Linda Dondero Hazlett

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. Hazlett L, Wu M. Defensins in innate immunity. Cell Tissue Res. 2011;343:175-88 pubmed publisher
    ..These studies of defensins in the innate immune system have implications for the prevention and treatment of a variety of infectious diseases, including bacterial ocular disease. ..
  2. request reprint
    Hazlett L, McClellan S, Barrett R, Rudner X. B7/CD28 costimulation is critical in susceptibility to Pseudomonas aeruginosa corneal infection: a comparative study using monoclonal antibody blockade and CD28-deficient mice. J Immunol. 2001;166:1292-9 pubmed
    ..These results support a critical role for B7/CD28 costimulation in susceptibility to P. aeruginosa ocular infection. ..
  3. request reprint
    Hazlett L, Rudner X, McClellan S, Barrett R, Lighvani S. Role of IL-12 and IFN-gamma in Pseudomonas aeruginosa corneal infection. Invest Ophthalmol Vis Sci. 2002;43:419-24 pubmed
    ....
  4. request reprint
    Hazlett L, McClellan S, Barrett R, Liu J, Zhang Y, Lighvani S. Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection. Invest Ophthalmol Vis Sci. 2007;48:797-807 pubmed
    ..The SP antagonist Spantide provides a novel approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea of B6 mice, leading to a significant reduction in corneal perforation and improved disease outcome. ..
  5. request reprint
    Hazlett L, Li Q, Liu J, McClellan S, Du W, Barrett R. NKT cells are critical to initiate an inflammatory response after Pseudomonas aeruginosa ocular infection in susceptible mice. J Immunol. 2007;179:1138-46 pubmed
    ....
  6. request reprint
    Huang X, Du W, Barrett R, Hazlett L. ST2 is essential for Th2 responsiveness and resistance to pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci. 2007;48:4626-33 pubmed
    ....
  7. Hazlett L, McClellan S, Barrett R, Huang X, Zhang Y, Wu M, et al. IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci. 2010;51:1524-32 pubmed publisher
    ..These data provide evidence that IL-33 promotes a Th2-type immune response and reduces inflammation by polarizing the Mvarphi production of anti-inflammatory mediators in the cornea. ..
  8. Hazlett L, Hendricks R. Reviews for immune privilege in the year 2010: immune privilege and infection. Ocul Immunol Inflamm. 2010;18:237-43 pubmed publisher
    ..HSK is more frequent and severe in BALB/c than C57BL/6 mice, and varies in severity with the strain and dose of HSV-1 used to infect the cornea...
  9. Peng X, Ekanayaka S, McClellan S, Barrett R, Vistisen K, Hazlett L. Characterization of Three Ocular Clinical Isolates of P. aeruginosa: Viability, Biofilm Formation, Adherence, Infectivity, and Effects of Glycyrrhizin. Pathogens. 2017;6: pubmed publisher
    ..This study provides evidence that GLY is bacteriostatic for G81007. It also affects biofilm production, adherence to cultured cells, and an improved keratitis outcome. ..

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Detail Information

Publications9

  1. Hazlett L, Wu M. Defensins in innate immunity. Cell Tissue Res. 2011;343:175-88 pubmed publisher
    ..These studies of defensins in the innate immune system have implications for the prevention and treatment of a variety of infectious diseases, including bacterial ocular disease. ..
  2. request reprint
    Hazlett L, McClellan S, Barrett R, Rudner X. B7/CD28 costimulation is critical in susceptibility to Pseudomonas aeruginosa corneal infection: a comparative study using monoclonal antibody blockade and CD28-deficient mice. J Immunol. 2001;166:1292-9 pubmed
    ..These results support a critical role for B7/CD28 costimulation in susceptibility to P. aeruginosa ocular infection. ..
  3. request reprint
    Hazlett L, Rudner X, McClellan S, Barrett R, Lighvani S. Role of IL-12 and IFN-gamma in Pseudomonas aeruginosa corneal infection. Invest Ophthalmol Vis Sci. 2002;43:419-24 pubmed
    ....
  4. request reprint
    Hazlett L, McClellan S, Barrett R, Liu J, Zhang Y, Lighvani S. Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection. Invest Ophthalmol Vis Sci. 2007;48:797-807 pubmed
    ..The SP antagonist Spantide provides a novel approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea of B6 mice, leading to a significant reduction in corneal perforation and improved disease outcome. ..
  5. request reprint
    Hazlett L, Li Q, Liu J, McClellan S, Du W, Barrett R. NKT cells are critical to initiate an inflammatory response after Pseudomonas aeruginosa ocular infection in susceptible mice. J Immunol. 2007;179:1138-46 pubmed
    ....
  6. request reprint
    Huang X, Du W, Barrett R, Hazlett L. ST2 is essential for Th2 responsiveness and resistance to pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci. 2007;48:4626-33 pubmed
    ....
  7. Hazlett L, McClellan S, Barrett R, Huang X, Zhang Y, Wu M, et al. IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci. 2010;51:1524-32 pubmed publisher
    ..These data provide evidence that IL-33 promotes a Th2-type immune response and reduces inflammation by polarizing the Mvarphi production of anti-inflammatory mediators in the cornea. ..
  8. Hazlett L, Hendricks R. Reviews for immune privilege in the year 2010: immune privilege and infection. Ocul Immunol Inflamm. 2010;18:237-43 pubmed publisher
    ..HSK is more frequent and severe in BALB/c than C57BL/6 mice, and varies in severity with the strain and dose of HSV-1 used to infect the cornea...
  9. Peng X, Ekanayaka S, McClellan S, Barrett R, Vistisen K, Hazlett L. Characterization of Three Ocular Clinical Isolates of P. aeruginosa: Viability, Biofilm Formation, Adherence, Infectivity, and Effects of Glycyrrhizin. Pathogens. 2017;6: pubmed publisher
    ..This study provides evidence that GLY is bacteriostatic for G81007. It also affects biofilm production, adherence to cultured cells, and an improved keratitis outcome. ..