Harry Chugani

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Hippocampal and thalamic diffusion abnormalities in children with temporal lobe epilepsy
    Tomomi Kimiwada
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 47:167-75. 2006
  2. pmc α-[11C]-Methyl-L-tryptophan--PET in 191 patients with tuberous sclerosis complex
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI, USA
    Neurology 81:674-80. 2013
  3. doi request reprint GABA(A) receptor imaging with positron emission tomography in the human newborn: a unique binding pattern
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Neurol 48:459-62. 2013
  4. pmc Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI, USA
    J Neuroinflammation 9:232. 2012
  5. ncbi request reprint Functional brain reorganization in children
    H T Chugani
    Department of Neurology, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201 2196, USA
    Brain Dev 18:347-56. 1996
  6. pmc Increased striatal serotonin synthesis following cortical resection in children with intractable epilepsy
    Harry T Chugani
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
    Epilepsy Res 78:124-30. 2008
  7. ncbi request reprint Transient hypermetabolism of the basal ganglia following perinatal hypoxia
    Carlos E A Batista
    Carman and Ann Adams, Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Neurol 36:330-3. 2007
  8. pmc Clinical and histopathologic correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 52:1692-8. 2011
  9. ncbi request reprint Autism with facial port-wine stain: a new syndrome?
    Harry T Chugani
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Pediatr Neurol 37:192-9. 2007
  10. ncbi request reprint A critical period of brain development: studies of cerebral glucose utilization with PET
    H T Chugani
    Division of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201, USA
    Prev Med 27:184-8. 1998

Research Grants

  1. LOCALIZATION OF EPILEPTIC FOCI WITH PET IN CHILDREN
    Harry Chugani; Fiscal Year: 2009
  2. LOCALIZATION OF EPILEPTIC FOCI WITH PET IN CHILDREN
    Harry Chugani; Fiscal Year: 2004
  3. LOCALIZATION OF EPILEPTIC FOCI WITH PET IN CHILDREN
    Harry Chugani; Fiscal Year: 1999
  4. Identifying Epileptogenic Tubers in TSC
    Harry T Chugani; Fiscal Year: 2010

Collaborators

Detail Information

Publications89

  1. ncbi request reprint Hippocampal and thalamic diffusion abnormalities in children with temporal lobe epilepsy
    Tomomi Kimiwada
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 47:167-75. 2006
    ....
  2. pmc α-[11C]-Methyl-L-tryptophan--PET in 191 patients with tuberous sclerosis complex
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI, USA
    Neurology 81:674-80. 2013
    ....
  3. doi request reprint GABA(A) receptor imaging with positron emission tomography in the human newborn: a unique binding pattern
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Neurol 48:459-62. 2013
    ....
  4. pmc Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI, USA
    J Neuroinflammation 9:232. 2012
    ..We studied the distribution and expression of translocator protein in the human brain using (11)C-[R]-PK-11195 positron emission tomography (PK11195 PET) and evaluated age-related changes...
  5. ncbi request reprint Functional brain reorganization in children
    H T Chugani
    Department of Neurology, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201 2196, USA
    Brain Dev 18:347-56. 1996
    ....
  6. pmc Increased striatal serotonin synthesis following cortical resection in children with intractable epilepsy
    Harry T Chugani
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
    Epilepsy Res 78:124-30. 2008
    ..In this study we used positron emission tomography (PET) with alpha[11C]methyl-l-tryptophan (AMT) to evaluate serotonergic alterations in subcortical structures following cortical resection in children with intractable epilepsy...
  7. ncbi request reprint Transient hypermetabolism of the basal ganglia following perinatal hypoxia
    Carlos E A Batista
    Carman and Ann Adams, Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Neurol 36:330-3. 2007
    ..Thus, positron emission tomography can help predict this form of cerebral palsy in neonates...
  8. pmc Clinical and histopathologic correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy
    Harry T Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 52:1692-8. 2011
    ..Therefore, in the present study, we evaluated the clinical and histopathologic correlates of AMT-PET abnormalities in children with intractable epilepsy undergoing resective surgery...
  9. ncbi request reprint Autism with facial port-wine stain: a new syndrome?
    Harry T Chugani
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Pediatr Neurol 37:192-9. 2007
    ..Unilateral facial port-wine stain and autism with no intracranial angioma on conventional imaging may represent a rare clinical entity distinct from both infantile autism and previously described variants of Sturge-Weber syndrome...
  10. ncbi request reprint A critical period of brain development: studies of cerebral glucose utilization with PET
    H T Chugani
    Division of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201, USA
    Prev Med 27:184-8. 1998
    ....
  11. doi request reprint Molecular and diffusion tensor imaging of epileptic networks
    Aimee F Luat
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    Epilepsia 49:15-22. 2008
    ..In this review, we illustrate how PET and DTI can be applied to depict the functional and microstructural alterations associated with chronic epilepsy...
  12. pmc Objective detection of epileptic foci by 18F-FDG PET in children undergoing epilepsy surgery
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Nucl Med 51:1901-7. 2010
    ..The purpose of the present study was to evaluate and optimize the performance (lateralization and lobar localization value of epileptic foci) of objective voxel-based analysis of (18)F-FDG PET scans in a pediatric epilepsy population...
  13. ncbi request reprint Metabolic changes of subcortical structures in intractable focal epilepsy
    Krisztina Benedek
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 45:1100-5. 2004
    ..In the present study, we analyzed alterations of glucose metabolism in subcortical nuclei and hippocampus by using FDG-PET in young patients with intractable epilepsy...
  14. ncbi request reprint Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome
    Michael Behen
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Mov Disord 22:2256-62. 2007
    ..This study demonstrates cortical and subcortical abnormalities of tryptophan metabolism in TS and provides neuroimaging evidence for a role of serotonergic mechanisms in the pathophysiology of TS...
  15. ncbi request reprint Longitudinal changes in cortical glucose hypometabolism in children with intractable epilepsy
    Krisztina Benedek
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Child Neurol 21:26-31. 2006
    ..The findings have implications on how aggressively persistent seizures should be treated in children. (J Child Neurol 2006;21:26-31)...
  16. pmc Long-term outcome in children with intractable epilepsy showing bilateral diffuse cortical glucose hypometabolism pattern on positron emission tomography
    Varun Shandal
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    J Child Neurol 27:39-45. 2012
    ..In conclusion, the long-term outcome in this patient population is poor, and they tend to suffer from genetic/neurodegenerative diseases...
  17. doi request reprint Alpha-methyl-l-tryptophan positron emission tomography in epilepsy with cortical developmental malformations
    Hiroyuki Wakamoto
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pediatr Neurol 39:181-8. 2008
    ..When an alpha-[(11)C]methyl-l-tryptophan focus is detected, it likely represents the epileptogenic region to be resected...
  18. ncbi request reprint Altered regional brain glucose metabolism in Duchenne muscular dystrophy: a pet study
    Joon Soo Lee
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, Michigan 48201, USA
    Muscle Nerve 26:506-12. 2002
    ....
  19. ncbi request reprint Significance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism
    Sreenivasa R Chandana
    Department of Pharmacology, Wayne State University School of Medicine, 3901 Beaubian Blvd, Detroit, MI 48201, USA
    Int J Dev Neurosci 23:171-82. 2005
    ..Global as well as focal abnormally asymmetric development in the serotonergic system could lead to miswiring of the neural circuits specifying hemispheric specialization...
  20. pmc Diffusion tensor analysis of temporal and extra-temporal lobe tracts in temporal lobe epilepsy
    Rajkumar Munian Govindan
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI, USA
    Epilepsy Res 80:30-41. 2008
    ..To determine whether the major temporal lobe white matter tracts in patients with temporal lobe epilepsy manifest abnormal water diffusion properties...
  21. ncbi request reprint Evaluation with alpha-[11C]methyl-L-tryptophan positron emission tomography for reoperation after failed epilepsy surgery
    Csaba Juhasz
    Department of Pediatrics, Children s Hospital of Michigan and Harper University Hospital, Detroit Medical Center, Wayne State University School of Medicine, 48201, USA
    Epilepsia 45:124-30. 2004
    ..This study analyzed whether increased cortical AMT uptake can detect nonresected epileptic foci in patients with previously failed neocortical resection...
  22. ncbi request reprint Cerebellar lesions in tuberous sclerosis complex: neurobehavioral and neuroimaging correlates
    Thomas J Eluvathingal
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI 48201, USA
    J Child Neurol 21:846-51. 2006
    ..Further investigation of the potential role of the right cerebellum in autism, particularly with regard to the dentatothalamofrontal circuit, is warranted...
  23. pmc Cortical glucose metabolism positively correlates with gamma-oscillations in nonlesional focal epilepsy
    Masaaki Nishida
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Neuroimage 42:1275-84. 2008
    ....
  24. pmc Altered water diffusivity in cortical association tracts in children with early deprivation identified with Tract-Based Spatial Statistics (TBSS)
    Rajkumar Munian Govindan
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Cereb Cortex 20:561-9. 2010
    ..It is suspected that the observed white matter abnormalities are associated with multiple depriving factors (e.g., poor prenatal care, postnatal stress) associated with institutional caregiving...
  25. ncbi request reprint Positron emission tomography methods with potential for increased understanding of mental retardation and developmental disabilities
    Senthil K Sundaram
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Ment Retard Dev Disabil Res Rev 11:325-30. 2005
    ....
  26. pmc Quantitative brain surface mapping of an electrophysiologic/metabolic mismatch in human neocortical epilepsy
    Balint Alkonyi
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    Epilepsy Res 87:77-87. 2009
    ..The clinical utility of FDG PET in guiding subdural electrode placement in neocortical epilepsy could be greatly enhanced by extending grid coverage to at least 2 cm beyond hypometabolic cortex, when feasible...
  27. ncbi request reprint Alpha[11C] methyl-L-typtophan positron emission tomography in patients with alternating hemiplegia of childhood
    Zoltan Pfund
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201, USA
    J Child Neurol 17:253-60. 2002
    ..Furthermore, the attack number may have an effect on neurodevelopmental delay, thus supporting the notion that alternating hemiplegia of childhood may be a progressive disorder...
  28. ncbi request reprint Quantitative interictal subdural EEG analyses in children with neocortical epilepsy
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Epilepsia 44:425-34. 2003
    ....
  29. ncbi request reprint Quantitative analysis of gray- and white-matter volumes and glucose metabolism in Sturge-Weber syndrome
    Zoltan Pfund
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Child Neurol 18:119-26. 2003
    ..Extensive gray- and white-matter volume loss and hypometabolism ipsilateral to the angioma likely contribute to the frequently observed progressive cognitive dysfunction in these patients, regardless of the extent of the angioma...
  30. doi request reprint Epilepsy surgery in a case of encephalitis: use of 11C-PK11195 positron emission tomography
    Ajay Kumar
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    Pediatr Neurol 38:439-42. 2008
    ..In such cases, (11)C-PK11195 positron emission tomography may highlight the region of maximal inflammation for palliative surgical treatment...
  31. pmc The role of the thalamus in neuro-cognitive dysfunction in early unilateral hemispheric injury: a multimodality imaging study of children with Sturge-Weber syndrome
    Balint Alkonyi
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Eur J Paediatr Neurol 14:425-33. 2010
    ..Sturge-Weber syndrome (SWS) with unilateral hemispheric involvement is a clinical model of early onset, chronic, often progressive hemispheric injury, resulting in variable neuro-cognitive impairment...
  32. ncbi request reprint Diffusion tensor imaging of the corticospinal tract following cerebral hemispherectomy
    Hiroyuki Wakamoto
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit 48201, USA
    J Child Neurol 21:566-71. 2006
    ....
  33. doi request reprint Altered fronto-striato-thalamic connectivity in children with Tourette syndrome assessed with diffusion tensor MRI and probabilistic fiber tracking
    Malek I Makki
    Department of Radiology, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Child Neurol 24:669-78. 2009
    ....
  34. pmc Incidence of specific absolute neurocognitive impairment in globally intact children with histories of early severe deprivation
    Michael E Behen
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Child Neuropsychol 14:453-69. 2008
    ..A substantial proportion of participants evidenced persistent, absolute impairment in one or more domains of neurocognitive function despite integrity of basic intellectual functions...
  35. doi request reprint Absence of arcuate fasciculus in children with global developmental delay of unknown etiology: a diffusion tensor imaging study
    Senthil K Sundaram
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Pediatr 152:250-5. 2008
    ..To investigate cortical association tracts using diffusion tensor imaging (DTI) in children with global developmental delay of unknown etiology...
  36. pmc The corticospinal tract in Sturge-Weber syndrome: a diffusion tensor tractography study
    Lalitha Sivaswamy
    Carman and Ann Adams Department of Pediatrics, Division of Pediatric Neurology, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI 48201, USA
    Brain Dev 30:447-53. 2008
    ..To utilize diffusion tensor tractography and evaluate the integrity of the corticospinal tract in children with unilateral Sturge-Weber syndrome (SWS)...
  37. doi request reprint Presurgical prediction of motor functional loss using tractography
    Rajkumar Munian Govindan
    Department of Pediatrics and Neurology, Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    Pediatr Neurol 43:70-2. 2010
    ..Tractography helped determine the extent of cortical resection and predict the extent of motor functional loss...
  38. pmc Intracranial recording and source localization of auditory brain responses elicited at the 50 ms latency in three children aged from 3 to 16 years
    Oleg Korzyukov
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Brain Topogr 22:166-75. 2009
    ..Moreover, the present source localisation results of auditory response at the 50 ms latency might be useful in paediatric neurosurgery practice...
  39. pmc Diffusion tensor imaging of frontal lobe in autism spectrum disorder
    Senthil K Sundaram
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Cereb Cortex 18:2659-65. 2008
    ..Abnormal frontal FA and ADC may be due to white matter organization abnormalities in ASD. Lack of evidence for excessive short range connectivity in ASD in this study may need to be re-examined with future advances in DTI technology...
  40. doi request reprint Alterations in frontal lobe tracts and corpus callosum in young children with autism spectrum disorder
    Ajay Kumar
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Cereb Cortex 20:2103-13. 2010
    ..Volume of bilateral UF and right AF and fiber density of left UF were positively associated with autistic features...
  41. pmc In vivo animation of auditory-language-induced gamma-oscillations in children with intractable focal epilepsy
    Erik C Brown
    MD PhD Program, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Neuroimage 41:1120-31. 2008
    ..Further studies are warranted to determine whether recording of language-induced gamma-oscillations can supplement language mapping using neurostimulation in presurgical evaluation of children with focal epilepsy...
  42. pmc Role of subdural electrocorticography in prediction of long-term seizure outcome in epilepsy surgery
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Street, Detroit, MI 48201, USA
    Brain 132:1038-47. 2009
    ..Yet, the additive clinical impact of interictal spike frequency measures to predict long-term surgical outcome may be modest in the presence of ictal ECoG and neuroimaging data...
  43. pmc Short-latency median-nerve somatosensory-evoked potentials and induced gamma-oscillations in humans
    Miho Fukuda
    Department of Pediatrics, Wayne State University, Detroit Medical Center, Detroit, MI, 48201, USA
    Brain 131:1793-805. 2008
    ....
  44. pmc Focal decreases of cortical GABAA receptor binding remote from the primary seizure focus: what do they indicate?
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan and Harper University Hospital, Detroit Medical Center, Wayne State University School of Medcine, Detroit, Michigan, USA
    Epilepsia 50:240-50. 2009
    ..To determine the electroclinical significance and histopathological correlates of cortical gamma-aminobutyric acid(A)(GABA(A)) receptor abnormalities detected in and remote from human neocortical epileptic foci...
  45. doi request reprint Role of external ventriculostomy in the management of fever after hemispherectomy
    Sandeep Sood
    Department of Pediatric Neurosurgery and, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosurg Pediatr 2:427-9. 2008
    ..Fever is a common occurrence after cerebral hemispherectomy in children and prolongs the hospital stay. The authors determined whether an external ventriculostomy might reduce the incidence of fever following a hemispherectomy...
  46. pmc MR susceptibility weighted imaging (SWI) complements conventional contrast enhanced T1 weighted MRI in characterizing brain abnormalities of Sturge-Weber Syndrome
    Jiani Hu
    Department of Radiology, Wayne State University, Detroit, Michigan 48201, USA
    J Magn Reson Imaging 28:300-7. 2008
    ..To evaluate the efficacy of susceptibility weighted imaging (SWI) in comparison to standard T1 weighted postgadolinium contrast (T1-Gd) MRI in patients with Sturge-Weber Syndrome (SWS)...
  47. doi request reprint Secondary tics or tourettism associated with a brain tumor
    Aimee F Luat
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    Pediatr Neurol 41:457-60. 2009
    ....
  48. doi request reprint Microstructural abnormalities of striatum and thalamus in children with Tourette syndrome
    Malek I Makki
    Radiology Department, Wayne State University School of Medicine, Detroit, Michigan, USA
    Mov Disord 23:2349-56. 2008
    ..035, right P = 0.006) compared with NC. These findings support the notion that microstructural dysfunction measured by DT-MRI in component regions of the FST circuit contribute to the pathophysiology in TS...
  49. doi request reprint PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Wayne State University PET Center, Children s Hospital of Michigan, Detroit Medical Center, Detroit, Michigan 48201, USA
    J Nucl Med 51:139-44. 2010
    ..The objective of this study was to derive the biodistribution and in vivo radiation dose estimates of PK in children studied for brain inflammatory conditions and in healthy adults...
  50. pmc Differential kinetics of α-[¹¹C]methyl-L-tryptophan on PET in low-grade brain tumors
    Csaba Juhasz
    PET Center, Children s Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    J Neurooncol 102:409-15. 2011
    ..Kinetic analysis of AMT uptake shows significantly higher tumor/cortex tryptophan metabolic ratios in astrocytomas and oligoastrocytomas in comparison with oligodendrogliomas and DNETs...
  51. ncbi request reprint Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L-tryptophan positron emission tomography (PET)
    Kenji Kagawa
    Department of Pediatrics, Pediatric Neurology PET Center, Children s Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201, USA
    J Child Neurol 20:429-38. 2005
    ..AMT PET can provide independent complementary information regarding the localization of epileptogenic regions in tuberous sclerosis complex and enhance the confidence of patient selection for successful epilepsy surgery...
  52. pmc Is intraoperative electrocorticography reliable in children with intractable neocortical epilepsy?
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Epilepsia 45:1091-9. 2004
    ..To study the relation between the spike frequency during intraoperative electrocorticography (ECoG) under general anesthesia with isoflurane and that during extraoperative ECoG monitoring in children with intractable neocortical epilepsy...
  53. ncbi request reprint Pharmacokinetics of buspirone in autistic children
    David J Edwards
    Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
    J Clin Pharmacol 46:508-14. 2006
    ..Plasma concentrations with 2.5- to 5.0-mg doses were similar to those observed in older children receiving 7.5- to 15-mg doses...
  54. ncbi request reprint Imaging the epileptic brain with positron emission tomography
    Csaba Juhasz
    Division of Pediatric Neurology, Wayne State University School of Medicine, Positron Emission Tomography Center, Children s Hospital of Michigan, Detroit, MI, USA
    Neuroimaging Clin N Am 13:705-16, viii. 2003
    ..Detailed comparisons of PET abnormalities with intracranial electroencephalographic findings also improve our understanding of the pathophysiology of human epilepsy...
  55. ncbi request reprint Functional neuroimaging in the preoperative evaluation of children with drug-resistant epilepsy
    Sandeep Sood
    Department of Neurosurgery, Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    Childs Nerv Syst 22:810-20. 2006
    ..g., in patients with tuberous sclerosis)...
  56. ncbi request reprint Relationship between brain glucose metabolism positron emission tomography (PET) and electroencephalography (EEG) in children with continuous spike-and-wave activity during slow-wave sleep
    Aimee F Luat
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    J Child Neurol 20:682-90. 2005
    ..Resective surgery can be effective in selected patients with uncontrolled seizures associated with continuous spike-and-wave activity during slow-wave sleep provided that there is concordance between focal abnormalities on PET and EEG...
  57. ncbi request reprint The diagnostic value of initial video-EEG monitoring in children--review of 1000 cases
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA
    Epilepsy Res 66:129-35. 2005
    ..We retrospectively reviewed the clinical utility of initial video-EEG monitoring in a series of 1000 children suspected of epileptic disorders...
  58. ncbi request reprint An almost missed leptomeningeal angioma in Sturge-Weber syndrome
    Csaba Juhasz
    Division of Pediatric Neurology PET Center, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Neurology 68:243. 2007
  59. ncbi request reprint Assessment of progression and treatment response of optic pathway glioma with positron emission tomography using alpha-[(11)C]methyl-L-tryptophan
    Fangyu Peng
    The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Imaging Biol 9:106-9. 2007
    ..To report the utility of positron emission tomography (PET) with alpha-[(11)C]methyl-L-tryptophan (AMT) for monitoring progression and response to treatment of an isolated optic pathway glioma (OPG) in a 16-year-old girl...
  60. ncbi request reprint Seizures lead to elevation of intracranial pressure in children undergoing invasive EEG monitoring
    Aash K Shah
    Department of Neurology, Wayne State University and Children s Hospital of Michigan, Detroit, MI 48201, USA
    Epilepsia 48:1097-103. 2007
    ..To study the effects of intracranial subdural grid electrode placement and seizures on intracranial pressure (ICP) in children undergoing invasive EEG monitoring...
  61. pmc Quantitative visualization of ictal subdural EEG changes in children with neocortical focal seizures
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Clin Neurophysiol 115:2718-27. 2004
    ..To quantify the ictal subdural electroencephalogram (EEG) changes using spectral analysis, and to delineate the quantitatively defined ictal onset zones on high-resolution 3D MR images in children with intractable neocortical epilepsy...
  62. pmc Origin and propagation of epileptic spasms delineated on electrocorticography
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Street, Detroit, MI 48201, U S A
    Epilepsia 46:1086-97. 2005
    ....
  63. pmc Cortical glucose metabolism correlates negatively with delta-slowing and spike-frequency in epilepsy associated with tuberous sclerosis
    Masaaki Nishida
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Hum Brain Mapp 29:1255-64. 2008
    ....
  64. ncbi request reprint In vivo uptake and metabolism of alpha-[11C]methyl-L-tryptophan in human brain tumors
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, 48201, USA
    J Cereb Blood Flow Metab 26:345-57. 2006
    ..AMT PET might be a useful molecular imaging method to guide therapeutic approaches aimed at controlling tumor cell proliferation by acting on tryptophan metabolism...
  65. pmc Young patients with focal seizures may have the primary motor area for the hand in the postcentral gyrus
    Ateeq Haseeb
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Epilepsy Res 76:131-9. 2007
    ..We determined whether the primary motor hand area was most frequently located in the precentral gyrus in young patients with intractable focal seizures...
  66. ncbi request reprint Significance of preserving the vein of Labbé in epilepsy surgery involving temporal lobe resection
    Sandeep Sood
    Division of Pediatric Neurology, Department of Pediatric Neurosurgery, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosurg 105:210-3. 2006
    ..Preservation of the vein of Labbé is recommended to prevent temporal lobe infarction after skull base surgery. However, the importance of preserving the vein in epilepsy surgery involving resection of the temporal lobe is unclear...
  67. ncbi request reprint White matter volume as a major predictor of cognitive function in Sturge-Weber syndrome
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Arch Neurol 64:1169-74. 2007
    ..To assess the role of gray and white matter volume loss vs seizures in cognitive impairment of children with Sturge-Weber syndrome with unilateral involvement...
  68. pmc Effect of sleep on interictal spikes and distribution of sleep spindles on electrocorticography in children with focal epilepsy
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Clin Neurophysiol 118:1360-8. 2007
    ....
  69. doi request reprint Congruence of happy and sad emotion in music and faces modifies cortical audiovisual activation
    Jeong Won Jeong
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neuroimage 54:2973-82. 2011
    ..We hypothesized that neural mechanisms involved in listening to music may differ when presented together with visual stimuli that conveyed the same emotion as the music when compared to visual stimuli with incongruent emotional content...
  70. ncbi request reprint Congenital perisylvian syndrome: MRI and glucose PET correlations
    Aimee F Luat
    The Carman and Ann Adams Department of Pediatrics, Childrens Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Neurol 35:21-9. 2006
    ....
  71. doi request reprint Panic versus epilepsy: a challenging differential diagnosis
    Nash N Boutros
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, School of Medicine, Detroit, MI, USA
    Clin EEG Neurosci 44:313-8. 2013
    ..The possibility is raised that there may be degrees of abnormal hyperexcitability, leading to the emergence of symptoms, but not enough to generate large potentials that can be detected at the scalp. ..
  72. doi request reprint Exome sequencing and diffusion tensor imaging in developmental disabilities
    Senthil Sundaram
    1 Department of Pediatrics, Wayne State University, Detroit, Michigan 2 Department of Neurology, Wayne State University, Detroit, Michigan 3 PET Center, Children s Hospital of Michigan, Detroit Medical Center, Detroit, Michigan
    Pediatr Res 75:443-7. 2014
    ..Two patients with underdeveloped arcuate fasciculus had novel, nonsynonymous variants in genes (MID1 and EN2) regulating axon guidance pathway.Conclusion:Exome sequencing identified several new genetic causes of IDD. ..
  73. doi request reprint Stiripentol in Dravet syndrome: results of a retrospective U.S. study
    Elaine C Wirrell
    Divisions of Child and Adolescent Neurology, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Epilepsia 54:1595-604. 2013
    ..To review the efficacy and tolerability of stiripentol in the treatment of U.S. children with Dravet syndrome...
  74. doi request reprint A diffusion tensor imaging study of the cerebellar pathways in children with autism spectrum disorder
    Lalitha Sivaswamy
    Department of Pediatrics and Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Child Neurol 25:1223-31. 2010
    ..This study reiterates the underconnectivity between the cerebellum and neocortex, using diffusion tensor imaging...
  75. ncbi request reprint Spontaneous long-term remission of intractable partial epilepsy in childhood
    Pratima Pandey
    Department of Transitional Medicine, Children s Hospital of Michigan Detroit Medical Center, Wayne State University School of Medicine, 48201, USA
    J Child Neurol 17:466-70. 2002
    ..The epileptiform abnormality disappeared on the follow-up EEGs, and a glucose PET scan also normalized. This boy has fully retained his cognitive and motor functions and has remained seizure free in the past 4z\x years off medications...
  76. ncbi request reprint Hypotheses from functional neuroimaging studies
    Csaba Juhasz
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Int Rev Neurobiol 49:37-55. 2002
    ....
  77. ncbi request reprint Does serotonin have trophic effects in temporal lobe epilepsy?
    Diane C Chugani
    Neurology 60:736-7. 2003
  78. ncbi request reprint A common pattern of persistent gene activation in human neocortical epileptic foci
    Sanjay N Rakhade
    Center for Molecular Medicine and Genetics, Detroit, MI 48201, USA
    Ann Neurol 58:736-47. 2005
    ....
  79. ncbi request reprint Diffusion tensor imaging of brain plasticity after occipital lobectomy
    Rajkumar Munian Govindan
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pediatr Neurol 38:27-33. 2008
    ..Such structural white-matter changes may represent an adaptive response because of unilateral occipital ablation, and may account for plasticity changes observed in functional magnetic resonance imaging...
  80. ncbi request reprint Episodic receptive aphasia in a child with Landau-Kleffner Syndrome: PET correlates
    Aimee F Luat
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    Brain Dev 28:592-6. 2006
    ..The clinical course of our patient with transient EEG and PET findings suggest that glucose metabolism in LKS cannot be attributed solely to interictal epileptiform activities on scalp EEG...
  81. ncbi request reprint Paroxysmal tonic upgaze of childhood with co-existent absence epilepsy
    Aimee F Luat
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, Michigan, USA
    Epileptic Disord 9:332-6. 2007
    ..Furthermore, valproate treatment may be associated with the development or unmasking of PTU suggesting that the pathophysiology of PTU may involve abnormal GABA neurotransmission. [Published with videosequences]...
  82. ncbi request reprint Synthesis procedure for routine production of [carbonyl-11C]desmethyl-WAY-100635
    Dilip K Maiti
    Department of Pediatrics, School of Medicine, PET Center, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Appl Radiat Isot 62:721-7. 2005
    ..0 Ci/micromol, EOS, n=2) when ca. 37.0 GBq (ca. 1.0 Ci) of starting [(11)C]CO(2) was used. Unlabeled mass of [(11)C]DWAY was found to be 0.15-0.24 microg/mL and the precursor was present in less than 50 ng/mL in final production solution...
  83. ncbi request reprint Pathophysiology of infantile spasms
    Harry T Chugani
    Division of Pediatric Neurology and PET Center Children s Hospital of Michigan, Wayne State University, Detroit 48201, USA
    Adv Exp Med Biol 497:111-21. 2002
    ..Dr. Chugani reviews the clinical data related to the pathophysiology of infantile spasms and proposes a hypothesis which involves both cortical and subcortical mechanisms...
  84. ncbi request reprint Psychosis as a manifestation of frontal lobe epilepsy
    Aimee F Luat
    Children s Hospital of Michigan Detroit Medical Center Wayne State University, Detroit, MI 48201, USA
    Epilepsy Behav 12:200-4. 2008
    ..We suggest that these cases may be underdiagnosed. When epilepsy is suspected and if MRI fails to demonstrate an abnormality, FDG PET scanning and video/EEG monitoring should be considered...
  85. ncbi request reprint Neuroimaging in tuberous sclerosis complex
    Aimee F Luat
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Curr Opin Neurol 20:142-50. 2007
    ..In this review we discuss recent advances in the neuroimaging of patients with tuberous sclerosis complex (TSC), highlighting its application in improving clinical management, particularly in the case of intractable epilepsy...
  86. ncbi request reprint Quantification of protein synthesis in the human brain using L-[1-11C]-leucine PET: incorporation of factors for large neutral amino acids in plasma and for amino acids recycled from tissue
    Senthil K Sundaram
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Nucl Med 47:1787-95. 2006
    ....
  87. ncbi request reprint Metabolic maturation of the brain: a study of local cerebral protein synthesis in the developing cat
    David A Hovda
    Department of Surgery, Division of Neurosurgery, UCLA, CA 90095 7039, USA
    Brain Res 1113:54-63. 2006
    ..We discuss the meaning of these maturational profiles in terms of time course of morphological development and of maturation of behavior in the cat. Correlations with findings in other mammalian species are also discussed...
  88. ncbi request reprint Abnormal brain connectivity in children after early severe socioemotional deprivation: a diffusion tensor imaging study
    Thomas J Eluvathingal
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    Pediatrics 117:2093-100. 2006
    ..The present study used diffusion tensor imaging tractography to examine the integrity of white matter tracts that connect these brain regions...
  89. ncbi request reprint What can we learn from functional neuroimaging in children?
    Harry T Chugani
    Indian Pediatr 43:203-6. 2006

Research Grants13

  1. LOCALIZATION OF EPILEPTIC FOCI WITH PET IN CHILDREN
    Harry Chugani; Fiscal Year: 2009
    ..abstract_text> ..
  2. LOCALIZATION OF EPILEPTIC FOCI WITH PET IN CHILDREN
    Harry Chugani; Fiscal Year: 2004
    ..The overall goal of our research is to improve the success rates of extratemporal lobe resections and to increase understanding of the basic mechanisms of epileptogenesis. ..
  3. LOCALIZATION OF EPILEPTIC FOCI WITH PET IN CHILDREN
    Harry Chugani; Fiscal Year: 1999
    ..Our studies are designed to further reduce the necessity for intracranial EEG monitoring in children being evaluated for epilepsy surgery and to increase understanding of the basic mechanisms of epileptogenesis. ..
  4. Identifying Epileptogenic Tubers in TSC
    Harry T Chugani; Fiscal Year: 2010
    ..Moreover, these studies will provide important mechanistic information which will likely translate into novel pharmacological approaches for epilepsy. ..