Michael P Diamond

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Hypoxia up-regulates the effects of prostaglandin E2 on tumor angiogenesis in ovarian cancer cells
    Genhai Zhu
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Wayne State University, 4160 John R, Detroit, MI 48201, USA
    Gynecol Oncol 94:422-6. 2004
  2. pmc Oestrogen-selective modulation of FSH and LH secretion by pituitary gland
    M F Mitwally
    Br J Cancer 92:416-7. 2005
  3. pmc Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome
    Michael P Diamond
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University, Detroit, MI 48201, USA
    Obstet Gynecol 119:902-8. 2012
  4. pmc The clinical need for a method of identification of embryos destined to become a blastocyst in assisted reproductive technology cycles
    Michael P Diamond
    Wayne State University, Detroit, MI, USA
    J Assist Reprod Genet 29:391-6. 2012
  5. doi request reprint Use of gonadotropins for initiation of singleton gestations in non-assisted reproductive technology cycles
    Michael P Diamond
    Wayne State University School of Medicine, Detroit, Michigan, USA
    Fertil Steril 97:810-2. 2012
  6. pmc The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment
    Mohamed F M Mitwally
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    Reprod Biol Endocrinol 3:54. 2005
  7. ncbi request reprint Regulation of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions
    Michael P Diamond
    Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Hutzel Hospital, Detroit, Michigan 48201, USA
    Fertil Steril 81:185-90. 2004
  8. ncbi request reprint Effect of Tisseel on expression of tissue plasminogen activator and plasminogen activator inhibitor-1
    Michael P Diamond
    Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Detroit, Michigan, USA
    Fertil Steril 81:1657-64. 2004
  9. ncbi request reprint Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions
    Michael P Diamond
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University Detroit Medical Center, Hutzel Hospital, Detroit, MI 48201, USA
    Am J Obstet Gynecol 190:926-34. 2004
  10. ncbi request reprint Challenges of evaluating surgical outcomes
    Michael P Diamond
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, University Women s Care Inc, Detroit, Michigan, USA
    Fertil Steril 84:1581. 2005

Research Grants

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint Hypoxia up-regulates the effects of prostaglandin E2 on tumor angiogenesis in ovarian cancer cells
    Genhai Zhu
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Wayne State University, 4160 John R, Detroit, MI 48201, USA
    Gynecol Oncol 94:422-6. 2004
    ....
  2. pmc Oestrogen-selective modulation of FSH and LH secretion by pituitary gland
    M F Mitwally
    Br J Cancer 92:416-7. 2005
  3. pmc Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome
    Michael P Diamond
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University, Detroit, MI 48201, USA
    Obstet Gynecol 119:902-8. 2012
    ....
  4. pmc The clinical need for a method of identification of embryos destined to become a blastocyst in assisted reproductive technology cycles
    Michael P Diamond
    Wayne State University, Detroit, MI, USA
    J Assist Reprod Genet 29:391-6. 2012
    ..To provide a rationale for continuation of efforts to improve the outcome of Assisted Reproductive Technology outcomes, thereby increasing the likelihood of the live birth of healthy neonates...
  5. doi request reprint Use of gonadotropins for initiation of singleton gestations in non-assisted reproductive technology cycles
    Michael P Diamond
    Wayne State University School of Medicine, Detroit, Michigan, USA
    Fertil Steril 97:810-2. 2012
    ..Financial considerations often limit enthusiasm for approaches which could reduce success in achieving pregnancy...
  6. pmc The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment
    Mohamed F M Mitwally
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    Reprod Biol Endocrinol 3:54. 2005
    ....
  7. ncbi request reprint Regulation of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions
    Michael P Diamond
    Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Hutzel Hospital, Detroit, Michigan 48201, USA
    Fertil Steril 81:185-90. 2004
    ....
  8. ncbi request reprint Effect of Tisseel on expression of tissue plasminogen activator and plasminogen activator inhibitor-1
    Michael P Diamond
    Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Detroit, Michigan, USA
    Fertil Steril 81:1657-64. 2004
    ..Reduction of plasminogen activator activity, as occurs with tissue trauma, results in increased postoperative adhesion development...
  9. ncbi request reprint Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions
    Michael P Diamond
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University Detroit Medical Center, Hutzel Hospital, Detroit, MI 48201, USA
    Am J Obstet Gynecol 190:926-34. 2004
    ....
  10. ncbi request reprint Challenges of evaluating surgical outcomes
    Michael P Diamond
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, University Women s Care Inc, Detroit, Michigan, USA
    Fertil Steril 84:1581. 2005
    ..IVF-embryo transfer to improve the potential for conception will vary as enhancements of these interventions occurs. Well-designed and conducted studies, controlling for the complexities of surgical trials are needed...
  11. pmc Estimating rates of multiple gestation pregnancies: sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial
    Michael P Diamond
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne Sate University, 3800 Woodward Avenue, Suite 320, Detroit, MI 48201, USA
    Contemp Clin Trials 32:902-8. 2011
    ....
  12. ncbi request reprint Use of the PROACT System for reduction of postsurgical peritoneal adhesions
    Michael P Diamond
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 79:198-202. 2003
    ..To assess the efficacy and safety of a new surgical device designed to prevent adhesions...
  13. doi request reprint A prospective, controlled, randomized, multicenter, exploratory pilot study evaluating the safety and potential trends in efficacy of Adhexil
    Michael P Diamond
    Division of Reproductive Endocrinology and Infertility, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 95:1086-90. 2011
    ..To present a multicenter, reviewer-blinded pilot study evaluating the safety and trends of efficacy of Adhexil, a novel product using fibrin sealant...
  14. ncbi request reprint Modulation of the expression of vascular endothelial growth factor in human fibroblasts
    Michael P Diamond
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Detroit, MI 48201, USA
    Fertil Steril 83:405-9. 2005
    ..To examine the up-regulation of vascular endothelial growth factor (VEGF) expression by hypoxia, a crucial event leading to neovascularization, as the reduction in VEGF expression may facilitate minimization of adhesion development...
  15. ncbi request reprint Antecubital vein venous sampling does not distort circulating levels of peptide and sex steroid hormones
    Michael P Diamond
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, The Detroit Medical Center, Detroit, Michigan 48201, USA
    Fertil Steril 83:1557-60. 2005
    ....
  16. ncbi request reprint Effects of cornual catheterization on uterotubal histology and function
    Michael P Diamond
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    Fertil Steril 84:212-6. 2005
    ..To assess histologic damage and functional impairment following coaxial tubal catheterization...
  17. ncbi request reprint Values of fasting glucose levels, glucose tolerance tests, and glucose-insulin ratios as predictors of glucose tolerance
    Michael P Diamond
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Hutzel Hospital, Detroit, Michigan 48201, USA
    Fertil Steril 80:1022-5. 2003
    ..To examine the ability to use parameters obtainable from an oral glucose tolerance test to predict insulin action as determined under hyperinsulinemic, hyperglycemic conditions...
  18. ncbi request reprint Regulation of transforming growth factor-beta, type III collagen, and fibronectin by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions
    Michael P Diamond
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Hutzel Hospital, Detroit, Michigan 48201, USA
    Fertil Steril 79:1161-7. 2003
    ....
  19. pmc PCBs enhance collagen I expression from human peritoneal fibroblasts
    Michael P Diamond
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan 48201, USA
    Fertil Steril 90:1372-5. 2008
    ....
  20. ncbi request reprint Metabolic regulation of collagen I in fibroblasts isolated from normal peritoneum and adhesions by dichloroacetic acid
    Michael P Diamond
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Hutzel Hospital, Mich 48201, USA
    Am J Obstet Gynecol 187:1456-60; discussion 1460-1. 2002
    ..Specifically, we have exposed human fibroblast cultures from normal peritoneum and adhesions to DCA (0, 50, and 100 microg/mL) for 24 hours under normal and hypoxic (2% oxygen) conditions...
  21. doi request reprint Science linking environmental contaminant exposures with fertility and reproductive health impacts in the adult male (respondent)
    Michael P Diamond
    Division of Reproductive Endocrinology and Infertility, Wayne State University, Detroit, Michigan 48202, USA
    Fertil Steril 89:e71. 2008
  22. ncbi request reprint Reduction of postoperative adhesions by N,O-carboxymethylchitosan: a pilot study
    Michael P Diamond
    Wayne State University Detroit Medical Center, Detroit, Michigan, USA
    Fertil Steril 80:631-6. 2003
    ..To examine the logistics, safety, and efficacy of N,O-carboxymethylchitosan (NOCC) in reducing adhesions in women...
  23. ncbi request reprint Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, M S Hershey Medical Center, Hershey, PA 17033, USA
    N Engl J Med 356:551-66. 2007
    ..The polycystic ovary syndrome is a common cause of infertility. Clomiphene and insulin sensitizers are used alone and in combination to induce ovulation, but it is unknown whether one approach is superior...
  24. pmc Myeloperoxidase acts as a source of free iron during steady-state catalysis by a feedback inhibitory pathway
    Dhiman Maitra
    Department of Obstetrics and Gynecology, The CS Mott Center for Human Growth and Development, Detroit, MI 48201, USA
    Free Radic Biol Med 63:90-8. 2013
    ..Collectively, this study elucidates the bidirectional relationship between MPO and HOCl, which highlights the potential role of MPO as a source of free iron...
  25. pmc Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, M S Hershey Medical Center, 500 University Drive, H103, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 93:792-800. 2008
    ..Clomiphene and insulin sensitizers such as metformin are used to induce ovulation in polycystic ovary syndrome (PCOS), but the ovulatory response is variable, and the causes of this variation are poorly understood...
  26. ncbi request reprint Endometrial thickness is related to miscarriage rate, but not to the estradiol concentration, in cycles down-regulated with gonadotropin-releasing hormone antagonist
    Laura Detti
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 89:998-1001. 2008
    ..However, there was a statistically significant inverse relationship with early pregnancy loss (31%) if the endometrial thickness was <9.8 mm (sensitivity 71%; specificity 76%)...
  27. pmc Myeloperoxidase serves as a redox switch that regulates apoptosis in epithelial ovarian cancer
    Ghassan M Saed
    Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Gynecol Oncol 116:276-81. 2010
    ..We sought to investigate the expression of myeloperoxidase (MPO) and iNOS in epithelial ovarian cancer (EOC) and determine their effect on S-nitrosylation of caspase-3 and its activity as well as apoptosis...
  28. ncbi request reprint The Pregnancy in Polycystic Ovary Syndrome study: baseline characteristics of the randomized cohort including racial effects
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    Fertil Steril 86:914-33. 2006
    ..To report the baseline characteristics and racial differences in the polycystic ovary syndrome (PCOS) phenotype from a large multicenter clinical trial (PPCOS)...
  29. pmc Hypochlorous acid-induced heme degradation from lactoperoxidase as a novel mechanism of free iron release and tissue injury in inflammatory diseases
    Carlos Eduardo A Souza
    Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan, United States of America
    PLoS ONE 6:e27641. 2011
    ....
  30. pmc Predictors of pregnancy in women with polycystic ovary syndrome
    Mary E Rausch
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 94:3458-66. 2009
    ..Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. The selection of first-line therapies for ovulation induction is empiric...
  31. ncbi request reprint Thiocyanate modulates the catalytic activity of mammalian peroxidases
    Yahya R Tahboub
    Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 280:26129-36. 2005
    ..A modified kinetic model, which incorporates our current findings with the mammalian peroxidases classic cycle, is presented...
  32. doi request reprint Melatonin attenuates hypochlorous acid-mediated heme destruction, free iron release, and protein aggregation in hemoglobin
    Dhiman Maitra
    Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Pineal Res 53:198-205. 2012
    ..Collectively, in addition to acting as an antioxidant and as a MPO inhibitor, melatonin can also exert its protective effect by inhibiting HOCl-mediated heme destruction of hemoproteins and subsequent free iron release...
  33. doi request reprint Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress
    Ghassan M Saed
    Department of Obstetrics and Gynecology, The CS Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Reprod Sci 18:1253-61. 2011
    ..In conclusion, reduction of enhanced oxidative stress-induced apoptosis of EOC cells, which may serve as future therapeutic intervention for ovarian cancer...
  34. ncbi request reprint Effect of oxidized regenerated cellulose (Interceed) on the expression of tissue plasminogen activator and plasminogen activator inhibitor-1 in human peritoneal fibroblasts and mesothelial cells
    L April Gago
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA
    Fertil Steril 86:1223-7. 2006
    ..New Brunswick, NJ)...
  35. pmc Reactive oxygen species and oocyte aging: role of superoxide, hydrogen peroxide, and hypochlorous acid
    Anuradha P Goud
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, USA
    Free Radic Biol Med 44:1295-304. 2008
    ..Overall, O2-, H2O2, and HOCl each augment oocyte aging, more so in relatively old oocytes, suggesting compromised antioxidant capacity in aging oocytes...
  36. doi request reprint S-nitrosylation of caspase-3 is the mechanism by which adhesion fibroblasts manifest lower apoptosis
    Zhong L Jiang
    Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Wound Repair Regen 17:224-9. 2009
    ..The mechanism by which caspase-3 S-nitrosylation occurs is not fully understood. However, the role of hypoxia in the formation of peroxynitrite via superoxide production may suggest a possible mechanism...
  37. pmc Reaction of hemoglobin with HOCl: mechanism of heme destruction and free iron release
    Dhiman Maitra
    Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Free Radic Biol Med 51:374-86. 2011
    ..This work provides a direct link between Hb heme destruction and subsequent free iron accumulation, as occurs under inflammatory conditions where HOCl is formed in substantial amounts...
  38. ncbi request reprint Vaginal micronized progesterone versus intramuscular progesterone for luteal support in women undergoing in vitro fertilization-embryo transfer
    Mohamed F Mitwally
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Women s Health, University of Minnesota, Minneapolis, Minnesota, USA
    Fertil Steril 93:554-69. 2010
    ..To study the outcome of IVF-ET in women who used vaginal P (vaginal P(4)) versus those who used P in oil via IM injection (IM-P(4)) for luteal support...
  39. ncbi request reprint Hypoxia upregulates cyclooxygenase-2 and prostaglandin E(2) levels in human peritoneal fibroblasts
    Ghassan M Saed
    The C S Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, 275 E Hancock, Detroit, MI 47201, USA
    Fertil Steril 83:1216-9. 2005
    ..To determine the levels of COX-1, COX-2, and prostaglandin (PG) E(2) in human fibroblasts isolated from normal peritoneal and adhesion tissues...
  40. ncbi request reprint Absence of secretory endometrium after false-positive home urine luteinizing hormone testing
    Peter G McGovern
    Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Newark 07103, USA
    Fertil Steril 82:1273-7. 2004
    ..To examine the proportion of cases with proliferative endometrium on biopsies performed after positive home urine LH testing...
  41. pmc Expression pattern and regulation of genes differ between fibroblasts of adhesion and normal human peritoneum
    Ujjwal K Rout
    Division of Reproduction Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Reprod Biol Endocrinol 3:1. 2005
    ..Therefore, identifying changes in gene expression pattern in the peritoneal fibroblasts during the process may provide clues to the mechanisms by which adhesion develop...
  42. doi request reprint Macrophages induce the adhesion phenotype in normal peritoneal fibroblasts
    Jennell C White
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan, USA
    Fertil Steril 96:758-763.e3. 2011
    ..The adhesion phenotype has been previously characterized, in part, by increased fibroblast expression of transforming growth factor (TGF) β1, vascular endothelial growth factor (VEGF), and type I collagen...
  43. pmc The presence, role and clinical use of spermatozoal RNAs
    Meritxell Jodar
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Hum Reprod Update 19:604-24. 2013
    ..Development is continuing on the use of spermatozoal RNA profiles as phenotypic markers of male factor status for use as clinical diagnostics of the father's contribution to the birth of a healthy child. ..
  44. ncbi request reprint Altered in vitro immune response to hypoxia-treated normal peritoneal fibroblasts
    Zeynep Alpay
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hutzel Hospital, Wayne State University, Detroit, Michigan 48201, USA
    Fertil Steril 87:426-9. 2007
    ....
  45. ncbi request reprint Myeloperoxidase and free iron levels: potential biomarkers for early detection and prognosis of ovarian cancer
    Nicole M Fletcher
    Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Biomark 10:267-75. 2011
    ..The study sought to identify whether a relationship exists between serum myeloperoxidase (MPO) and free iron with stages of ovarian cancer...
  46. ncbi request reprint Effects of hyperglycemia on the differential expression of insulin and insulin-like growth factor-I receptors in human normal peritoneal and adhesion fibroblasts
    Natalie N Rizk
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan 48201, USA
    Fertil Steril 86:1217-22. 2006
    ....
  47. doi request reprint Microarray expression profiling in adhesion and normal peritoneal tissues
    Dana R Ambler
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Geisinger Medical Center, Danville, Pennsylvania, USA
    Fertil Steril 97:1158-64.e1-4. 2012
    ..To identify molecular markers associated with adhesion and normal peritoneal tissue using microarray expression profiling...
  48. pmc Establishing a biologic specimens repository for reproductive clinical trials: technical aspects
    Stephen A Krawetz
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA
    Syst Biol Reprod Med 57:222-7. 2011
    ..To facilitate such interoperability, the reagents and protocols that have been adopted by the RMN Biorepository for the collection and storage of serum, blood, saliva and sperm are described...
  49. doi request reprint Adverse obstetric outcomes associated with sonographically identified large uterine fibroids
    Valerie I Shavell
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    Fertil Steril 97:107-10. 2012
    ..To determine the impact of sonographically identified large uterine fibroids (>5 cm in diameter) on obstetric outcomes...
  50. ncbi request reprint Expression of transforming growth factor-beta and extracellular matrix by human peritoneal mesothelial cells and by fibroblasts from normal peritoneum and adhesions: effect of Tisseel
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Hutzel Hospital, 4707 St Antoine Boulevard, Detroit, MI 48201, USA
    Wound Repair Regen 12:557-64. 2004
    ....
  51. pmc Nitric oxide synthase isoforms expression in fibroblasts isolated from human normal peritoneum and adhesion tissues
    Zhong L Jiang
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 90:769-74. 2008
    ..To determine the expression of nitric oxide synthases (NOSs) and their modulation by hypoxia in human peritoneal (NF) and adhesion fibroblasts (ADF)...
  52. pmc Hypoxia regulates iNOS expression in human normal peritoneal and adhesion fibroblasts through nuclear factor kappa B activation mechanism
    Zhong L Jiang
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 91:616-21. 2009
    ..To determine the mechanism by which hypoxia increases expression of iNOS in human normal peritoneal and adhesion fibroblasts...
  53. ncbi request reprint Measurement of oxygen and nitric oxide levels in vitro and in vivo: relationship to postoperative adhesions
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    Fertil Steril 84:235-8. 2005
    ....
  54. ncbi request reprint Transforming growth factors beta1, beta2 and beta3 and their receptors are differentially expressed in human peritoneal fibroblasts in response to hypoxia
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University, Detroit, MI 48201, USA
    Am J Reprod Immunol 48:387-93. 2002
    ..TGF-beta isoforms and their receptors have been implicated as mediators of the healing process and adhesion development...
  55. ncbi request reprint Endometrial thickness dynamics and morphologic characteristics during pituitary downregulation with antagonists in assisted reproductive technology cycles
    Laura Detti
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, Detroit, MI 48201 USA
    J Ultrasound Med 27:1591-6. 2008
    ....
  56. ncbi request reprint Role of nitric oxide in apoptosis of human peritoneal and adhesion fibroblasts after hypoxia
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, The C S Mott Center for Human Growth and Development, Detroit, Michigan 48201, USA
    Fertil Steril 82:1198-205. 2004
    ..To study the modulation of the inducible nitric oxide synthase/nitric oxide (iNOS/NO) expression system in fibroblasts isolated from human peritoneum and adhesion tissues by hypoxia...
  57. pmc Timing and duration of use of GnRH antagonist down-regulation for IVF/ICSI cycles have no impact on oocyte quality or pregnancy outcomes
    Laura Detti
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, 3750 Woodward Ave, Suite 200 D, Detroit, MI, 48201, USA
    J Assist Reprod Genet 25:177-81. 2008
    ....
  58. ncbi request reprint Effects of oxidized regenerated cellulose on the expression of extracellular matrix and transforming growth factor-beta1 in human peritoneal fibroblasts and mesothelial cells
    L April Gago
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, 4707 St Antoine Boulevard, Detroit, MI 48201, USA
    Am J Obstet Gynecol 189:1620-5; discussion 1625-6. 2003
    ....
  59. pmc High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples
    Richard E Leach
    Michigan State University Spectrum Health Medical Group, Grand Rapids, MI, USA
    Hum Reprod 27:814-28. 2012
    ....
  60. ncbi request reprint Serum human chorionic gonadotropin level after ovulation triggering is influenced by the patient's body mass index and the number of larger follicles
    Laura Detti
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, and the University Women s Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 88:152-5. 2007
    ..To identify determinants of the serum concentration of hCG levels after triggering of ovulation with exogenous hCG during controlled ovarian stimulation cycles for in vitro fertilization with or without intracytoplasmic sperm injection...
  61. pmc The reaction of HOCl and cyanocobalamin: corrin destruction and the liberation of cyanogen chloride
    Husam M Abu-Soud
    Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Free Radic Biol Med 52:616-25. 2012
    ..Additionally, it can liberate free Co, which can perpetuate metal-ion-induced oxidant stress. Taken together, these results are the first report of the generation of toxic molecular products through the interaction of Cobl with HOCl...
  62. doi request reprint Uncoupling oxidative phosphorylation with 2,4-dinitrophenol promotes development of the adhesion phenotype
    Valerie I Shavell
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The CS Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 97:729-33. 2012
    ..To determine the effect of uncoupling oxidative phosphorylation with 2,4-dinitrophenol (DNP) on adhesion phenotype development...
  63. pmc Nitric oxide extends the oocyte temporal window for optimal fertilization
    Pravin T Goud
    Department of Obstetrics and Gynecology, The CS Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Free Radic Biol Med 45:453-9. 2008
    ..Thus, NO is essential for sustenance of oocyte quality postovulation...
  64. ncbi request reprint Racial disparity in the clinical determinants and outcomes of cesarean hysterectomy
    Anthony N Imudia
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine Detroit Medical Center, Detroit, Michigan 48201, USA
    J Natl Med Assoc 101:565-8. 2009
    ..In conclusion, beyond higher rates of cardiopulmonary complications and urological injury among whites, no significant racial differences exist in the risk factors, indications for, and complications from cesarean hysterectomy...
  65. pmc The effect of estradiol on the expression of estrogen, progesterone, androgen, and prolactin receptors in human peritoneal fibroblasts
    Laura Detti
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA
    J Assist Reprod Genet 25:245-50. 2008
    ..To assess the ability of fibroblasts isolated from normal peritoneum and adhesion tissues to express various hormone receptors when cultured with exogenous estradiol...
  66. pmc Endometrial morphology and modulation of hormone receptors during ovarian stimulation for assisted reproductive technology cycles
    Laura Detti
    Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    Fertil Steril 95:1037-41. 2011
    ..To study the biochemical and morphologic implications of different hormonal levels on endometrial development during assisted reproductive technology (ART) cycles...
  67. pmc Increasing burden of institutional review in multicenter clinical trials of infertility: the Reproductive Medicine Network experience with the Pregnancy in Polycystic Ovary Syndrome (PPCOS) I and II studies
    William D Schlaff
    Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Academic Office Building 1, 12631 E 17th Avenue, Aurora, CO 80045, USA
    Fertil Steril 96:15-8. 2011
    ..It is timely to consider whether these changes better protect the interests and safety of human research participants...
  68. ncbi request reprint Adenovirus-mediated expression of cyclooxygenase-2 antisense reverse abnormal genetic profile of human adhesion fibroblasts
    Ghassan M Saed
    Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 89:1455-60. 2008
    ....
  69. ncbi request reprint Expression of transforming growth factor beta isoform mRNA in injured peritoneum that healed with adhesions and without adhesions and in uninjured peritoneum
    Michael L Freeman
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA
    Fertil Steril 80:708-13. 2003
    ....
  70. ncbi request reprint Antiadhesion effects of docosahexaenoic acid on normal human peritoneal and adhesion fibroblasts
    Rahi Victory
    Department of Obstetrics and Gynecology, C S Mott Center, Wayne State University, Detroit, Michigan 48201, USA
    Fertil Steril 88:1657-62. 2007
    ..To determine whether docosahexaenoic acid (DHA) reduces adhesion marker mRNA levels in normal peritoneal and adhesion fibroblasts...
  71. ncbi request reprint Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblasts
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and the C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    Fertil Steril 79:164-8. 2003
    ..To determine whether normal peritoneal and adhesion fibroblasts express tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI-I) and whether their expression is regulated by oxygen...
  72. ncbi request reprint Activation of the cGMP signaling pathway is essential in delaying oocyte aging in diabetes mellitus
    Anuradha P Goud
    Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Detroit, Michigan 48201, USA
    Biochemistry 45:11366-78. 2006
    ..A comprehensive model incorporating our current findings with NOS, GC, and G kinase cycles is presented...
  73. ncbi request reprint Seprafilm (modified hyaluronic acid and carboxymethylcellulose) acts as a physical barrier
    L April Gago
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Fertil Steril 80:612-6. 2003
    ..To characterize the molecular changes that occur in normal fibroblasts, adhesion fibroblasts, and mesothelial cells as a result of exposure to modified hyaluronic acid and carboxymethylcellulose (Seprafilm)...
  74. ncbi request reprint Reconstruction of ooplasm recipient oocytes with frozen-thawed donor microcytoplasts and influence on the microtubular spindle
    Anuradha P Goud
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 87:923-33. 2007
    ....
  75. ncbi request reprint Female infertility and free radicals: potential role in adhesions and endometriosis
    Zeynep Alpay
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    J Soc Gynecol Investig 13:390-8. 2006
    ..As our knowledge of both conditions expands, we believe there will be opportunities for specific steps to intervention in free radical metabolism to reduce and/or prevent further development of endometriosis and adhesions...
  76. doi request reprint Pathogenesis of benign metastasizing leiomyoma: a review
    Awoniyi O Awonuga
    Division of Reproductive Endocrinology and Infertility, Wayne State University, Detroit, MI 48201, USA
    Obstet Gynecol Surv 65:189-95. 2010
    ..It is hoped that analyses of the etiology and features of this disorder will facilitate a better understanding of its pathogenesis and treatment...
  77. doi request reprint The role of myeloperoxidase in the pathogenesis of postoperative adhesions
    Ghassan M Saed
    Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Wound Repair Regen 17:531-9. 2009
    ..These studies identify MPO and iNOS as key enzymes in the cellular response to hypoxia and consequent development of tissue fibrosis...
  78. pmc Exposure to polychlorinated biphenyls enhances lipid peroxidation in human normal peritoneal and adhesion fibroblasts: a potential role for myeloperoxidase
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Free Radic Biol Med 48:845-50. 2010
    ..This is evident by lower iNOS, MPO, and nitrite/nitrate and a simultaneous increase in LPO. Loss of MPO activity, possibly through a mechanism involving MPO heme depletion and free iron release, is yet another source of oxidative stress...
  79. ncbi request reprint Modulation of the BCL-2/BAX ratio by interferon-gamma and hypoxia in human peritoneal and adhesion fibroblasts
    Ghassan M Saed
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, CS Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    Fertil Steril 90:1925-30. 2008
    ..To examine the effect of interferon (IFN)-gamma treatment under normal and hypoxic conditions on the BCL-2/BAX ratio of fibroblasts obtained from normal peritoneal and adhesion tissues of the same patients...
  80. ncbi request reprint Reasons for poststerilization hysterosalpingography noncompliance in a clinic population
    Valerie I Shavell
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, and Hutzel Women s Health Specialists, Detroit Medical Center, Detroit, Michigan 48201, USA
    J Reprod Med 55:459-63. 2010
    ..We were interested in determining the reason(s) for HSG noncompliance in this urban-based patient population...
  81. ncbi request reprint Molecular characterization of postoperative adhesions: the adhesion phenotype
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    J Am Assoc Gynecol Laparosc 11:307-14. 2004
    ..Improved understanding of these events and their regulation will provide the opportunity to regulate better postoperative adhesion development and tissue fibrosis, thereby reducing the morbidity and mortality they cause...
  82. pmc Hypoxia-generated superoxide induces the development of the adhesion phenotype
    Nicole M Fletcher
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The CS Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Free Radic Biol Med 45:530-6. 2008
    ..Scavenging superoxide, even in the presence of hypoxia, prevented the development of the adhesion phenotype. These findings further support the central role of free radicals in the development of adhesions...
  83. ncbi request reprint Success and failure in human spermatogenesis as revealed by teratozoospermic RNAs
    Adrian E Platts
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Hum Mol Genet 16:763-73. 2007
    ..The origin of the perturbation could be traced as far back as the pachytene stage of spermatogenesis. It is anticipated that this diagnostic strategy will prove valuable for understanding male factor infertility...
  84. ncbi request reprint Nitric oxide delays oocyte aging
    Anuradha P Goud
    Department of Obstetrics and Gynecology, The C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biochemistry 44:11361-8. 2005
    ..11-0.23 microM/min NO, P < 0.0001). Collectively, our results demonstrate for the first time that exposure to NO delays oocyte aging and improves the integrity of the microtubular spindle apparatus in young and old oocytes...
  85. pmc Physiologic measures of sexual function in women: a review
    Terri L Woodard
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, 3750 Woodward Avenue, Detroit, MI 48201, USA
    Fertil Steril 92:19-34. 2009
    ..To review and describe physiologic measures of assessing sexual function in women...
  86. ncbi request reprint The transcriptome of the uterine cervix before and after spontaneous term parturition
    Sonia S Hassan
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA
    Am J Obstet Gynecol 195:778-86. 2006
    ..This study was designed to identify genes differentially expressed in the human uterine cervix after spontaneous term labor...
  87. ncbi request reprint Apoptosis and proliferation of human peritoneal fibroblasts in response to hypoxia
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and the C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    Fertil Steril 78:137-43. 2002
    ..To determine the effect of hypoxia on apoptosis and proliferation of fibroblasts cultured from normal peritoneum or adhesions...
  88. ncbi request reprint Dynamic changes in microtubular cytoskeleton of human postmature oocytes revert after ooplasm transfer
    Anuradha P Goud
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    Fertil Steril 81:323-31. 2004
    ..Study of the influence of ooplasm transfer on the microtubule dynamics in human postmature oocytes...
  89. ncbi request reprint The determinants of the apnea threshold during NREM sleep in normal subjects
    James A Rowley
    Sleep Research Laboratory, John D Dingell VA Medical Center Division of Pulmonary, Critical Care and Sleep Medicine, Department of Ilnternal Medicine, Detroit, MI, USA
    Sleep 29:95-103. 2006
    ..To determine whether (1) postmenopausal women have a higher apnea threshold than premenopausal women and men and (2) hormone replacement therapy would decrease the apnea threshold in postmenopausal women...
  90. doi request reprint Contribution of imaging to our understanding of sexual function and dysfunction
    Terri L Woodard
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Adv Psychosom Med 29:150-68. 2008
    ..The purpose of this chapter is to review and discuss these techniques with an emphasis on how they contribute to our understanding of sexual function and dysfunction...
  91. ncbi request reprint Cyclooxygenase-2 is expressed in human fibroblasts isolated from intraperitoneal adhesions but not from normal peritoneal tissues
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Detroit, Michigan 48201, USA
    Fertil Steril 79:1404-8. 2003
    ..To determine whether the COX-2 gene is expressed in human fibroblasts isolated from normal peritoneal and adhesion tissues...
  92. ncbi request reprint Clinical update of smooth muscle tumors of the uterus
    Leigh A Solomon
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wayne State University, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    J Minim Invasive Gynecol 12:401-8. 2005
    ..The goal of this review is to present the most recent information about common smooth muscle tumors of the uterus including their etiology, histopathology, radiographic and clinical presentations, and available treatment options...
  93. ncbi request reprint Role of plasminogen activators during healing after uterine serosal lesioning in the rat
    Ujjwal Kumar Rout
    C S Mott Center for Human Growth and Development, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 79:138-45. 2003
    ..Study the expression pattern of tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activators during uterine serosal healing after lesioning in a rat model...
  94. ncbi request reprint A three-stage alcohol clamp procedure in human subjects
    Marappa G Subramanian
    Department of Obstetrics and Gynecology University School of Medicine, Detroit, Michigan 48201, USA
    Alcohol Clin Exp Res 26:1479-83. 2002
    ..To minimize the variability in BALs, an alcohol "clamping" method in which alcohol is administered intravenously has been previously reported. We have modified this method and developed a multistage alcohol clamp procedure in humans...
  95. ncbi request reprint Hormone-independent ovarian influence on adhesion development
    Michael L Freeman
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA
    Fertil Steril 78:340-6. 2002
    ..To determine which ovarian sex steroid(s), when removed from an intact organism, reduce(s) postoperative adhesion development...
  96. ncbi request reprint Transforming growth factor-beta1 modulates expression of adhesion and cytoskeletal proteins in human peritoneal fibroblasts
    Ujjwal K Rout
    C S Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 78:154-61. 2002
    ..To determine the effects of TGF-beta1 on the expression of the alpha1, alpha2, alpha5, alpha(v), and alpha6 integrin subunits and on vinculin, and F-actin in human peritoneal fibroblasts...
  97. ncbi request reprint Villar's nodule: a case report and systematic literature review of endometriosis externa of the umbilicus
    Rahi Victory
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan 48201, USA
    J Minim Invasive Gynecol 14:23-32. 2007
    ..Surgical intervention is recommended, but medical therapy may result in long-term symptom control with minimal malignancy risk...
  98. ncbi request reprint Adhesions in patients with chronic pelvic pain: a role for adhesiolysis?
    Ahmad Hammoud
    Department of Obstetrics and Gynecology, Wayne State University The Detroit Medical Center, Detroit, Michigan, USA
    Fertil Steril 82:1483-91. 2004
    ..To review the relation between adhesions and pelvic pain and the effectiveness of adhesiolysis in pain control...
  99. ncbi request reprint The role of sonographic endometrial patterns and endometrial thickness in the differential diagnosis of ectopic pregnancy
    Ahmad O Hammoud
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, Mich 48201, USA
    Am J Obstet Gynecol 192:1370-5. 2005
    ..The purpose of this study was to examine the usefulness of the endometrial trilaminar pattern and thickness in the diagnosis of ectopic pregnancy...

Research Grants4

  1. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    Michael Diamond; Fiscal Year: 2004
    ..abstract_text> ..
  2. Wayne State University Clinical Translational Science
    Michael Diamond; Fiscal Year: 2006
    ....
  3. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    Michael Diamond; Fiscal Year: 2007
    ....