ROBERT F FREEDMAN

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi Estrogen raises the sweating threshold in postmenopausal women with hot flashes
    Robert R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Fertil Steril 77:487-90. 2002
  2. ncbi Pathophysiology and treatment of menopausal hot flashes
    Robert R Freedman
    Obstetrics and Gynecology, Wayne State University School of Medicine, C S Mott Center, 275 E Hancock Avenue, Detroit, MI 48201, USA
    Semin Reprod Med 23:117-25. 2005
  3. pmc Treatment of menopausal hot flashes with 5-hydroxytryptophan
    Robert R Freedman
    Departments of Psychiatry and Behavioral Neurosciences and Obstetrics and Gynecology, Wayne State University School of Medicine, C S Mott Center for Human Growth and Development, 275 E Hancock, Detroit, MI 48201, USA
    Maturitas 65:383-5. 2010
  4. ncbi Biochemical, metabolic, and vascular mechanisms in menopausal hot flashes
    R R Freedman
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    Fertil Steril 70:332-7. 1998
  5. ncbi Effects of symptomatic status and the menstrual cycle on hot flash-related thermoregulatory parameters
    Robert R Freedman
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA
    Menopause 12:156-9. 2005
  6. ncbi Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans
    Robert R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Psychopharmacology (Berl) 183:248-56. 2005
  7. ncbi Hot flashes: behavioral treatments, mechanisms, and relation to sleep
    Robert R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Med 118:124-30. 2005
  8. ncbi Cortical activation during menopausal hot flashes
    Robert R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA
    Fertil Steril 85:674-8. 2006
  9. ncbi Effects of REM sleep and ambient temperature on hot flash-induced sleep disturbance
    Robert R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Menopause 13:576-83. 2006
  10. pmc Miniature hygrometric hot flash recorder
    Robert R Freedman
    Departments of Obstetrics and Gynecology and Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
    Fertil Steril 88:494-6. 2007

Research Grants

  1. BEHAVIORAL TREATMENT OF MENOPAUSAL HOT FLASHES
    Robert Freedman; Fiscal Year: 2007
  2. BEHAVIORAL TREATMENT OF MENOPAUSAL HOT FLASHES
    Robert Freedman; Fiscal Year: 2009
  3. Sleep Disturbance in Menopause
    Robert Freedman; Fiscal Year: 2006
  4. BEHAVIORAL TREATMENT OF MENOPAUSAL HOT FLASHES
    Robert Freedman; Fiscal Year: 1993

Detail Information

Publications28

  1. ncbi Estrogen raises the sweating threshold in postmenopausal women with hot flashes
    Robert R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Fertil Steril 77:487-90. 2002
    ....
  2. ncbi Pathophysiology and treatment of menopausal hot flashes
    Robert R Freedman
    Obstetrics and Gynecology, Wayne State University School of Medicine, C S Mott Center, 275 E Hancock Avenue, Detroit, MI 48201, USA
    Semin Reprod Med 23:117-25. 2005
    ..Estrogen ameliorates hot flashes by increasing the T(c) sweating threshold, although the underlying mechanism is not known. Recent studies of hot flashes during sleep call into question their role in producing sleep disturbance...
  3. pmc Treatment of menopausal hot flashes with 5-hydroxytryptophan
    Robert R Freedman
    Departments of Psychiatry and Behavioral Neurosciences and Obstetrics and Gynecology, Wayne State University School of Medicine, C S Mott Center for Human Growth and Development, 275 E Hancock, Detroit, MI 48201, USA
    Maturitas 65:383-5. 2010
    ..Selective, serotonergic, reuptake inhibitors (SSRIs), which increase the amount of serotonin in the synaptic gap, have shown some promise in the amelioration of hot flashes...
  4. ncbi Biochemical, metabolic, and vascular mechanisms in menopausal hot flashes
    R R Freedman
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    Fertil Steril 70:332-7. 1998
    ..To determine if increases in core body temperature preceding most hot flashes are caused by increased metabolic rate, peripheral vasoconstriction, or central noradrenergic activation...
  5. ncbi Effects of symptomatic status and the menstrual cycle on hot flash-related thermoregulatory parameters
    Robert R Freedman
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA
    Menopause 12:156-9. 2005
    ..To compare core body temperature variation, sweating thresholds, and sweat rate in symptomatic and asymptomatic postmenopausal women and in eumenorrheic women in the follicular and luteal phases...
  6. ncbi Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans
    Robert R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Psychopharmacology (Berl) 183:248-56. 2005
    ..In rats, MDMA causes hyperthermia at warm ambient temperatures but hypothermia at cold ones...
  7. ncbi Hot flashes: behavioral treatments, mechanisms, and relation to sleep
    Robert R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Med 118:124-30. 2005
    ..Therefore, sleep complaints in women at midlife should not routinely be attributed to hot flashes or to menopause...
  8. ncbi Cortical activation during menopausal hot flashes
    Robert R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA
    Fertil Steril 85:674-8. 2006
    ..To determine regions of brain activation associated with menopausal hot flashes and sweating...
  9. ncbi Effects of REM sleep and ambient temperature on hot flash-induced sleep disturbance
    Robert R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Menopause 13:576-83. 2006
    ..To determine whether hot flashes produce sleep disturbance in postmenopausal women...
  10. pmc Miniature hygrometric hot flash recorder
    Robert R Freedman
    Departments of Obstetrics and Gynecology and Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
    Fertil Steril 88:494-6. 2007
    ..To design and test a miniature ambulatory hot flash recorder that uses neither electrodes nor gel...
  11. ncbi Sleep disturbance in menopause
    Robert R Freedman
    Department of Psychiatry, Wayne State University School of Medicine, and Henry Ford Hospital Sleep Disorders Center, Detroit, MI 48201, USA
    Menopause 14:826-9. 2007
    ..To determine the sources of sleep complaints in peri- and postmenopausal women reporting disturbed sleep...
  12. pmc Heart rate variability in menopausal hot flashes during sleep
    Robert R Freedman
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Menopause 18:897-900. 2011
    ..The aim of this study was to determine if heart rate variability changes during hot flashes recorded during sleep...
  13. ncbi Lack of sleep disturbance from menopausal hot flashes
    Robert R Freedman
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 82:138-44. 2004
    ..To determine whether hot flashes produce disordered sleep in symptomatic postmenopausal women...
  14. pmc Escitalopram treatment of menopausal hot flashes
    Robert R Freedman
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Menopause 18:893-6. 2011
    ..The aim of this study was to determine the effects of 10 and 20 mg/day of escitalopram on objectively recorded hot flashes and on the rectal temperature threshold for sweating...
  15. ncbi Endothelial and adrenergic dysfunction in Raynaud's phenomenon and scleroderma
    R R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Rheumatol 26:2386-8. 1999
    ..To investigate the involvement of endothelial and adrenergic mechanisms in patients with Raynaud's phenomenon (RP) and scleroderma...
  16. ncbi Effects of menstrual cycle and race on peripheral vascular alpha-adrenergic responsiveness
    R R Freedman
    Departments of Psychiatry and Behavioral Neurosciences and Obstetrics and Gynecology and Internal Medicine Pulmonary, Wayne State University School of Medicine, Detroit, MI, USA
    Hypertension 35:795-9. 2000
    ..The lack of luteal-phase reduction in alpha(2)-adrenergic vasoconstriction in black women may contribute to their increased pressor responses to adrenergic stimuli...
  17. ncbi Clonidine raises the sweating threshold in symptomatic but not in asymptomatic postmenopausal women
    R R Freedman
    Wayne State University School of Medicine, Detroit, Michigan, USA
    Fertil Steril 74:20-3. 2000
    ..To determine the effects of clonidine, which reduces central sympathetic activation, on the sweating threshold in postmenopausal women with and without hot flashes...
  18. ncbi Abnormal responses to endothelial agonists in Raynaud's phenomenon and scleroderma
    R R Freedman
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Rheumatol 28:119-21. 2001
    ..To further specify the site of vascular dysfunction in patients with Raynaud's phenomenon (RP) and scleroderma...
  19. ncbi Physiology of hot flashes
    R R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48201, USA
    Am J Hum Biol 13:453-64. 2001
    ..Clonidine reduces central sympathetic activation, widens the thermoneutral zone, and ameliorates hot flashes. Estrogen virtually eliminates hot flashes but its mechanism of action is not known...
  20. ncbi Core body temperature variation in symptomatic and asymptomatic postmenopausal women: brief report
    Robert R Freedman
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
    Menopause 9:399-401. 2002
    ..To determine if core body temperature (T) fluctuations occur in asymptomatic as well as symptomatic postmenopausal women...
  21. ncbi Increased tyrosine phosphorylation mediates the cooling-induced contraction and increased vascular reactivity of Raynaud's disease
    Philip B Furspan
    C S Mott Center, Wayne State University, 275 East Hancock Avenue, Detroit, MI 48201, USA
    Arthritis Rheum 50:1578-85. 2004
    ..This study tests the hypothesis that increased PTK activity mediates the increased vascular reactivity to agonists and cooling associated with primary Raynaud's disease (RD)...
  22. ncbi Hot flash trends and mechanisms
    Robert R Freedman
    Menopause 9:151-2. 2002
  23. ncbi Measurement of hot flashes by sternal skin conductance and subjective hot flash report in Puebla, Mexico
    Lynnette Leidy Sievert
    Department of Anthropology, University of Massachusetts at Amherst, Amherst, Massachusetts 01003 4805, USA
    Menopause 9:367-76. 2002
    ..To measure hot flashes by sternal skin conductance in an urban Mexican population and to determine variables associated with hot flash reporting and measurement...
  24. ncbi It's all in your head
    Robert R Freedman
    Menopause 12:483. 2005
  25. ncbi A woman attempting to discontinue hormone therapy
    Robert R Freedman
    JAMA 288:2264; author reply 2264-5. 2002
  26. ncbi How much of a difference does it take to make a difference
    Robert R Freedman
    Fertil Steril 87:1497; author reply 1497-8. 2007
  27. ncbi Hot flashes, core body temperature, and metabolic parameters in breast cancer survivors
    Janet S Carpenter
    Indiana University School of Nursing, 1111 Middle Drive NU 340D, Indianapolis, IN 46202 5107, USA
    Menopause 11:375-81. 2004
    ..To examine core body temperature, energy expenditure, and respiratory quotient among breast cancer survivors experiencing hot flashes and compare these data to published studies from healthy women...
  28. pmc Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society
    Wulf H Utian
    Menopause 15:584-602. 2008
    ....

Research Grants14

  1. BEHAVIORAL TREATMENT OF MENOPAUSAL HOT FLASHES
    Robert Freedman; Fiscal Year: 2007
    ....
  2. BEHAVIORAL TREATMENT OF MENOPAUSAL HOT FLASHES
    Robert Freedman; Fiscal Year: 2009
    ....
  3. Sleep Disturbance in Menopause
    Robert Freedman; Fiscal Year: 2006
    ..In Study 5, we will determine the effects of elevated sympathetic activation on HFs and sleep using a stimulus that does not, by itself, disrupt sleep (orthostasis). ..
  4. BEHAVIORAL TREATMENT OF MENOPAUSAL HOT FLASHES
    Robert Freedman; Fiscal Year: 1993