G Chen

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Valproate robustly enhances AP-1 mediated gene expression
    G Chen
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, WSU School of Medicine, 2301 Scott Hall, 540 E Canfield Avenue, Detroit, MI 48201, USA
    Brain Res Mol Brain Res 64:52-8. 1999
  2. ncbi request reprint Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo
    G Chen
    Department of Psychiatry and Behavioral Neurosciences, WSU School of Medicine, Detroit, MI 48201, USA
    Bipolar Disord 2:217-36. 2000
  3. ncbi request reprint Enhancement of hippocampal neurogenesis by lithium
    G Chen
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurochem 75:1729-34. 2000
  4. pmc Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania
    G Shaltiel
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 13:858-72. 2008
  5. ncbi request reprint Mood stabilizers regulate cytoprotective and mRNA-binding proteins in the brain: long-term effects on cell survival and transcript stability
    G Chen
    Laboratory of Molecular Pathophysiology, NIMH Bethesda, MD 20892-4405, USA
    Int J Neuropsychopharmacol 4:47-64. 2001
  6. ncbi request reprint Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness
    H K Manji
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    J Clin Psychiatry 61:82-96. 2000
  7. ncbi request reprint The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth
    P X Yuan
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 276:31674-83. 2001
  8. ncbi request reprint The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS
    G Chen
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurochem 72:879-82. 1999
  9. ncbi request reprint Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers
    H K Manji
    Laboratory of Molecular Pathophysiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Br J Psychiatry Suppl 41:s107-19. 2001
  10. ncbi request reprint Neuroplasticity and cellular resilience in mood disorders
    H K Manji
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, USA
    Mol Psychiatry 5:578-93. 2000

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Valproate robustly enhances AP-1 mediated gene expression
    G Chen
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, WSU School of Medicine, 2301 Scott Hall, 540 E Canfield Avenue, Detroit, MI 48201, USA
    Brain Res Mol Brain Res 64:52-8. 1999
    ....
  2. ncbi request reprint Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo
    G Chen
    Department of Psychiatry and Behavioral Neurosciences, WSU School of Medicine, Detroit, MI 48201, USA
    Bipolar Disord 2:217-36. 2000
    ..Together, these results suggest that the PKC signaling pathway and PKC-mediated gene expression may be important mediators of lithium's long-term therapeutic effects in a disorder as complex as BD...
  3. ncbi request reprint Enhancement of hippocampal neurogenesis by lithium
    G Chen
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurochem 75:1729-34. 2000
    ..These results add to the growing body of evidence suggesting that mood stabilizers and antidepressants exert neurotrophic effects and may therefore be of use in the long-term treatment of other neuropsychiatric disorders...
  4. pmc Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania
    G Shaltiel
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 13:858-72. 2008
    ..The molecular mechanism underlying the behavioral effects of lithium in GluR6 KO mice remains to be elucidated...
  5. ncbi request reprint Mood stabilizers regulate cytoprotective and mRNA-binding proteins in the brain: long-term effects on cell survival and transcript stability
    G Chen
    Laboratory of Molecular Pathophysiology, NIMH Bethesda, MD 20892-4405, USA
    Int J Neuropsychopharmacol 4:47-64. 2001
    ....
  6. ncbi request reprint Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness
    H K Manji
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    J Clin Psychiatry 61:82-96. 2000
    ....
  7. ncbi request reprint The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth
    P X Yuan
    Laboratory of Molecular Pathophysiology, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 276:31674-83. 2001
    ..These data demonstrate that VPA is an ERK pathway activator and produces neurotrophic effects...
  8. ncbi request reprint The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS
    G Chen
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurochem 72:879-82. 1999
    ..These novel findings represent the first report of medication-induced increases in CNS bcl-2 levels and may have implications not only for mood disorders, but also for long-term treatment of various neurodegenerative disorders...
  9. ncbi request reprint Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers
    H K Manji
    Laboratory of Molecular Pathophysiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Br J Psychiatry Suppl 41:s107-19. 2001
    ..New research is dramatically altering our understanding of the molecular mechanisms underlying neuronal communication...
  10. ncbi request reprint Neuroplasticity and cellular resilience in mood disorders
    H K Manji
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, USA
    Mol Psychiatry 5:578-93. 2000
    ....
  11. ncbi request reprint Signalling pathways in the brain: cellular transduction of mood stabilisation in the treatment of manic-depressive illness
    H K Manji
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Aust N Z J Psychiatry 33:S65-83. 1999
    ....
  12. pmc The extracellular signal-regulated kinase pathway contributes to the control of behavioral excitement
    S R Engel
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, MD 20892 3711, USA
    Mol Psychiatry 14:448-61. 2009
    ..Whether there is a shared mechanism through which mood stabilizers produce their clinical actions on mood, thought and behavioral symptoms of mania also requires further investigation...
  13. ncbi request reprint Possible involvement of the ERK signaling cascade in bipolar disorder: behavioral leads from the study of mutant mice
    H Einat
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4405, USA
    Drug News Perspect 16:453-63. 2003
    ....
  14. pmc Targeting the BH3-interacting domain death agonist to develop mechanistically unique antidepressants
    O Malkesman
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA
    Mol Psychiatry 17:770-80. 2012
    ..Taken together, the results suggest that functional perturbation of apoptotic proteins such as Bid and, alternatively, enhancement of Bcl-2 function, is a putative strategy for developing novel therapeutics for mood disorders...
  15. ncbi request reprint PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers
    H K Manji
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, MD 20892, USA
    Mol Psychiatry 7:S46-56. 2002
    ....
  16. ncbi request reprint Post-receptor signaling pathways in the pathophysiology and treatment of mood disorders
    H K Manji
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, 10 Center Drive, 10 4N 222 MSC 1381, Bethesda, MD, 20892, USA
    Curr Psychiatry Rep 2:479-89. 2000
    ....