Cathryn Hufford Bock
Affiliation: Wayne State University
- Prostate cancer early detection practices among men with a family history of diseaseCathryn H Bock
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109 0946, USA
Urology 62:470-5. 2003....
- Grilled meat consumption and PhIP-DNA adducts in prostate carcinogenesisDeliang Tang
Environmental Health Science, Columbia University Mailman School of Public Health, 630 W 168th Street, P and S 19 407, New York, NY, USA
Cancer Epidemiol Biomarkers Prev 16:803-8. 2007..Our results suggest that dietary interventions targeted at lower consumption of grilled red meats may reduce prostate cancer risk via the PhIP prostate carcinogenic pathway...
- NQO1 T allele associated with decreased risk of later age at diagnosis lung cancer among never smokers: results from a population-based studyC H Bock
Population Studies and Prevention Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
Carcinogenesis 26:381-6. 2005..The observed risk reductions may be attributable to the greatly reduced procarcinogen activating of NAD(P)H:quinone oxidoreductase 1 in individuals with at least one copy of the T allele...
- Decreasing age at prostate cancer diagnosis over successive generations in prostate cancer familiesCathryn H Bock
Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, Michigan 48201, USA
Prostate 64:60-6. 2005..The decline in age at prostate cancer diagnosis over the past decade is partially attributable to prostate specific antigen (PSA) screening. We examined age at diagnosis over successive generations within prostate cancer families...
- Prostate cancer risk from occupational exposure to polycyclic aromatic hydrocarbons interacting with the GSTP1 Ile105Val polymorphismBenjamin A Rybicki
Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI 48202, USA
Cancer Detect Prev 30:412-22. 2006..An Ile/Val polymorphism in codon 105 of GSTP1 affects its enzymatic activity toward PAH detoxification, a possible mechanism in prostate carcinogenesis...
- Results from a prostate cancer admixture mapping study in African-American menCathryn Hufford Bock
Wayne State University School of Medicine, Detroit, MI 48201, USA
Hum Genet 126:637-42. 2009..In conclusion, we confirmed ancestry associations on 8q24, and identified additional ancestry-associated regions potentially harboring prostate cancer susceptibility loci...
- Evidence supports a faster growth rate and/or earlier transformation to clinically significant prostate cancer in black than in white American men, and influences racial progression and mortality disparityIsaac J Powell
Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan, USA
J Urol 183:1792-6. 2010..We propose that a more rapid prostate cancer growth rate and/or earlier transformation from latent to aggressive prostate cancer in black than in white men contribute to this disparity...
- SRD5A2 and HSD3B2 polymorphisms are associated with prostate cancer risk and aggressivenessChristine Neslund-Dudas
Department of Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, MI 48202, USA
Prostate 67:1654-63. 2007..Two polymorphisms, a valine (V) for leucine (L) substitution at the 89 codon of the SRD5A2 gene and a (TG)n,(TA)n,(CA)n repeat polymorphism within the third intron of the HSD3B2 gene were evaluated with regard to prostate cancer risk...
- Racial differences in risk of prostate cancer associated with metabolic syndromeJennifer L Beebe-Dimmer
Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michiga 48201 1379, USA
Urology 74:185-90. 2009..A number of recent reports have linked metabolic syndrome to prostate cancer; however, most studies have not had racially diverse populations to explore differences in risk...
- Sexually transmitted diseases and other urogenital conditions as risk factors for prostate cancer: a case--control study in Wayne County, MichiganDivya A Patel
Karmanos Cancer Institute, Wayne State University, Detroit, MI 48109 0276, USA
Cancer Causes Control 16:263-73. 2005....
- Polycyclic aromatic hydrocarbon--DNA adducts in prostate and biochemical recurrence after prostatectomyBenjamin A Rybicki
Departments of Biostatistics and Research Epidemiology and Surgical Pathology, Henry Ford Health System, Detroit, Michigan 48202, USA
Clin Cancer Res 14:750-7. 2008..DNA adduct levels may be influenced by metabolic activity, DNA repair capabilities, and genomic integrity, all of which play a role in cancer progression...
- The molecular epidemiology of lung cancerAnn G Schwartz
Population Studies and Prevention Program, Karmanos Cancer Institute, and Department of Internal Medicine, Wayne State University School of Medicine, 110 E Warren Avenue, Detroit, MI 48103, USA
Carcinogenesis 28:507-18. 2007..In the future, studies that focus on complex interactions between multiple genes and environmental exposures within pertinent pathways are needed. New technological advances in genotyping will help move the field forward...
- Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by raceNora L Nock
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
Cancer Epidemiol Biomarkers Prev 16:1236-45. 2007..2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05). We present evidence, for the first time in human prostate that the association between smoking and PAH-DNA adducts differs by race and is modified by common genetic variants...
- Racial differences in clinical and pathological associations with PhIP-DNA adducts in prostateDeliang Tang
Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA
Int J Cancer 121:1319-24. 2007..In conclusion, while PhIP-DNA adduct levels in prostate cells do not vary significantly by race, our results suggest that PhIP exposure may have stronger effects on prostate tumor differentiation in African-American men...
- Association between family history of prostate and breast cancer among African-American men with prostate cancerJennifer L Beebe-Dimmer
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 48109 0946, USA
Urology 68:1072-6. 2006..To explore the familial aggregation of prostate and breast cancer using data from a population-based case-control study of African-American men participating in the Flint Men's Health Study...
- Association between Agent Orange and prostate cancer: a pilot case-control studyVeda Nargund Giri
Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0946, USA
Urology 63:757-60; discussion 760-1. 2004..Prostate cancer is the most common cancer diagnosed in American men and the second leading cause of cancer deaths. An association between Agent Orange and prostate cancer has been suggested by epidemiologic studies...
- Oxidative Stress, Antioxidants and Racial Disparities in Prostate CancerCATHRYN BOCK; Fiscal Year: 2007....