QING PING DOU

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Evaluation of proteasome-inhibitory and apoptosis-inducing potencies of novel (-)-EGCG analogs and their prodrugs
    Kristin R Landis-Piwowar
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Int J Mol Med 15:735-42. 2005
  2. pmc Prodrugs of Fluoro-Substituted Benzoates of EGC as Tumor Cellular Proteasome Inhibitors and Apoptosis Inducers
    Zhiyong Yu
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan, USA
    Int J Mol Sci 9:951-61. 2008
  3. pmc Sensitizing human multiple myeloma cells to the proteasome inhibitor bortezomib by novel curcumin analogs
    Taskeen Mujtaba
    Barbara Ann Karmanos Cancer Institute, Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201 2013, USA
    Int J Mol Med 29:102-6. 2012
  4. pmc Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis
    Vino T Cheriyan
    Department of Oncology, Wayne State University, Detroit, Michigan, United States of America John D Dingell VA Medical Center, Detroit, Michigan, United States of America
    PLoS ONE 9:e93711. 2014
  5. pmc Activation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo
    Di Chen
    Department of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, United States of America
    PLoS ONE 7:e47186. 2012
  6. pmc Withaferin A inhibits the proteasome activity in mesothelioma in vitro and in vivo
    Huanjie Yang
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 7:e41214. 2012
  7. pmc From bortezomib to other inhibitors of the proteasome and beyond
    Daniela Buac
    Department of Oncology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R Street Hudson Webber Cancer Research Center Room 540 1, Detroit Michigan 48201 USA
    Curr Pharm Des 19:4025-38. 2013
  8. pmc Targeting tumor ubiquitin-proteasome pathway with polyphenols for chemosensitization
    Min Shen
    Karmanos Cancer Institute, Wayne State University, 540 1 HWCRC, 4100 John R Road, Detroit, MI 48201, USA
    Anticancer Agents Med Chem 12:891-901. 2012
  9. pmc Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells
    Daniela Buac
    Departments of Oncology, Pharmacology and Pathology, and Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R Street Hudson Webber Cancer Research Center Room 516, Detroit, MI 48201, USA
    Mini Rev Med Chem 12:1193-201. 2012
  10. pmc Black tea polyphenols inhibit tumor proteasome activity
    Taskeen Mujtaba
    the Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute and Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201 2013, USA
    In Vivo 26:197-202. 2012

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Evaluation of proteasome-inhibitory and apoptosis-inducing potencies of novel (-)-EGCG analogs and their prodrugs
    Kristin R Landis-Piwowar
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Int J Mol Med 15:735-42. 2005
    ..These data suggest that the B-ring/D-ring peracetate-protected EGCG analogs have great potential to be developed into novel anti-cancer and cancer-preventive agents...
  2. pmc Prodrugs of Fluoro-Substituted Benzoates of EGC as Tumor Cellular Proteasome Inhibitors and Apoptosis Inducers
    Zhiyong Yu
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan, USA
    Int J Mol Sci 9:951-61. 2008
    ....
  3. pmc Sensitizing human multiple myeloma cells to the proteasome inhibitor bortezomib by novel curcumin analogs
    Taskeen Mujtaba
    Barbara Ann Karmanos Cancer Institute, Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201 2013, USA
    Int J Mol Med 29:102-6. 2012
    ..These findings justify further investigation into those combinations that may yield potential therapeutic benefit...
  4. pmc Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis
    Vino T Cheriyan
    Department of Oncology, Wayne State University, Detroit, Michigan, United States of America John D Dingell VA Medical Center, Detroit, Michigan, United States of America
    PLoS ONE 9:e93711. 2014
    ..Post-translational modification of podoplanin and cleavage of vimentin by DSF-Cu underscore a metastasis inhibitory property of this agent and together with our in vivo studies underscore its potential as an anti-MPM agent. ..
  5. pmc Activation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo
    Di Chen
    Department of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, United States of America
    PLoS ONE 7:e47186. 2012
    ..These results suggest that B-DIM could be used as a potential anti-cancer agent in the clinic for prevention and/or treatment of prostate cancer regardless of androgen responsiveness, although functional AR may be required...
  6. pmc Withaferin A inhibits the proteasome activity in mesothelioma in vitro and in vivo
    Huanjie Yang
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 7:e41214. 2012
    ..Together our in vitro and in vivo studies suggest that WA suppresses MPM growth by targeting multiple pathways that include blockage of proteasome activity and stimulation of apoptosis, and thus holds promise as an anti-MPM agent...
  7. pmc From bortezomib to other inhibitors of the proteasome and beyond
    Daniela Buac
    Department of Oncology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R Street Hudson Webber Cancer Research Center Room 540 1, Detroit Michigan 48201 USA
    Curr Pharm Des 19:4025-38. 2013
    ..Other proteasome inhibitors currently in clinical trials and those that are currently experimental grade will also be discussed...
  8. pmc Targeting tumor ubiquitin-proteasome pathway with polyphenols for chemosensitization
    Min Shen
    Karmanos Cancer Institute, Wayne State University, 540 1 HWCRC, 4100 John R Road, Detroit, MI 48201, USA
    Anticancer Agents Med Chem 12:891-901. 2012
    ..In-depth mechanistic studies and identification of optimal regimen are needed in order to eventually translate this laboratory concept into clinical trials to actually benefit current chemotherapy...
  9. pmc Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells
    Daniela Buac
    Departments of Oncology, Pharmacology and Pathology, and Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R Street Hudson Webber Cancer Research Center Room 516, Detroit, MI 48201, USA
    Mini Rev Med Chem 12:1193-201. 2012
    ..Here we discuss the origins, mechanism, and evolution of dithiocarbamates as potent proteasome inhibitors and therefore anti-cancer agents...
  10. pmc Black tea polyphenols inhibit tumor proteasome activity
    Taskeen Mujtaba
    the Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute and Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201 2013, USA
    In Vivo 26:197-202. 2012
    ....
  11. pmc Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts
    Di Chen
    The Prevention Program, Barbara Ann Karmanos Cancer Institute and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201 2013, USA
    Breast Cancer Res 9:R80. 2007
    ..Whether apigenin has proteasome-inhibitory activity in the highly metastatic human breast MDA-MB-231 cells and xenografts,however, is unknown...
  12. pmc Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells
    Kenyon G Daniel
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan, USA
    Breast Cancer Res 7:R897-908. 2005
    ..Tetrathiomolybdate (TM), a strong copper chelator currently being tested in clinical trials, is used as a comparison...
  13. pmc Green tea polyphenols as a natural tumour cell proteasome inhibitor
    Q P Dou
    The Prevention Program, Barbara Ann Karmanos Cancer Institute and Department of Pathology, School of Medicine, Wayne State University, 540 1 HWCRC, 4100 John R Rd, Detroit, Michigan 48201, USA
    Inflammopharmacology 16:208-12. 2008
    ....
  14. pmc Molecular mechanisms of green tea polyphenols
    Q Ping Dou
    Barbara Ann Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Nutr Cancer 61:827-35. 2009
    ....
  15. ncbi request reprint Lessons learned from Art Pardee in cell cycle, science, and life
    Q Ping Dou
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, 4100 John R Road, Detroit, MI 48201, USA
    J Cell Physiol 209:663-9. 2006
    ..Finally, I have discussed the potential use of these proteasome inhibitors in cancer prevention and treatment...
  16. ncbi request reprint Targeting the ubiquitin-proteasome pathway: an emerging concept in cancer therapy
    Michael Frezza
    the Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA
    Curr Top Med Chem 11:2888-905. 2011
    ..The clinical significance of targeting the tumor survival-associated proteasome pathway for cancer treatment, intervention and prevention will be discussed...
  17. pmc Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives
    D Chen
    the Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, and Department of Oncology, School of Medicine, Wayne State University, Detroit, Michigan, USA
    Curr Cancer Drug Targets 11:239-53. 2011
    ....
  18. ncbi request reprint Methylation suppresses the proteasome-inhibitory function of green tea polyphenols
    Kristin R Landis-Piwowar
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan, USA
    J Cell Physiol 213:252-60. 2007
    ..Therefore, methylation on GTPs, under physiological conditions, could decrease their proteasome-inhibitory activity, contributing to decreased cancer-preventive effects of tea consumption...
  19. pmc Inhibition of catechol-Omicron-methyltransferase activity in human breast cancer cells enhances the biological effect of the green tea polyphenol (-)-EGCG
    Kristin Landis-Piwowar
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Oncol Rep 24:563-9. 2010
    ....
  20. pmc Molecular study on copper-mediated tumor proteasome inhibition and cell death
    Yan Xiao
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Int J Oncol 37:81-7. 2010
    ....
  21. ncbi request reprint Evaluation of copper-dependent proteasome-inhibitory and apoptosis-inducing activities of novel pyrrolidine dithiocarbamate analogues
    Zhiyong Yu
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201 2013, USA
    Int J Mol Med 20:919-25. 2007
    ..Our data further support the novel concept of using accumulated copper in human cancer cells as a selective approach for chemotherapy...
  22. ncbi request reprint Synthetic peracetate tea polyphenols as potent proteasome inhibitors and apoptosis inducers in human cancer cells
    Deborah Kuhn
    The Prevention Program, Barbara Ann Karmanos Cancer Institute and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Front Biosci 10:1010-23. 2005
    ..Identification of the cytosolic metabolite(s) of peracetate-protected polyphenols in cultured tumor cells and examination of their in vivo tumor growth-inhibitory activity are currently underway in our laboratory...
  23. ncbi request reprint Methylation of green tea polyphenols affects their binding to and inhibitory poses of the proteasome beta5 subunit
    Kenyon G Daniel
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, MI 448201, USA
    Int J Mol Med 18:625-32. 2006
    ....
  24. ncbi request reprint Copper-binding compounds as proteasome inhibitors and apoptosis inducers in human cancer
    Kenyon G Daniel
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Front Biosci 12:135-44. 2007
    ..This strategy would convert tumor cellular copper into a potent, specific proteasome inhibitor and apoptosis inducer. Thus, this approach could pave the way for the development of nontoxic anticancer therapy...
  25. ncbi request reprint Green tea and tea polyphenols in cancer prevention
    Di Chen
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Front Biosci 9:2618-31. 2004
    ..At this time, more mechanistic research, animal studies, and clinical trials are necessary to further evaluate the role of green tea in cancer prevention...
  26. ncbi request reprint Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells
    Di Chen
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Front Biosci 12:1935-45. 2007
    ..This finding may provide a molecular basis for the clinically observed cancer-preventive effects of fruits and vegetables...
  27. pmc Metals in anticancer therapy: copper(II) complexes as inhibitors of the 20S proteasome
    Sarmad Sahiel Hindo
    Department of Chemistry, Wayne State University, Detroit, MI 48202, USA
    Eur J Med Chem 44:4353-61. 2009
    ....
  28. pmc Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity
    Vesna Milacic
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan, USA
    Toxicol Appl Pharmacol 231:24-33. 2008
    ....
  29. pmc Relationship between the methylation status of dietary flavonoids and their growth-inhibitory and apoptosis-inducing activities in human cancer cells
    Kristin R Landis-Piwowar
    Barbara Ann Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    J Cell Biochem 105:514-23. 2008
    ..We conclude that methylated flavonoids lack potent cytotoxicity against human leukemia cells and most likely have limited ability as chemopreventive agents...
  30. ncbi request reprint Inhibition of proteasome activity by various fruits and vegetables is associated with cancer cell death
    Marina S Chen
    The Prevention Program, Barbara Ann Karmanos Cancer Institute and Department of Pathology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    In Vivo 18:73-80. 2004
    ....
  31. pmc Recent advances on tea polyphenols
    Jyoti Kanwar
    the Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, and Department of Oncology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Front Biosci (Elite Ed) 4:111-31. 2012
    ..Herein, we describe the various mechanisms of action of EGCG and also discuss previous and current ongoing clinical trials of EGCG and green tea polyphenols in different cancer types...
  32. pmc Induction of tumor cell apoptosis by a novel class of N-thiolated beta-lactam antibiotics with structural modifications at N1 and C3 of the lactam ring
    Michael Frezza
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Int J Mol Med 21:689-95. 2008
    ..Our results strongly warrant further investigation into these novel beta-lactams as potential anti-cancer therapeutics...
  33. ncbi request reprint Metal complexes, their cellular targets and potential for cancer therapy
    Di Chen
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Curr Pharm Des 15:777-91. 2009
    ..This review provides a comprehensive overview of various non platinum metal complexes and metal-chelating compounds and discusses their potential molecular targets in tumor cells and their applications in cancer therapy...
  34. ncbi request reprint Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts
    Di Chen
    Barbara Ann Karmanos Cancer Institute and Department of Pathology, School of Medicine, Wayne State University, 4100 John R Road, Detroit, MI 48201, USA
    Cancer Res 67:1636-44. 2007
    ....
  35. ncbi request reprint Sodium diethyldithiocarbamate, an AIDS progression inhibitor and a copper-binding compound, has proteasome-inhibitory and apoptosis-inducing activities in cancer cells
    Haiyan Pang
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Int J Mol Med 19:809-16. 2007
    ..Our data support the concept of using accumulated copper in cancer cells and tissues as a novel target for chemotherapy. This study provides a mechanistic interpretation for utilization of copper chelators in cancer treatment...
  36. pmc Comparative activities of nickel(II) and zinc(II) complexes of asymmetric [NN'O] ligands as 26S proteasome inhibitors
    Michael Frezza
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Inorg Chem 48:5928-37. 2009
    ..Our results present a compelling rationale for 2 along with its gallium(III) and copper(II) congeners to be further investigated as potential anticancer drugs that act as proteasome inhibitiors...
  37. pmc Inhibition of tumor proteasome activity by gold-dithiocarbamato complexes via both redox-dependent and -independent processes
    Xia Zhang
    The Prevention Program, Department of Pathology, Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan
    J Cell Biochem 109:162-72. 2010
    ..Our study provides strong evidence that the cellular proteasome is an important target of both gold(I) and gold(III)-dithiocarbamates, but distinct cellular mechanisms of action are responsible for their different overall effect...
  38. pmc Novel 8-hydroxylquinoline analogs induce copper-dependent proteasome inhibition and cell death in human breast cancer cells
    Vesna Milacic
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201 2013, USA
    Int J Oncol 35:1481-91. 2009
    ....
  39. pmc Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells
    Andrew Davenport
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA
    Int J Mol Med 25:465-70. 2010
    ..Taken together, our findings present a compelling rationale for the development of combination strategies using natural products in the treatment of hematological malignancies...
  40. pmc New uses for old copper-binding drugs: converting the pro-angiogenic copper to a specific cancer cell death inducer
    Di Chen
    Wayne State University, The Prevention Program, Barbara Ann Karmanos Cancer Institute, Department of Pathology, School of Medicine, Detroit, Michigan, USA
    Expert Opin Ther Targets 12:739-48. 2008
    ..The conventional approach toward anticancer drug development is a time-consuming and expensive procedure...
  41. pmc Targeting tumor proteasome with traditional Chinese medicine
    Huanjie Yang
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Curr Drug Discov Technol 7:46-53. 2010
    ..This short review focuses mainly on the TCMs that potentially target the tumor cellular proteasome and NF-kappaB pathway whose activation is dependent on the proteasome activity...
  42. ncbi request reprint A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent
    Kristin R Landis-Piwowar
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 67:4303-10. 2007
    ....
  43. ncbi request reprint Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells
    Di Chen
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, 640 HWCRC, 4100 John R, Detroit, MI 48201, USA
    Biochem Pharmacol 69:1421-32. 2005
    ..Our results suggested that the proteasome may be a target of these dietary flavonoids in human tumor cells and that inhibition of the proteasome by flavonoids may be one of the mechanisms responsible for their cancer-preventive effects...
  44. pmc Targeted proteasome inhibition by Velcade induces apoptosis in human mesothelioma and breast cancer cell lines
    Ying Wang
    John D Dingell VA Medical Center, Karmanos Cancer Institute, Wayne State University, VAMC, 4646 John R, Detroit, MI, 48201, USA
    Cancer Chemother Pharmacol 66:455-66. 2010
    ..Although proteasome inhibitor Velcade (Bortezomib) has been under clinical investigation for a number of cancers, limited preclinical studies with this agent have thus far been conducted in HBC and MPM malignancies...
  45. ncbi request reprint Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis
    Di Chen
    Barbara Ann Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Front Biosci 10:2932-9. 2005
    ....
  46. ncbi request reprint A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts
    Vesna Milacic
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 66:10478-86. 2006
    ..Our findings reveal the proteasome as a primary target for gold(III) dithiocarbamates and support the idea for their potential use as anticancer therapeutics...
  47. pmc New applications of old metal-binding drugs in the treatment of human cancer
    Sara M Schmitt
    Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Front Biosci (Schol Ed) 4:375-91. 2012
    ..In vitro and in vivo experimental evidence along with mechanisms of action (e.g., via targeting the tumor proteasome) will also be discussed with anticipation of strengthening this exciting new concept...
  48. pmc Disulfiram treatment facilitates phosphoinositide 3-kinase inhibition in human breast cancer cells in vitro and in vivo
    Haijun Zhang
    Department of Pathology and Biostatistics Core, Barbara Ann Karmanos Cancer Institute, Department of Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 70:3996-4004. 2010
    ..Our study also suggests that the combination of DSF and a PI3K inhibitor may offer a new combinational treatment model for breast cancer, particularly for those with PIK3CA mutations...
  49. pmc Cell cycle-dependent effects of 3,3'-diindolylmethane on proliferation and apoptosis of prostate cancer cells
    Kannagi Chinnakannu
    Vattikuti Urology Institute, Henry Ford Health System, Detroit, Michigan, USA
    J Cell Physiol 219:94-9. 2009
    ..These results suggest that B-DIM could be a potent agent for the prevention and/or treatment of both hormone sensitive as well as hormone-refractory prostate cancer...
  50. ncbi request reprint Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells
    Shreelekha Adsule
    The Prevention Program and Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, 9374 Scott Hall, 540 East Canfield Avenue, Detroit, Michigan 48201, USA
    J Med Chem 49:7242-6. 2006
    ..2 microM, respectively) compared to clioquinol and pyrrolidine dithiocarbamate (IC50 of 10 and 20 microM), supporting the novelty of 2...
  51. ncbi request reprint Copper storage diseases: Menkes, Wilsons, and cancer
    Kenyon G Daniel
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan, USA
    Front Biosci 9:2652-62. 2004
    ..This review will examine the chemical nature and biological roles of copper, Wilsons and Menkes disease and their therapies, and the use of copper related therapies in cancer...
  52. ncbi request reprint Beta-lactams and their potential use as novel anticancer chemotherapeutics drugs
    Deborah Kuhn
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan, USA
    Front Biosci 9:2605-17. 2004
    ..These data indicate that synthesis and evaluation of beta-lactams are a promising area for further development in anticancer research...
  53. pmc Antitumor activity of novel fluoro-substituted (-)-epigallocatechin-3-gallate analogs
    Huanjie Yang
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI, USA
    Cancer Lett 292:48-53. 2010
    ....
  54. pmc Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo
    Huanjie Yang
    Department of Pathophysiology, Guangzhou Medical College, Guangzhou, Guangdong, People s Republic of China
    Int J Cancer 124:2450-9. 2009
    ..Our results indicate that the tumor proteasome is one of the cellular targets of shikonin and inhibition of the proteasome activity by shikonin contributes to its antitumor property...
  55. ncbi request reprint Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity
    Di Chen
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 66:10425-33. 2006
    ..Our study shows that inhibition of the proteasomal activity can be achieved by targeting tumor cellular copper with the nontoxic compound DSF, resulting in selective apoptosis induction within tumor cells...
  56. ncbi request reprint The proteasome as a potential target for novel anticancer drugs and chemosensitizers
    Kristin R Landis-Piwowar
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201 2013, USA
    Drug Resist Updat 9:263-73. 2006
    ..Further studies on natural proteasome inhibitors as chemo-sensitizers could lead to identification of more potent and less toxic compounds that could be used in combination therapies for drug-resistant tumors...
  57. ncbi request reprint Pristimerin induces apoptosis by targeting the proteasome in prostate cancer cells
    Huanjie Yang
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan, USA
    J Cell Biochem 103:234-44. 2008
    ....
  58. ncbi request reprint The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from "Indian winter cherry"
    Huanjie Yang
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, 640 1 HWCRC, 4100 John R Road, Detroit, MI 48201, USA
    Mol Pharmacol 71:426-37. 2007
    ....
  59. ncbi request reprint Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells
    Yiwei Li
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 282:21542-50. 2007
    ..Therefore, B-DIM could be a promising non-toxic agent for possible treatment of hormone-sensitive but most importantly hormone-refractory prostate cancers...
  60. ncbi request reprint Chemotherapeutic inhibitors in the treatment of prostate cancer
    Rahul R Deshmukh
    Wayne State University, Karmanos Cancer Institute, School of Medicine, Department of Pathology, 540 1 HWCRC, 4100 John R Road, Detroit, MI 48201, USA
    Expert Opin Pharmacother 15:11-22. 2014
    ....
  61. ncbi request reprint Anti-angiogenic and anti-tumor properties of proteasome inhibitors
    Kenyon G Daniel
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Curr Cancer Drug Targets 5:529-41. 2005
    ..Furthermore, proteasome inhibitors, both natural and synthetic, and their anti-angiogenic effects as well as future approaches to anti-angiogenic chemotherapies are also discussed...
  62. ncbi request reprint Maspin augments proteasome inhibitor-induced apoptosis in prostate cancer cells
    Xiaohua Li
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Physiol 212:298-306. 2007
    ..Our results suggest that gene therapy involving ectopic maspin expression may dramatically improve the efficacy of proteasome inhibitors for the treatment of prostate cancer...
  63. pmc Clinical development of novel proteasome inhibitors for cancer treatment
    Huanjie Yang
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and the Department of Pathology, School of Medicine, Wayne State University, 540 1 HWCRC, 4100 John R Road, Detroit, Michigan 48201, USA
    Expert Opin Investig Drugs 18:957-71. 2009
    ..Emerging evidence demonstrates that targeting the tumor proteasome is a promising strategy for cancer therapy...
  64. ncbi request reprint Apoptotic-inducing activity of novel polycyclic aromatic compounds in human leukemic cells
    Kristin R Landis-Piwowar
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Int J Mol Med 17:931-5. 2006
    ..Importantly, no effect was demonstrated in a normal, non-transformed line of human natural killer cells. These results provide additional evidence for the potential chemotherapeutic use of PAH...
  65. pmc Disulfiram promotes the conversion of carcinogenic cadmium to a proteasome inhibitor with pro-apoptotic activity in human cancer cells
    Lihua Li
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Toxicol Appl Pharmacol 229:206-14. 2008
    ..Our work suggests the potential use of DSF for treatment of cells with accumulated levels of carcinogen Cd...
  66. pmc Computational modeling of the potential interactions of the proteasome beta5 subunit and catechol-O-methyltransferase-resistant EGCG analogs
    Jyoti Kanwar
    The Prevention Program, Barbara Ann Karmanos Cancer Institute and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Int J Mol Med 26:209-15. 2010
    ..The absence of a second gallate group in structure 16 and 21 significantly decreases the ability to inhibit the proteasome...
  67. ncbi request reprint Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
    Huanjie Yang
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 66:4758-65. 2006
    ..Our results show that Celastrol is a natural proteasome inhibitor that has a great potential for cancer prevention and treatment...
  68. ncbi request reprint Inhibition of the proteasome activity by gallium(III) complexes contributes to their anti prostate tumor effects
    Di Chen
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 67:9258-65. 2007
    ..Our results strongly suggest that gallium complexes, acting as potent proteasome inhibitors, have a great potential to be developed into novel anticancer drugs...
  69. ncbi request reprint Regulatory processes affecting androgen receptor expression, stability, and function: potential targets to treat hormone-refractory prostate cancer
    G Prem Veer Reddy
    Vattikuti Urology Institute, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Cell Biochem 98:1408-23. 2006
    ....
  70. pmc Anti-tumor activity of N-thiolated beta-lactam antibiotics
    Di Chen
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, 540 1 HWCRC, 4100 John R Road, Detroit, MI 48201, USA
    Cancer Lett 268:63-9. 2008
    ..These results suggest that the synthetic antibiotic N-thiolated beta-lactams hold great potential to be developed as novel anti-cancer drugs...
  71. pmc Inhibition of tumor cellular proteasome activity by triptolide extracted from the Chinese medicinal plant 'thunder god vine'
    Li Lu
    Department of Pathophysiology, Guangzhou Medical University, Guangzhou, Guangdong 510082, China
    Anticancer Res 31:1-10. 2011
    ..The ubiquitin/proteasome system is an important pathway of protein degradation in cells. This study investigated whether triptolide may inhibit proteasomal activity and induce apoptosis in human cancer cells...
  72. pmc Green tea polyphenols as proteasome inhibitors: implication in chemoprevention
    H Yang
    the Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, and Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Curr Cancer Drug Targets 11:296-306. 2011
    ..This risk reduction may be attributed not only to proteasome inhibition, but also to numerous other intracellular molecules targeted by EGCG that are involved in cell cycle regulation, apoptosis, angiogenesis, and metastasis...
  73. pmc Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance
    Ayman Khdair
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
    J Control Release 141:137-44. 2010
    ..These data suggest that nanoparticle-mediated combination chemotherapy and photodynamic therapy using doxorubicin and methylene blue has significant therapeutic potential against drug-resistant tumors...
  74. pmc Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer
    Huanjie Yang
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Oncology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Curr Drug Targets 11:733-44. 2010
    ..The efficacy of these terpenoids against breast or prostate cancer cells, as demonstrated in pre-clinical studies support clinical application of these naturally occurring terpenoids in treatment of hormone-related human cancers...
  75. pmc Calpain-mediated androgen receptor breakdown in apoptotic prostate cancer cells
    Huanjie Yang
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    J Cell Physiol 217:569-76. 2008
    ..Taken together, these results demonstrate calpain involvement in proteasome inhibitor-induced AR breakdown, and suggest that AR degradation is intrinsic to the induction of apoptosis in prostate cancer cells...
  76. ncbi request reprint Calmodulin-androgen receptor (AR) interaction: calcium-dependent, calpain-mediated breakdown of AR in LNCaP prostate cancer cells
    Ronald P Pelley
    Vattikuti Urology Institute and Department of Dermatology, Henry Ford Hospital, Detroit, MI 48202, USA
    Cancer Res 66:11754-62. 2006
    ..Taken together, these observations suggest potential involvement of AR-bound CaM in calcium-controlled, calpain-mediated breakdown of AR in prostate cancer cells...
  77. ncbi request reprint Polyphenols: biological activities, molecular targets, and the effect of methylation
    K R Landis-Piwowar
    Barbara Ann Karmanos Cancer Institute and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201 2013, USA
    Curr Mol Pharmacol 1:233-43. 2008
    ..Finally, the future of polyphenols in both cancer prevention and cancer intervention will be addressed...
  78. ncbi request reprint The role of interleukin-2 receptor alpha in cancer
    Deborah J Kuhn
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Front Biosci 10:1462-74. 2005
    ..This review details the current known functions of IL-2Ralpha in cancer cells and some of the therapies used to combat IL-2Ralpha-mediated cell signaling...
  79. ncbi request reprint Direct inhibition of interleukin-2 receptor alpha-mediated signaling pathway induces G1 arrest and apoptosis in human head-and-neck cancer cells
    Deborah J Kuhn
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    J Cell Biochem 95:379-90. 2005
    ..These results indicate that daclizumab inhibits the proliferative potential of IL-2Ralpha(+) cells via inhibition of cell cycle progression and induction of apoptosis...
  80. pmc Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo
    Vesna Milacic
    Barbara Ann Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 68:7283-92. 2008
    ....
  81. pmc Ni(II), Cu(II), and Zn(II) diethyldithiocarbamate complexes show various activities against the proteasome in breast cancer cells
    Boris Cvek
    Department of Medical Chemistry and Biochemistry, Department of Cell Biology and Genetics, Palacky University, Olomouc 77515, Czech Republic
    J Med Chem 51:6256-8. 2008
    ..One of the possible explanations is inhibition of JAMM domain in the 19S proteasome lid...
  82. ncbi request reprint Study of the green tea polyphenols catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) as proteasome inhibitors
    Sheng Biao Wan
    Department of Applied Biology and Chemical Technology and the Open Laboratory of Chirotechnology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, SAR, China
    Bioorg Med Chem 12:3521-7. 2004
    ..Their potencies to inhibit the proteasome activity were measured. The unnatural enantiomers were found to be equally potent to the natural compounds...
  83. ncbi request reprint Structure-activity relationships of synthetic analogs of (-)-epigallocatechin-3-gallate as proteasome inhibitors
    Aslamuzzaman Kazi
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Anticancer Res 24:943-54. 2004
    ..We previously showed that (-)-EGCG is a potent and specific inhibitor of the proteasomal chymotrypsin-like activity in vitro and in vivo...
  84. ncbi request reprint Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells
    Kenyon G Daniel
    Drug Discovery Program, Departments of Biochemistry and Molecular Biology and Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, College of Medicine, University of South Florida, Tampa, FL, USA
    Biochem Pharmacol 67:1139-51. 2004
    ..Our results suggest that certain types of organic ligands could bind to tumor cellular copper, forming potent proteasome inhibitors and apoptosis inducers at copper concentrations found in tumor tissues...
  85. ncbi request reprint Docking studies and model development of tea polyphenol proteasome inhibitors: applications to rational drug design
    David M Smith
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, and Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, Florida, USA
    Proteins 54:58-70. 2004
    ..This model is validated by comparison of predicted and actual activities of several EGCG analogs, either naturally occurring, previously synthesized, or rationally synthesized...
  86. ncbi request reprint Interruption of tumor cell cycle progression through proteasome inhibition: implications for cancer therapy
    Q Ping Dou
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Departments of Interdisciplinary Oncology and Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Prog Cell Cycle Res 5:441-6. 2003
    ..Both in vitro and in vivo experimental and clinical results have demonstrated the potential use of proteasome inhibitors as novel anticancer drugs...
  87. ncbi request reprint Potential molecular targets of tea polyphenols in human tumor cells: significance in cancer prevention
    Aslamuzzaman Kazi
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Departments of Interdisciplinary Oncology and Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    In Vivo 16:397-403. 2002
    ..However, by understanding the in vivo concentrations of tea polyphenols required to inhibit each of these activities, we may start to sort out in the future the mechanisms responsible for the cancer-preventive effects of tea...
  88. ncbi request reprint Inhibition of bcl-x(l) phosphorylation by tea polyphenols or epigallocatechin-3-gallate is associated with prostate cancer cell apoptosis
    Aslamuzzaman Kazi
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    Mol Pharmacol 62:765-71. 2002
    ..Studies using specific inhibitors suggest that tea inhibits p38 mitogen-activated protein kinase and the proteasome activities, leading to inhibition of Bcl-X(L) phosphorylation and induction of prostate cancer cell death...
  89. ncbi request reprint A potential prodrug for a green tea polyphenol proteasome inhibitor: evaluation of the peracetate ester of (-)-epigallocatechin gallate [(-)-EGCG]
    Wai Har Lam
    Department of Applied Biology and Chemical Technology and the Open Laboratory for Chiral Technology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hong Kong SAR, China
    Bioorg Med Chem 12:5587-93. 2004
    ..Inhibition of cellular proteasome activity by 1 is associated with induction of cell death. Therefore, our results indicate that the protected analog 1 may function as a prodrug of the green tea polyphenol proteasome inhibitor (-)-EGCG...
  90. ncbi request reprint Structure-activity study of epi-gallocatechin gallate (EGCG) analogs as proteasome inhibitors
    Sheng Biao Wan
    Department of Applied Biology and Chemical Technology and the Open Laboratory of Chirotechnology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, SAR, China
    Bioorg Med Chem 13:2177-85. 2005
    ..It was found that in B ring, a decrease in the number of OH groups led to decreased potency. Introduction of a hydrophobic benzyl group into the 8 position of A ring did not significantly affect the proteasome-inhibitory potency...
  91. doi request reprint Chemical and biological profiles of novel copper(II) complexes containing S-donor ligands for the treatment of cancer
    Lorena Giovagnini
    Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy
    Inorg Chem 47:6336-43. 2008
    ..The results show that cytotoxicity levels of all of the tested complexes are comparable or even greater than that of the reference drug (cisplatin)...
  92. pmc Synthetic analogs of green tea polyphenols as proteasome inhibitors
    David M Smith
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Departments of Interdisciplinary Oncology and Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, FL 33612 9497, USA
    Mol Med 8:382-92. 2002
    ..Our interest in designing and developing novel synthetic GTPs as proteasome inhibitors and potential cancer-preventive agents prompted our current study...
  93. pmc A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducer
    Kumi Osanai
    Department of Applied Biology and Chemical Technology and the Open Laboratory of Chirotechnology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, SAR, China
    Bioorg Med Chem 15:5076-82. 2007
    ..These data suggest that the acetylated amino-GTP analogs have the potential to be developed into novel anticancer agents...
  94. ncbi request reprint Differential effects of proteasome inhibitors on cell cycle and apoptotic pathways in human YT and Jurkat cells
    Min Lu
    Department of Molecular Biology and Immunology, Institute for Cancer Research, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    J Cell Biochem 97:122-34. 2006
    ..In summary, proteasome inhibitors may act differentially in cell cycle arrest and apoptosis of tumors of NK and T cell origin, and may have similar effects on normal NK and T cells...
  95. ncbi request reprint Novel N-thiolated beta-lactam antibiotics selectively induce apoptosis in human tumor and transformed, but not normal or nontransformed, cells
    Aslamuzzaman Kazi
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Department of Interdisciplinary Oncology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Biochem Pharmacol 67:365-74. 2004
    ..Our results suggest that there is potential for developing this class of beta-lactams into novel anticancer agents...
  96. ncbi request reprint Naturally occurring proteasome inhibitors from mate tea (Ilex paraguayensis) serve as models for topical proteasome inhibitors
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Invest Dermatol 125:207-12. 2005
    ..Based upon these findings, preclinical and clinical trials of topical cinnamate esters as proteasome inhibitors are warranted for psoriasis and other inflammatory disorders...
  97. ncbi request reprint Direct inhibition of the ubiquitin-proteasome pathway by ester bond-containing green tea polyphenols is associated with increased expression of sterol regulatory element-binding protein 2 and LDL receptor
    Deborah J Kuhn
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Biochim Biophys Acta 1682:1-10. 2004
    ..This identified molecular mechanism may be related to the previously reported cholesterol-lowering and heart disease-preventative effects of green tea...
  98. ncbi request reprint Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein
    Aslamuzzaman Kazi
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Department of Interdisciplinary Oncology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Biochem Pharmacol 66:965-76. 2003
    ..Our results suggest that the proteasome is a potential target of genistein in human tumor cells and that inhibition of the proteasome activity by genistein might contribute to its cancer-preventive properties...
  99. ncbi request reprint Overexpression of interleukin-2 receptor alpha in a human squamous cell carcinoma of the head and neck cell line is associated with increased proliferation, drug resistance, and transforming ability
    Deborah J Kuhn
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, College of Medicine, University of South Florida, Tampa, Florida 33612 9497, USA
    J Cell Biochem 89:824-36. 2003
    ....
  100. ncbi request reprint Association of mitochondrial calpain activation with increased expression and autolysis of calpain small subunit in an early stage of apoptosis
    Kenyon G Daniel
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Departments of Interdisciplinary Oncology and Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Int J Mol Med 12:247-52. 2003
    ....
  101. ncbi request reprint Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer
    Ahmed O Kaseb
    Department of Hematology Oncology, Henry Ford Hospital, MI 458202, USA
    Cancer Res 67:7782-8. 2007
    ..Furthermore, because of its selective effect on cancer cells, we believe that thymoquinone can also be used safely to help prevent the development of prostate cancer...

Research Grants8

  1. TEA TARGETING PROTEASOME--A ROLE IN CANCER PREVENTION
    QING DOU; Fiscal Year: 2002
    ..A Future Aim is to determine whether in vivo proteasome-inhibitory ability of tea polyphenols is related to their antitumor activity using nude mice bearing human prostate tumors. ..
  2. The Proteasome as Molecular Target of Grape Polyphenols
    QING PING DOU; Fiscal Year: 2005
    ..abstract_text> ..
  3. Roles of polymorphic COMT, tea polyphenols and proteasome in cancer prevention
    QING PING DOU; Fiscal Year: 2006
    ....
  4. Roles of polymorphic COMT, tea polyphenols and proteasome in cancer prevention
    QING PING DOU; Fiscal Year: 2007
    ....
  5. Roles of polymorphic COMT, tea polyphenols and proteasome in cancer prevention
    QING PING DOU; Fiscal Year: 2009
    ..abstract_text> ..
  6. Roles of polymorphic COMT, tea polyphenols and proteasome in cancer prevention
    QING PING DOU; Fiscal Year: 2010
    ..abstract_text> ..
  7. Roles of polymorphic COMT, tea polyphenols and proteasome in cancer prevention
    QING PING DOU; Fiscal Year: 2009
    ..abstract_text> ..