D C Chugani

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. pmc Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI, USA
    J Neuroinflammation 9:232. 2012
  2. doi request reprint Neuroimaging and neurochemistry of autism
    Diane C Chugani
    Carman and Ann Adams Department of Pediatrics, Division of Clinical Pharmacology and Toxicology, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, 3901 Beaubien Boulevard, Detroit, MI 48201 USA
    Pediatr Clin North Am 59:63-73, x. 2012
  3. ncbi request reprint Evidence of altered energy metabolism in autistic children
    D C Chugani
    Department of Pediatrics, Wayne State University School of Medicine, Children s Hospital of Michigan, Detroit, USA
    Prog Neuropsychopharmacol Biol Psychiatry 23:635-41. 1999
  4. ncbi request reprint Role of altered brain serotonin mechanisms in autism
    D C Chugani
    PET Center, Wayne State University and Children s Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201, USA
    Mol Psychiatry 7:S16-7. 2002
  5. ncbi request reprint Serotonin in autism and pediatric epilepsies
    Diane C Chugani
    Departments of Pediatrics and Radiology, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Ment Retard Dev Disabil Res Rev 10:112-6. 2004
  6. pmc α-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions
    Diane C Chugani
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine and Translational Imaging Laboratory, Children s Hospital of Michigan, Detroit, MI, USA
    Biomark Med 5:567-75. 2011
  7. ncbi request reprint Postnatal maturation of human GABAA receptors measured with positron emission tomography
    D C Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Detroit 48201, USA
    Ann Neurol 49:618-26. 2001
  8. ncbi request reprint Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction
    E Asano
    Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit 48201, USA
    Neurology 57:1269-77. 2001
  9. ncbi request reprint Objective method for localization of cortical asymmetries using positron emission tomography to aid surgical resection of epileptic foci
    O Muzik
    Department of Radiology, Children s Hospital of Michigan, Detroit 48201, USA
    Comput Aided Surg 3:74-82. 1998
  10. ncbi request reprint Bilateral medial prefrontal and temporal neocortical hypometabolism in children with epilepsy and aggression
    C Juhasz
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan, USA
    Epilepsia 42:991-1001. 2001

Research Grants

  1. BRAIN SEROTONIN SYNTHESIS IN AUTISM
    Diane Chugani; Fiscal Year: 2001
  2. Imaging tryptophan metabolism in children with epilepsy
    Diane Chugani; Fiscal Year: 2007
  3. IMAGING TRYPTOPHAN METABOLISM IN TUBEROUS SCLEROSIS
    Diane Chugani; Fiscal Year: 2003

Collaborators

Detail Information

Publications68

  1. pmc Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET
    Ajay Kumar
    Department of Pediatrics, School of Medicine, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI, USA
    J Neuroinflammation 9:232. 2012
    ..We studied the distribution and expression of translocator protein in the human brain using (11)C-[R]-PK-11195 positron emission tomography (PK11195 PET) and evaluated age-related changes...
  2. doi request reprint Neuroimaging and neurochemistry of autism
    Diane C Chugani
    Carman and Ann Adams Department of Pediatrics, Division of Clinical Pharmacology and Toxicology, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, 3901 Beaubien Boulevard, Detroit, MI 48201 USA
    Pediatr Clin North Am 59:63-73, x. 2012
    ..Many tracers have not been applied in autism, and new molecules and signaling pathways might be targeted as genes associated with autism are identified...
  3. ncbi request reprint Evidence of altered energy metabolism in autistic children
    D C Chugani
    Department of Pediatrics, Wayne State University School of Medicine, Children s Hospital of Michigan, Detroit, USA
    Prog Neuropsychopharmacol Biol Psychiatry 23:635-41. 1999
    ..The findings of altered brain NAA and lactate in autistic children suggest that MRS may be useful characterizing regional neurochemical and metabolic abnormalities in autistic children...
  4. ncbi request reprint Role of altered brain serotonin mechanisms in autism
    D C Chugani
    PET Center, Wayne State University and Children s Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201, USA
    Mol Psychiatry 7:S16-7. 2002
  5. ncbi request reprint Serotonin in autism and pediatric epilepsies
    Diane C Chugani
    Departments of Pediatrics and Radiology, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Ment Retard Dev Disabil Res Rev 10:112-6. 2004
    ..Finally, a role for altered metabolism of the serotonin precursur, tryptophan, in both epilepsy and autism is discussed...
  6. pmc α-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions
    Diane C Chugani
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine and Translational Imaging Laboratory, Children s Hospital of Michigan, Detroit, MI, USA
    Biomark Med 5:567-75. 2011
    ..Kinetic analyses of AMT in brain tumors indicate changes in tryptophan transport and tissue retention in other pools as well. These studies indicate that AMT PET may be a biomarker of immune activation in the epileptogenic process...
  7. ncbi request reprint Postnatal maturation of human GABAA receptors measured with positron emission tomography
    D C Chugani
    Department of Pediatrics, Children s Hospital of Michigan, Detroit 48201, USA
    Ann Neurol 49:618-26. 2001
    ..The ontogeny data of FMZ VD from children may contribute to understanding regional differences in synaptic plasticity as well as improve rational therapeutic use of drugs acting at the GABAA receptor in the pediatric population...
  8. ncbi request reprint Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction
    E Asano
    Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit 48201, USA
    Neurology 57:1269-77. 2001
    ....
  9. ncbi request reprint Objective method for localization of cortical asymmetries using positron emission tomography to aid surgical resection of epileptic foci
    O Muzik
    Department of Radiology, Children s Hospital of Michigan, Detroit 48201, USA
    Comput Aided Surg 3:74-82. 1998
    ..90). This objective PET method allows the accurate determination of cortical asymmetries, and it proved to be highly efficient in guiding epilepsy surgery...
  10. ncbi request reprint Bilateral medial prefrontal and temporal neocortical hypometabolism in children with epilepsy and aggression
    C Juhasz
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan, USA
    Epilepsia 42:991-1001. 2001
    ..To identify brain regions with abnormal function in children with intractable partial epilepsy and aggressive behavior by using 2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET)...
  11. ncbi request reprint Relationship of flumazenil and glucose PET abnormalities to neocortical epilepsy surgery outcome
    C Juhasz
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurology 56:1650-8. 2001
    ....
  12. ncbi request reprint A mathematical model for the analysis of cross-sectional brain glucose metabolism data in children
    O Muzik
    Department of Radiology, Wayne State University, Children s Hospital of Michigan, Detroit, USA
    Prog Neuropsychopharmacol Biol Psychiatry 23:589-600. 1999
    ..Furthermore, this function may provide a useful framework for interpretation of other data sets during development...
  13. ncbi request reprint Impairment of dentato-thalamo-cortical pathway in autistic men: language activation data from positron emission tomography
    R A Muller
    Department of Pediatrics at Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201 2196, USA
    Neurosci Lett 245:1-4. 1998
    ..The results may indicate atypical functional specialization of the dentato-thalamo-cortical pathway and are compatible with a model of region-specific biochemical disturbances in the developing autistic brain...
  14. ncbi request reprint Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy
    C Juhasz
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurology 60:960-8. 2003
    ..In children with tuberous sclerosis, the PET tracer alpha[11C]methyl-L-tryptophan (AMT) has been shown to be selectively taken up by epileptogenic tubers, thus allowing differentiation from nonepileptogenic tubers in the interictal state...
  15. ncbi request reprint Prolonged vigabatrin treatment modifies developmental changes of GABA(A)-receptor binding in young children with epilepsy
    C Juhasz
    Department of Pediatrics, Children s Hospital of Michigan, The Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 42:1320-6. 2001
    ....
  16. pmc Aberrant diffusion and geometric properties in the left arcuate fasciculus of developmentally delayed children: a diffusion tensor imaging study
    J W Jeong
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    AJNR Am J Neuroradiol 32:323-30. 2011
    ..We sought to determine whether this manifests as aberrant regional changes in diffusivity or geometry of the left AF...
  17. ncbi request reprint Brain mapping of language and auditory perception in high-functioning autistic adults: a PET study
    R A Muller
    Department of Pediatrics, Wayne State University Medical Center, Detroit, Michigan, USA
    J Autism Dev Disord 29:19-31. 1999
    ..These results are compatible with findings of cerebellar anomalies and may suggest a tendency towards atypical dominance for language in autism...
  18. ncbi request reprint Sturge-Weber syndrome: correlation between clinical course and FDG PET findings
    J S Lee
    Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, 48201, USA
    Neurology 57:189-95. 2001
    ..Thus, the extent and degree of glucose asymmetry detected by PET are sensitive markers of seizure severity and cognitive decline in SWS...
  19. ncbi request reprint Longitudinal changes in cortical glucose hypometabolism in children with intractable epilepsy
    Krisztina Benedek
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Child Neurol 21:26-31. 2006
    ..The findings have implications on how aggressively persistent seizures should be treated in children. (J Child Neurol 2006;21:26-31)...
  20. doi request reprint Sharp curvature of frontal lobe white matter pathways in children with autism spectrum disorders: tract-based morphometry analysis
    J W Jeong
    Carman and Ann Adams Departments of Pediatrics, Wayne State University School of Medicine, MI, USA
    AJNR Am J Neuroradiol 32:1600-6. 2011
    ..Because we had previously observed geometric changes of frontal lobe association pathways in children with ASD, in the present study we analyzed the curvature of these white matter pathways by using an objective TBM analysis...
  21. ncbi request reprint Increased visual cortex glucose metabolism contralateral to angioma in children with Sturge-Weber syndrome
    Carlos E A Batista
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    Dev Med Child Neurol 49:567-73. 2007
    ..012). These findings indicate that early, severe unilateral cortical damage in SWS may induce increased glucose metabolism in the contralateral visual cortex, probably reflecting reorganization...
  22. ncbi request reprint Local brain functional activity following early deprivation: a study of postinstitutionalized Romanian orphans
    H T Chugani
    Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Neuroimage 14:1290-301. 2001
    ..Dysfunction of these brain regions may result from the stress of early global deprivation and may be involved in the long-term cognitive and behavioral deficits displayed by some Romanian orphans...
  23. doi request reprint Alpha-methyl-l-tryptophan positron emission tomography in epilepsy with cortical developmental malformations
    Hiroyuki Wakamoto
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pediatr Neurol 39:181-8. 2008
    ..When an alpha-[(11)C]methyl-l-tryptophan focus is detected, it likely represents the epileptogenic region to be resected...
  24. ncbi request reprint Surgical treatment of West syndrome
    E Asano
    Department of Pediatrics, Children's Hospital of Michigan and Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Brain Dev 23:668-76. 2001
    ..Thus, the introduction of newer more specific PET probes for epilepsy has led to improved and more accurate localization of seizure foci that should ultimately improve outcome of epilepsy surgery in West syndrome...
  25. pmc Diffusion tensor imaging study of the cortical origin and course of the corticospinal tract in healthy children
    A Kumar
    Departments of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    AJNR Am J Neuroradiol 30:1963-70. 2009
    ....
  26. pmc Evolution of cortical metabolic abnormalities and their clinical correlates in Sturge-Weber syndrome
    C Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI, USA
    Eur J Paediatr Neurol 11:277-84. 2007
    ..The natural course of Sturge-Weber syndrome (SWS) is poorly understood, although neurological symptoms are often progressive...
  27. ncbi request reprint Significance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism
    Sreenivasa R Chandana
    Department of Pharmacology, Wayne State University School of Medicine, 3901 Beaubian Blvd, Detroit, MI 48201, USA
    Int J Dev Neurosci 23:171-82. 2005
    ..Global as well as focal abnormally asymmetric development in the serotonergic system could lead to miswiring of the neural circuits specifying hemispheric specialization...
  28. ncbi request reprint Altered regional brain glucose metabolism in Duchenne muscular dystrophy: a pet study
    Joon Soo Lee
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, Michigan 48201, USA
    Muscle Nerve 26:506-12. 2002
    ....
  29. ncbi request reprint Metabolic changes of subcortical structures in intractable focal epilepsy
    Krisztina Benedek
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 45:1100-5. 2004
    ..In the present study, we analyzed alterations of glucose metabolism in subcortical nuclei and hippocampus by using FDG-PET in young patients with intractable epilepsy...
  30. ncbi request reprint Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome
    C Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    AJNR Am J Neuroradiol 28:900-6. 2007
    ....
  31. ncbi request reprint Evaluation with alpha-[11C]methyl-L-tryptophan positron emission tomography for reoperation after failed epilepsy surgery
    Csaba Juhasz
    Department of Pediatrics, Children s Hospital of Michigan and Harper University Hospital, Detroit Medical Center, Wayne State University School of Medicine, 48201, USA
    Epilepsia 45:124-30. 2004
    ..This study analyzed whether increased cortical AMT uptake can detect nonresected epileptic foci in patients with previously failed neocortical resection...
  32. ncbi request reprint Hippocampal and thalamic diffusion abnormalities in children with temporal lobe epilepsy
    Tomomi Kimiwada
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 47:167-75. 2006
    ....
  33. ncbi request reprint Positron emission tomography methods with potential for increased understanding of mental retardation and developmental disabilities
    Senthil K Sundaram
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Ment Retard Dev Disabil Res Rev 11:325-30. 2005
    ....
  34. ncbi request reprint Quantitative interictal subdural EEG analyses in children with neocortical epilepsy
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Epilepsia 44:425-34. 2003
    ....
  35. ncbi request reprint Neuroradiological assessment of brain structure and function and its implication in the pathogenesis of West syndrome
    C Juhasz
    Department of Pediatrics, Children s Hospital of Michigan, The Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Brain Dev 23:488-95. 2001
    ..These systems are implicated in epileptogenesis, and their involvement in the pathophysiology of West syndrome can be further addressed by future functional neuroimaging studies...
  36. ncbi request reprint A study of novel polymorphisms in the upstream region of vasoactive intestinal peptide receptor type 2 gene in autism
    E Asano
    Department of Pediatrics, Children's Hospital of Michigan and Wayne State University School of Medicine, Detroit 48201, USA
    J Child Neurol 16:357-63. 2001
    ....
  37. pmc Quantification of tryptophan transport and metabolism in lung tumors using PET
    Csaba Juhasz
    PET Center, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    J Nucl Med 50:356-63. 2009
    ..The goal of this study was to evaluate the in vivo kinetics of alpha-(11)C-methyl-l-tryptophan (AMT), a PET tracer for tryptophan metabolism, in human lung tumors...
  38. ncbi request reprint Microglial activation in perinatal rabbit brain induced by intrauterine inflammation: detection with 11C-(R)-PK11195 and small-animal PET
    Sujatha Kannan
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
    J Nucl Med 48:946-54. 2007
    ....
  39. ncbi request reprint White matter volume as a major predictor of cognitive function in Sturge-Weber syndrome
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Arch Neurol 64:1169-74. 2007
    ..To assess the role of gray and white matter volume loss vs seizures in cognitive impairment of children with Sturge-Weber syndrome with unilateral involvement...
  40. pmc Increased striatal serotonin synthesis following cortical resection in children with intractable epilepsy
    Harry T Chugani
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
    Epilepsy Res 78:124-30. 2008
    ..In this study we used positron emission tomography (PET) with alpha[11C]methyl-l-tryptophan (AMT) to evaluate serotonergic alterations in subcortical structures following cortical resection in children with intractable epilepsy...
  41. pmc Diffusion tensor imaging of frontal lobe in autism spectrum disorder
    Senthil K Sundaram
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Cereb Cortex 18:2659-65. 2008
    ..Abnormal frontal FA and ADC may be due to white matter organization abnormalities in ASD. Lack of evidence for excessive short range connectivity in ASD in this study may need to be re-examined with future advances in DTI technology...
  42. doi request reprint Congruence of happy and sad emotion in music and faces modifies cortical audiovisual activation
    Jeong Won Jeong
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neuroimage 54:2973-82. 2011
    ..We hypothesized that neural mechanisms involved in listening to music may differ when presented together with visual stimuli that conveyed the same emotion as the music when compared to visual stimuli with incongruent emotional content...
  43. pmc Decreased cortical serotonin in neonatal rabbits exposed to endotoxin in utero
    Sujatha Kannan
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cereb Blood Flow Metab 31:738-49. 2011
    ..This may be a common link in neurodevelopmental disorders resulting in impairment of the somatosensory system, such as cerebral palsy and autism...
  44. doi request reprint Alterations in frontal lobe tracts and corpus callosum in young children with autism spectrum disorder
    Ajay Kumar
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Cereb Cortex 20:2103-13. 2010
    ..Volume of bilateral UF and right AF and fiber density of left UF were positively associated with autistic features...
  45. pmc Focal decreases of cortical GABAA receptor binding remote from the primary seizure focus: what do they indicate?
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan and Harper University Hospital, Detroit Medical Center, Wayne State University School of Medcine, Detroit, Michigan, USA
    Epilepsia 50:240-50. 2009
    ..To determine the electroclinical significance and histopathological correlates of cortical gamma-aminobutyric acid(A)(GABA(A)) receptor abnormalities detected in and remote from human neocortical epileptic foci...
  46. ncbi request reprint Assessment of progression and treatment response of optic pathway glioma with positron emission tomography using alpha-[(11)C]methyl-L-tryptophan
    Fangyu Peng
    The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Imaging Biol 9:106-9. 2007
    ..To report the utility of positron emission tomography (PET) with alpha-[(11)C]methyl-L-tryptophan (AMT) for monitoring progression and response to treatment of an isolated optic pathway glioma (OPG) in a 16-year-old girl...
  47. pmc Is intraoperative electrocorticography reliable in children with intractable neocortical epilepsy?
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Epilepsia 45:1091-9. 2004
    ..To study the relation between the spike frequency during intraoperative electrocorticography (ECoG) under general anesthesia with isoflurane and that during extraoperative ECoG monitoring in children with intractable neocortical epilepsy...
  48. ncbi request reprint Quantitative analysis of gray- and white-matter volumes and glucose metabolism in Sturge-Weber syndrome
    Zoltan Pfund
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Child Neurol 18:119-26. 2003
    ..Extensive gray- and white-matter volume loss and hypometabolism ipsilateral to the angioma likely contribute to the frequently observed progressive cognitive dysfunction in these patients, regardless of the extent of the angioma...
  49. pmc Quantitative visualization of ictal subdural EEG changes in children with neocortical focal seizures
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Clin Neurophysiol 115:2718-27. 2004
    ..To quantify the ictal subdural electroencephalogram (EEG) changes using spectral analysis, and to delineate the quantitatively defined ictal onset zones on high-resolution 3D MR images in children with intractable neocortical epilepsy...
  50. ncbi request reprint Pharmacokinetics of buspirone in autistic children
    David J Edwards
    Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
    J Clin Pharmacol 46:508-14. 2006
    ..Plasma concentrations with 2.5- to 5.0-mg doses were similar to those observed in older children receiving 7.5- to 15-mg doses...
  51. ncbi request reprint Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L-tryptophan positron emission tomography (PET)
    Kenji Kagawa
    Department of Pediatrics, Pediatric Neurology PET Center, Children s Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201, USA
    J Child Neurol 20:429-38. 2005
    ..AMT PET can provide independent complementary information regarding the localization of epileptogenic regions in tuberous sclerosis complex and enhance the confidence of patient selection for successful epilepsy surgery...
  52. pmc Origin and propagation of epileptic spasms delineated on electrocorticography
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Street, Detroit, MI 48201, U S A
    Epilepsia 46:1086-97. 2005
    ....
  53. ncbi request reprint In vivo uptake and metabolism of alpha-[11C]methyl-L-tryptophan in human brain tumors
    Csaba Juhasz
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, 48201, USA
    J Cereb Blood Flow Metab 26:345-57. 2006
    ..AMT PET might be a useful molecular imaging method to guide therapeutic approaches aimed at controlling tumor cell proliferation by acting on tryptophan metabolism...
  54. pmc Application of an objective method for localizing bilateral cortical FDG PET abnormalities to guide the resection of epileptic foci
    Otto Muzik
    Department of Pediatrics and Radiology, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    IEEE Trans Biomed Eng 52:1574-81. 2005
    ..The accuracy of this approach with respect to invasive subdural electroencephalography (EEG) data was assessed in a group of children with neocortical epilepsy...
  55. ncbi request reprint Evidence of somatic mosaicism in Sturge-Weber syndrome
    A H M Mahbubul Huq
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Neurology 59:780-2. 2002
  56. ncbi request reprint Cerebellar lesions in tuberous sclerosis complex: neurobehavioral and neuroimaging correlates
    Thomas J Eluvathingal
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI 48201, USA
    J Child Neurol 21:846-51. 2006
    ..Further investigation of the potential role of the right cerebellum in autism, particularly with regard to the dentatothalamofrontal circuit, is warranted...
  57. ncbi request reprint Alpha[11C] methyl-L-typtophan positron emission tomography in patients with alternating hemiplegia of childhood
    Zoltan Pfund
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201, USA
    J Child Neurol 17:253-60. 2002
    ..Furthermore, the attack number may have an effect on neurodevelopmental delay, thus supporting the notion that alternating hemiplegia of childhood may be a progressive disorder...
  58. ncbi request reprint Pathophysiology and functional consequences of human partial epilepsy: lessons from positron emission tomography studies
    Cs Juhász
    Department of Pediatrics, Wayne State University, School of Medicine, Detroit, Michigan, USA
    Acta Physiol Hung 90:281-303. 2003
    ....
  59. ncbi request reprint Characteristics of abnormal diffusivity in normal-appearing white matter investigated with diffusion tensor MR imaging in tuberous sclerosis complex
    M I Makki
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI 48201, USA
    AJNR Am J Neuroradiol 28:1662-7. 2007
    ..Our objective was to determine in vivo whether there was evidence for WM microstructural changes by using diffusion tensor imaging (DTI)...
  60. ncbi request reprint Functional brain reorganization in children
    H T Chugani
    Department of Neurology, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201 2196, USA
    Brain Dev 18:347-56. 1996
    ....
  61. pmc Imaging correlates of differential expression of indoleamine 2,3-dioxygenase in human brain tumors
    Carlos E A Batista
    Carman and Ann Adams Department of Pediatrics, School of Medicine, Wayne State University, Detroit, MI, USA
    Mol Imaging Biol 11:460-6. 2009
    ..In the present study, we investigated whether increased tryptophan metabolism in brain tumors measured by PET is related to expression of IDO in resected brain tumor specimens...
  62. ncbi request reprint Association of tryptophan 2,3 dioxygenase gene polymorphism with autism
    Rafiqun Nabi
    Department of Pediatrics, Wayne State University, Detroit, Michigan, USA
    Am J Med Genet B Neuropsychiatr Genet 125:63-8. 2004
    ..0027). Our results suggest the presence of a susceptibility mutation in the TDO2 or a nearby gene, but may also represent a chance finding...
  63. ncbi request reprint Hypotheses from functional neuroimaging studies
    Csaba Juhasz
    Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Int Rev Neurobiol 49:37-55. 2002
    ....
  64. ncbi request reprint Synthesis procedure for routine production of [carbonyl-11C]desmethyl-WAY-100635
    Dilip K Maiti
    Department of Pediatrics, School of Medicine, PET Center, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Appl Radiat Isot 62:721-7. 2005
    ..0 Ci/micromol, EOS, n=2) when ca. 37.0 GBq (ca. 1.0 Ci) of starting [(11)C]CO(2) was used. Unlabeled mass of [(11)C]DWAY was found to be 0.15-0.24 microg/mL and the precursor was present in less than 50 ng/mL in final production solution...
  65. ncbi request reprint Quantification of protein synthesis in the human brain using L-[1-11C]-leucine PET: incorporation of factors for large neutral amino acids in plasma and for amino acids recycled from tissue
    Senthil K Sundaram
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Nucl Med 47:1787-95. 2006
    ....
  66. ncbi request reprint Does serotonin have trophic effects in temporal lobe epilepsy?
    Diane C Chugani
    Neurology 60:736-7. 2003
  67. ncbi request reprint Autism clinical trials: biological and medical issues in patient selection and treatment response
    George M Anderson
    Department of Child Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    CNS Spectr 9:57-64. 2004
    ..The potential utility and desirability of specific measures are considered and the general approach to choosing measures for incorporation is discussed...
  68. pmc Offering to share: how to put heads together in autism neuroimaging
    Matthew K Belmonte
    Department of Human Development, Cornell University, Martha Van Rensselaer Hall, Ithaca, NY 14853 4401, USA
    J Autism Dev Disord 38:2-13. 2008
    ..A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on...

Research Grants13

  1. BRAIN SEROTONIN SYNTHESIS IN AUTISM
    Diane Chugani; Fiscal Year: 2001
    ..An understanding of the neurochemical disturbances in autism is important for the development of new treatment approaches. ..
  2. Imaging tryptophan metabolism in children with epilepsy
    Diane Chugani; Fiscal Year: 2007
    ..Our research will contribute to a better understanding of the pathophysiology and improve localization of focal epilepsy. ..
  3. IMAGING TRYPTOPHAN METABOLISM IN TUBEROUS SCLEROSIS
    Diane Chugani; Fiscal Year: 2003
    ..4) To determine whether autistic children with TSC and epilepsy differ from non-autistic children with TSC and epilepsy with regard to focal [C-11]AMT abnormalities in thalamus and cerebellum. ..