    ..The present findings suggest that skeletrophin may be a novel actin-binding cytoskeleton-related molecule, expression of which is silenced in a considerable number of melanoma specimens...
  23. pmc Recent segmental and gene duplications in the mouse genome
    Joseph Cheung
    Program in Genetics and Genomic Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Genome Biol 4:R47. 2003
    ..Here we present a database of recently duplicated regions of the mouse genome found in the mouse genome sequencing consortium (MGSC) February 2002 and February 2003 assemblies...
  24. pmc Human chromosome 7: DNA sequence and biology
    Stephen W Scherer
    Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    Science 300:767-72. 2003
    ..This approach enabled the discovery of candidate genes for developmental diseases including autism...
  25. pmc Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus
    Anna Derjuga
    Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada H3T 1E2
    Mol Cell Biol 24:3286-94. 2004
    ..We hypothesize that the role of Nrf3 in vivo may become apparent only after appropriate challenge to the mice...
  26. ncbi request reprint Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3
    Shuo Dong
    Department of Biochemistry, University of Hong Kong, 5 Sassoon Road, Hong Kong SAR, China
    Genomics 79:777-84. 2002
    ..Ysb and Lcc show for the first time, to our knowledge, the presence of genes in the B-C region of chromosome 3 important for balance and hearing and the pigmentation and specification of coat hair...