Research Topics
Genomes and Genes
| Michael P DiamondSummaryAffiliation: Wayne State University Country: USA Publications
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Publications
Hypoxia up-regulates the effects of prostaglandin E2 on tumor angiogenesis in ovarian cancer cellsGenhai Zhu
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Wayne State University, 4160 John R, Detroit, MI 48201, USA
Gynecol Oncol 94:422-6. 2004..CONCLUSION: PGE(2) is a potent stimulator of VEGF expression in ovarian cancer cells. This effect of PG is further potentiated under hypoxic conditions where it is also associated with a significant increase in HIF-1alpha expression...
Endometrial shedding effect on conception and live birth in women with polycystic ovary syndromeMichael P Diamond
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University, Detroit, MI 48201, USA
Obstet Gynecol 119:902-8. 2012....
The clinical need for a method of identification of embryos destined to become a blastocyst in assisted reproductive technology cyclesMichael P Diamond
Wayne State University, Detroit, MI, USA
J Assist Reprod Genet 29:391-6. 2012..To provide a rationale for continuation of efforts to improve the outcome of Assisted Reproductive Technology outcomes, thereby increasing the likelihood of the live birth of healthy neonates...
Use of gonadotropins for initiation of singleton gestations in non-assisted reproductive technology cyclesMichael P Diamond
Wayne State University School of Medicine, Detroit, Michigan, USA
Fertil Steril 97:810-2. 2012..Financial considerations often limit enthusiasm for approaches which could reduce success in achieving pregnancy...
The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatmentMohamed F M Mitwally
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
Reprod Biol Endocrinol 3:54. 2005....
Values of fasting glucose levels, glucose tolerance tests, and glucose-insulin ratios as predictors of glucose toleranceMichael P Diamond
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Hutzel Hospital, Detroit, Michigan 48201, USA
Fertil Steril 80:1022-5. 2003..To examine the ability to use parameters obtainable from an oral glucose tolerance test to predict insulin action as determined under hyperinsulinemic, hyperglycemic conditions...
Science linking environmental contaminant exposures with fertility and reproductive health impacts in the adult male (respondent)Michael P Diamond
Division of Reproductive Endocrinology and Infertility, Wayne State University, Detroit, Michigan 48202, USA
Fertil Steril 89:e71. 2008
Regulation of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesionsMichael P Diamond
Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Hutzel Hospital, Detroit, Michigan 48201, USA
Fertil Steril 81:185-90. 2004....
Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesionsMichael P Diamond
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University Detroit Medical Center, Hutzel Hospital, Detroit, MI 48201, USA
Am J Obstet Gynecol 190:926-34. 2004....
Effect of Tisseel on expression of tissue plasminogen activator and plasminogen activator inhibitor-1Michael P Diamond
Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Detroit, Michigan, USA
Fertil Steril 81:1657-64. 2004..Reduction of plasminogen activator activity, as occurs with tissue trauma, results in increased postoperative adhesion development...
Estimating rates of multiple gestation pregnancies: sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trialMichael P Diamond
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne Sate University, 3800 Woodward Avenue, Suite 320, Detroit, MI 48201, USA
Contemp Clin Trials 32:902-8. 2011....
Challenges of evaluating surgical outcomesMichael P Diamond
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, University Women s Care Inc, Detroit, Michigan, USA
Fertil Steril 84:1581. 2005..IVF-embryo transfer to improve the potential for conception will vary as enhancements of these interventions occurs. Well-designed and conducted studies, controlling for the complexities of surgical trials are needed...
Effects of cornual catheterization on uterotubal histology and functionMichael P Diamond
Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
Fertil Steril 84:212-6. 2005..To assess histologic damage and functional impairment following coaxial tubal catheterization...
A prospective, controlled, randomized, multicenter, exploratory pilot study evaluating the safety and potential trends in efficacy of AdhexilMichael P Diamond
Division of Reproductive Endocrinology and Infertility, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
Fertil Steril 95:1086-90. 2011..To present a multicenter, reviewer-blinded pilot study evaluating the safety and trends of efficacy of Adhexil, a novel product using fibrin sealant...
Modulation of the expression of vascular endothelial growth factor in human fibroblastsMichael P Diamond
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Detroit, MI 48201, USA
Fertil Steril 83:405-9. 2005..To examine the up-regulation of vascular endothelial growth factor (VEGF) expression by hypoxia, a crucial event leading to neovascularization, as the reduction in VEGF expression may facilitate minimization of adhesion development...
Reduction of postoperative adhesions by N,O-carboxymethylchitosan: a pilot studyMichael P Diamond
Wayne State University Detroit Medical Center, Detroit, Michigan, USA
Fertil Steril 80:631-6. 2003..To examine the logistics, safety, and efficacy of N,O-carboxymethylchitosan (NOCC) in reducing adhesions in women...
Antecubital vein venous sampling does not distort circulating levels of peptide and sex steroid hormonesMichael P Diamond
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, The Detroit Medical Center, Detroit, Michigan 48201, USA
Fertil Steril 83:1557-60. 2005....
Metabolic regulation of collagen I in fibroblasts isolated from normal peritoneum and adhesions by dichloroacetic acidMichael P Diamond
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Hutzel Hospital, Mich 48201, USA
Am J Obstet Gynecol 187:1456-60; discussion 1460-1. 2002..Specifically, we have exposed human fibroblast cultures from normal peritoneum and adhesions to DCA (0, 50, and 100 microg/mL) for 24 hours under normal and hypoxic (2% oxygen) conditions...
PCBs enhance collagen I expression from human peritoneal fibroblastsMichael P Diamond
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan 48201, USA
Fertil Steril 90:1372-5. 2008....
Use of the PROACT System for reduction of postsurgical peritoneal adhesionsMichael P Diamond
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Fertil Steril 79:198-202. 2003..To assess the efficacy and safety of a new surgical device designed to prevent adhesions...
Regulation of transforming growth factor-beta, type III collagen, and fibronectin by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesionsMichael P Diamond
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Hutzel Hospital, Detroit, Michigan 48201, USA
Fertil Steril 79:1161-7. 2003....
Clomiphene, metformin, or both for infertility in the polycystic ovary syndromeRichard S Legro
Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, M S Hershey Medical Center, Hershey, PA 17033, USA
N Engl J Med 356:551-66. 2007..The polycystic ovary syndrome is a common cause of infertility. Clomiphene and insulin sensitizers are used alone and in combination to induce ovulation, but it is unknown whether one approach is superior...
Endometrial thickness is related to miscarriage rate, but not to the estradiol concentration, in cycles down-regulated with gonadotropin-releasing hormone antagonistLaura Detti
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Fertil Steril 89:998-1001. 2008..However, there was a statistically significant inverse relationship with early pregnancy loss (31%) if the endometrial thickness was <9.8 mm (sensitivity 71%; specificity 76%)...
Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 geneRichard S Legro
Department of Obstetrics and Gynecology, Pennsylvania State University, M S Hershey Medical Center, 500 University Drive, H103, Hershey, Pennsylvania 17033, USA
J Clin Endocrinol Metab 93:792-800. 2008..Clomiphene and insulin sensitizers such as metformin are used to induce ovulation in polycystic ovary syndrome (PCOS), but the ovulatory response is variable, and the causes of this variation are poorly understood...
Myeloperoxidase serves as a redox switch that regulates apoptosis in epithelial ovarian cancerGhassan M Saed
Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
Gynecol Oncol 116:276-81. 2010..We sought to investigate the expression of myeloperoxidase (MPO) and iNOS in epithelial ovarian cancer (EOC) and determine their effect on S-nitrosylation of caspase-3 and its activity as well as apoptosis...
The Pregnancy in Polycystic Ovary Syndrome study: baseline characteristics of the randomized cohort including racial effectsRichard S Legro
Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
Fertil Steril 86:914-33. 2006..To report the baseline characteristics and racial differences in the polycystic ovary syndrome (PCOS) phenotype from a large multicenter clinical trial (PPCOS)...
Hypochlorous acid-induced heme degradation from lactoperoxidase as a novel mechanism of free iron release and tissue injury in inflammatory diseasesCarlos Eduardo A Souza
Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan, United States of America
PLoS ONE 6:e27641. 2011....
Predictors of pregnancy in women with polycystic ovary syndromeMary E Rausch
Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 94:3458-66. 2009..Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. The selection of first-line therapies for ovulation induction is empiric...
Thiocyanate modulates the catalytic activity of mammalian peroxidasesYahya R Tahboub
Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
J Biol Chem 280:26129-36. 2005..A modified kinetic model, which incorporates our current findings with the mammalian peroxidases classic cycle, is presented...
Melatonin attenuates hypochlorous acid-mediated heme destruction, free iron release, and protein aggregation in hemoglobinDhiman Maitra
Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Pineal Res 53:198-205. 2012..Collectively, in addition to acting as an antioxidant and as a MPO inhibitor, melatonin can also exert its protective effect by inhibiting HOCl-mediated heme destruction of hemoproteins and subsequent free iron release...
Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stressGhassan M Saed
Department of Obstetrics and Gynecology, The CS Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
Reprod Sci 18:1253-61. 2011..In conclusion, reduction of enhanced oxidative stress-induced apoptosis of EOC cells, which may serve as future therapeutic intervention for ovarian cancer...
Effect of oxidized regenerated cellulose (Interceed) on the expression of tissue plasminogen activator and plasminogen activator inhibitor-1 in human peritoneal fibroblasts and mesothelial cellsL April Gago
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA
Fertil Steril 86:1223-7. 2006..Thus, the ability of Interceed to reduce postoperative adhesion development may be derived from both a barrier and biologic effect...
Reactive oxygen species and oocyte aging: role of superoxide, hydrogen peroxide, and hypochlorous acidAnuradha P Goud
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, USA
Free Radic Biol Med 44:1295-304. 2008..Overall, O2-, H2O2, and HOCl each augment oocyte aging, more so in relatively old oocytes, suggesting compromised antioxidant capacity in aging oocytes...
S-nitrosylation of caspase-3 is the mechanism by which adhesion fibroblasts manifest lower apoptosisZhong L Jiang
Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Wound Repair Regen 17:224-9. 2009..The mechanism by which caspase-3 S-nitrosylation occurs is not fully understood. However, the role of hypoxia in the formation of peroxynitrite via superoxide production may suggest a possible mechanism...
Vaginal micronized progesterone versus intramuscular progesterone for luteal support in women undergoing in vitro fertilization-embryo transferMohamed F Mitwally
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Women s Health, University of Minnesota, Minneapolis, Minnesota, USA
Fertil Steril 93:554-69. 2010..To study the outcome of IVF-ET in women who used vaginal P (vaginal P(4)) versus those who used P in oil via IM injection (IM-P(4)) for luteal support...
Hypoxia upregulates cyclooxygenase-2 and prostaglandin E(2) levels in human peritoneal fibroblastsGhassan M Saed
The C S Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, 275 E Hancock, Detroit, MI 47201, USA
Fertil Steril 83:1216-9. 2005..To determine the levels of COX-1, COX-2, and prostaglandin (PG) E(2) in human fibroblasts isolated from normal peritoneal and adhesion tissues...
Absence of secretory endometrium after false-positive home urine luteinizing hormone testingPeter G McGovern
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Newark 07103, USA
Fertil Steril 82:1273-7. 2004..To examine the proportion of cases with proliferative endometrium on biopsies performed after positive home urine LH testing...
Reaction of hemoglobin with HOCl: mechanism of heme destruction and free iron releaseDhiman Maitra
Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
Free Radic Biol Med 51:374-86. 2011..This work provides a direct link between Hb heme destruction and subsequent free iron accumulation, as occurs under inflammatory conditions where HOCl is formed in substantial amounts...
Expression pattern and regulation of genes differ between fibroblasts of adhesion and normal human peritoneumUjjwal K Rout
Division of Reproduction Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
Reprod Biol Endocrinol 3:1. 2005..Therefore, identifying changes in gene expression pattern in the peritoneal fibroblasts during the process may provide clues to the mechanisms by which adhesion develop...
Macrophages induce the adhesion phenotype in normal peritoneal fibroblastsJennell C White
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan, USA
Fertil Steril 96:758-763.e3. 2011..The adhesion phenotype has been previously characterized, in part, by increased fibroblast expression of transforming growth factor (TGF) β1, vascular endothelial growth factor (VEGF), and type I collagen...
Myeloperoxidase and free iron levels: potential biomarkers for early detection and prognosis of ovarian cancerNicole M Fletcher
Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
Cancer Biomark 10:267-75. 2011..The study sought to identify whether a relationship exists between serum myeloperoxidase (MPO) and free iron with stages of ovarian cancer...
Effects of hyperglycemia on the differential expression of insulin and insulin-like growth factor-I receptors in human normal peritoneal and adhesion fibroblastsNatalie N Rizk
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan 48201, USA
Fertil Steril 86:1217-22. 2006....
Microarray expression profiling in adhesion and normal peritoneal tissuesDana R Ambler
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Geisinger Medical Center, Danville, Pennsylvania, USA
Fertil Steril 97:1158-64.e1-4. 2012..To identify molecular markers associated with adhesion and normal peritoneal tissue using microarray expression profiling...
Establishing a biologic specimens repository for reproductive clinical trials: technical aspectsStephen A Krawetz
Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA
Syst Biol Reprod Med 57:222-7. 2011..To facilitate such interoperability, the reagents and protocols that have been adopted by the RMN Biorepository for the collection and storage of serum, blood, saliva and sperm are described...
Adverse obstetric outcomes associated with sonographically identified large uterine fibroidsValerie I Shavell
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
Fertil Steril 97:107-10. 2012..To determine the impact of sonographically identified large uterine fibroids (>5 cm in diameter) on obstetric outcomes...
Expression of transforming growth factor-beta and extracellular matrix by human peritoneal mesothelial cells and by fibroblasts from normal peritoneum and adhesions: effect of TisseelGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University/Detroit Medical Center, Hutzel Hospital, 4707 St. Antoine Boulevard, Detroit, MI 48201, USA
Wound Repair Regen 12:557-64. 2004....
Measurement of oxygen and nitric oxide levels in vitro and in vivo: relationship to postoperative adhesionsGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
Fertil Steril 84:235-8. 2005....
Transforming growth factors beta1, beta2 and beta3 and their receptors are differentially expressed in human peritoneal fibroblasts in response to hypoxiaGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University, Detroit, MI 48201, USA
Am J Reprod Immunol 48:387-93. 2002..TGF-beta isoforms and their receptors have been implicated as mediators of the healing process and adhesion development...
Nitric oxide synthase isoforms expression in fibroblasts isolated from human normal peritoneum and adhesion tissuesZhong L Jiang
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Fertil Steril 90:769-74. 2008..To determine the expression of nitric oxide synthases (NOSs) and their modulation by hypoxia in human peritoneal (NF) and adhesion fibroblasts (ADF)...
Timing and duration of use of GnRH antagonist down-regulation for IVF/ICSI cycles have no impact on oocyte quality or pregnancy outcomesLaura Detti
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, 3750 Woodward Ave, Suite 200 D, Detroit, MI, 48201, USA
J Assist Reprod Genet 25:177-81. 2008....
Role of nitric oxide in apoptosis of human peritoneal and adhesion fibroblasts after hypoxiaGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, The C S Mott Center for Human Growth and Development, Detroit, Michigan 48201, USA
Fertil Steril 82:1198-205. 2004..To study the modulation of the inducible nitric oxide synthase/nitric oxide (iNOS/NO) expression system in fibroblasts isolated from human peritoneum and adhesion tissues by hypoxia...
Endometrial thickness dynamics and morphologic characteristics during pituitary downregulation with antagonists in assisted reproductive technology cyclesLaura Detti
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, Detroit, MI 48201 USA
J Ultrasound Med 27:1591-6. 2008....
Hypoxia regulates iNOS expression in human normal peritoneal and adhesion fibroblasts through nuclear factor kappa B activation mechanismZhong L Jiang
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Fertil Steril 91:616-21. 2009..To determine the mechanism by which hypoxia increases expression of iNOS in human normal peritoneal and adhesion fibroblasts...
Effects of oxidized regenerated cellulose on the expression of extracellular matrix and transforming growth factor-beta1 in human peritoneal fibroblasts and mesothelial cellsL April Gago
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, 4707 St Antoine Boulevard, Detroit, MI 48201, USA
Am J Obstet Gynecol 189:1620-5; discussion 1625-6. 2003....
High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couplesRichard E Leach
Michigan State University Spectrum Health Medical Group, Grand Rapids, MI, USA
Hum Reprod 27:814-28. 2012....
Serum human chorionic gonadotropin level after ovulation triggering is influenced by the patient's body mass index and the number of larger folliclesLaura Detti
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, and the University Women s Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Fertil Steril 88:152-5. 2007..To identify determinants of the serum concentration of hCG levels after triggering of ovulation with exogenous hCG during controlled ovarian stimulation cycles for in vitro fertilization with or without intracytoplasmic sperm injection...
The reaction of HOCl and cyanocobalamin: corrin destruction and the liberation of cyanogen chlorideHusam M Abu-Soud
Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
Free Radic Biol Med 52:616-25. 2012..Additionally, it can liberate free Co, which can perpetuate metal-ion-induced oxidant stress. Taken together, these results are the first report of the generation of toxic molecular products through the interaction of Cobl with HOCl...
Uncoupling oxidative phosphorylation with 2,4-dinitrophenol promotes development of the adhesion phenotypeValerie I Shavell
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The CS Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Fertil Steril 97:729-33. 2012..To determine the effect of uncoupling oxidative phosphorylation with 2,4-dinitrophenol (DNP) on adhesion phenotype development...
Endometrial morphology and modulation of hormone receptors during ovarian stimulation for assisted reproductive technology cyclesLaura Detti
Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
Fertil Steril 95:1037-41. 2011..To study the biochemical and morphologic implications of different hormonal levels on endometrial development during assisted reproductive technology (ART) cycles...
Increasing burden of institutional review in multicenter clinical trials of infertility: the Reproductive Medicine Network experience with the Pregnancy in Polycystic Ovary Syndrome (PPCOS) I and II studiesWilliam D Schlaff
Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Academic Office Building 1, 12631 E 17th Avenue, Aurora, CO 80045, USA
Fertil Steril 96:15-8. 2011..It is timely to consider whether these changes better protect the interests and safety of human research participants. Clinical trial registration: ClinicalTrials.gov NCT00068861 and NCT00719186...
The effect of estradiol on the expression of estrogen, progesterone, androgen, and prolactin receptors in human peritoneal fibroblastsLaura Detti
Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA
J Assist Reprod Genet 25:245-50. 2008..To assess the ability of fibroblasts isolated from normal peritoneum and adhesion tissues to express various hormone receptors when cultured with exogenous estradiol...
Racial disparity in the clinical determinants and outcomes of cesarean hysterectomyAnthony N Imudia
Department of Obstetrics and Gynecology, Wayne State University School of Medicine Detroit Medical Center, Detroit, Michigan 48201, USA
J Natl Med Assoc 101:565-8. 2009..In conclusion, beyond higher rates of cardiopulmonary complications and urological injury among whites, no significant racial differences exist in the risk factors, indications for, and complications from cesarean hysterectomy...
Nitric oxide extends the oocyte temporal window for optimal fertilizationPravin T Goud
Department of Obstetrics and Gynecology, The CS Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
Free Radic Biol Med 45:453-9. 2008..Thus, NO is essential for sustenance of oocyte quality postovulation...
Adenovirus-mediated expression of cyclooxygenase-2 antisense reverse abnormal genetic profile of human adhesion fibroblastsGhassan M Saed
Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Fertil Steril 89:1455-60. 2008....
Activation of the cGMP signaling pathway is essential in delaying oocyte aging in diabetes mellitusAnuradha P Goud
Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Detroit, Michigan 48201, USA
Biochemistry 45:11366-78. 2006..A comprehensive model incorporating our current findings with NOS, GC, and G kinase cycles is presented...
Seprafilm (modified hyaluronic acid and carboxymethylcellulose) acts as a physical barrierL April Gago
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
Fertil Steril 80:612-6. 2003..To characterize the molecular changes that occur in normal fibroblasts, adhesion fibroblasts, and mesothelial cells as a result of exposure to modified hyaluronic acid and carboxymethylcellulose (Seprafilm)...
Reconstruction of ooplasm recipient oocytes with frozen-thawed donor microcytoplasts and influence on the microtubular spindleAnuradha P Goud
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Fertil Steril 87:923-33. 2007....
Expression of transforming growth factor beta isoform mRNA in injured peritoneum that healed with adhesions and without adhesions and in uninjured peritoneumMichael L Freeman
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA
Fertil Steril 80:708-13. 2003....
Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblastsGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and the C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
Fertil Steril 79:164-8. 2003..To determine whether normal peritoneal and adhesion fibroblasts express tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI-I) and whether their expression is regulated by oxygen...
Antiadhesion effects of docosahexaenoic acid on normal human peritoneal and adhesion fibroblastsRahi Victory
Department of Obstetrics and Gynecology, C S Mott Center, Wayne State University, Detroit, Michigan 48201, USA
Fertil Steril 88:1657-62. 2007..To determine whether docosahexaenoic acid (DHA) reduces adhesion marker mRNA levels in normal peritoneal and adhesion fibroblasts...
Altered in vitro immune response to hypoxia-treated normal peritoneal fibroblastsZeynep Alpay
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hutzel Hospital, Wayne State University, Detroit, Michigan 48201, USA
Fertil Steril 87:426-9. 2007....
Pathogenesis of benign metastasizing leiomyoma: a reviewAwoniyi O Awonuga
Division of Reproductive Endocrinology and Infertility, Wayne State University, Detroit, MI 48201, USA
Obstet Gynecol Surv 65:189-95. 2010..Compare the potential pathophysiology with endometriosis and differentiate benign metastasizing Leiomyoma from Leiomyosarcoma...
Exposure to polychlorinated biphenyls enhances lipid peroxidation in human normal peritoneal and adhesion fibroblasts: a potential role for myeloperoxidaseGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
Free Radic Biol Med 48:845-50. 2010..This is evident by lower iNOS, MPO, and nitrite/nitrate and a simultaneous increase in LPO. Loss of MPO activity, possibly through a mechanism involving MPO heme depletion and free iron release, is yet another source of oxidative stress...
The role of myeloperoxidase in the pathogenesis of postoperative adhesionsGhassan M Saed
Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Wound Repair Regen 17:531-9. 2009..These studies identify MPO and iNOS as key enzymes in the cellular response to hypoxia and consequent development of tissue fibrosis...
Reasons for poststerilization hysterosalpingography noncompliance in a clinic populationValerie I Shavell
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, and Hutzel Women s Health Specialists, Detroit Medical Center, Detroit, Michigan 48201, USA
J Reprod Med 55:459-63. 2010..We were interested in determining the reason(s) for HSG noncompliance in this urban-based patient population...
Female infertility and free radicals: potential role in adhesions and endometriosisZeynep Alpay
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, C.S. Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
J Soc Gynecol Investig 13:390-8. 2006..As our knowledge of both conditions expands, we believe there will be opportunities for specific steps to intervention in free radical metabolism to reduce and/or prevent further development of endometriosis and adhesions...
Modulation of the BCL-2/BAX ratio by interferon-gamma and hypoxia in human peritoneal and adhesion fibroblastsGhassan M Saed
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, CS Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
Fertil Steril 90:1925-30. 2008..To examine the effect of interferon (IFN)-gamma treatment under normal and hypoxic conditions on the BCL-2/BAX ratio of fibroblasts obtained from normal peritoneal and adhesion tissues of the same patients...
Molecular characterization of postoperative adhesions: the adhesion phenotypeGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
J Am Assoc Gynecol Laparosc 11:307-14. 2004..Improved understanding of these events and their regulation will provide the opportunity to regulate better postoperative adhesion development and tissue fibrosis, thereby reducing the morbidity and mortality they cause...
Hypoxia-generated superoxide induces the development of the adhesion phenotypeNicole M Fletcher
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The CS Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
Free Radic Biol Med 45:530-6. 2008..Scavenging superoxide, even in the presence of hypoxia, prevented the development of the adhesion phenotype. These findings further support the central role of free radicals in the development of adhesions...
Success and failure in human spermatogenesis as revealed by teratozoospermic RNAsAdrian E Platts
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
Hum Mol Genet 16:763-73. 2007..The origin of the perturbation could be traced as far back as the pachytene stage of spermatogenesis. It is anticipated that this diagnostic strategy will prove valuable for understanding male factor infertility...
Physiologic measures of sexual function in women: a reviewTerri L Woodard
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, 3750 Woodward Avenue, Detroit, MI 48201, USA
Fertil Steril 92:19-34. 2009..To review and describe physiologic measures of assessing sexual function in women...
Nitric oxide delays oocyte agingAnuradha P Goud
Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Biochemistry 44:11361-8. 2005..11-0.23 microM/min NO, P < 0.0001). Collectively, our results demonstrate for the first time that exposure to NO delays oocyte aging and improves the integrity of the microtubular spindle apparatus in young and old oocytes...
A three-stage alcohol clamp procedure in human subjectsMarappa G Subramanian
Department of Obstetrics and Gynecology University School of Medicine, Detroit, Michigan 48201, USA
Alcohol Clin Exp Res 26:1479-83. 2002..We have modified this method and developed a multistage alcohol clamp procedure in humans...
Adhesions in patients with chronic pelvic pain: a role for adhesiolysis?Ahmad Hammoud
Department of Obstetrics and Gynecology, Wayne State University The Detroit Medical Center, Detroit, Michigan, USA
Fertil Steril 82:1483-91. 2004..To review the relation between adhesions and pelvic pain and the effectiveness of adhesiolysis in pain control...
Cyclooxygenase-2 is expressed in human fibroblasts isolated from intraperitoneal adhesions but not from normal peritoneal tissuesGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Detroit, Michigan 48201, USA
Fertil Steril 79:1404-8. 2003..To determine whether the COX-2 gene is expressed in human fibroblasts isolated from normal peritoneal and adhesion tissues...
Small bowel obstruction subsequent to Essure microinsert sterilization: a case reportJimmy Belotte
Department of Obstetrics and Gynecology, Wayne State University and the Detroit Medical Center, 3990 John R, Mailbox 165, Detroit, Michigan 48201, USA
Fertil Steril 96:e4-6. 2011..To report a case of small bowel obstruction (SBO) subsequent to Essure microinsert sterilization...
Apoptosis and proliferation of human peritoneal fibroblasts in response to hypoxiaGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and the C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
Fertil Steril 78:137-43. 2002..To determine the effect of hypoxia on apoptosis and proliferation of fibroblasts cultured from normal peritoneum or adhesions...
Role of plasminogen activators during healing after uterine serosal lesioning in the ratUjjwal Kumar Rout
C S Mott Center for Human Growth and Development, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Fertil Steril 79:138-45. 2003..Study the expression pattern of tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activators during uterine serosal healing after lesioning in a rat model...
Dynamic changes in microtubular cytoskeleton of human postmature oocytes revert after ooplasm transferAnuradha P Goud
Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
Fertil Steril 81:323-31. 2004..Study of the influence of ooplasm transfer on the microtubule dynamics in human postmature oocytes...
The role of sonographic endometrial patterns and endometrial thickness in the differential diagnosis of ectopic pregnancyAhmad O Hammoud
Department of Obstetrics and Gynecology, Wayne State University, Detroit, Mich 48201, USA
Am J Obstet Gynecol 192:1370-5. 2005..The purpose of this study was to examine the usefulness of the endometrial trilaminar pattern and thickness in the diagnosis of ectopic pregnancy...
Molecular typing of epithelial ovarian carcinomas using inflammatory markersRouba Ali-Fehmi
Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer 117:301-9. 2011..The present study sought to molecularly characterize type I and II tumors using known molecular markers...
What kind of erotic film clips should we use in female sex research? An exploratory studyTerri L Woodard
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, Detroit, MI, USA
J Sex Med 5:146-54. 2008..Erotic film clips are used in sex research, including studies of female sexual dysfunction and arousal. However, little is known about which clips optimize female sexual response. Furthermore, their use is not well standardized...
The transcriptome of the uterine cervix before and after spontaneous term parturitionSonia S Hassan
Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA
Am J Obstet Gynecol 195:778-86. 2006..This study was designed to identify genes differentially expressed in the human uterine cervix after spontaneous term labor...
Transforming growth factor-beta1 modulates expression of adhesion and cytoskeletal proteins in human peritoneal fibroblastsUjjwal K Rout
C S Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Fertil Steril 78:154-61. 2002..To determine the effects of TGF-beta1 on the expression of the alpha1, alpha2, alpha5, alpha(v), and alpha6 integrin subunits and on vinculin, and F-actin in human peritoneal fibroblasts...
Ureterocele misdiagnosed as pelvic inflammatory disease in an adolescentValerie I Shavell
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
Obstet Gynecol 113:522-5. 2009..Acute pelvic pain in reproductive-aged women presents a diagnostic challenge. In the case that follows, we report the management of a patient initially misdiagnosed with pelvic inflammatory disease...
Incidence, trends, risk factors, indications for, and complications associated with cesarean hysterectomy: a 17-year experience from a single institutionAnthony N Imudia
Department of Obstetrics and Gynecology, Hutzel Women s Hospital, Wayne State University School of Medicine Detroit Medical Center, 3980 John R, 7 Brush North, Detroit, MI 48201, USA
Arch Gynecol Obstet 280:619-23. 2009..To review the incidence, trends, risk factors, indications for, and complications associated with cesarean hysterectomy (CH) in our institution...
Contribution of imaging to our understanding of sexual function and dysfunctionTerri L Woodard
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Adv Psychosom Med 29:150-68. 2008..The purpose of this chapter is to review and discuss these techniques with an emphasis on how they contribute to our understanding of sexual function and dysfunction...
First-trimester Doppler investigation of the uterine circulationLaura Detti
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA
Am J Obstet Gynecol 195:1210-8. 2006..This article comprehensively reviews the literature on first-trimester Doppler in both normal and complicated pregnancies, and briefly discusses potential future areas of application...
The determinants of the apnea threshold during NREM sleep in normal subjectsJames A Rowley
Sleep Research Laboratory, John D Dingell VA Medical Center Division of Pulmonary, Critical Care and Sleep Medicine, Department of Ilnternal Medicine, Detroit, MI, USA
Sleep 29:95-103. 2006..To determine whether (1) postmenopausal women have a higher apnea threshold than premenopausal women and men and (2) hormone replacement therapy would decrease the apnea threshold in postmenopausal women...
Clinical update of smooth muscle tumors of the uterusLeigh A Solomon
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wayne State University, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
J Minim Invasive Gynecol 12:401-8. 2005..The goal of this review is to present the most recent information about common smooth muscle tumors of the uterus including their etiology, histopathology, radiographic and clinical presentations, and available treatment options...
Villar's nodule: a case report and systematic literature review of endometriosis externa of the umbilicusRahi Victory
Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan 48201, USA
J Minim Invasive Gynecol 14:23-32. 2007..Surgical intervention is recommended, but medical therapy may result in long-term symptom control with minimal malignancy risk...
Research Grants
- COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORKMichael Diamond; Fiscal Year: 2004..abstract_text> ..
- Wayne State University Clinical Translational ScienceMichael Diamond; Fiscal Year: 2006....
- COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORKMichael Diamond; Fiscal Year: 2007....
