Jalal K Ghali

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Lixivaptan, a non-peptide vasopressin V2 receptor antagonist for the potential oral treatment of hyponatremia
    Jalal K Ghali
    Detroit Medical Center Cardiovascular Institute, Clinical Cardiology, 3990 John R Street, Suite 9370, Detroit, MI 48201, USA
    IDrugs 13:782-92. 2010
  2. pmc Tolvaptan, hyponatremia, and heart failure
    Hammam D Zmily
    Wayne State University Detroit Medical Center, Detroit, MI, USA
    Int J Nephrol Renovasc Dis 4:57-71. 2011
  3. pmc Conivaptan and its role in the treatment of hyponatremia
    Jalal K Ghali
    Detroit Medical Center, Detroit, MI, USA
    Drug Des Devel Ther 3:253-68. 2009
  4. doi request reprint The efficacy and safety of lixivaptan in outpatients with heart failure and volume overload: results of a multicentre, randomized, double-blind, placebo-controlled, parallel-group study
    Jalal K Ghali
    Detroit Medical Center Cardiovascular Institute, Detroit, MI 48201, USA
    Eur J Heart Fail 14:642-51. 2012
  5. doi request reprint Anemia and heart failure
    Jalal K Ghali
    Harper University Hospital, 3990 John R Street, 9 Webber Core, Detroit, MI 48201, USA
    Curr Opin Cardiol 24:172-8. 2009
  6. ncbi request reprint Tolvaptan
    Jalal K Ghali
    Harper University Hospital, 3990 John R Street, 9 Webber Core, Detroit, MI 48201, USA
    Nat Rev Drug Discov 8:611-2. 2009
  7. doi request reprint The critical link of hypervolemia and hyponatremia in heart failure and the potential role of arginine vasopressin antagonists
    Jalal K Ghali
    Detroit Medical Center, Detroit, MI
    J Card Fail 16:419-31. 2010
  8. doi request reprint Guidelines, performance measures, and the practice of medicine: mind the gap
    Jalal K Ghali
    DMC Cardiovascular Institute, Detroit, MI, USA
    J Card Fail 16:915-8. 2010
  9. doi request reprint Heart failure guidelines, performance measures, and the practice of medicine: mind the gap
    Jalal K Ghali
    DMC Cardiovascular Institute, Detroit, Michigan 48201, USA
    J Am Coll Cardiol 56:2077-80. 2010
  10. ncbi request reprint Heart failure guidelines, performance measures, and the practice of medicine: mind the gap
    Jalal K Ghali
    DMC Cardiovascular Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Card Fail 17:90.e1-4. 2011

Detail Information

Publications31

  1. ncbi request reprint Lixivaptan, a non-peptide vasopressin V2 receptor antagonist for the potential oral treatment of hyponatremia
    Jalal K Ghali
    Detroit Medical Center Cardiovascular Institute, Clinical Cardiology, 3990 John R Street, Suite 9370, Detroit, MI 48201, USA
    IDrugs 13:782-92. 2010
    ..Ongoing phase III trials will determine the role of lixivaptan in the management of hyponatremia, especially when associated with heart failure...
  2. pmc Tolvaptan, hyponatremia, and heart failure
    Hammam D Zmily
    Wayne State University Detroit Medical Center, Detroit, MI, USA
    Int J Nephrol Renovasc Dis 4:57-71. 2011
    ....
  3. pmc Conivaptan and its role in the treatment of hyponatremia
    Jalal K Ghali
    Detroit Medical Center, Detroit, MI, USA
    Drug Des Devel Ther 3:253-68. 2009
    ..The nonselectivity of conivaptan offers a theoretical advantage for its use in heart failure that may merit further exploration...
  4. doi request reprint The efficacy and safety of lixivaptan in outpatients with heart failure and volume overload: results of a multicentre, randomized, double-blind, placebo-controlled, parallel-group study
    Jalal K Ghali
    Detroit Medical Center Cardiovascular Institute, Detroit, MI 48201, USA
    Eur J Heart Fail 14:642-51. 2012
    ..Vasopressin receptor antagonists such as lixivaptan may provide effective volume unloading. This study assessed weight loss after 1 day and 8 weeks of treatment with lixivaptan in outpatients with HF and volume overload...
  5. doi request reprint Anemia and heart failure
    Jalal K Ghali
    Harper University Hospital, 3990 John R Street, 9 Webber Core, Detroit, MI 48201, USA
    Curr Opin Cardiol 24:172-8. 2009
    ..The earlier enthusiasm for raising hemoglobin in heart failure has been followed by skepticism and concern of potential harm from using erythropoiesis-stimulating agents (ESAs)...
  6. ncbi request reprint Tolvaptan
    Jalal K Ghali
    Harper University Hospital, 3990 John R Street, 9 Webber Core, Detroit, MI 48201, USA
    Nat Rev Drug Discov 8:611-2. 2009
    ..In May 2009, tolvaptan (Samsca; Otsuka), a selective vasopressin V(2) receptor antagonist, was approved by the US FDA for the treatment of clinically significant hypervolaemic and euvolaemic hyponatraemia...
  7. doi request reprint The critical link of hypervolemia and hyponatremia in heart failure and the potential role of arginine vasopressin antagonists
    Jalal K Ghali
    Detroit Medical Center, Detroit, MI
    J Card Fail 16:419-31. 2010
    ..Both conditions share many pathophysiologic and prognostic features and each has been associated with increased morbidity and mortality. When both conditions coexist, therapeutic options are limited...
  8. doi request reprint Guidelines, performance measures, and the practice of medicine: mind the gap
    Jalal K Ghali
    DMC Cardiovascular Institute, Detroit, MI, USA
    J Card Fail 16:915-8. 2010
    ....
  9. doi request reprint Heart failure guidelines, performance measures, and the practice of medicine: mind the gap
    Jalal K Ghali
    DMC Cardiovascular Institute, Detroit, Michigan 48201, USA
    J Am Coll Cardiol 56:2077-80. 2010
    ....
  10. ncbi request reprint Heart failure guidelines, performance measures, and the practice of medicine: mind the gap
    Jalal K Ghali
    DMC Cardiovascular Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Card Fail 17:90.e1-4. 2011
    ....
  11. doi request reprint Exploring the potential synergistic action of spironolactone on nitric oxide-enhancing therapy: insights from the African-American Heart Failure Trial
    Jalal K Ghali
    Wayne State University, Detroit, MI 48201, USA
    J Card Fail 14:718-23. 2008
    ..The beneficial effects of aldosterone antagonist (spironolactone [SP]), however have not been adequately assessed in black patients with or without the use of FDC I/H...
  12. doi request reprint Association between bilirubin and mode of death in severe systolic heart failure
    Audrey H Wu
    University of Michigan Health System, Ann Arbor, MI, USA
    Am J Cardiol 111:1192-7. 2013
    ..21, 95% confidence interval 0.98 to 1.49, p = 0.08). In conclusion, an increasing bilirubin level was significantly associated with the risk of pump failure death but not for sudden death in patients with severe systolic heart failure...
  13. pmc Safety of symptom-limited cardiopulmonary exercise testing in patients with chronic heart failure due to severe left ventricular systolic dysfunction
    Steven J Keteyian
    Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USA
    Am Heart J 158:S72-7. 2009
    ..We hypothesized that exercise testing would be safe, as defined by a rate for all-cause death of <0.1 per 1,000 tests and a rate of nonfatal CV events <1.0 per 1,000 tests...
  14. doi request reprint Gender and ethnic differences in red cell distribution width and its association with mortality among low risk healthy United state adults
    Sandip K Zalawadiya
    Division of Cardiology, Department of Internal Medicine, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA
    Am J Cardiol 109:1664-70. 2012
    ..In conclusion, blacks and men have significantly greater RCDWs compared to whites and women. Greater RCDW is associated with a greater risk of mortality in men compared to women, whereas no effect modification is observed by ethnicity...
  15. doi request reprint Mechanisms, risks, and new treatment options for hyponatremia
    Jalal K Ghali
    Wayne State University, Detroit, Michigan, USA
    Cardiology 111:147-57. 2008
    ..The AVP receptor antagonists (conivaptan, tolvaptan, lixivaptan, and satavaptan) are a new class of agents that have been shown to normalize serum [Na(+)] by promoting aquaresis - the electrolyte-sparing excretion of free water...
  16. doi request reprint Randomized double-blind trial of darbepoetin alfa in patients with symptomatic heart failure and anemia
    Jalal K Ghali
    Wayne State University, Detroit, Mich, USA
    Circulation 117:526-35. 2008
    ..The Study of Anemia in Heart Failure Trial (STAMINA-HeFT) is the largest multicenter, randomized, double-blind, placebo-controlled trial to date evaluating the effect of treating anemia in HF...
  17. doi request reprint The potential role for lixivaptan in heart failure and in hyponatremia
    Hammam D Zmily
    Detroit Medical Center Wayne State University, Harper University Hospital, 3990 John R, Suite 9370, Detroit, MI 48201, USA
    Expert Opin Investig Drugs 20:831-48. 2011
    ....
  18. ncbi request reprint Conivaptan: a dual vasopressin receptor v1a/v2 antagonist [corrected]
    Farhan Ali
    Division of Cardiology, Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA
    Cardiovasc Drug Rev 25:261-79. 2007
    ..Consideration should be given to further evaluation of its potential benefits in patients with acute decompensated heart failure...
  19. ncbi request reprint Therapeutic potential of vasopressin receptor antagonists
    Farhan Ali
    Heart Failure Program, Wayne State University, Detroit, Michigan, USA
    Drugs 67:847-58. 2007
    ..Ongoing clinical trials should further define the scope of the potential therapeutic role of VRAs...
  20. doi request reprint Does aspirin use adversely influence intermediate-term postdischarge outcomes for hospitalized patients who are treated with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers? Findings from Organized Program to Facilitate Life-Savi
    Phillip D Levy
    Department of Emergency Medicine and the Cardiovascular Research Institute, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Am Heart J 159:222-230.e2. 2010
    ..How such an interaction may be influenced by underlying etiology of HF and whether it extends to patients treated with angiotensin receptor blockers (ARBs), however, are not known...
  21. doi request reprint The influence of renal function on clinical outcome and response to beta-blockade in systolic heart failure: insights from Metoprolol CR/XL Randomized Intervention Trial in Chronic HF (MERIT-HF)
    Jalal K Ghali
    Detroit Medical Center, Detroit, Michigan, USA
    J Card Fail 15:310-8. 2009
    ..Limited information is available on the risk and impact of renal dysfunction on the response to beta-blockade and mode of death in systolic heart failure (HF)...
  22. pmc Effect of dronedarone on exercise capacity and cardiac function in patients with severe left ventricular dysfunction and compensated stable heart failure
    T Barry Levine
    Michigan Institute for Heart Failure and Transplant Care, Farmington Hills, MI, USA
    Cardiovasc Drugs Ther 24:449-58. 2010
    ..The aim of this study was to investigate the effects of dronedarone on functional capacity in patients with severe left ventricular (LV) dysfunction and compensated stable heart failure (HF)...
  23. doi request reprint Uric acid level and allopurinol use as risk markers of mortality and morbidity in systolic heart failure
    Audrey H Wu
    University of Michigan Health System, Ann Arbor, MI, USA
    Am Heart J 160:928-33. 2010
    ..Previous studies have not extensively examined the association of hyperuricemia and adverse outcomes in systolic heart failure (HF) in relation to xanthine oxidase inhibitor therapy...
  24. ncbi request reprint Influence of diabetes on cardiac resynchronization therapy with or without defibrillator in patients with advanced heart failure
    Jalal K Ghali
    Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Card Fail 13:769-73. 2007
    ..We performed a post hoc analysis to determine the influence of cardiac resynchronization therapy with a defibrillator (CRT-D) or without a defibrillator (CRT-P) on outcomes among diabetic patients with advanced heart failure (HF)...
  25. doi request reprint Red cell distribution width and mortality in predominantly African-American population with decompensated heart failure
    Sandip K Zalawadiya
    Detroit Medical Center, Wayne State University, Detroit, MI 47201, USA
    J Card Fail 17:292-8. 2011
    ..However, evidence is limited for its predictive value in the setting of patients hospitalized with decompensated heart failure (DHF) and no data are available for African Americans (AA)...
  26. ncbi request reprint Efficacy and safety of oral conivaptan: a V1A/V2 vasopressin receptor antagonist, assessed in a randomized, placebo-controlled trial in patients with euvolemic or hypervolemic hyponatremia
    Jalal K Ghali
    Division of Cardiology, Wayne State University, 4201 St Antoine, Detroit, Michigan 48201, USA
    J Clin Endocrinol Metab 91:2145-52. 2006
    ..Hyponatremia [serum sodium concentration ([Na(+)]), <135 mEq/liter] is the most common fluid and electrolyte abnormality among hospitalized patients. It is frequently caused by the inappropriate release of arginine vasopressin...
  27. doi request reprint Sex differences in response to chronic heart failure therapies
    Jalal K Ghali
    University Health Care Center, Wayne State University, 4201 St Antoine, 2E, Detroit, MI 48201, USA
    Expert Rev Cardiovasc Ther 6:555-65. 2008
    ..Future clinical trials should be conducted either exclusively in women or have a larger representation of women to insure the adequate assessment of the potential benefit versus risk in women...
  28. doi request reprint Anemia and iron deficiency in heart failure
    Natasha P Arora
    Division of Cardiovascular Services, Saint John Hospital and Medical Center, 22101 Moross Road, Detroit, MI 48236, USA
    Heart Fail Clin 10:281-94. 2014
    ....
  29. doi request reprint Iron deficiency anemia in heart failure
    Natasha P Arora
    Detroit Medical Center, Wayne State University, Detroit, MI, USA
    Heart Fail Rev 18:485-501. 2013
    ..In this review, the etiology and relevance of iron deficiency, iron metabolism in the setting of HF, studies on iron supplementation in patients with HF and potential cardiovascular effects of subclinical iron overload are discussed...
  30. pmc Relationship of Doppler-Echocardiographic left ventricular diastolic function to exercise performance in systolic heart failure: the HF-ACTION study
    Julius M Gardin
    St John Hospital and Medical Center, Detroit, MI Hackensack University Medical Center, Hackensack, NJ 07601, USA
    Am Heart J 158:S45-52. 2009
    ..Although in animal models diastolic dysfunction is associated with worsening exercise capacity and prognosis, information regarding these relationships in patients with established systolic heart failure (HF) is sparse...
  31. ncbi request reprint Effects of ACE inhibitors or beta-blockers in patients treated with the fixed-dose combination of isosorbide dinitrate/hydralazine in the African-American Heart Failure Trial
    Jalal K Ghali
    University Health Center, Wayne State University, Detroit, MI 48201, USA
    Am J Cardiovasc Drugs 7:373-80. 2007
    ....