Linda Dondero Hazlett

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Pathogenic mechanisms of P. aeruginosa keratitis: a review of the role of T cells, Langerhans cells, PMN, and cytokines
    Linda D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    DNA Cell Biol 21:383-90. 2002
  2. pmc Flagellin suppresses the inflammatory response and enhances bacterial clearance in a murine model of Pseudomonas aeruginosa keratitis
    Ashok Kumar
    Kresge Eye Institute Department of Ophthalmo, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Infect Immun 76:89-96. 2008
  3. ncbi request reprint Inflammatory response to Pseudomonas aeruginosa keratitis
    Linda D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA
    Ocul Surf 3:S139-41. 2005
  4. pmc HIF-1α is essential for effective PMN bacterial killing, antimicrobial peptide production and apoptosis in Pseudomonas aeruginosa keratitis
    Elizabeth A Berger
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
    PLoS Pathog 9:e1003457. 2013
  5. doi request reprint Pseudomonas aeruginosa: my research passion
    Linda Hazlett
    Wayne State University School of Medicine, Department of Anatomy and Cell Biology, Detroit, MI, USA
    Future Microbiol 8:833-4. 2013
  6. ncbi request reprint Complement defects in aged mice compromise phagocytosis of Pseudomonas aeruginosa
    L D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Eye Res 19:26-32. 1999
  7. ncbi request reprint Corneal response to Pseudomonas aeruginosa infection
    Linda Dondero Hazlett
    Department of Anatomy and Cell Biology, Wayne State University, 540 E Canfield, Room 7341, Detroit, MI 48201, USA
    Prog Retin Eye Res 23:1-30. 2004
  8. ncbi request reprint ST2 is essential for Th2 responsiveness and resistance to pseudomonas aeruginosa keratitis
    Xi Huang
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 48:4626-33. 2007
  9. ncbi request reprint NKT cells are critical to initiate an inflammatory response after Pseudomonas aeruginosa ocular infection in susceptible mice
    Linda D Hazlett
    Department of Anatomy and Cell Biology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    J Immunol 179:1138-46. 2007
  10. ncbi request reprint Bacterial infections of the cornea (Pseudomonas aeruginosa)
    Linda D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Chem Immunol Allergy 92:185-94. 2007

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Pathogenic mechanisms of P. aeruginosa keratitis: a review of the role of T cells, Langerhans cells, PMN, and cytokines
    Linda D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    DNA Cell Biol 21:383-90. 2002
    ..In the absence of T-cell infiltration into the cornea, PMN do not persist in the stroma, and cytokines and chemokines are better balanced, resulting in decreased stromal destruction and the resistance response...
  2. pmc Flagellin suppresses the inflammatory response and enhances bacterial clearance in a murine model of Pseudomonas aeruginosa keratitis
    Ashok Kumar
    Kresge Eye Institute Department of Ophthalmo, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Infect Immun 76:89-96. 2008
    ..This is the first report that describes the protective mechanisms induced by a Toll-like receptor agonist that not only curbs the host inflammatory response but also eliminates invading bacteria in the B6 mouse cornea...
  3. ncbi request reprint Inflammatory response to Pseudomonas aeruginosa keratitis
    Linda D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA
    Ocul Surf 3:S139-41. 2005
    ..When combined with antibiotic, the caspase-1 inhibitor provided better disease outcome than either the inhibitor or antibiotic alone, supporting the possibility of alternate therapy for this disease...
  4. pmc HIF-1α is essential for effective PMN bacterial killing, antimicrobial peptide production and apoptosis in Pseudomonas aeruginosa keratitis
    Elizabeth A Berger
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
    PLoS Pathog 9:e1003457. 2013
    ....
  5. doi request reprint Pseudomonas aeruginosa: my research passion
    Linda Hazlett
    Wayne State University School of Medicine, Department of Anatomy and Cell Biology, Detroit, MI, USA
    Future Microbiol 8:833-4. 2013
    ....
  6. ncbi request reprint Complement defects in aged mice compromise phagocytosis of Pseudomonas aeruginosa
    L D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Curr Eye Res 19:26-32. 1999
    ..The role of complement in phagocytosis and killing of P. aeruginosa was examined using serum from aged vs young donor mice...
  7. ncbi request reprint Corneal response to Pseudomonas aeruginosa infection
    Linda Dondero Hazlett
    Department of Anatomy and Cell Biology, Wayne State University, 540 E Canfield, Room 7341, Detroit, MI 48201, USA
    Prog Retin Eye Res 23:1-30. 2004
    ..Future studies will be aimed at better defining the role of Toll receptors, neuropeptides (as unconventional modulators of the immune response) and exploitation of disease control by new techniques, such as RNA silencing...
  8. ncbi request reprint ST2 is essential for Th2 responsiveness and resistance to pseudomonas aeruginosa keratitis
    Xi Huang
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 48:4626-33. 2007
    ..To elucidate the role of ST2, a member of the TLR/IL-1R (TIR) superfamily, in protecting against Pseudomonas aeruginosa keratitis in BALB/c mice...
  9. ncbi request reprint NKT cells are critical to initiate an inflammatory response after Pseudomonas aeruginosa ocular infection in susceptible mice
    Linda D Hazlett
    Department of Anatomy and Cell Biology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    J Immunol 179:1138-46. 2007
    ....
  10. ncbi request reprint Bacterial infections of the cornea (Pseudomonas aeruginosa)
    Linda D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Chem Immunol Allergy 92:185-94. 2007
    ..Overall, studies with these inbred mice provide a better understanding of the mechanisms of innate immune responsiveness and abrogation of immune privilege operative after P. aeruginosa corneal infection...
  11. ncbi request reprint The role of nitric oxide in resistance to P. aeruginosa ocular infection
    Linda D Hazlett
    Department of Anatomy Cell Biology, Wayne State University, Detroit, MI 48201, USA
    Ocul Immunol Inflamm 13:279-88. 2005
    ..This study determined the role of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) in the resistance response of BALB/c mice to P. aeruginosa-induced keratitis...
  12. ncbi request reprint Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection
    Linda D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 48:797-807. 2007
    ..To determine the effects of blocking substance P (SP) interactions with its major receptor (NK1-R) using the antagonist spantide I in susceptible mice infected with Pseudomonas aeruginosa...
  13. ncbi request reprint Further studies on the role of IL-12 in Pseudomonas aeruginosa corneal infection
    L D Hazlett
    Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Eye (Lond) 17:863-71. 2003
    ..Therefore, the purpose of this study was to test whether BALB/c mice are capable of responding to exogenous IL-12 administration, and whether disease responsiveness following P. aeruginosa challenge is modified...
  14. pmc IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis
    Linda D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 51:1524-32. 2010
    ..To determine the role of IL-33 in resistance to Pseudomonas aeruginosa keratitis...
  15. doi request reprint Reviews for immune privilege in the year 2010: immune privilege and infection
    Linda D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Ocul Immunol Inflamm 18:237-43. 2010
    ..HSK is more frequent and severe in BALB/c than C57BL/6 mice, and varies in severity with the strain and dose of HSV-1 used to infect the cornea...
  16. doi request reprint Defensins in innate immunity
    Linda Hazlett
    Anatomy Cell Biology, Wayne State University, 540 E Canfield Ave, Detroit, MI 48201, USA
    Cell Tissue Res 343:175-88. 2011
    ..These studies of defensins in the innate immune system have implications for the prevention and treatment of a variety of infectious diseases, including bacterial ocular disease...
  17. ncbi request reprint Increased severity of Pseudomonas aeruginosa corneal infection in strains of mice designated as Th1 versus Th2 responsive
    L D Hazlett
    Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 41:805-10. 2000
    ..K) response development were evaluated for their response to infection with Pseudomonas aeruginosa. This study addresses the question of whether Th1 versus Th2 response propensity affects the pathogenesis of bacterial keratitis in mice...
  18. ncbi request reprint B7/CD28 costimulation is critical in susceptibility to Pseudomonas aeruginosa corneal infection: a comparative study using monoclonal antibody blockade and CD28-deficient mice
    L D Hazlett
    Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 166:1292-9. 2001
    ..These results support a critical role for B7/CD28 costimulation in susceptibility to P. aeruginosa ocular infection...
  19. ncbi request reprint Role of IL-12 and IFN-gamma in Pseudomonas aeruginosa corneal infection
    Linda D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 43:419-24. 2002
    ..Despite its potential importance, the role of IL-12 in ocular infection with P. aeruginosa remains unexplored and was the purpose of this study...
  20. ncbi request reprint The role of Langerhans cells in Pseudomonas aeruginosa infection
    Linda D Hazlett
    Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 43:189-97. 2002
    ....
  21. ncbi request reprint IFN-gamma: regulation of nitric oxide in the P. aeruginosa-infected cornea
    Sharon A McClellan
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Ocul Immunol Inflamm 14:21-8. 2006
    ..BALB/c mice are resistant to Pseudomonas aeruginosa (P. aeruginosa) keratitis and bacterial killing/stasis requires nitric oxide (NO). NO regulation in the cornea is unknown and was tested in this model...
  22. doi request reprint Substance P promotes susceptibility to Pseudomonas aeruginosa keratitis in resistant mice: anti-inflammatory mediators downregulated
    Sharon A McClellan
    Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 49:1502-11. 2008
    ..This study tested the effect of SP injection on the resistance response (cornea heals) of BALB/c mice...
  23. pmc Role of the Fas pathway in Pseudomonas aeruginosa keratitis
    Zimei Zhou
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Invest Ophthalmol Vis Sci 51:2537-47. 2010
    ..The role of the Fas pathway was tested in Pseudomonas aeruginosa-infected mouse cornea by contrasting the responses of FasL(-/-) and wild-type (WT) mice...
  24. ncbi request reprint Matrix metalloproteinase-9 amplifies the immune response to Pseudomonas aeruginosa corneal infection
    Sharon A McClellan
    Department of Anatomy Cell Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 47:256-64. 2006
    ..The purpose of this study was to determine the role of matrix metalloproteinases (MMP) in Pseudomonas aeruginosa keratitis...
  25. doi request reprint Substance P delays apoptosis, enhancing keratitis after Pseudomonas aeruginosa infection
    Zimei Zhou
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Invest Ophthalmol Vis Sci 49:4458-67. 2008
    ..Apoptosis was examined after Pseudomonas aeruginosa corneal infection in C57BL/6 (B6, susceptible) and BALB/c (resistant) mice...
  26. ncbi request reprint Macrophages restrict Pseudomonas aeruginosa growth, regulate polymorphonuclear neutrophil influx, and balance pro- and anti-inflammatory cytokines in BALB/c mice
    Sharon A McClellan
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 170:5219-27. 2003
    ..These data provide evidence that macrophages control resistance to P. aeruginosa corneal infection through regulation of PMN number, bacterial killing and balancing pro- and anti-inflammatory cytokine levels...
  27. ncbi request reprint Analysis of Pseudomonas aeruginosa corneal infection using an oligonucleotide microarray
    Xi Huang
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Invest Ophthalmol Vis Sci 44:3409-16. 2003
    ..To compare the early gene expression pattern of normal versus Pseudomonas aeruginosa-infected corneas in resistant (cornea heals) versus susceptible (cornea perforates) mice...
  28. ncbi request reprint Pseudomonas aeruginosa-induced inflammation in the rat extended-wear contact lens model
    E A Szliter
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Eye Contact Lens 32:12-8. 2006
    ..To examine the early host response to Pseudomonas aeruginosa challenge in the extended contact lens-wearing rat model...
  29. ncbi request reprint Substance P regulates natural killer cell interferon-gamma production and resistance to Pseudomonas aeruginosa infection
    Shahrzad Lighvani
    Department of Anatomy Cell Biology, Wayne State University, Detroit, USA
    Eur J Immunol 35:1567-75. 2005
    ..The data suggest a unique link between the nervous system and development of innate immunity in the cornea...
  30. ncbi request reprint IL-18 contributes to host resistance against infection with Pseudomonas aeruginosa through induction of IFN-gamma production
    Xi Huang
    Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201
    J Immunol 168:5756-63. 2002
    ..These data provide evidence that IL-18 contributes to the resistance response by induction of IFN-gamma and that IFN-gamma is required for bacterial killing...
  31. doi request reprint Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis
    Minhao Wu
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 183:8054-60. 2009
    ..Collectively, the data provide evidence that mBD2 and mBD3 together promote resistance against corneal infection...
  32. ncbi request reprint Caspase-1 inhibitor reduces severity of pseudomonas aeruginosa keratitis in mice
    Archana Thakur
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48230, USA
    Invest Ophthalmol Vis Sci 45:3177-84. 2004
    ..To test an inhibitor of IL-1beta converting enzyme (ICE), with or without ciprofloxacin, in a C57BL/6 mouse model of keratitis induced by Pseudomonas aeruginosa in which corneal perforation is expected...
  33. pmc Rat silicone hydrogel contact lens model: effects of high- versus low-Dk lens wear
    Yunfan Zhang
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Eye Contact Lens 34:306-11. 2008
    ..This study used a rat contact lens (CL) model to test if high- versus low-Dk lens wear caused changes in (1) conjunctival Langerhans cell (LC) number or location; (2) Bcl-2 expression; and (3) infection risk...
  34. ncbi request reprint Role of innate and adaptive immunity in the pathogenesis of keratitis
    Linda D Hazlett
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Ocul Immunol Inflamm 13:133-8. 2005
    ..aeruginosa challenge, determining susceptibility vs. resistance to disease, and are consistent with long-term goals of providing targets for better treatment of disease...
  35. ncbi request reprint Beta-defensin-2 promotes resistance against infection with P. aeruginosa
    Minhao Wu
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 182:1609-16. 2009
    ..Collectively, the data provide evidence that mBD2, but not mBD1, is required for host resistance against P. aeruginosa-induced corneal infection...
  36. ncbi request reprint Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta
    Gabriel Sosne
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Exp Cell Res 293:175-83. 2004
    ..Tbeta(4) and TGFbeta-1 increase LM-5 gamma2 chain expression by independent pathways. Suppression of TGFbeta-1 further increases LM-5 gamma2 chain expression...
  37. pmc Toll-like receptors and the eye
    Fu Shin X Yu
    Kresge Eye Institute Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Invest Ophthalmol Vis Sci 47:1255-63. 2006
  38. pmc VIP promotes resistance in the Pseudomonas aeruginosa-infected cornea by modulating adhesion molecule expression
    Elizabeth A Berger
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 51:5776-82. 2010
    ....
  39. ncbi request reprint SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling
    Xi Huang
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    J Immunol 177:548-56. 2006
    ..These data provide evidence that SIGIRR is critical in resistance to P. aeruginosa corneal infection by down-regulating type 1 immunity, and that it negatively regulates IL-1 and TLR4 signaling...
  40. ncbi request reprint Silencing Toll-like receptor-9 in Pseudomonas aeruginosa keratitis
    Xi Huang
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Invest Ophthalmol Vis Sci 46:4209-16. 2005
    ..To determine the effects of silencing Toll-like receptor (TLR) 9 signaling in Pseudomonas aeruginosa keratitis...
  41. ncbi request reprint Vasoactive intestinal peptide balances pro- and anti-inflammatory cytokines in the Pseudomonas aeruginosa-infected cornea and protects against corneal perforation
    Elizabeth A Szliter
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 178:1105-14. 2007
    ..These data provide evidence that neuroimmune regulation of the cytokine network and host inflammatory cells functions to promote resistance against P. aeruginosa corneal infection...
  42. ncbi request reprint Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice
    Archana Thakur
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 4820, USA
    Curr Eye Res 29:225-33. 2004
    ..To elucidate these mechanisms, caspase-1 knockout (ICE(-/-)) mice, that do not release mature IL-1 beta after endotoxin challenge, were tested...
  43. ncbi request reprint TLR4 is required for host resistance in Pseudomonas aeruginosa keratitis
    Xi Huang
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Invest Ophthalmol Vis Sci 47:4910-6. 2006
    ..To determine the role of Toll-like receptor 4 (TLR4) in Pseudomonas aeruginosa (P. aeruginosa) keratitis in resistant (cornea-healing) BALB/c mice...
  44. ncbi request reprint TIMP-1 role in protection against Pseudomonas aeruginosa-induced corneal destruction
    Karen A Kernacki
    Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Exp Eye Res 78:1155-62. 2004
    ..These studies suggest that adequate expression of TIMP-1 protects against BM and stromal degradation via multiple processes...
  45. ncbi request reprint Pseudomonas aeruginosa binds to extracellular matrix deposited by human corneal epithelial cells
    Miechia A Esco
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 43:3654-9. 2002
    ..To measure the effect of extracellular matrix substrate, pH, and O(2) on Pseudomonas aeruginosa binding...
  46. ncbi request reprint Development of a new extended-wear contact lens model in the rat
    Elizabeth A Szliter
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    CLAO J 28:119-23. 2002
    ..To develop a rat model to experimentally monitor the potential inflammatory effects of soft contact lens (CL) usage on the cornea during extended wear (EW)...