Research Topics
Genomes and GenesSpecies | Linda Dondero HazlettSummaryAffiliation: Wayne State University Country: USA Publications
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Detail Information
Publications
Pathogenic mechanisms of P. aeruginosa keratitis: a review of the role of T cells, Langerhans cells, PMN, and cytokines
Linda D Hazlett
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
DNA Cell Biol 21:383-90. 2002..In the absence of T-cell infiltration into the cornea, PMN do not persist in the stroma, and cytokines and chemokines are better balanced, resulting in decreased stromal destruction and the resistance response...Flagellin suppresses the inflammatory response and enhances bacterial clearance in a murine model of Pseudomonas aeruginosa keratitis
Ashok Kumar
Kresge Eye Institute Department of Ophthalmo, Wayne State University School of Medicine, Detroit, MI 48201, USA
Infect Immun 76:89-96. 2008..This is the first report that describes the protective mechanisms induced by a Toll-like receptor agonist that not only curbs the host inflammatory response but also eliminates invading bacteria in the B6 mouse cornea...Inflammatory response to Pseudomonas aeruginosa keratitis
Linda D Hazlett
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA
Ocul Surf 3:S139-41. 2005..When combined with antibiotic, the caspase-1 inhibitor provided better disease outcome than either the inhibitor or antibiotic alone, supporting the possibility of alternate therapy for this disease...HIF-1α is essential for effective PMN bacterial killing, antimicrobial peptide production and apoptosis in Pseudomonas aeruginosa keratitis
Elizabeth A Berger
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
PLoS Pathog 9:e1003457. 2013....Pseudomonas aeruginosa: my research passion
Linda Hazlett
Wayne State University School of Medicine, Department of Anatomy and Cell Biology, Detroit, MI, USA
Future Microbiol 8:833-4. 2013....Complement defects in aged mice compromise phagocytosis of Pseudomonas aeruginosa
L D Hazlett
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Curr Eye Res 19:26-32. 1999..The role of complement in phagocytosis and killing of P. aeruginosa was examined using serum from aged vs young donor mice...Corneal response to Pseudomonas aeruginosa infection
Linda Dondero Hazlett
Department of Anatomy and Cell Biology, Wayne State University, 540 E Canfield, Room 7341, Detroit, MI 48201, USA
Prog Retin Eye Res 23:1-30. 2004..Future studies will be aimed at better defining the role of Toll receptors, neuropeptides (as unconventional modulators of the immune response) and exploitation of disease control by new techniques, such as RNA silencing...ST2 is essential for Th2 responsiveness and resistance to pseudomonas aeruginosa keratitis
Xi Huang
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Invest Ophthalmol Vis Sci 48:4626-33. 2007..To elucidate the role of ST2, a member of the TLR/IL-1R (TIR) superfamily, in protecting against Pseudomonas aeruginosa keratitis in BALB/c mice...NKT cells are critical to initiate an inflammatory response after Pseudomonas aeruginosa ocular infection in susceptible mice
Linda D Hazlett
Department of Anatomy and Cell Biology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
J Immunol 179:1138-46. 2007....Bacterial infections of the cornea (Pseudomonas aeruginosa)
Linda D Hazlett
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Chem Immunol Allergy 92:185-94. 2007..Overall, studies with these inbred mice provide a better understanding of the mechanisms of innate immune responsiveness and abrogation of immune privilege operative after P. aeruginosa corneal infection...The role of nitric oxide in resistance to P. aeruginosa ocular infection
Linda D Hazlett
Department of Anatomy Cell Biology, Wayne State University, Detroit, MI 48201, USA
Ocul Immunol Inflamm 13:279-88. 2005..This study determined the role of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) in the resistance response of BALB/c mice to P. aeruginosa-induced keratitis...Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection
Linda D Hazlett
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Invest Ophthalmol Vis Sci 48:797-807. 2007..To determine the effects of blocking substance P (SP) interactions with its major receptor (NK1-R) using the antagonist spantide I in susceptible mice infected with Pseudomonas aeruginosa...Further studies on the role of IL-12 in Pseudomonas aeruginosa corneal infection
L D Hazlett
Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Eye (Lond) 17:863-71. 2003..Therefore, the purpose of this study was to test whether BALB/c mice are capable of responding to exogenous IL-12 administration, and whether disease responsiveness following P. aeruginosa challenge is modified...IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis
Linda D Hazlett
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Invest Ophthalmol Vis Sci 51:1524-32. 2010..To determine the role of IL-33 in resistance to Pseudomonas aeruginosa keratitis...Reviews for immune privilege in the year 2010: immune privilege and infection
Linda D Hazlett
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Ocul Immunol Inflamm 18:237-43. 2010..HSK is more frequent and severe in BALB/c than C57BL/6 mice, and varies in severity with the strain and dose of HSV-1 used to infect the cornea...Defensins in innate immunity
Linda Hazlett
Anatomy Cell Biology, Wayne State University, 540 E Canfield Ave, Detroit, MI 48201, USA
Cell Tissue Res 343:175-88. 2011..These studies of defensins in the innate immune system have implications for the prevention and treatment of a variety of infectious diseases, including bacterial ocular disease...Increased severity of Pseudomonas aeruginosa corneal infection in strains of mice designated as Th1 versus Th2 responsive
L D Hazlett
Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Invest Ophthalmol Vis Sci 41:805-10. 2000..K) response development were evaluated for their response to infection with Pseudomonas aeruginosa. This study addresses the question of whether Th1 versus Th2 response propensity affects the pathogenesis of bacterial keratitis in mice...B7/CD28 costimulation is critical in susceptibility to Pseudomonas aeruginosa corneal infection: a comparative study using monoclonal antibody blockade and CD28-deficient mice
L D Hazlett
Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Immunol 166:1292-9. 2001..These results support a critical role for B7/CD28 costimulation in susceptibility to P. aeruginosa ocular infection...Role of IL-12 and IFN-gamma in Pseudomonas aeruginosa corneal infection
Linda D Hazlett
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Invest Ophthalmol Vis Sci 43:419-24. 2002..Despite its potential importance, the role of IL-12 in ocular infection with P. aeruginosa remains unexplored and was the purpose of this study...The role of Langerhans cells in Pseudomonas aeruginosa infection
Linda D Hazlett
Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Invest Ophthalmol Vis Sci 43:189-97. 2002....IFN-gamma: regulation of nitric oxide in the P. aeruginosa-infected cornea
Sharon A McClellan
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Ocul Immunol Inflamm 14:21-8. 2006..BALB/c mice are resistant to Pseudomonas aeruginosa (P. aeruginosa) keratitis and bacterial killing/stasis requires nitric oxide (NO). NO regulation in the cornea is unknown and was tested in this model...Substance P promotes susceptibility to Pseudomonas aeruginosa keratitis in resistant mice: anti-inflammatory mediators downregulated
Sharon A McClellan
Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
Invest Ophthalmol Vis Sci 49:1502-11. 2008..This study tested the effect of SP injection on the resistance response (cornea heals) of BALB/c mice...Role of the Fas pathway in Pseudomonas aeruginosa keratitis
Zimei Zhou
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Invest Ophthalmol Vis Sci 51:2537-47. 2010..The role of the Fas pathway was tested in Pseudomonas aeruginosa-infected mouse cornea by contrasting the responses of FasL(-/-) and wild-type (WT) mice...Matrix metalloproteinase-9 amplifies the immune response to Pseudomonas aeruginosa corneal infection
Sharon A McClellan
Department of Anatomy Cell Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan 48201, USA
Invest Ophthalmol Vis Sci 47:256-64. 2006..The purpose of this study was to determine the role of matrix metalloproteinases (MMP) in Pseudomonas aeruginosa keratitis...Substance P delays apoptosis, enhancing keratitis after Pseudomonas aeruginosa infection
Zimei Zhou
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA
Invest Ophthalmol Vis Sci 49:4458-67. 2008..Apoptosis was examined after Pseudomonas aeruginosa corneal infection in C57BL/6 (B6, susceptible) and BALB/c (resistant) mice...Macrophages restrict Pseudomonas aeruginosa growth, regulate polymorphonuclear neutrophil influx, and balance pro- and anti-inflammatory cytokines in BALB/c mice
Sharon A McClellan
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Immunol 170:5219-27. 2003..These data provide evidence that macrophages control resistance to P. aeruginosa corneal infection through regulation of PMN number, bacterial killing and balancing pro- and anti-inflammatory cytokine levels...Analysis of Pseudomonas aeruginosa corneal infection using an oligonucleotide microarray
Xi Huang
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA
Invest Ophthalmol Vis Sci 44:3409-16. 2003..To compare the early gene expression pattern of normal versus Pseudomonas aeruginosa-infected corneas in resistant (cornea heals) versus susceptible (cornea perforates) mice...Pseudomonas aeruginosa-induced inflammation in the rat extended-wear contact lens model
E A Szliter
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Eye Contact Lens 32:12-8. 2006..To examine the early host response to Pseudomonas aeruginosa challenge in the extended contact lens-wearing rat model...Substance P regulates natural killer cell interferon-gamma production and resistance to Pseudomonas aeruginosa infection
Shahrzad Lighvani
Department of Anatomy Cell Biology, Wayne State University, Detroit, USA
Eur J Immunol 35:1567-75. 2005..The data suggest a unique link between the nervous system and development of innate immunity in the cornea...IL-18 contributes to host resistance against infection with Pseudomonas aeruginosa through induction of IFN-gamma production
Xi Huang
Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201
J Immunol 168:5756-63. 2002..These data provide evidence that IL-18 contributes to the resistance response by induction of IFN-gamma and that IFN-gamma is required for bacterial killing...Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis
Minhao Wu
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Immunol 183:8054-60. 2009..Collectively, the data provide evidence that mBD2 and mBD3 together promote resistance against corneal infection...Caspase-1 inhibitor reduces severity of pseudomonas aeruginosa keratitis in mice
Archana Thakur
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48230, USA
Invest Ophthalmol Vis Sci 45:3177-84. 2004..To test an inhibitor of IL-1beta converting enzyme (ICE), with or without ciprofloxacin, in a C57BL/6 mouse model of keratitis induced by Pseudomonas aeruginosa in which corneal perforation is expected...Rat silicone hydrogel contact lens model: effects of high- versus low-Dk lens wear
Yunfan Zhang
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Eye Contact Lens 34:306-11. 2008..This study used a rat contact lens (CL) model to test if high- versus low-Dk lens wear caused changes in (1) conjunctival Langerhans cell (LC) number or location; (2) Bcl-2 expression; and (3) infection risk...Role of innate and adaptive immunity in the pathogenesis of keratitis
Linda D Hazlett
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Ocul Immunol Inflamm 13:133-8. 2005..aeruginosa challenge, determining susceptibility vs. resistance to disease, and are consistent with long-term goals of providing targets for better treatment of disease...Beta-defensin-2 promotes resistance against infection with P. aeruginosa
Minhao Wu
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Immunol 182:1609-16. 2009..Collectively, the data provide evidence that mBD2, but not mBD1, is required for host resistance against P. aeruginosa-induced corneal infection...Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta
Gabriel Sosne
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Exp Cell Res 293:175-83. 2004..Tbeta(4) and TGFbeta-1 increase LM-5 gamma2 chain expression by independent pathways. Suppression of TGFbeta-1 further increases LM-5 gamma2 chain expression...Toll-like receptors and the eye
Fu Shin X Yu
Kresge Eye Institute Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Invest Ophthalmol Vis Sci 47:1255-63. 2006VIP promotes resistance in the Pseudomonas aeruginosa-infected cornea by modulating adhesion molecule expression
Elizabeth A Berger
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Invest Ophthalmol Vis Sci 51:5776-82. 2010....SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling
Xi Huang
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
J Immunol 177:548-56. 2006..These data provide evidence that SIGIRR is critical in resistance to P. aeruginosa corneal infection by down-regulating type 1 immunity, and that it negatively regulates IL-1 and TLR4 signaling...Silencing Toll-like receptor-9 in Pseudomonas aeruginosa keratitis
Xi Huang
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Invest Ophthalmol Vis Sci 46:4209-16. 2005..To determine the effects of silencing Toll-like receptor (TLR) 9 signaling in Pseudomonas aeruginosa keratitis...Vasoactive intestinal peptide balances pro- and anti-inflammatory cytokines in the Pseudomonas aeruginosa-infected cornea and protects against corneal perforation
Elizabeth A Szliter
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Immunol 178:1105-14. 2007..These data provide evidence that neuroimmune regulation of the cytokine network and host inflammatory cells functions to promote resistance against P. aeruginosa corneal infection...Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice
Archana Thakur
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 4820, USA
Curr Eye Res 29:225-33. 2004..To elucidate these mechanisms, caspase-1 knockout (ICE(-/-)) mice, that do not release mature IL-1 beta after endotoxin challenge, were tested...TLR4 is required for host resistance in Pseudomonas aeruginosa keratitis
Xi Huang
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
Invest Ophthalmol Vis Sci 47:4910-6. 2006..To determine the role of Toll-like receptor 4 (TLR4) in Pseudomonas aeruginosa (P. aeruginosa) keratitis in resistant (cornea-healing) BALB/c mice...TIMP-1 role in protection against Pseudomonas aeruginosa-induced corneal destruction
Karen A Kernacki
Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Exp Eye Res 78:1155-62. 2004..These studies suggest that adequate expression of TIMP-1 protects against BM and stromal degradation via multiple processes...Pseudomonas aeruginosa binds to extracellular matrix deposited by human corneal epithelial cells
Miechia A Esco
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Invest Ophthalmol Vis Sci 43:3654-9. 2002..To measure the effect of extracellular matrix substrate, pH, and O(2) on Pseudomonas aeruginosa binding...Development of a new extended-wear contact lens model in the rat
Elizabeth A Szliter
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
CLAO J 28:119-23. 2002..To develop a rat model to experimentally monitor the potential inflammatory effects of soft contact lens (CL) usage on the cornea during extended wear (EW)...