Safwan Badr

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Central sleep apnea
    M Safwan Badr
    Pulmonary and Critical Care Division, Wayne State University School of Medicine, Harper University Hospital, 3 Hudson, 3990 John R Street, Detroit, MI 48201, USA
    Prim Care 32:361-74, vi. 2005
  2. pmc Central sleep apnea in patients with congestive heart failure
    Safwan Badr
    Wayne State University, Detroit, USA
    Heart Fail Rev 14:135-41. 2009
  3. ncbi request reprint The ventilatory response to carbon dioxide and sustained hypoxia is enhanced after episodic hypoxia in OSA patients
    Bradley Khodadadeh
    John D Dingell Veterans Administration Medical Center, 4646 John R 11R, Room 4308, Detroit, MI 48201, USA
    Respir Physiol Neurobiol 150:122-34. 2006
  4. ncbi request reprint Measurement of pharyngeal cross-sectional area by finite element analysis
    Khaled F Mansour
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University, Detroit, Michigan, USA
    J Appl Physiol 100:294-303. 2006
  5. ncbi request reprint The determinants of the apnea threshold during NREM sleep in normal subjects
    James A Rowley
    Sleep Research Laboratory, John D Dingell VA Medical Center Division of Pulmonary, Critical Care and Sleep Medicine, Department of Ilnternal Medicine, Detroit, MI, USA
    Sleep 29:95-103. 2006
  6. ncbi request reprint Long-term facilitation of ventilation and genioglossus muscle activity is evident in the presence of elevated levels of carbon dioxide in awake humans
    Daniel P Harris
    John D Dingell VA Medical Center, 4646 John R 11R Rm 4308, Detroit, MI 48201, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1111-9. 2006
  7. ncbi request reprint Ventilatory sensitivity to carbon dioxide before and after episodic hypoxia in women treated with testosterone
    Deepti Ahuja
    John D Dingell VA Medical Center, Detroit, MI 48201, USA
    J Appl Physiol 102:1832-8. 2007
  8. ncbi request reprint Treatment compliance in patients lost to follow-up after polysomnography
    Ho Sheng Lin
    Department of Otolaryngology Head and Neck Surgery, Wayne State University School of Medicine, and Department of Surgery, John D Dingell VA Medical Center, Detroit, MI 48201, USA
    Otolaryngol Head Neck Surg 136:236-40. 2007
  9. ncbi request reprint The influence of episodic hypoxia on upper airway collapsibility in subjects with obstructive sleep apnea
    James A Rowley
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Detroit, MI, USA
    J Appl Physiol 103:911-6. 2007
  10. pmc Long-term facilitation of genioglossus activity is present in normal humans during NREM sleep
    Susmita Chowdhuri
    Medical Service, John D Dingell Veterans Affairs Medical Center, Detroit, MI 48201, USA
    Respir Physiol Neurobiol 160:65-75. 2008

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Central sleep apnea
    M Safwan Badr
    Pulmonary and Critical Care Division, Wayne State University School of Medicine, Harper University Hospital, 3 Hudson, 3990 John R Street, Detroit, MI 48201, USA
    Prim Care 32:361-74, vi. 2005
    ..Thus, there is a significant overlap between obstructive and central apnea. This article addresses the pathophysiology, clinical features, and management of normocapnic and hypercapnic CSA...
  2. pmc Central sleep apnea in patients with congestive heart failure
    Safwan Badr
    Wayne State University, Detroit, USA
    Heart Fail Rev 14:135-41. 2009
    ..This article will review the determinants of central apnea, the specific features of CHF-related central apnea, and outline a management approach...
  3. ncbi request reprint The ventilatory response to carbon dioxide and sustained hypoxia is enhanced after episodic hypoxia in OSA patients
    Bradley Khodadadeh
    John D Dingell Veterans Administration Medical Center, 4646 John R 11R, Room 4308, Detroit, MI 48201, USA
    Respir Physiol Neurobiol 150:122-34. 2006
    ..We conclude that the VRCO2 (hypoxia) is enhanced after exposure to acute episodic hypoxia and that enhancement of the VRCO2 (hypoxia) occurs even though long-term facilitation is not evident...
  4. ncbi request reprint Measurement of pharyngeal cross-sectional area by finite element analysis
    Khaled F Mansour
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University, Detroit, Michigan, USA
    J Appl Physiol 100:294-303. 2006
    ..0 mm2 (95% CI, -0.1, 0.1 mm2). For NREM validation breaths, the mean difference between mCSA and cCSA was 1.1 mm2 (95% CI 1.3, 1.5 mm2). Pharyngeal CSA can be accurately calculated from measured pharyngeal pressure and flow by FEA...
  5. ncbi request reprint The determinants of the apnea threshold during NREM sleep in normal subjects
    James A Rowley
    Sleep Research Laboratory, John D Dingell VA Medical Center Division of Pulmonary, Critical Care and Sleep Medicine, Department of Ilnternal Medicine, Detroit, MI, USA
    Sleep 29:95-103. 2006
    ..To determine whether (1) postmenopausal women have a higher apnea threshold than premenopausal women and men and (2) hormone replacement therapy would decrease the apnea threshold in postmenopausal women...
  6. ncbi request reprint Long-term facilitation of ventilation and genioglossus muscle activity is evident in the presence of elevated levels of carbon dioxide in awake humans
    Daniel P Harris
    John D Dingell VA Medical Center, 4646 John R 11R Rm 4308, Detroit, MI 48201, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1111-9. 2006
    ....
  7. ncbi request reprint Ventilatory sensitivity to carbon dioxide before and after episodic hypoxia in women treated with testosterone
    Deepti Ahuja
    John D Dingell VA Medical Center, Detroit, MI 48201, USA
    J Appl Physiol 102:1832-8. 2007
    ..We also conclude that exposure to episodic hypoxia enhances the VSco(2 hypoxia), but that this enhancement is unaffected by treatment with testosterone...
  8. ncbi request reprint Treatment compliance in patients lost to follow-up after polysomnography
    Ho Sheng Lin
    Department of Otolaryngology Head and Neck Surgery, Wayne State University School of Medicine, and Department of Surgery, John D Dingell VA Medical Center, Detroit, MI 48201, USA
    Otolaryngol Head Neck Surg 136:236-40. 2007
    ..In this study, we examined patients who failed to follow-up after their initial polysomnogram (PSG) and PAP titration to determine their treatment status in terms of PAP usage...
  9. ncbi request reprint The influence of episodic hypoxia on upper airway collapsibility in subjects with obstructive sleep apnea
    James A Rowley
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Detroit, MI, USA
    J Appl Physiol 103:911-6. 2007
    ..These results corroborate previous evidence that changes in upper airway resistance and caliber can be dissociated from changes in upper airway collapsibility...
  10. pmc Long-term facilitation of genioglossus activity is present in normal humans during NREM sleep
    Susmita Chowdhuri
    Medical Service, John D Dingell Veterans Affairs Medical Center, Detroit, MI 48201, USA
    Respir Physiol Neurobiol 160:65-75. 2008
    ..2) GG activity during the recovery period correlates with the magnitude of GG activation during hypoxia, and inversely with age...
  11. pmc Impact of intermittent hypoxia on long-term facilitation of minute ventilation and heart rate variability in men and women: do sex differences exist?
    Harpreet Wadhwa
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Appl Physiol 104:1625-33. 2008
    ..In contrast, sustained alterations in autonomic nervous system activity were evident in men but not in women...
  12. ncbi request reprint The use of a predicted CPAP equation improves CPAP titration success
    James A Rowley
    Sleep Disorders Center at Hutzel Hospital, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Wayne State University, Detroit, MI 48201, USA
    Sleep Breath 9:26-32. 2005
    ..The equation does not accurately predict the prescribed CPAP level, reaffirming the need for a titration study to determine the optimal prescribed level in a given patient...
  13. pmc Treatment with leuprolide acetate decreases the threshold of the ventilatory response to carbon dioxide in healthy males
    Jason H Mateika
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Physiol 561:637-46. 2004
    ..56 +/- 0.25 versus 4.06 +/- 0.29 Torr; P = 0.004). We conclude that suppression of testosterone decreases the threshold of the ventilatory response to carbon dioxide during both wakefulness and sleep...
  14. ncbi request reprint Ventilatory responses to carbon dioxide at low and high levels of oxygen are elevated after episodic hypoxia in men compared with women
    Chris Morelli
    John D Dingell Veterans Medical Center, Wayne State University School of Medicine, Detroit, MI, 48201, USA
    J Appl Physiol 97:1673-80. 2004
    ..71 l x min(-1) x Torr(-1); 150 Torr: men, 5.73 +/- 0.81 vs. women, 3.83 +/- 0.56 l x min(-1) x Torr(-1)). Thus we conclude that enhancement of the acute ventilatory response to carbon dioxide after episodic hypoxia is sex dependent...
  15. ncbi request reprint Effect of episodic hypoxia on upper airway mechanics in humans during NREM sleep
    Mahdi Shkoukani
    Medical Service, John D Dingell Veterans Affairs Medical Center, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Appl Physiol 92:2565-70. 2002
    ....
  16. ncbi request reprint A mathematical model to detect inspiratory flow limitation during sleep
    Khaled F Mansour
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University, Detroit, Michigan 48201, USA
    J Appl Physiol 93:1084-92. 2002
    ..We conclude that a polynomial function can be used to predict the relationship between pressure and flow in the upper airway and objectively determine the presence of IFL...
  17. ncbi request reprint Effect of surfactant on pharyngeal mechanics in sleeping humans: implications for sleep apnoea
    M J Morrell
    National Heart and Lung Institute, Imperial College School of Medicine, Sleep and Ventilation Unit, Royal Brompton Hospital, London, UK
    Eur Respir J 20:451-7. 2002
    ..The authors speculate that surfactant may delay occlusion by reducing the liquid "bridging" within the folded pharyngeal lining...
  18. ncbi request reprint Determinants of long-term facilitation in humans during NREM sleep
    Mark Babcock
    Sleep Research Laboratory, Medical Service, John D Dingell Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
    J Appl Physiol 94:53-9. 2003
    ....
  19. ncbi request reprint Maximal dynamic expiratory pressures with fast and slow inspirations
    Ashraf Altarifi
    John D Dingell Veterans Affairs Medical Center, Detroit, MI 48201, USA
    Eur J Appl Physiol 89:74-8. 2003
    ....
  20. ncbi request reprint Lack of gender difference in ventilatory chemoresponsiveness and post-hypoxic ventilatory decline
    Abdul Ghani S Tarbichi
    Wayne State University Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, 4646 John R, Detroit, MI 48201, USA
    Respir Physiol Neurobiol 137:41-50. 2003
    ..6+/-1.7 L/min vs. women, 4.9+/-1.9 L/min, P = ns). We conclude that the gender difference in SDB is not explained by a difference in the ventilatory response to hypocapnic hypoxia...
  21. ncbi request reprint Peripheral chemoreflex responsiveness is increased at elevated levels of carbon dioxide after episodic hypoxia in awake humans
    Jason H Mateika
    Department of Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA
    J Appl Physiol 96:1197-205; discussion 1196. 2004
    ..Nevertheless, despite this lack of expression, the acute ventilatory response to hypoxia in the presence of hypercapnia is increased after exposure to episodic hypoxia...
  22. ncbi request reprint Mathematical determination of inspiratory upper airway resistance using a polynomial equation
    Khaled Mansour
    Sleep Research Laboratory, John D Dingell VA Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
    Sleep Breath 7:151-8. 2003
    ..We conclude that R(UA) can be measured in a simple, objective, and reproducible fashion from a polynomial function that characterizes the upper airway pressure-flow relationship...
  23. ncbi request reprint Posthypoxic ventilatory decline during NREM sleep: influence of sleep apnea
    Amal M Omran
    Medical Service, John D Dingell Veterans Affairs Medical Center, Detroit, MI 48201, USA
    J Appl Physiol 96:2220-5. 2004
    ....
  24. ncbi request reprint Gender differences in upper airway compliance during NREM sleep: role of neck circumference
    James A Rowley
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Appl Physiol 92:2535-41. 2002
    ..We conclude that the gender difference in retropalatal compliance is more accurately attributed to differences in neck circumference between the genders...
  25. ncbi request reprint Cardiovascular complications of respiratory diseases
    Susmita Chowdhuri
    John D Dingell VA Medical Center, Detroit, Michigan, USA
    Am J Med Sci 334:361-80. 2007
    ..This review examines the current evidence that links both reduced lung function and SDB to CV diseases...
  26. ncbi request reprint Noninvasive determination of upper airway resistance and flow limitation
    Khaled F Mansour
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University, Detroit, Michigan 48201, USA
    J Appl Physiol 97:1840-8. 2004
    ..8 cmH2O x l(-1) x s(-1). We conclude that a polynomial equation can be used to model the flow-time relationship, allowing for the objective and accurate determination of upper airway resistance and the presence of IFL...

Research Grants9

  1. CENTRAL SLEEP APNEA--ROLE OF LONGTERM FACILITATION
    M Badr; Fiscal Year: 2002
    ..The presence/absence of LTF under baseline conditions and after 4 weeks of therapy with nasal CPAP will be investigated. If LTF is absent at baseline, the follow-up study will determine whether this is a primary or secondary effect. ..
  2. Sleep Apnea: Determinants and Consequences
    M Badr; Fiscal Year: 2007
    ..The work environment is outstanding and the institutional commitment is superb. ..
  3. Central Sleep Apnea: Determinants of Consequences
    M Badr; Fiscal Year: 2009
    ..The proposed protocols are likely to yield critical insight into the pathogenesis of breathing instability during sleep and may point toward effective pharmacologic therapy for sleep apnea. ..