M K Greenwald

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Cocaine behavioral economics: From the naturalistic environment to the controlled laboratory setting
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA Electronic address
    Drug Alcohol Depend 141:27-33. 2014
  2. ncbi request reprint Effect of experimental analogs of contingency management treatment on cocaine seeking behavior
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA Electronic address
    Drug Alcohol Depend 139:164-8. 2014
  3. pmc BDNF Val(66)Met genotype is associated with drug-seeking phenotypes in heroin-dependent individuals: a pilot study
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Addict Biol 18:836-45. 2013
  4. pmc Yohimbine increases opioid-seeking behavior in heroin-dependent, buprenorphine-maintained individuals
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 2761 East Jefferson Ave, Detroit, MI 48207, USA
    Psychopharmacology (Berl) 225:811-24. 2013
  5. ncbi request reprint Buprenorphine duration of action: mu-opioid receptor availability and pharmacokinetic and behavioral indices
    Mark Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences Wayne State University, Detroit, Michigan 48207, USA
    Biol Psychiatry 61:101-10. 2007
  6. pmc Behavioral economic analysis of drug preference using multiple choice procedure data
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Drug Alcohol Depend 93:103-10. 2008
  7. pmc Opioid abstinence reinforcement delays heroin lapse during buprenorphine dose tapering
    Mark K Greenwald
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48207, USA
    J Appl Behav Anal 41:603-7. 2008
  8. pmc Behavioral economic analysis of opioid consumption in heroin-dependent individuals: effects of alternative reinforcer magnitude and post-session drug supply
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 2761 East Jefferson Ave, Detroit, MI 48207, USA
    Drug Alcohol Depend 104:84-93. 2009
  9. pmc Effects of experimental Unemployment, Employment and Punishment analogs on opioid seeking and consumption in heroin-dependent volunteers
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48207, USA
    Drug Alcohol Depend 111:64-73. 2010
  10. pmc Teens with heavy prenatal cocaine exposure respond to experimental social provocation with escape not aggression
    M K Greenwald
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Neurotoxicol Teratol 33:198-204. 2011

Detail Information

Publications31

  1. ncbi request reprint Cocaine behavioral economics: From the naturalistic environment to the controlled laboratory setting
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA Electronic address
    Drug Alcohol Depend 141:27-33. 2014
    ..The present study sought to replicate and extend these prior findings with regular cocaine users...
  2. ncbi request reprint Effect of experimental analogs of contingency management treatment on cocaine seeking behavior
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA Electronic address
    Drug Alcohol Depend 139:164-8. 2014
    ..5% chance of $24; analogs of prize CM) similarly affect cocaine choice...
  3. pmc BDNF Val(66)Met genotype is associated with drug-seeking phenotypes in heroin-dependent individuals: a pilot study
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Addict Biol 18:836-45. 2013
    ..Whether this genotype is relevant to other abused substances besides opioids or nicotine, or treatment response, remains to be determined...
  4. pmc Yohimbine increases opioid-seeking behavior in heroin-dependent, buprenorphine-maintained individuals
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 2761 East Jefferson Ave, Detroit, MI 48207, USA
    Psychopharmacology (Berl) 225:811-24. 2013
    ..Human laboratory studies have demonstrated that psychological stressors can increase drug craving but not that stressors alter drug seeking...
  5. ncbi request reprint Buprenorphine duration of action: mu-opioid receptor availability and pharmacokinetic and behavioral indices
    Mark Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences Wayne State University, Detroit, Michigan 48207, USA
    Biol Psychiatry 61:101-10. 2007
    ..This study examined the duration of action of BUP at microORs and correlations with pharmacokinetic and pharmacodynamic outcomes in 10 heroin-dependent volunteers...
  6. pmc Behavioral economic analysis of drug preference using multiple choice procedure data
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Drug Alcohol Depend 93:103-10. 2008
    ....
  7. pmc Opioid abstinence reinforcement delays heroin lapse during buprenorphine dose tapering
    Mark K Greenwald
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48207, USA
    J Appl Behav Anal 41:603-7. 2008
    ..The abstinence reinforcement group (n=10) received $30.00 for each consecutive opioid-free urine sample; this significantly delayed heroin lapse (median, 15 days)...
  8. pmc Behavioral economic analysis of opioid consumption in heroin-dependent individuals: effects of alternative reinforcer magnitude and post-session drug supply
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 2761 East Jefferson Ave, Detroit, MI 48207, USA
    Drug Alcohol Depend 104:84-93. 2009
    ..In summary, opioid-seeking behavior is influenced by the availability of concurrent non-drug and drug alternatives. These findings show that drug availability and non-drug alternatives interact to modulate drug-seeking behavior...
  9. pmc Effects of experimental Unemployment, Employment and Punishment analogs on opioid seeking and consumption in heroin-dependent volunteers
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48207, USA
    Drug Alcohol Depend 111:64-73. 2010
    ..e., lower "essential value" of HYD) and O(max) (maximum HYD responding) compared to Punishment or Unemployment. These effects were not significantly altered by post-session drug availability...
  10. pmc Teens with heavy prenatal cocaine exposure respond to experimental social provocation with escape not aggression
    M K Greenwald
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Neurotoxicol Teratol 33:198-204. 2011
    ....
  11. pmc Sustained release d-amphetamine reduces cocaine but not 'speedball'-seeking in buprenorphine-maintained volunteers: a test of dual-agonist pharmacotherapy for cocaine/heroin polydrug abusers
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48207, USA
    Neuropsychopharmacology 35:2624-37. 2010
    ..Further research is warranted to ascertain whether SR-AMP combined with BUP could be a useful dual-agonist pharmacotherapy...
  12. ncbi request reprint Behavioral economic analysis of opioid consumption in heroin-dependent individuals: effects of unit price and pre-session drug supply
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 2761 E Jefferson Ave, Detroit, MI 48207, USA
    Drug Alcohol Depend 85:35-48. 2006
    ..Consumption was functionally equivalent at differing FR/unit dose combinations. Thus, opioid demand in heroin-dependent individuals not in treatment is a function of drug supply, unit price, and cocaine use...
  13. ncbi request reprint Early impact of methadone induction for heroin dependence: differential effects of two dose sequences in a randomized controlled study
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, MI 48207, USA
    Exp Clin Psychopharmacol 14:52-67. 2006
    ..Although these specific dosing procedures would not necessarily be used in clinical settings, they provide a procedural template that might be applied safely and effectively with a broader range of treatment-seeking individuals...
  14. ncbi request reprint Startle potentiation: shock sensitization, aversive learning, and affective picture modulation
    M K Greenwald
    Center for the Study of Emotion and Attention, University of Florida, USA
    Behav Neurosci 112:1069-79. 1998
    ..e., amygdaloid-reticular projections) mediate these effects. The present results also indicate that sensitization of startle in human volunteers is a relatively more robust defensive response to aversive stimulation...
  15. ncbi request reprint Effects of buprenorphine sublingual tablet maintenance on opioid drug-seeking behavior by humans
    Mark K Greenwald
    Addiction Research Institute, Wayne State University School of Medicine, 2761 E Jefferson, Detroit, MI 48207, USA
    Psychopharmacology (Berl) 160:344-52. 2002
    ..e. motivational measures) among outpatient volunteers using clinically relevant dosing schedules has not been extensively studied...
  16. ncbi request reprint Effects of buprenorphine maintenance dose on mu-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteers
    Mark K Greenwald
    Department of Psychiatry and Behavioral Neurosciences and Addiction Research Institute, Wayne State University, Detroit, MI 48207, USA
    Neuropsychopharmacology 28:2000-9. 2003
    ....
  17. ncbi request reprint Behavioral measurement of thermal pain sensitivity in humans: effects of stimulus intensity and instructions
    M K Greenwald
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detriot, Michigan 48207, USA
    Exp Clin Psychopharmacol 9:209-14. 2001
    ..Instruction set differences were significantly larger at higher stimulus intensities. This technique may be useful in human psychopharmacological research...
  18. ncbi request reprint Antinociceptive, subjective and behavioral effects of smoked marijuana in humans
    M K Greenwald
    Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Drug Alcohol Depend 59:261-75. 2000
    ..Naltrexone did not significantly influence marijuana dose-effect curves, suggesting no role of endogenous opiates in marijuana-induced antinociception under these conditions...
  19. ncbi request reprint Transferring methadone-maintained outpatients to the buprenorphine sublingual tablet: a preliminary study
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48207, USA
    Am J Addict 12:365-74. 2003
    ..It may be feasible to transfer outpatients on METH 60 mg/day to BUP 8 mg/day s.l. tablet, although this pilot protocol needs refinements to improve tolerability and clinical efficacy...
  20. ncbi request reprint Effects of opioid dependence and tobacco use on ventilatory response to progressive hypercapnia
    Mark K Greenwald
    Addiction Research Institute and Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 2761 East Jefferson Avenue, Detroit, MI 48207, USA
    Pharmacol Biochem Behav 77:39-47. 2004
    ....
  21. ncbi request reprint Opioid reinforcement in heroin-dependent volunteers during outpatient buprenorphine maintenance
    M K Greenwald
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48207, USA
    Drug Alcohol Depend 56:191-203. 1999
    ..In summary, BUP effects on opioid reinforcement were consistent from outpatient setting (heroin abstinence) to laboratory setting (decreased HYD reinforcement), supporting the validity of this laboratory model...
  22. ncbi request reprint Mu-opioid self-administration vs passive administration in heroin abusers produces differential EEG activation
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48207, USA
    Neuropsychopharmacology 30:212-21. 2005
    ..The EEG increase and its attenuation by naloxone agree with preclinical evidence and suggest that SA-related EEG responses were mediated by opioid receptors...
  23. ncbi request reprint Opioid craving and seeking behavior in physically dependent volunteers: effects of acute withdrawal and drug reinforcement opportunity
    Mark K Greenwald
    Department of Psychiatry and Behavioral Neuroscienes, Wayne State University, Detroit, MI 48207, USA
    Exp Clin Psychopharmacol 13:3-14. 2005
    ..However, drug versus money reinforcement opportunity did not significantly increase opioid craving or seeking behavior...
  24. ncbi request reprint Heroin craving and drug use in opioid-maintained volunteers: effects of methadone dose variations
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48207, USA
    Exp Clin Psychopharmacol 10:39-46. 2002
    ..In Phase 2 (detoxification), craving and heroin use significantly increased as methadone dose decreased. Thus, loss of micro-receptor agonist effect increased craving and risk of relapse...
  25. pmc Just say "I don't": lack of concordance between teen report and biological measures of drug use
    Virginia Delaney-Black
    Carmen and Ann Adams Department of Pediatrics, Wayne State University, Children s Hospital of Michigan, 3901 Beaubien St, Detroit, MI 48201, USA
    Pediatrics 126:887-93. 2010
    ..While data comparing teen self-report with biological measures are limited, adult studies identify varying degrees of under-reporting...
  26. doi request reprint Prenatal and postnatal cocaine exposure predict teen cocaine use
    Virginia Delaney-Black
    The Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
    Neurotoxicol Teratol 33:110-9. 2011
    ..These data provide further evidence of the importance of prenatal exposure, family and community factors in the intergenerational transmission of teen/young adult substance abuse/use...
  27. ncbi request reprint Differential effect of codeine on thermal nociceptive sensitivity in sleepy versus nonsleepy healthy subjects
    Caren L Steinmiller
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48207, USA
    Exp Clin Psychopharmacol 18:277-83. 2010
    ..These data show the analgesic effects of codeine are diminished in sleepy versus nonsleepy individuals. They suggest clinical differences in response to analgesics are partly explained by basal state of sleepiness-alertness...
  28. pmc A 14-year retrospective maternal report of alcohol consumption in pregnancy predicts pregnancy and teen outcomes
    John H Hannigan
    Merrill Palmer Skillman Institute, Wayne State University, Detroit, MI 48202, USA
    Alcohol 44:583-94. 2010
    ....
  29. doi request reprint Predicting cocaine group treatment outcome in cocaine-abusing methadone patients
    Golfo K Tzilos
    Department of Psychology, Substance Abuse Research Division, Wayne State University, Detroit, MI 48207, USA
    Exp Clin Psychopharmacol 17:320-5. 2009
    ..Treatment completion (i.e., cocaine abstinence) was significantly associated with baseline cocaine-free urinalysis and higher methadone dose...
  30. ncbi request reprint An enantiomer-selective liquid chromatography-tandem mass spectrometry method for methadone and EDDP validated for use in human plasma, urine, and liver microsomes
    David E Moody
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84108, USA
    J Anal Toxicol 32:208-19. 2008
    ....
  31. ncbi request reprint A preliminary study of 24-hour post-cesarean patient controlled analgesia: postoperative pain reports and morphine requests/utilization are greater in abstaining smokers than non-smokers
    Alan P Marco
    Department of Anesthesiology, Medical College of Ohio, Toledo, OH 43614, USA
    Med Sci Monit 11:CR255-261. 2005
    ..This study investigated IV morphine self-administration [patient controlled analgesia (PCA)], subjective pain/drug effects and other measures during post-operative (elective Cesarean section) recovery...

Research Grants11

  1. Biobehavioral Studies of Opioid Drug Seeking Behavior
    Mark Greenwald; Fiscal Year: 2003
    ..We predict that employment and punishment will increase HYD demand elasticity relative to unemployment, and that these effects will be greater under open than closed economic conditions. ..
  2. Human Laboratory Model of Cocaine Treatment: Behavioral Economic Analysis
    Mark Greenwald; Fiscal Year: 2009
    ....
  3. Reducing Cocaine/Heroin Abuse with SR-Amphetamine and Buprenorphine
    Mark Greenwald; Fiscal Year: 2009
    ..The innovative aims, rigorous methods and clinical/public health significance of this project (i.e. whether SR-AMP has potential efficacy for reducing cocaine use) is highly concordant with this RFA. ..
  4. Reducing Cocaine/Heroin Abuse with SR-Amphetamine and Buprenorphine
    Mark Greenwald; Fiscal Year: 2007
    ..The innovative aims, rigorous methods and clinical/public health significance of this project (i.e. whether SR-AMP has potential efficacy for reducing cocaine use) is highly concordant with this RFA. ..
  5. Biobehavioral Studies of Opioid Drug Seeking Behavior
    Mark Greenwald; Fiscal Year: 2007
    ..We predict that employment and punishment will increase HYD demand elasticity relative to unemployment, and that these effects will be greater under open than closed economic conditions. ..
  6. Reducing Cocaine/Heroin Abuse with SR-Amphetamine and Buprenorphine
    Mark Greenwald; Fiscal Year: 2006
    ..The innovative aims, rigorous methods and clinical/public health significance of this project (i.e. whether SR-AMP has potential efficacy for reducing cocaine use) is highly concordant with this RFA. ..
  7. Biobehavioral Studies of Opioid Drug Seeking Behavior
    Mark Greenwald; Fiscal Year: 2006
    ..We predict that employment and punishment will increase HYD demand elasticity relative to unemployment, and that these effects will be greater under open than closed economic conditions. ..
  8. Biobehavioral Studies of Opioid Drug Seeking Behavior
    Mark Greenwald; Fiscal Year: 2004
    ..We predict that employment and punishment will increase HYD demand elasticity relative to unemployment, and that these effects will be greater under open than closed economic conditions. ..
  9. Biobehavioral Studies of Opioid Drug Seeking Behavior
    Mark Greenwald; Fiscal Year: 2005
    ..We predict that employment and punishment will increase HYD demand elasticity relative to unemployment, and that these effects will be greater under open than closed economic conditions. ..
  10. Biobehavioral Studies of Opioid Drug Seeking Behavior
    Mark Greenwald; Fiscal Year: 2004
    ..We predict that employment and punishment will increase HYD demand elasticity relative to unemployment, and that these effects will be greater under open than closed economic conditions. ..
  11. Human Laboratory Model of Cocaine Treatment: Behavioral Economic Analysis
    Mark K Greenwald; Fiscal Year: 2010
    ....