Henry H Heng

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Cancer progression by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Biochem 98:1424-35. 2006
  2. pmc Reviewer acknowledgement 2013
    Thomas Liehr
    Jena University Hospital, Institute of Human Genetics, Jena, Germany
    Mol Cytogenet 6:9. 2013
  3. doi request reprint Karyotype heterogeneity and unclassified chromosomal abnormalities
    H H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    Cytogenet Genome Res 139:144-57. 2013
  4. ncbi request reprint Cancer genome sequencing: the challenges ahead
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Bioessays 29:783-94. 2007
  5. ncbi request reprint Elimination of altered karyotypes by sexual reproduction preserves species identity
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Karmanos Cancer Institute, Department of Pathology, 3226 Scott Hall, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Genome 50:517-24. 2007
  6. ncbi request reprint Stochastic cancer progression driven by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Cell Physiol 208:461-72. 2006
  7. ncbi request reprint Clonal and non-clonal chromosome aberrations and genome variation and aberration
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Genome 49:195-204. 2006
  8. doi request reprint The conflict between complex systems and reductionism
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 3226 Scott Hall, 540 E Canfield, Detroit, MI 48201, USA
    JAMA 300:1580-1. 2008
  9. ncbi request reprint Genetic and epigenetic heterogeneity in cancer: the ultimate challenge for drug therapy
    H H Heng
    The Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Drug Targets 11:1304-16. 2010
  10. pmc Comparison of mitotic cell death by chromosome fragmentation to premature chromosome condensation
    Joshua B Stevens
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, USA
    Mol Cytogenet 3:20. 2010

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Cancer progression by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Biochem 98:1424-35. 2006
    ..To further illustrate the involvement of NCCA/CCA cycles in the pattern of cancer evolution, four cancer evolutionary models have been proposed based on the comparative analysis of karyotype patterns of various types of cancer...
  2. pmc Reviewer acknowledgement 2013
    Thomas Liehr
    Jena University Hospital, Institute of Human Genetics, Jena, Germany
    Mol Cytogenet 6:9. 2013
    ..CONTRIBUTING REVIEWERS: The editors of Molecular Cytogenetics would like to thank all our reviewers who have contributed to the journal in volume 5 (2012)...
  3. doi request reprint Karyotype heterogeneity and unclassified chromosomal abnormalities
    H H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    Cytogenet Genome Res 139:144-57. 2013
    ..Finally, we call for the systematic discovery/characterization and classification of karyotype abnormalities in human diseases, as karyotype heterogeneity is the common factor that is essential for somatic cell evolution...
  4. ncbi request reprint Cancer genome sequencing: the challenges ahead
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Bioessays 29:783-94. 2007
    ..This analysis suggests that cancer is a disease of probability and the most-challenging issue to the TCGA project, as well as the development of general strategies for fighting cancer, lie at the conceptual level...
  5. ncbi request reprint Elimination of altered karyotypes by sexual reproduction preserves species identity
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Karmanos Cancer Institute, Department of Pathology, 3226 Scott Hall, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Genome 50:517-24. 2007
    ..Genetic recombination does contribute to genetic diversity, but it does so secondarily and within the framework of the chromosomally defined genome...
  6. ncbi request reprint Stochastic cancer progression driven by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Cell Physiol 208:461-72. 2006
    ..The dynamic relationship between NCCAs and CCAs provides a mechanism underlying chromosomal based cancer evolution and could have broad clinical applications...
  7. ncbi request reprint Clonal and non-clonal chromosome aberrations and genome variation and aberration
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Genome 49:195-204. 2006
    ..This study raises challenging questions regarding the concept of cancer evolution driven by stochastic chromosomal aberration mediated genome irregularities that could have repercussions reaching far beyond cancer and organismal genomes...
  8. doi request reprint The conflict between complex systems and reductionism
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 3226 Scott Hall, 540 E Canfield, Detroit, MI 48201, USA
    JAMA 300:1580-1. 2008
  9. ncbi request reprint Genetic and epigenetic heterogeneity in cancer: the ultimate challenge for drug therapy
    H H Heng
    The Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Drug Targets 11:1304-16. 2010
    ..By briefly mentioning some newly introduced treatment options, this review further discusses the common challenges for the field as well as possible future directions of research...
  10. pmc Comparison of mitotic cell death by chromosome fragmentation to premature chromosome condensation
    Joshua B Stevens
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, USA
    Mol Cytogenet 3:20. 2010
    ..Finally, biological aspects of chromosome fragmentation are discussed, including its application as one form of non-clonal chromosome aberration (NCCA), the driving force of cancer evolution...
  11. doi request reprint Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Physiol 220:538-47. 2009
    ..Compared to the degree of heterogeneity, individual molecular pathways will have limited predictability during stochastic cancer evolution where genome dynamics (reflected by karyotypic heterogeneity) will dominate...
  12. pmc Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer
    Christine J Ye
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Physiol 219:288-300. 2009
    ..This study reconciles the difference between evolutionary and molecular mechanisms of cancer and suggests that NCCAs can serve as a biomarker to monitor the probability of cancer progression...
  13. ncbi request reprint Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis
    Li V Yang
    Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA
    Dev Dyn 228:606-16. 2003
    ..Finally, fluorescence in situ hybridization demonstrates that HEMGN is localized to chromosome 4 A5-B2 in mouse and to chromosome 9q22 in human, which is a region known to harbor a cluster of leukemia breakpoints...
  14. ncbi request reprint Chromatin loops are selectively anchored using scaffold/matrix-attachment regions
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48202, USA
    J Cell Sci 117:999-1008. 2004
    ..Consequently, S/MAR anchors were necessary but not sufficient for chromatin loops to form. These observations reconcile many seemingly contradictory attributes previously associated with S/MARs...
  15. pmc Sequential molecular and cellular events during neoplastic progression: a mouse syngeneic ovarian cancer model
    Paul C Roberts
    Department of Immunology Microbiology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Neoplasia 7:944-56. 2005
    ....
  16. ncbi request reprint Mitotic cell death by chromosome fragmentation
    Joshua B Stevens
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 67:7686-94. 2007
    ..Paradoxically, this process could result in genome aberrations common in cancer. The characterization of chromosome fragmentation may also shine light on the mechanism of chromosomal pulverization...
  17. doi request reprint The evolutionary mechanism of cancer
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201
    J Cell Biochem 109:1072-84. 2010
    ..Recognizing the fundamental importance of the underlying basis of the evolutionary mechanism of cancer mandates the development of new strategies in cancer research...
  18. pmc DNA vaccination controls Her-2+ tumors that are refractory to targeted therapies
    Paula J Whittington
    Department of Immunology and Microbiology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 68:7502-11. 2008
    ..These results warrant Her-2 vaccination whether tumor cells are sensitive or resistant to Her-2-targeted drugs or antibody therapy...
  19. ncbi request reprint Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts
    Larry R Tait
    Breast Program of the Barbara Ann Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA
    Int J Cancer 120:2127-34. 2007
    ..Although the phenotype of the epithelial cells may be dependent upon the stroma, the malignant epithelium induces the development of the stroma necessary for progression to the invasive stage. (c) 2007 Wiley-Liss, Inc...
  20. ncbi request reprint A mathematical model relating chromosome aberrations to cancer progression
    Julia DiPierdomenico
    Coll of Electr and Comput Eng, Wayne State Univ, Detroit, MI 48202, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2028-31. 2006
    ..Lastly, this novel approach to quantifying and predicting the dynamics of cancer in an in vitro model may be extended to other forms of malignancies...
  21. doi request reprint The genome-centric concept: resynthesis of evolutionary theory
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Bioessays 31:512-25. 2009
    ....
  22. doi request reprint High-resolution FISH analysis
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Curr Protoc Hum Genet . 2005
    ..The Basic Protocol 2, high-resolution FISH mapping with free chromatin, is a modification of the method used for FISH mapping of interphase nuclei...
  23. pmc Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis
    Lijie Gong
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 550 East Canfield, Detroit, MI 48201, USA
    Endocrinology 149:3346-54. 2008
    ..We conclude that Stat3 in Agrp/Npy neurons is required for normal energy homeostasis, but Stat3 signaling in other brain areas also contributes to the regulation of energy homeostasis...
  24. pmc Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus
    Anna Derjuga
    Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada H3T 1E2
    Mol Cell Biol 24:3286-94. 2004
    ..We hypothesize that the role of Nrf3 in vivo may become apparent only after appropriate challenge to the mice...
  25. pmc Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma
    Tamotsu Takeuchi
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Am J Pathol 163:1395-404. 2003
    ..The present findings suggest that skeletrophin may be a novel actin-binding cytoskeleton-related molecule, expression of which is silenced in a considerable number of melanoma specimens...
  26. pmc Recent segmental and gene duplications in the mouse genome
    Joseph Cheung
    Program in Genetics and Genomic Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Genome Biol 4:R47. 2003
    ..Here we present a database of recently duplicated regions of the mouse genome found in the mouse genome sequencing consortium (MGSC) February 2002 and February 2003 assemblies...
  27. pmc Human chromosome 7: DNA sequence and biology
    Stephen W Scherer
    Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    Science 300:767-72. 2003
    ..This approach enabled the discovery of candidate genes for developmental diseases including autism...
  28. ncbi request reprint Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3
    Shuo Dong
    Department of Biochemistry, University of Hong Kong, 5 Sassoon Road, Hong Kong SAR, China
    Genomics 79:777-84. 2002
    ..Ysb and Lcc show for the first time, to our knowledge, the presence of genes in the B-C region of chromosome 3 important for balance and hearing and the pigmentation and specification of coat hair...