J C Dunbar

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Effect of aldose reductase inhibition on interleukin-1beta-induced nitric oxide (NO) synthesis in vascular tissue
    Juan Morales
    Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201 1928, USA
    Int J Exp Diabetes Res 3:11-20. 2002
  2. ncbi request reprint Leptin-induced increase in sympathetic nervous and cardiovascular tone is mediated by proopiomelanocortin (POMC) products
    J C Dunbar
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 1928, USA
    Brain Res Bull 50:215-21. 1999
  3. ncbi request reprint Hypothalamic agouti-related protein immunoreactivity in food-restricted, obese, and insulin-treated animals: evidence for glia cell localization
    Joseph Dunbar
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 1928, USA
    Exp Neurol 191:184-92. 2005
  4. ncbi request reprint Chronic intracerebroventricular insulin attenuates the leptin-mediated but not alpha melanocyte stimulating hormone increase in sympathetic and cardiovascular responses
    J C Dunbar
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Brain Res Bull 52:123-6. 2000
  5. ncbi request reprint Proopiomelanocortin (POMC) products in the central regulation of sympathetic and cardiovascular dynamics: studies on melanocortin and opioid interactions
    J C Dunbar
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Peptides 21:211-7. 2000
  6. ncbi request reprint Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats
    J C Dunbar
    Department of Physiology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Diabetes 46:2040-3. 1997
  7. ncbi request reprint Plasma glucose, insulin and cardiovascular responses after intravenous intracerebroventricular injections of insulin, 2-deoxyglucose and glucose in rats
    S Schultz-Klarr
    Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201
    Diabetes Res Clin Pract 26:81-9. 1994
  8. ncbi request reprint Obesity due to high fat diet decreases the sympathetic nervous and cardiovascular responses to intracerebroventricular leptin in rats
    H Lu
    Department of Physiology, Wayne State University, Detroit, MI 48201, USA
    Brain Res Bull 47:331-5. 1998
  9. ncbi request reprint Central IGF-1 decreases systemic blood pressure and increases blood flow in selective vascular beds
    Y Hu
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Horm Metab Res 28:211-4. 1996
  10. ncbi request reprint Cardiorespiratory response patterns elicited by microinjections of neuropeptide Y in the nucleus tractus solitarius
    R A Barraco
    Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201
    Brain Res Bull 24:465-85. 1990

Research Grants

  1. COR HONORS HIGH SCHOOL RESEARCH EDUCATION
    Joseph Dunbar; Fiscal Year: 2005
  2. IMSD PROGRAM AT WAYNE STATE UNIVERSITY
    Joseph Dunbar; Fiscal Year: 2007

Collaborators

  • Haikun Li
  • Jeffrey L Ram
  • D M Lawson
  • N F Rossi
  • A A F Sima
  • Natalie N Rizk
  • K-L Catherine Jen
  • Y Hu
  • Sumangala P Rao
  • Maria J Barnes
  • Karen Lapanowski
  • Crystal Hill-Pryor
  • Crystal Hill
  • Joseph Levy
  • Alexandria Conley
  • Jose A Rafols
  • Juan Morales
  • Crystal R McRae
  • Nahla Salem
  • Atul Rajpurkar
  • R L Hammond
  • B Martinez-Nieves
  • M J Barnes
  • K Lapanowski
  • H Lu
  • DaShawnda Lindsey
  • Zhengxian Zhu
  • Theodore W Kurtz
  • Monique Churchill
  • Crystal McRae
  • L Carlock
  • C B Dhabuwala
  • Yang Jiang
  • J A Rafols
  • R A Augustyniak
  • S Schultz-Klarr
  • A Buison
  • C Houck
  • Z Duanmu
  • E Ergene
  • D Wisniewski
  • D Bessert
  • M Lorincz
  • P D Walker
  • T Vo
  • R A Barraco
  • J Wright-Richey
  • M R el-Ridi

Detail Information

Publications38

  1. pmc Effect of aldose reductase inhibition on interleukin-1beta-induced nitric oxide (NO) synthesis in vascular tissue
    Juan Morales
    Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201 1928, USA
    Int J Exp Diabetes Res 3:11-20. 2002
    ..Nitric oxide production may be linked to redox influences caused by the polyol pathway...
  2. ncbi request reprint Leptin-induced increase in sympathetic nervous and cardiovascular tone is mediated by proopiomelanocortin (POMC) products
    J C Dunbar
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 1928, USA
    Brain Res Bull 50:215-21. 1999
    ..The naloxone antagonism of the leptin response is likely due to the blockade of presynaptic opioid inhibition of the MC4 receptor-mediated pressor response...
  3. ncbi request reprint Hypothalamic agouti-related protein immunoreactivity in food-restricted, obese, and insulin-treated animals: evidence for glia cell localization
    Joseph Dunbar
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 1928, USA
    Exp Neurol 191:184-92. 2005
    ..In addition to its presence in nerve fibers, AGRP localization in astroglia-like cells suggests a possible role for these elements in its synthesis or its sequestration from the neuronal compartment...
  4. ncbi request reprint Chronic intracerebroventricular insulin attenuates the leptin-mediated but not alpha melanocyte stimulating hormone increase in sympathetic and cardiovascular responses
    J C Dunbar
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Brain Res Bull 52:123-6. 2000
    ..The decreased responsiveness is not due to decreased sensitivity of the melanocortin, alphaMSH, mediated pathway.We suggest that the hyperinsulinemia of obesity may play a role in the obesity-induced leptin resistance...
  5. ncbi request reprint Proopiomelanocortin (POMC) products in the central regulation of sympathetic and cardiovascular dynamics: studies on melanocortin and opioid interactions
    J C Dunbar
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Peptides 21:211-7. 2000
    ....
  6. ncbi request reprint Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats
    J C Dunbar
    Department of Physiology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Diabetes 46:2040-3. 1997
    ..This increased peripheral resistance is the result of an increased activity of the sympathetic nerves. We suggest that increased leptin may serve as a link in the triad of obesity and hyperinsulinism and hypertension...
  7. ncbi request reprint Plasma glucose, insulin and cardiovascular responses after intravenous intracerebroventricular injections of insulin, 2-deoxyglucose and glucose in rats
    S Schultz-Klarr
    Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201
    Diabetes Res Clin Pract 26:81-9. 1994
    ..Both systemic and central glucose administration suppressed the cardiovascular tone to a lesser extent than did administration of insulin.(ABSTRACT TRUNCATED AT 250 WORDS)..
  8. ncbi request reprint Obesity due to high fat diet decreases the sympathetic nervous and cardiovascular responses to intracerebroventricular leptin in rats
    H Lu
    Department of Physiology, Wayne State University, Detroit, MI 48201, USA
    Brain Res Bull 47:331-5. 1998
    ..reduction. We conclude that obesity is associated with a decreased CNS response to leptin leading to a decrease in leptin effects to increase the activities of the autonomic nervous and cardiovascular systems...
  9. ncbi request reprint Central IGF-1 decreases systemic blood pressure and increases blood flow in selective vascular beds
    Y Hu
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Horm Metab Res 28:211-4. 1996
    ..We conclude that IGF-1 can decrease MAP by selectively increasing blood flow to skeletal muscle through a direct action on the central nervous system...
  10. ncbi request reprint Cardiorespiratory response patterns elicited by microinjections of neuropeptide Y in the nucleus tractus solitarius
    R A Barraco
    Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201
    Brain Res Bull 24:465-85. 1990
    ..On the other hand, vagotomy abolished the NPY-evoked bradycardia which had a similar magnitude in both intact and decerebrate rats.(ABSTRACT TRUNCATED AT 400 WORDS)..
  11. ncbi request reprint The effect of diabetes and sex on nitric oxide-mediated cardiovascular dynamics
    B Martinez-Nieves
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Exp Biol Med (Maywood) 226:37-42. 2001
    ..And the impaired constriction response of the renal vessels noted in female diabetic rats may provide a basis for the increased renal pathology observed in diabetic humans...
  12. ncbi request reprint Visceroendocrine responses elicited by neuropeptide Y in the nucleus tractus solitarius
    E Ergene
    Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201
    Brain Res Bull 32:461-5. 1993
    ..abstract truncated at 250 words)..
  13. ncbi request reprint GnRH and gonadotropin release is decreased in chronic nitric oxide deficiency
    M J Barnes
    Department of Physiology, Wayne State University School of Medicine, 540 East Canfield, Detroit, MI 48201, USA
    Exp Biol Med (Maywood) 226:701-6. 2001
    ..We concluded that chronic NO deficiency is associated with a decreased GnRH in neurosecretory terminals in the external capillary layer of the median eminence, accompanied by a decrease in LH and FSH release from the pituitaries...
  14. ncbi request reprint Expression of cAMP-responsive element modulator (CREM) in rat testes following chronic cocaine administration
    Haikun Li
    Department of Urology, Wayne State University, School of Medicine, Detroit, Michigan, USA
    J Environ Pathol Toxicol Oncol 22:111-6. 2003
    ..As a further step toward understanding this process, we have studied the role of CREM in cocaine-induced testicular damage...
  15. ncbi request reprint Alteration of humoral and peripheral vascular responses during graded exercise in heart failure
    R L Hammond
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Appl Physiol 90:55-61. 2001
    ..However, with heavier workloads, sympathoactivation begins at lower workloads and becomes progressively exaggerated at higher workloads, thus altering distribution of blood flow...
  16. ncbi request reprint Neuropeptide-Y stimulation of insulin secretion is mediated via the nucleus tractus solitarius
    J C Dunbar
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan
    Horm Metab Res 24:103-5. 1992
    ..We conclude that NPY can act directly on the NTS to increase circulating insulin levels. Thus, the NTS may be a major brainstem site that directly mediates the central action of NPY on nutrient homeostasis...
  17. ncbi request reprint Cigarette smoking induces apoptosis in rat testis
    Atul Rajpurkar
    Department of Urology, Wayne State University, School of Medicine, Detroit, Michigan, USA
    J Environ Pathol Toxicol Oncol 21:243-8. 2002
    ..In conclusion, chronic cigarette smoke induces apoptosis in the rat testis. Apoptosis may be one of the pathogenic mechanisms responsible for defective spermatogenesis in the rat following chronic cigarette smoking...
  18. ncbi request reprint Role of mitochondrial cytochrome c in cocaine-induced apoptosis in rat testes
    Haikun Li
    Department of Urology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Urology 61:646-50. 2003
    ..We also determined the caspase 3, caspase 8, and caspase 9 activities in rat testes after chronic cocaine exposure...
  19. ncbi request reprint Variable subcellular localization of a neuron-specific protein during NTera 2 differentiation into post-mitotic human neurons
    L Carlock
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Brain Res Mol Brain Res 42:202-12. 1996
    ....
  20. ncbi request reprint Effects of C-peptide on expression of eNOS and iNOS in human cavernosal smooth muscle cells
    Haikun Li
    Department of Urology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Urology 64:622-7. 2004
    ..It has been suggested that impairment of penile relaxation is related to a reduction of penile NOS. Plasma levels of C-peptide and insulin are decreased in individuals with type 1 diabetes and late-stage type 2 diabetes...
  21. ncbi request reprint High fat feeding is associated with increased blood pressure, sympathetic nerve activity and hypothalamic mu opioid receptors
    Maria J Barnes
    Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48201 1928, USA
    Brain Res Bull 61:511-9. 2003
    ..The increased mu opioid receptors may contribute to the higher MAP and RSNA observed in HF animals...
  22. ncbi request reprint A role for the central histaminergic system in the leptin-mediated increase in cardiovascular dynamics
    Sumangala P Rao
    Department of Physiology, 5374 Scott Hall, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201 1928, USA
    Brain Res Bull 64:425-32. 2005
    ..It appears that leptin directly or indirectly stimulates histaminergic neurons that lead to increased cardiovascular activity...
  23. ncbi request reprint The effect of global brain ischemia in normal and diabetic animals: the influence of calcium channel blockers
    Joseph Levy
    Department of Medicine, Wayne State University School of Medicine, Detroit, MI 48201 1928, USA
    Endocrine 25:91-5. 2004
    ..We conclude that the enhanced CNS damage following cerebral ischemia in diabetes is not correlated with ATP or lactate levels and may be mediated in part by increased glutamate. Calcium channel antagonist may augment this process...
  24. ncbi request reprint Cerebral ischemia induced apoptosis and necrosis in normal and diabetic rats
    Natalie N Rizk
    Department of Physiology, Wayne State University School of Medicine, 5374 Scott Hall, 540 E Canfield, Detroit, MI 48201 1928, USA
    Brain Res 1053:1-9. 2005
    ..Furthermore, restoration of blood flow did not decrease lesion volume in insulinopenic diabetic animals...
  25. ncbi request reprint The cardiovascular responses to mu opioid agonist and antagonist in conscious normal and obese rats
    Crystal Hill-Pryor
    Wayne State University School of Medicine, Department of Physiology, 5374 Scott Hall, 540 E Canfield, Detroit, MI 48201 1928, USA
    Peptides 27:1520-6. 2006
    ..The expression of mu opioid receptors was increased in obese rats. We conclude that the mu opioids can stimulate cardiovascular responses, but the excitatory responsiveness was not increased in conscious obese rats...
  26. ncbi request reprint The effect of high fat-induced obesity on cardiovascular and physical activity and opioid responsiveness in conscious rats
    Crystal Hill-Pryor
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Exp Hypertens 28:133-45. 2006
    ..We concluded that HF rats consumed more calories, gained more weight, and had higher SBP. However, the responsiveness to the mu-receptor agonist was not higher in the HF rats...
  27. ncbi request reprint Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide
    Natalie N Rizk
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 1928, USA
    Brain Res 1096:204-12. 2006
    ..Maintenance insulin concentrations with or without C-peptide were without effect...
  28. ncbi request reprint The effect of CNS opioid on autonomic nervous and cardiovascular responses in diet-induced obese rats
    Maria J Barnes
    Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48201 1928, USA
    Peptides 25:71-9. 2004
    ..Additionally there is a decreased kappa responsiveness and tone in the HF rats. Both these changes, increased mu and decreased kappa responsiveness could strongly contribute to the increased blood pressure in obese animals...
  29. ncbi request reprint Insulin-mediated increase in sympathetic nerve activity is attenuated by C-peptide in diabetic rats
    Natalie Rizk
    Department of Physiology, Wayne State University School of Medicine Detroit, Michigan 48201, USA
    Exp Biol Med (Maywood) 229:80-4. 2004
    ..We concluded that the C-peptides play a role in modulating the insulin-stimulated sympathetic nerve response...
  30. ncbi request reprint Cardiovascular responses to central administration of mu and kappa opioid receptor agonist and antagonist in normal rats
    Sumangala P Rao
    Department of Physiology, 5374 Scott Hall, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201 1928, USA
    Peptides 24:745-54. 2003
    ..We conclude that mu receptor activation decrease or increase MAP depending on the mu agonist concentration. However, kappa receptor activation is consistently associated with a decrease in MAP...
  31. ncbi request reprint Insulin mediated hemodynamic responses in spontaneous hypertensive rats (SHRs): effect of chromosome 4 gene transfer
    Sumangala P Rao
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201 1928, USA
    Clin Exp Hypertens 25:131-42. 2003
    ..These findings indicate that transfer of segment of chromosome 4 from Brown Norway rats onto spontaneous hypertensive background eliminates hyperinsulinemia and pressor effects of insulin...
  32. ncbi request reprint Cardiovascular action of insulin-like growth factor-1 is not mediated by calcitonin gene-related peptide neurons
    Crystal R McRae
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 1928, USA
    Endocrine 19:163-7. 2002
    ..We concluded that unlike insulin the IGF-1-mediated vasodilatory response is not mediated by the CGRP-dependent perivascular neurons...
  33. ncbi request reprint The effects of beta-endorphin (beta-END) on cardiovascular and behavioral dynamics in conscious rats
    Crystal Hill
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 1928, USA
    Brain Res Bull 59:29-34. 2002
    ....
  34. ncbi request reprint Chronic nitric oxide deficiency is associated with altered leutinizing hormone and follicle-stimulating hormone release in ovariectomized rats
    Maria J Barnes
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Exp Biol Med (Maywood) 227:817-22. 2002
    ..We conclude that NO has a chronic stimulatory effect on LH and FSH release and the subsequent altered secretory responsiveness to NO agonist or antagonist is the result of chronic NO suppression...
  35. ncbi request reprint The effects of acute and chronic alpha melanocyte stimulating hormone (alphaMSH) on cardiovascular dynamics in conscious rats
    Crystal Hill
    Department of Physiology, Wayne State University School of Medicine, 5374 Scott Hall, 540 E Canfield, Detroit, MI 48201 1928, USA
    Peptides 23:1625-30. 2002
    ..We conclude that in the conscious unrestrained animal the acute administration of alphaMSH increased MAP and HR, however, chronic infusion is associated with decreased MAP, physical activity and food intake...
  36. ncbi request reprint The insulin-mediated vascular and blood pressure responses are suppressed in CGRP-deficient normal and diabetic rats
    Nahla Salem
    Department of Physiology, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201 1928, USA
    Diabetes Metab Res Rev 18:238-44. 2002
    ..CGRP is a potent vasodilator and its release is associated with dilation of these blood vessels. The present study investigated the contribution of the CGRP-mediated vasodilation to the insulin-induced vasodilatory response...
  37. ncbi request reprint Insulin like growth factor-1 (IGF-1) decreases ischemia-reperfusion induced apoptosis and necrosis in diabetic rats
    Natalie N Rizk
    Department of Physiology, Wayne State University School of Medicine, 5374 Scott Hall, 540 E Canfield, Detroit, MI 48201 1928, USA
    Endocrine 31:66-71. 2007
    ..We conclude that treatment with IGF-1 before or after ischemic insult significantly decreases both lesion volume and apoptosis in selected areas of the cortex and hippocampus...

Research Grants4

  1. COR HONORS HIGH SCHOOL RESEARCH EDUCATION
    Joseph Dunbar; Fiscal Year: 2005
    ..abstract_text> ..
  2. IMSD PROGRAM AT WAYNE STATE UNIVERSITY
    Joseph Dunbar; Fiscal Year: 2007
    ..The IMSD program has served as a base for recruitment, career development and support for department-based research and training programs. Our undergraduate and graduate components will continue to be successful. ..