Research Topics
| JOHN HANNIGANSummaryAffiliation: Wayne State University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Amelioration of fetal alcohol-related neurodevelopmental disorders in rats: exploring pharmacological and environmental treatmentsJ H Hannigan
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, C S Mott Center for Human Growth and Development, Detroit, MI 48201, USA
Neurotoxicol Teratol 22:103-11. 2000....- Postnatal environmental or experiential amelioration of neurobehavioral effects of perinatal alcohol exposure in ratsJohn H Hannigan
Department of Obstetrics and Gynecology, Wayne State University, 275 East Hancock, Detroit, MI 48201, USA
Neurosci Biobehav Rev 31:202-11. 2007.... 
Reproductive toxicology and teratology of abused tolueneJohn H Hannigan
Merrill Palmer Skillman Institute, Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University, Detroit, MI 48202, USA
Syst Biol Reprod Med 56:184-200. 2010..While substantial research has been done on the reproductive effects of occupational exposures to organic solvents, more research is needed on the outcomes and mechanisms of exposures typical of inhalant abuse...
A 14-year retrospective maternal report of alcohol consumption in pregnancy predicts pregnancy and teen outcomesJohn H Hannigan
Merrill Palmer Skillman Institute, Wayne State University, Detroit, MI 48202, USA
Alcohol 44:583-94. 2010....- Just say "I don't": lack of concordance between teen report and biological measures of drug useVirginia Delaney-Black
Carmen and Ann Adams Department of Pediatrics, Wayne State University, Children s Hospital of Michigan, 3901 Beaubien St, Detroit, MI 48201, USA
Pediatrics 126:887-93. 2010..While data comparing teen self-report with biological measures are limited, adult studies identify varying degrees of under-reporting... - Gestational toluene exposure effects on spontaneous and amphetamine-induced locomotor behavior in ratsScott E Bowen
Department of Psychology, Wayne State University, Detroit, MI 48202, USA
Neurotoxicol Teratol 29:236-46. 2007..The expression of these effects also appears to depend upon the postnatal age of testing. These results imply that abuse of organic solvents during pregnancy in humans may also produce long-lasting effects on biobehavioral development... - Blood lead levels and specific attention effects in young childrenLisa M Chiodo
Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, University Health Center, Schoo Be Research Study, Detroit, MI 48201, USA
Neurotoxicol Teratol 29:538-46. 2007..In light of the consistency of these findings with those of several other groups, it is advisable to consider whether the threshold for an acceptable blood lead level should be reduced... - Maternal and fetal blood and organ toluene levels in rats following acute and repeated binge inhalation exposureScott E Bowen
Department of Psychology, Wayne State University, Detroit, MI 48202, USA
Reprod Toxicol 24:343-52. 2007..Measurement of toluene levels in blood and other tissues following repeated toluene exposure demonstrated that toluene readily reaches a variety of potential sites of action throughout the maternal-placental-fetal unit... - Abuse pattern of gestational toluene exposure alters behavior in rats in a "waiting-for-reward" taskScott E Bowen
Department of Psychology, Wayne State University, Detroit, MI 48202, USA
Neurotoxicol Teratol 31:89-97. 2009..These outcomes in young adult rats also suggest that there may be long-term behavioral deficits due to prenatal toluene exposure... - A metric of maternal prenatal risk drinking predicts neurobehavioral outcomes in preschool childrenLisa M Chiodo
Carman and Ann Adams Department of Pediatrics, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
Alcohol Clin Exp Res 33:634-44. 2009.... - Alterations in rat fetal morphology following abuse patterns of toluene exposureScott E Bowen
Department of Psychology, Wayne State University, Detroit, MI 48202, USA
Reprod Toxicol 27:161-9. 2009..These results indicate that animals exposed prenatally to levels and patterns of toluene typical of inhalant abuse are at increased risk for skeletal and soft tissue abnormalities... - Validity of the T-ACE in pregnancy in predicting child outcome and risk drinkingLisa M Chiodo
College of Nursing, Wayne State University, Detroit, MI 48202, USA
Alcohol 44:595-603. 2010..Efficient in-pregnancy screens for risk drinking afford greater opportunities for intervention that could prevent/limit FASDs... - Prenatal and postnatal cocaine exposure predict teen cocaine useVirginia Delaney-Black
The Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
Neurotoxicol Teratol 33:110-9. 2011..These data provide further evidence of the importance of prenatal exposure, family and community factors in the intergenerational transmission of teen/young adult substance abuse/use... - The impact of maternal age on the effects of prenatal alcohol exposure on attentionLisa M Chiodo
College of Nursing, Wayne State University, Detroit, Michigan 48201, USA
Alcohol Clin Exp Res 34:1813-21. 2010..Establishing maternal characteristics, such as maternal age, that increase the risk of FASD is critical for targeted pregnancy intervention... - Reversal learning after prenatal or early postnatal alcohol exposure in juvenile and adult ratsShonagh K O'Leary-Moore
Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, 275 East Hancock, Detroit, MI 48201, USA
Alcohol 38:99-110. 2006..These results demonstrate how the timing of alcohol exposure leads to variability in the age-dependent expression of learning deficits associated with fetal alcohol effects... - Developmental toxicity of prenatal exposure to tolueneScott E Bowen
Department of Psychology, Wayne State University, Detroit, MI, USA
AAPS J 8:E419-24. 2006.... - Prenatal cocaine: quantity of exposure and gender moderationVirginia Delaney-Black
Department of Pediatrics, School of Medicine, Wayne State University, Detroit, Michigan, USA
J Dev Behav Pediatr 25:254-63. 2004.... - Abuse pattern of gestational toluene exposure and early postnatal development in ratsScott E Bowen
Department of Psychology, Wayne State University, 71 West Warren, Detroit, MI 48202, United States
Neurotoxicol Teratol 27:105-16. 2005..Since the pattern of exposure in this experiment models binge exposure in human solvent abuse, the results imply that abuse of inhaled organic solvents, such as toluene, can cause similar teratogenic outcomes in humans... - Gender and alcohol moderate caregiver reported child behavior after prenatal cocaineBeena G Sood
Carman and Ann Adams Department of Pediatrics, School of Medicine, Wayne State University, Detroit, MI, United States
Neurotoxicol Teratol 27:191-201. 2005..This study evaluates the effects of prenatal cocaine exposure on child behavior in analyses stratified by gender and prenatal alcohol exposure status... - Fatty acid ethyl esters in meconium: are they biomarkers of fetal alcohol exposure and effect?Enrique M Ostrea
Department of Pediatrics, Hutzel Women s Hospital and the Mott Center for Human Growth and Development, Detroit, Michigan 48201, USA
Alcohol Clin Exp Res 30:1152-9. 2006..The aim of this study was to analyze long-chain fatty acid ethyl esters (FAEEs) in meconium as potential biomarkers of fetal alcohol exposure and effect... - Differential effects of inhaled toluene on locomotor activity in adolescent and adult ratsJeffery C Batis
Department of Psychology, Wayne State University, Detroit, MI 48202, USA
Pharmacol Biochem Behav 96:438-48. 2010..The results imply that both pharmacological and psychosocial factors contribute to the teen prevalence of inhalant abuse... - Neurochemical changes after acute binge toluene inhalation in adolescent and adult rats: a high-resolution magnetic resonance spectroscopy studyShonagh K O'Leary-Moore
Department of Psychology, Wayne State University, Detroit, MI 48201, USA
Neurotoxicol Teratol 31:382-9. 2009.... - Neonatal alcohol-induced region-dependent changes in rat brain neurochemistry measured by high-resolution magnetic resonance spectroscopyShonagh K O'Leary-Moore
Departments of Psychology, Wayne State University School of Medicine, Detroit, Michigan, USA
Alcohol Clin Exp Res 32:1697-707. 2008..To date, however, results with MRS have been inconsistent regarding the degree and/or nature of abnormalities... - Effects of prenatal alcohol exposure on forepaw digit length and digit ratios in ratsAndrew P McMechan
Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA
Dev Psychobiol 45:251-8. 2004..An alternate interpretation is consistent with a retinoic acid-mediated effect of alcohol on digit length and ratios... - Gender and alcohol moderate prenatal cocaine effects on teacher-report of child behaviorBeth Nordstrom Bailey
Department of Family Medicine, James H Quillen College of Medicine, East Tennessee State University, P O Box 70621, Johnson City, TN 37614, United States
Neurotoxicol Teratol 27:181-9. 2005..These findings are similar to what we have reported for independent parent-reported behavioral evaluation... - Prenatal exposure to binge drinking and cognitive and behavioral outcomes at age 7 yearsBeth Nordstrom Bailey
Department of Family Medicine, East Tennessee State University, Johnson City 37614, USA
Am J Obstet Gynecol 191:1037-43. 2004..The goal of this study was to examine differential effects of amount and pattern of prenatal alcohol exposure on child outcome... - Influence of prenatal alcohol exposure on myocardial contractile function in adult rat hearts: role of intracellular calcium and apoptosisJun Ren
Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
Alcohol Alcohol 37:30-7. 2002..These results suggest that prenatal ethanol exposure alters myocardial contractile function and may contribute to the development of postnatal cardiac dysfunction through, in part, increased intracellular Ca(2+) loading and apoptosis... - Comparison of bloodstream fatty acid composition from African-American women at gestation, delivery, and postpartumKen D Stark
Laboratory of Membrane Biochemistry and Biophysics, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
J Lipid Res 46:516-25. 2005..The low dietary intake and blood levels of DHA in this population compared with others may not support optimal fetal DHA accretion and subsequent neural development... - Maternal smoking is associated with decreased 5-methyltetrahydrofolate in cord plasmaKen D Stark
Laboratory of Nutritional and Nutraceutical Research, Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada
Am J Clin Nutr 85:796-802. 2007..The effect of maternal smoking on fetal folate status has not been documented... - Alcohol consumption in pregnant, black women is associated with decreased plasma and erythrocyte docosahexaenoic acidKen D Stark
Laboratory of Membrane Biochemistry and Biophysics, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
Alcohol Clin Exp Res 29:130-40. 2005..The present findings indicate that maternal DHA deficiency is associated with high-risk drinking and may contribute to the mechanism(s) of alcohol-related neurodevelopmental disorders... - The role of maternal acceptance in the relation between community violence exposure and child functioningBeth Nordstrom Bailey
Department of Family Medicine, East Tennessee State University, Johnson City, 37614, USA
J Abnorm Child Psychol 34:57-70. 2006..In this sample of urban first graders, low levels of maternal acceptance placed children at greater risk for adverse outcomes associated with community violence exposure compared to moderate and high levels of maternal acceptance... - Effects of alcohol intake during pregnancy on docosahexaenoic acid and arachidonic acid in umbilical cord vessels of black womenSkadi Beblo
Laboratory of Membrane Biochemistry and Biophysics, NIAAA, National Institutes of Health, Rockville, Maryland 20852, USA
Pediatrics 115:e194-203. 2005..Although differences may be due to either metabolism and/or distribution, it is most likely a result of a direct influence of alcohol on fetal metabolism... - Status of plasma folate after folic acid fortification of the food supply in pregnant African American women and the influences of diet, smoking, and alcohol consumptionKen D Stark
Laboratory of Membrane Biochemistry and Biophysics, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20852, USA
Am J Clin Nutr 81:669-77. 2005..Programs to reduce smoking and raise awareness about the importance of folate and multivitamin supplementation during pregnancy need to target this population... - Magnetic resonance and spectroscopic imaging in prenatal alcohol-exposed children: preliminary findings in the caudate nucleusBernadette M Cortese
Department of Psychiatry, Pennsylvania State University, College of Medicine Hershey, PA 17033, USA
Neurotoxicol Teratol 28:597-606. 2006..The present study demonstrates that prenatal alcohol-exposed children, with or without facial dysmorphology, have abnormal brain anatomy and chemistry...
Research Grants
- AMELIORATION OF FETAL ALCOHOL EFFECTSJOHN HANNIGAN; Fiscal Year: 2004..The results could have direct implications for the development of effective and appropriate treatments for FAS/ARNDs in children. ..