Paula Dore-Duffy

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Glucocorticoid-induced apoptosis in CNS microvascular pericytes
    Andre Katychev
    Multiple Sclerosis Clinical Research Center, Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, Mich 48201, USA
    Dev Neurosci 25:436-46. 2003
  2. ncbi request reprint Pericyte migration from the vascular wall in response to traumatic brain injury
    P Dore-Duffy
    Department of Neurology, Detroit Medical Center, MI 48201, USA
    Microvasc Res 60:55-69. 2000
  3. pmc The CNS microvascular pericyte: pericyte-astrocyte crosstalk in the regulation of tissue survival
    Drew Bonkowski
    Department of Neurology, Wayne State University School of Medicine, 421 East Canfield Road, Detroit, Michigan 48201, USA
    Fluids Barriers CNS 8:8. 2011
  4. ncbi request reprint Differential expression of capillary VEGF isoforms following traumatic brain injury
    Paula Dore-Duffy
    Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine Detroit, MI 48201, USA
    Neurol Res 29:395-403. 2007
  5. ncbi request reprint CNS microvascular pericytes exhibit multipotential stem cell activity
    Paula Dore-Duffy
    Department of Neurology, Division of Neuroimmunology, Multiple Sclerosis Clinical Research Center, Wayne State University School of Medicine, Detroit Medical Center, Detroit, Michigan 48201, USA
    J Cereb Blood Flow Metab 26:613-24. 2006
  6. ncbi request reprint The CNS pericyte response to low oxygen: early synthesis of cyclopentenone prostaglandins of the J-series
    Paula Dore-Duffy
    Multiple Sclerosis Clinical Research Center, Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI 48201, USA
    Microvasc Res 69:79-88. 2005
  7. doi request reprint Chronic mild hypoxia ameliorates chronic inflammatory activity in myelin oligodendrocyte glycoprotein (MOG) peptide induced experimental autoimmune encephalomyelitis (EAE)
    Paula Dore-Duffy
    Department of Neurology, Division of Immunology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Adv Exp Med Biol 701:165-73. 2011
  8. pmc Immortalized CNS pericytes are quiescent smooth muscle actin-negative and pluripotent
    Paula Dore-Duffy
    Department of Neurology, Division of Neuroimmunology Wayne State University School of Medicine, Detroit, MI 48201, USA
    Microvasc Res 82:18-27. 2011
  9. doi request reprint Pericyte-mediated vasoconstriction underlies TBI-induced hypoperfusion
    Paula Dore-Duffy
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurol Res 33:176-86. 2011
  10. ncbi request reprint Pericytes: pluripotent cells of the blood brain barrier
    Paula Dore-Duffy
    Department of Neurology, Wayne State University School of Medicine, 421 East Canfield Avenue, 3126 Elliman Clinical Research Building, Detroit, Michigan 48201, USA
    Curr Pharm Des 14:1581-93. 2008

Research Grants

  1. CNS MICROVASCULAR PERICYTE AND EAE
    Paula Dore Duffy; Fiscal Year: 1999
  2. CNS MICROVASCULAR PERICYTE AND EAE
    Paula Dore Duffy; Fiscal Year: 2000
  3. CNS MICROVASCULAR PERICYTE AND EAE
    Paula Dore Duffy; Fiscal Year: 2001
  4. CNS MICROVASCULAR PERICYTE AND EAE
    Paula Dore Duffy; Fiscal Year: 2002
  5. CNS MICROVASCULAR PERICYTE AND EAE
    Paula Dore Duffy; Fiscal Year: 2003
  6. VEGF gene expression in CNS microvascular pericyte
    Paula Dore Duffy; Fiscal Year: 2004
  7. VEGF gene expression in CNS microvascular pericyte
    Paula Dore Duffy; Fiscal Year: 2005
  8. VEGF gene expression in CNS microvascular pericyte
    Paula Dore Duffy; Fiscal Year: 2006
  9. VEGF gene expression in central nervous system microvascular pericyte
    Paula Dore Duffy; Fiscal Year: 2007

Detail Information

Publications18

  1. ncbi request reprint Glucocorticoid-induced apoptosis in CNS microvascular pericytes
    Andre Katychev
    Multiple Sclerosis Clinical Research Center, Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, Mich 48201, USA
    Dev Neurosci 25:436-46. 2003
    ..Deregulation of pericyte involvement in vascular homeostasis and hemostasis may result in clinical disease...
  2. ncbi request reprint Pericyte migration from the vascular wall in response to traumatic brain injury
    P Dore-Duffy
    Department of Neurology, Detroit Medical Center, MI 48201, USA
    Microvasc Res 60:55-69. 2000
    ..Nonmigrating pericytes in the same section displayed cytoplasmic alterations and nuclear chromatin changes consistent with a rapid degenerative process...
  3. pmc The CNS microvascular pericyte: pericyte-astrocyte crosstalk in the regulation of tissue survival
    Drew Bonkowski
    Department of Neurology, Wayne State University School of Medicine, 421 East Canfield Road, Detroit, Michigan 48201, USA
    Fluids Barriers CNS 8:8. 2011
    ..These regulatory changes involve trans-cellular communication networks between cells. In this review we consider evidence for cell-to-cell crosstalk between pericytes and astrocytes during development and in adult brain...
  4. ncbi request reprint Differential expression of capillary VEGF isoforms following traumatic brain injury
    Paula Dore-Duffy
    Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine Detroit, MI 48201, USA
    Neurol Res 29:395-403. 2007
    ..Further, we sought to characterize pericyte cell death in isolated capillaries...
  5. ncbi request reprint CNS microvascular pericytes exhibit multipotential stem cell activity
    Paula Dore-Duffy
    Department of Neurology, Division of Neuroimmunology, Multiple Sclerosis Clinical Research Center, Wayne State University School of Medicine, Detroit Medical Center, Detroit, Michigan 48201, USA
    J Cereb Blood Flow Metab 26:613-24. 2006
    ..With prolonged culture fully differentiated cells of neural lineage were present. Results indicate that adult CNS microvascular pericytes have neural stem cell capability...
  6. ncbi request reprint The CNS pericyte response to low oxygen: early synthesis of cyclopentenone prostaglandins of the J-series
    Paula Dore-Duffy
    Multiple Sclerosis Clinical Research Center, Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI 48201, USA
    Microvasc Res 69:79-88. 2005
    ..The exogenous addition of 15-deoxyDelta(12,14) PGJ2 to pericytes under normoxic conditions increased glut-1 protein in the absence of hypoxia. PGD2 and PGJ2 may be early signaling molecules in the pericyte stress response...
  7. doi request reprint Chronic mild hypoxia ameliorates chronic inflammatory activity in myelin oligodendrocyte glycoprotein (MOG) peptide induced experimental autoimmune encephalomyelitis (EAE)
    Paula Dore-Duffy
    Department of Neurology, Division of Immunology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Adv Exp Med Biol 701:165-73. 2011
    ..In addition, spinal cord pathology was decreased.While the mechanism of protection is unclear, results suggest that hypoxia has therapeutic potential in EAE...
  8. pmc Immortalized CNS pericytes are quiescent smooth muscle actin-negative and pluripotent
    Paula Dore-Duffy
    Department of Neurology, Division of Neuroimmunology Wayne State University School of Medicine, Detroit, MI 48201, USA
    Microvasc Res 82:18-27. 2011
    ..Finally, the addition of endothelial cells to purified IMP cultures augments their rate of self-renewal and differentiation, possibly in a cell-to-cell contact dependent manner...
  9. doi request reprint Pericyte-mediated vasoconstriction underlies TBI-induced hypoperfusion
    Paula Dore-Duffy
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurol Res 33:176-86. 2011
    ..In this study we question the role of the microvascular pericyte in endothelin-1-mediated pathophysiology in TBI...
  10. ncbi request reprint Pericytes: pluripotent cells of the blood brain barrier
    Paula Dore-Duffy
    Department of Neurology, Wayne State University School of Medicine, 421 East Canfield Avenue, 3126 Elliman Clinical Research Building, Detroit, Michigan 48201, USA
    Curr Pharm Des 14:1581-93. 2008
    ..We will also speculate on the importance of pericyte stem cell activity in survival and DNA repair and how dysregulation of pericyte function may lead to disease...
  11. doi request reprint Pericyte coculture models to study astrocyte, pericyte, and endothelial cell interactions
    Vladimir Katyshev
    Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, Detroit, MI, USA
    Methods Mol Biol 814:467-81. 2012
    ..We also present data to show that triple cultures are ideal to study the role of the CNS pericyte in CNS angiogenesis...
  12. ncbi request reprint Physiologic angiodynamics in the brain
    Paula Dore-Duffy
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Antioxid Redox Signal 9:1363-71. 2007
    ..The capacity for adaptation is diminished in older rats because of the attenuation of the hypoxia-inducible factor-1 response...
  13. ncbi request reprint Isolation and characterization of cerebral microvascular pericytes
    Paula Dore-Duffy
    Division of Neuroimmunology, Department of Neurology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI, USA
    Methods Mol Med 89:375-82. 2003
  14. ncbi request reprint Chronic cerebrospinal venous insufficiency and multiple sclerosis
    Omar Khan
    Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48323, USA
    Ann Neurol 67:286-90. 2010
    ..At present, invasive and potentially dangerous endovascular procedures as therapy for patients with MS should be discouraged until such studies have been completed, analyzed, and debated in the scientific arena...
  15. doi request reprint Morphology and properties of pericytes
    Paula Dore-Duffy
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    Methods Mol Biol 686:49-68. 2011
    ..Further understanding of the role played by this intriguing cell may lead to novel targeted therapies for neurovascular diseases...
  16. ncbi request reprint Cytokine regulation of E-selectin in rat CNS microvascular endothelial cells: differential response of CNS and non-CNS vessels
    Jarmila Wagnerova
    Wayne State University School of Medicine, Department of Neurology, Division of Neuroimmunology, Detroit Medical Center, 421 E Canfield Ave, Detroit, MI 48201, USA
    J Neurol Sci 195:51-62. 2002
    ..This was in contrast to the transient expression in non-CNS EC indicating that pure primary CNS EC display slightly different kinetics of E-selectin expression than non-CNS EC...
  17. ncbi request reprint New frontiers in translational research in neuro-oncology and the blood-brain barrier: report of the tenth annual Blood-Brain Barrier Disruption Consortium Meeting
    Nancy D Doolittle
    Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    Clin Cancer Res 11:421-8. 2005
    ..Transport across the BBB relates to the neurovascular unit, which consists not only of endothelial cells but also of pericyte, glia, and neuronal elements...
  18. pmc Increased expression of fibronectin and the alpha 5 beta 1 integrin in angiogenic cerebral blood vessels of mice subject to hypobaric hypoxia
    Richard Milner
    Department of Molecular and Experimental Medicine, MEM 132, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Neurosci 38:43-52. 2008
    ..In light of the defined angiogenic role for fibronectin in other systems, this work suggests that induction of fibronectin-alpha5beta1 integrin expression may be an important molecular switch driving angiogenesis in the hypoxic CNS...

Research Grants9

  1. CNS MICROVASCULAR PERICYTE AND EAE
    Paula Dore Duffy; Fiscal Year: 1999
    ..The potential role of PC cytokines will be examined. ..
  2. CNS MICROVASCULAR PERICYTE AND EAE
    Paula Dore Duffy; Fiscal Year: 2000
    ..The potential role of PC cytokines will be examined. ..
  3. CNS MICROVASCULAR PERICYTE AND EAE
    Paula Dore Duffy; Fiscal Year: 2001
    ..The potential role of PC cytokines will be examined. ..
  4. CNS MICROVASCULAR PERICYTE AND EAE
    Paula Dore Duffy; Fiscal Year: 2002
    ..The potential role of PC cytokines will be examined. ..
  5. CNS MICROVASCULAR PERICYTE AND EAE
    Paula Dore Duffy; Fiscal Year: 2003
    ..The potential role of PC cytokines will be examined. ..
  6. VEGF gene expression in CNS microvascular pericyte
    Paula Dore Duffy; Fiscal Year: 2004
    ..We propose that the CNS microvascular pericyte is a regulatory cell important in the vascular response to hypoxic stress and that cyclopentenone prostagladins are involved in the pericyte stress response. ..
  7. VEGF gene expression in CNS microvascular pericyte
    Paula Dore Duffy; Fiscal Year: 2005
    ..We propose that the CNS microvascular pericyte is a regulatory cell important in the vascular response to hypoxic stress and that cyclopentenone prostagladins are involved in the pericyte stress response. ..
  8. VEGF gene expression in CNS microvascular pericyte
    Paula Dore Duffy; Fiscal Year: 2006
    ..We propose that the CNS microvascular pericyte is a regulatory cell important in the vascular response to hypoxic stress and that cyclopentenone prostagladins are involved in the pericyte stress response. ..
  9. VEGF gene expression in central nervous system microvascular pericyte
    Paula Dore Duffy; Fiscal Year: 2007
    ..We propose that the CNS microvascular pericyte is a regulatory cell important in the vascular response to hypoxic stress and that cyclopentenone prostagladins are involved in the pericyte stress response. ..