Nash Boutros

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. doi request reprint Abnormal coherence imaging in panic disorder: a magnetoencephalography investigation
    Nash N Boutros
    Department of Psychiatry and Behavioral Neurosciences, Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA
    Neuroreport 24:487-91. 2013
  2. pmc Mapping repetition suppression of the P50 evoked response to the human cerebral cortex
    Nash N Boutros
    Wayne State University, School of Medicine, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI, USA
    Clin Neurophysiol 124:675-85. 2013
  3. doi request reprint Advances in electrophysiology in the diagnosis of behavioral disorders
    Nash N Boutros
    Wayne State University, School of Medicine, Department of Psychiatry and Behavioral Neurosciences, 2751 E Jefferson, Suite 305, Detroit, MI 48207, USA 1 313 577 6687 1 313 0577 2301
    Expert Opin Med Diagn 5:441-52. 2011
  4. pmc Event-related potential studies of post-traumatic stress disorder: a critical review and synthesis
    Arash Javanbakht
    Department of Psychiatry, University of Michigan, Ann Arbor, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Biol Mood Anxiety Disord 1:5. 2011
  5. ncbi request reprint Mid-latency auditory-evoked responses and sensory gating in focal epilepsy: a preliminary exploration
    Nash N Boutros
    Wayne State University School of Medicine, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI 48207, USA
    J Neuropsychiatry Clin Neurosci 18:409-16. 2006
  6. ncbi request reprint Cocaine-dependence and cocaine-induced paranoia and mid-latency auditory evoked responses and sensory gating
    Nash N Boutros
    Wayne State University, Department of Psychiatry and Behavioral Neurosciences, USA
    Psychiatry Res 145:147-54. 2006
  7. ncbi request reprint A four-step approach for developing diagnostic tests in psychiatry
    N N Boutros
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, School of Medicine, 2751 E Jefferson, Detroit, MI 48207, USA
    Clin EEG Neurosci 38:62-5. 2007
  8. ncbi request reprint Sensory gating in the human hippocampal and rhinal regions: regional differences
    N N Boutros
    Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Jefferson, Detroit, Michigan 48207, USA
    Hippocampus 18:310-6. 2008
  9. pmc The status of spectral EEG abnormality as a diagnostic test for schizophrenia
    Nash N Boutros
    Wayne State University, School of Medicine, UPC Jefferson, 2751 E Jefferson, Detroit, MI 48207, United States
    Schizophr Res 99:225-37. 2008
  10. pmc Sensory-gating deficit of the N100 mid-latency auditory evoked potential in medicated schizophrenia patients
    Nash N Boutros
    Wayne State University, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI, USA
    Schizophr Res 113:339-46. 2009

Research Grants

  1. Intracranial Mapping of Sensory Gating in Humans
    Nashaat Boutros; Fiscal Year: 2006
  2. Electrophysiology: Integrating Modalities and Discipline
    Nashaat Boutros; Fiscal Year: 2007
  3. Cortical Excitability in Cocaine-Dependent Subjects
    Nashaat Boutros; Fiscal Year: 2007
  4. Cortical Excitability in Cocaine-Dependent Subjects
    Nashaat Boutros; Fiscal Year: 2006
  5. PHASE RESETTING AND SENSORY INHIBITION IN THE CNS
    Nashaat Boutros; Fiscal Year: 2005
  6. PHASE RESETTING AND SENSORY INHIBITION IN THE CNS
    Nashaat Boutros; Fiscal Year: 1999
  7. Cortical Excitability in Cocaine-Dependent Subjects
    Nashaat Boutros; Fiscal Year: 2009

Detail Information

Publications36

  1. doi request reprint Abnormal coherence imaging in panic disorder: a magnetoencephalography investigation
    Nash N Boutros
    Department of Psychiatry and Behavioral Neurosciences, Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA
    Neuroreport 24:487-91. 2013
    ..e. increased excitability) being a biomarker for favorable responses to medications that limit excitatory transmission, such as benzodiazepines or antiseizure drugs...
  2. pmc Mapping repetition suppression of the P50 evoked response to the human cerebral cortex
    Nash N Boutros
    Wayne State University, School of Medicine, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI, USA
    Clin Neurophysiol 124:675-85. 2013
    ..The cerebral network subserving repetition suppression (RS) of the P50 auditory evoked response as observed using paired-identical-stimulus (S1-S2) paradigms is not well-described...
  3. doi request reprint Advances in electrophysiology in the diagnosis of behavioral disorders
    Nash N Boutros
    Wayne State University, School of Medicine, Department of Psychiatry and Behavioral Neurosciences, 2751 E Jefferson, Suite 305, Detroit, MI 48207, USA 1 313 577 6687 1 313 0577 2301
    Expert Opin Med Diagn 5:441-52. 2011
    ..The authors propose that the first steps are to establish such laboratories and train psychiatrists to competently provide the service...
  4. pmc Event-related potential studies of post-traumatic stress disorder: a critical review and synthesis
    Arash Javanbakht
    Department of Psychiatry, University of Michigan, Ann Arbor, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Biol Mood Anxiety Disord 1:5. 2011
    ..Based on the available data, we suggest that ERP abnormalities in PTSD are possibly affected by the level of illness severity. If supported by future research, ERP studies may be used for both initial assessment and treatment follow-up...
  5. ncbi request reprint Mid-latency auditory-evoked responses and sensory gating in focal epilepsy: a preliminary exploration
    Nash N Boutros
    Wayne State University School of Medicine, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI 48207, USA
    J Neuropsychiatry Clin Neurosci 18:409-16. 2006
    ..Though alteration of sensory gating can be demonstrated in epileptic patients, it seems to be qualitatively different from alterations reported in association with schizophrenia...
  6. ncbi request reprint Cocaine-dependence and cocaine-induced paranoia and mid-latency auditory evoked responses and sensory gating
    Nash N Boutros
    Wayne State University, Department of Psychiatry and Behavioral Neurosciences, USA
    Psychiatry Res 145:147-54. 2006
    ..The data also suggest that prolonged latency of the evoked potentials may be a correlate of cocaine-induced psychosis. Finally, the data suggest that some recovery of amplitude and gating occurs with abstinence...
  7. ncbi request reprint A four-step approach for developing diagnostic tests in psychiatry
    N N Boutros
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, School of Medicine, 2751 E Jefferson, Detroit, MI 48207, USA
    Clin EEG Neurosci 38:62-5. 2007
    ..Multicenter trials should pave the road towards standardization of laboratory procedures used to conduct the test, as well as providing data regarding cost effectiveness and impact on both short-term and long-term clinical outcomes...
  8. ncbi request reprint Sensory gating in the human hippocampal and rhinal regions: regional differences
    N N Boutros
    Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Jefferson, Detroit, Michigan 48207, USA
    Hippocampus 18:310-6. 2008
    ..The data support the need for further exploration of the contribution of these regions to sensory gating. This information helps to increase our understanding of this basic but important and complex function...
  9. pmc The status of spectral EEG abnormality as a diagnostic test for schizophrenia
    Nash N Boutros
    Wayne State University, School of Medicine, UPC Jefferson, 2751 E Jefferson, Detroit, MI 48207, United States
    Schizophr Res 99:225-37. 2008
    ..A literature review was conducted to ascertain whether or not EEG spectral abnormalities are consistent enough to warrant additional effort towards developing them into a clinical diagnostic test for schizophrenia...
  10. pmc Sensory-gating deficit of the N100 mid-latency auditory evoked potential in medicated schizophrenia patients
    Nash N Boutros
    Wayne State University, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI, USA
    Schizophr Res 113:339-46. 2009
    ..Data also suggest that improving the signal to noise ratio (MOAD data) increases the sensitivity for detecting gating abnormalities and assessing their clinical correlates...
  11. ncbi request reprint Epileptiform discharges in psychiatric patients: a controversy in need of resurrection
    Nash Boutros
    Wayne State University, Department of Psychiatry and Behavioral Neurosciences, 2751 E Jefferson, Detroit, Ml 48207, USA
    Clin EEG Neurosci 40:239-44. 2009
    ....
  12. pmc Mapping repetition suppression of the N100 evoked response to the human cerebral cortex
    Nash N Boutros
    Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, Michigan 48207, USA
    Biol Psychiatry 69:883-9. 2011
    ..Repetition suppression (RS) phenomena, such as those observed using paired-identical-stimulus (S1-S2) paradigms, likely reflect adaptive functions such as habituation and, more specifically, sensory gating...
  13. doi request reprint Internal gating and somatization disorders: proposing a yet un-described neural system
    Nash N Boutros
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, School of Medicine, College of Nursing, Detroit, MI 48207, United States
    Med Hypotheses 78:174-8. 2012
    ..If the hypothesis proves to be true and such a system does exist, the implications are many and significant including developing methods for assessing the system and possibly correcting it...
  14. ncbi request reprint A four-step approach for developing diagnostic tests in psychiatry: EEG in ADHD as a test case
    Nash Boutros
    Psychiatry and Neurology, Wayne State University School of Medicine, UPC Jefferson, Suite 305, 2751 E Jefferson, Detroit, MI 48207, USA
    J Neuropsychiatry Clin Neurosci 17:455-64. 2005
    ..Based on the meta-analysis, the authors conclude that increased EEG theta activity in ADHD is promising and should be further developed as a diagnostic test...
  15. ncbi request reprint Sensory gating in the human hippocampal and rhinal regions
    N N Boutros
    Wayne State University School of Medicine, Department of Psychiatry and Behavioral Neurosciences, School of Medicine, UPC Jefferson, 2751 E Jefferson, Suite 401, Detroit, MI 48207, USA
    Clin Neurophysiol 116:1967-74. 2005
    ..The objective of this work was to ascertain if sensory gating can be demonstrated within the human medial temporal lobe...
  16. doi request reprint Neuroendocrinal study of depression in male epileptic patients
    Samah Afifi
    Department of Psychiatry and Behavioral Neurosciences, Division of Endocrinology and Metabolism, Wayne State University School of Medicine, Detroit, MI, and the Department of Neuropsychiatry, Faculty of Medicine, Tanta University, Egypt
    J Neuropsychiatry Clin Neurosci 23:163-7. 2011
    ..Depressed patients had higher cortisol levels than nondepressed. Data suggest that the effects of epilepsy and depression on cortisol, but not other hormones, may be additive...
  17. pmc Dysbalance of cortical inhibition and excitation in abstinent cocaine-dependent patients
    Klevest Gjini
    Wayne State University, School of Medicine, Department of Psychiatry and Behavioral Neurosciences, 2751 E Jefferson, Detroit, MI 48207, USA
    J Psychiatr Res 46:248-55. 2012
    ..Overall, the data point to the complex nature of chronic cocaine dependence on the balance of cortical inhibitory/excitatory mechanisms...
  18. pmc Generators of the intracranial P50 response in auditory sensory gating
    Oleg Korzyukov
    Department of Psychiatry, Wayne State University, 2751 E Jefferson, Suite 304, Detroit, MI 48207, USA
    Neuroimage 35:814-26. 2007
    ..Present findings suggest that while the temporal lobe is the main generator of the P50 component, the frontal lobe seems to be a substantial contributor to the process of sensory gating as observed from scalp recordings...
  19. doi request reprint The DEX/CRH test for major depression: a potentially useful diagnostic test
    Mohammadreza Mokhtari
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, 2751 East Jefferson Avenue, Suite 437, Detroit, MI 48207, USA
    Psychiatry Res 208:131-9. 2013
    ..Particularly, additional step-3 and step-4 studies are necessary. ..
  20. ncbi request reprint Cortical inhibition and excitation in abstinent cocaine-dependent patients: a transcranial magnetic stimulation study
    Karthik Sundaresan
    Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, USA
    Neuroreport 18:289-92. 2007
    ..Although the increase in long-interval intracortical facilitation suggests exaggerated cortical glutamatergic excitability, the increase in resting motor threshold may signify a protective mechanism against seizures and psychosis...
  21. ncbi request reprint Electrophysiological aberrations in borderline personality disorder: state of the evidence
    Nashaat N Boutros
    Department of Psychiatry at Yale University School of Medicine, New Haven, USA
    J Neuropsychiatry Clin Neurosci 15:145-54. 2003
    ..We conclude that although the existing literature reflects a preliminary stage of the field, it suggests that electrophysiological investigations may be useful in investigating BPD...
  22. ncbi request reprint Risk factors for experiencing psychosis during cocaine use: a preliminary report
    Alicia G Floyd
    School of Medicine and VA Connecticut Healthcare System, Yale University, New York, NY 10032, USA
    J Psychiatr Res 40:178-82. 2006
    ..This study tests the hypothesis that earlier age of initiation of regular use may increase the likelihood of developing CIP, or the severity of CIP symptoms...
  23. ncbi request reprint Neuronal substrates of sensory gating within the human brain
    Thomas Grunwald
    Department of Epileptology, University of Bonn, Germany
    Biol Psychiatry 53:511-9. 2003
    ..To identify its neural correlates, we recorded electrical traces of sensory gating directly from the human hippocampus and neocortex...
  24. ncbi request reprint Sensory gating and psychosis vulnerability in cocaine-dependent individuals: preliminary data
    Nashaat N Boutros
    VA Connecticut Healthcare System West Haven Campus, Yale University School of Medicine, 950 Campbell Avenue 116A, West Haven, CT 06516, USA
    Biol Psychiatry 51:683-6. 2002
    ..Deficits in sensory gating and attention, such as those occurring in idiopathic psychosis, might represent experimentally tractable factors contributing to vulnerability to cocaine-induced paranoia...
  25. ncbi request reprint Contribution of different EEG frequencies to auditory evoked potential abnormalities in schizophrenia
    Ben H Jansen
    Department of Electrical and Computer Engineering, University of Houston, Houston, TX 77204 4005, USA
    Clin Neurophysiol 115:523-33. 2004
    ..In the present study, we investigate whether schizophrenia patients suffer from phase synchronization deficits as compared to normal subjects...
  26. ncbi request reprint Sensory gating deficits during the mid-latency phase of information processing in medicated schizophrenia patients
    Nashaat N Boutros
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychiatry Res 126:203-15. 2004
    ..Furthermore, the data suggest that N100 and P200 gating indices may influence subsequent information processing...
  27. ncbi request reprint Electrophysiological assessment of neuropsychiatric disorders
    Nashaat N Boutros
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, CT, USA
    Semin Clin Neuropsychiatry 7:30-41. 2002
    ..Finally, the limitations of the routine EEG are discussed. The article concludes with a brief mention of the future promise of other electrophysiological testing modalities such as quantified EEG, evoked potentials, and sleep studies...
  28. ncbi request reprint Short-term habituation of the intracranially recorded auditory evoked potentials P50 and N100
    Timm Rosburg
    Department of Epileptology, University of Bonn, Sigmund Freud Street 25, D 53105 Bonn, Germany
    Neurosci Lett 372:245-9. 2004
    ..Current results indicate that the P50 suppression as investigated in sensory gating experiments seems to be completed after the 2nd stimulus...
  29. ncbi request reprint Target probability affects the likelihood that a P300 will be generated in response to a target stimulus, but not its amplitude
    Bharat Bonala
    Department of Electrical and Computer Engineering, University of Houston, Houston, Texas 77204 4005, USA
    Psychophysiology 45:93-9. 2008
    ..This suggests that local target probability affects the consistency with which a subject responds to target stimuli, but not the P300 amplitude...
  30. ncbi request reprint Cortical excitability in cocaine-dependent patients: a replication and extension of TMS findings
    Nashaat N Boutros
    Department of Psychiatry, c o VA Connecticut Healthcare System, Yale University School of Medicine, 950 Campbell Avenue, 116A West Haven, CT 06516, USA
    J Psychiatr Res 39:295-302. 2005
    ..These data support our initial finding of decreased cortical excitability in abstinent cocaine-dependent subjects. We interpret this finding as a compensatory mechanism against the stimulating and epileptogenic effects of cocaine...
  31. ncbi request reprint Subdural recordings of the mismatch negativity (MMN) in patients with focal epilepsy
    Timm Rosburg
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Brain 128:819-28. 2005
    ..Current findings have, however, to be interpreted with caution owing to the placement and limited extension of the used electrode arrays...
  32. ncbi request reprint Genetic and environmental influences on sensory gating of mid-latency auditory evoked responses: a twin study
    Andrey P Anokhin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Schizophr Res 89:312-9. 2007
    ..These results suggest that gating measures derived from the N1/P2 wave complex may be useful endophenotypes for population-based genetic studies of the sensory gating function and its impairments in psychopathology...
  33. ncbi request reprint Habituation of auditory evoked potentials in intracranial and extracranial recordings
    Timm Rosburg
    Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
    Psychophysiology 43:137-44. 2006
    ..This dissociation between the intracranial and scalp recordings might be explained by a different sensitivity of the two measurements for N100 generators...
  34. ncbi request reprint Phase synchronization of the ongoing EEG and auditory EP generation
    Ben H Jansen
    Department of Electrical and Computer Engineering, University of Houston, Houston, TX, USA
    Clin Neurophysiol 114:79-85. 2003
    ..We investigated the role of phase synchronization of the spontaneous electroencephalogram (EEG) in auditory evoked potential (EP) generation in a sample of healthy individuals...
  35. ncbi request reprint Lack of a therapeutic effect of a 2-week sub-threshold transcranial magnetic stimulation course for treatment-resistant depression
    Nashaat N Boutros
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Psychiatry Res 113:245-54. 2002
    ..The duration of the therapeutic effects of rTMS delivered to the left prefrontal cortex using the above-described parameters is highly variable...
  36. ncbi request reprint Morphological and latency abnormalities of the mid-latency auditory evoked responses in schizophrenia: a preliminary report
    Nashaat N Boutros
    Yale University School of Medicine and VA Connecticut Healthcare System, 950 Campbell Ave 116A, West Haven, CT, USA
    Schizophr Res 70:303-13. 2004
    ..Morphological abnormalities of the mid-latency auditory evoked responses (MLAERs; P50, N100, P200), on the other hand, received very little attention...

Research Grants21

  1. Intracranial Mapping of Sensory Gating in Humans
    Nashaat Boutros; Fiscal Year: 2006
    ..These data will shed more light on this crucial function and will help further our understanding of the mechanisms that lead to the development of psychotic disorders. ..
  2. Electrophysiology: Integrating Modalities and Discipline
    Nashaat Boutros; Fiscal Year: 2007
    ..Both career awards and travel grants will be offered for young investigators to attend the conference. This is again designed to facilitate the interaction between established and new investigators. ..
  3. Cortical Excitability in Cocaine-Dependent Subjects
    Nashaat Boutros; Fiscal Year: 2007
    ..An additional exploratory aim is to probe the personality correlates of TMS-based cortical excitability changes in cocaine-dependent subjects. ..
  4. Cortical Excitability in Cocaine-Dependent Subjects
    Nashaat Boutros; Fiscal Year: 2006
    ..A normal control group will be included. The TMS measured motor threshold and length of the TMS induced silent periods will be compared between the three groups. ..
  5. PHASE RESETTING AND SENSORY INHIBITION IN THE CNS
    Nashaat Boutros; Fiscal Year: 2005
    ....
  6. PHASE RESETTING AND SENSORY INHIBITION IN THE CNS
    Nashaat Boutros; Fiscal Year: 1999
    ....
  7. Cortical Excitability in Cocaine-Dependent Subjects
    Nashaat Boutros; Fiscal Year: 2009
    ..An additional exploratory aim is to probe the personality correlates of TMS-based cortical excitability changes in cocaine-dependent subjects. ..