Dora Cavallo-Medved

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells
    Dora Cavallo-Medved
    Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Neoplasia 5:507-19. 2003
  2. ncbi Cell-surface cathepsin B: understanding its functional significance
    Dora Cavallo-Medved
    Department of Pharmacology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Curr Top Dev Biol 54:313-41. 2003
  3. ncbi Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment
    Bonnie F Sloane
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Semin Cancer Biol 15:149-57. 2005
  4. ncbi Cathepsin B: a potential prognostic marker for inflammatory breast cancer
    Mohamed A Nouh
    Department of Pathology, National Cancer Institute, Cairo University, Giza 12613 Egypt
    J Transl Med 9:1. 2011
  5. ncbi Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells
    Dora Cavallo-Medved
    Department of Pharmacology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    J Cell Sci 118:1493-503. 2005
  6. ncbi Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation
    Dora Cavallo-Medved
    Department of Pharmacology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Exp Cell Res 315:1234-46. 2009
  7. ncbi Functional live-cell imaging demonstrates that beta1-integrin promotes type IV collagen degradation by breast and prostate cancer cells
    Mansoureh Sameni
    Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Mol Imaging 7:199-213. 2008
  8. ncbi Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion
    Bernadette C Victor
    Department of Pharmacology, Wayne State University, Detroit, Michigan 48201, USA
    Breast Cancer Res 13:R115. 2011
  9. ncbi Functional imaging of tumor proteolysis
    Bonnie F Sloane
    Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Annu Rev Pharmacol Toxicol 46:301-15. 2006
  10. ncbi Imaging and quantifying the dynamics of tumor-associated proteolysis
    Mansoureh Sameni
    Department of Pharmacology, School of Medicine, Wayne State University, 540 E Canfield, Detroit, MI 48201, USA
    Clin Exp Metastasis 26:299-309. 2009

Collaborators

Detail Information

Publications12

  1. ncbi Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells
    Dora Cavallo-Medved
    Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Neoplasia 5:507-19. 2003
    ..g., urokinase plasminogen activator and urokinase plasminogen activator receptor) are also present in HCT 116 caveolae...
  2. ncbi Cell-surface cathepsin B: understanding its functional significance
    Dora Cavallo-Medved
    Department of Pharmacology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Curr Top Dev Biol 54:313-41. 2003
  3. ncbi Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment
    Bonnie F Sloane
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Semin Cancer Biol 15:149-57. 2005
    ..Using a confocal assay to analyze the contribution of tumor-stromal interactions to proteolysis, we have been able to confirm enhanced degradation of extracellular matrices by all three classes of proteases...
  4. ncbi Cathepsin B: a potential prognostic marker for inflammatory breast cancer
    Mohamed A Nouh
    Department of Pathology, National Cancer Institute, Cairo University, Giza 12613 Egypt
    J Transl Med 9:1. 2011
    ..In non-IBC, the cysteine protease cathepsin B (CTSB) is known to be involved in cancer progression and invasion; however, very little is known about its role in IBC...
  5. ncbi Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells
    Dora Cavallo-Medved
    Department of Pharmacology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    J Cell Sci 118:1493-503. 2005
    ....
  6. ncbi Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation
    Dora Cavallo-Medved
    Department of Pharmacology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Exp Cell Res 315:1234-46. 2009
    ..Our findings are the first to demonstrate through live-cell imaging ECM degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation...
  7. ncbi Functional live-cell imaging demonstrates that beta1-integrin promotes type IV collagen degradation by breast and prostate cancer cells
    Mansoureh Sameni
    Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Mol Imaging 7:199-213. 2008
    ..This is the first study to demonstrate through functional live-cell imaging that downregulation of beta1-integrin expression and function reduces proteolysis of collagen IV by breast and prostate cancer cells...
  8. ncbi Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion
    Bernadette C Victor
    Department of Pharmacology, Wayne State University, Detroit, Michigan 48201, USA
    Breast Cancer Res 13:R115. 2011
    ..Breast cancer invasion has been linked to proteolytic activity at the tumor cell surface. Here we explored a role for active cathepsin B on the cell surface in the invasiveness of IBC...
  9. ncbi Functional imaging of tumor proteolysis
    Bonnie F Sloane
    Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Annu Rev Pharmacol Toxicol 46:301-15. 2006
    ..These should be useful clinically as surrogate endpoints for therapies that alter protease activities...
  10. ncbi Imaging and quantifying the dynamics of tumor-associated proteolysis
    Mansoureh Sameni
    Department of Pharmacology, School of Medicine, Wayne State University, 540 E Canfield, Detroit, MI 48201, USA
    Clin Exp Metastasis 26:299-309. 2009
    ..The assays and models described here could serve as screening platforms for the identification of proteolytic pathways that are potential therapeutic targets and for further development of technologies and imaging probes for in vivo use...
  11. ncbi Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH
    Derek T Jane
    Biological Sciences, University of Windsor, Windsor N9B 3P4, ON, Canada
    Biol Chem 387:223-34. 2006
    ..Collectively, these studies support an association of active cathepsin B with plasma membrane caveolae and the secretion of active cathepsin B from differentiating myoblasts during myoblast fusion...
  12. ncbi Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells
    Rebecca S Henkhaus
    Department of Cancer Biology, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Neoplasia 10:140-8. 2008
    ..This study demonstrates that proteins such as CAV-1 and AKT, which are known to be altered in colon cancer, affect KLK6 expression and KLK6 secretion...