M Safwan Badr

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Central sleep apnea
    M Safwan Badr
    Pulmonary and Critical Care Division, Wayne State University School of Medicine, Harper University Hospital, 3 Hudson, 3990 John R Street, Detroit, MI 48201, USA
    Prim Care 32:361-74, vi. 2005
  2. doi request reprint Effects of clonidine on breathing during sleep and susceptibility to central apnoea
    Abdul Ghani Sankri-Tarbichi
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Wayne State University, 4646 John R, Detroit, MI 48201, USA
    Respir Physiol Neurobiol 185:356-61. 2013
  3. pmc Impact of repeated daily exposure to intermittent hypoxia and mild sustained hypercapnia on apnea severity
    Sanar S Yokhana
    Department of Physiology, Wayne State University School of Medicine, Wayne State University, Detroit, Michigan, USA
    J Appl Physiol (1985) 112:367-77. 2012
  4. ncbi request reprint Posthypoxic ventilatory decline during NREM sleep: influence of sleep apnea
    Amal M Omran
    Medical Service, John D Dingell Veterans Affairs Medical Center, Detroit, MI 48201, USA
    J Appl Physiol 96:2220-5. 2004
  5. pmc Sustained hyperoxia stabilizes breathing in healthy individuals during NREM sleep
    Susmita Chowdhuri
    Medical Service, John D Dingell Veterans Affairs Medical Center, Detroit, MI 48201, USA
    J Appl Physiol (1985) 109:1378-83. 2010
  6. pmc Increased propensity for central apnea in patients with obstructive sleep apnea: effect of nasal continuous positive airway pressure
    Anan Salloum
    Wayne State University School of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep, Harper University Hospital, 3 Hudson 3990 John R, Detroit, MI 48201, USA
    Am J Respir Crit Care Med 181:189-93. 2010
  7. ncbi request reprint Lack of gender difference in ventilatory chemoresponsiveness and post-hypoxic ventilatory decline
    Abdul Ghani S Tarbichi
    Wayne State University Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, 4646 John R, Detroit, MI 48201, USA
    Respir Physiol Neurobiol 137:41-50. 2003
  8. pmc The influence of race on the severity of sleep disordered breathing
    Sukanya Pranathiageswaran
    Sleep Disorders Center at Detroit Receiving Hospital, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI, USA
    J Clin Sleep Med 9:303-9. 2013
  9. ncbi request reprint Ventilatory sensitivity to carbon dioxide before and after episodic hypoxia in women treated with testosterone
    Deepti Ahuja
    John D Dingell VA Medical Center, Detroit, MI 48201, USA
    J Appl Physiol 102:1832-8. 2007
  10. ncbi request reprint Effect of episodic hypoxia on upper airway mechanics in humans during NREM sleep
    Mahdi Shkoukani
    Medical Service, John D Dingell Veterans Affairs Medical Center, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Appl Physiol 92:2565-70. 2002

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Central sleep apnea
    M Safwan Badr
    Pulmonary and Critical Care Division, Wayne State University School of Medicine, Harper University Hospital, 3 Hudson, 3990 John R Street, Detroit, MI 48201, USA
    Prim Care 32:361-74, vi. 2005
    ..Thus, there is a significant overlap between obstructive and central apnea. This article addresses the pathophysiology, clinical features, and management of normocapnic and hypercapnic CSA...
  2. doi request reprint Effects of clonidine on breathing during sleep and susceptibility to central apnoea
    Abdul Ghani Sankri-Tarbichi
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Wayne State University, 4646 John R, Detroit, MI 48201, USA
    Respir Physiol Neurobiol 185:356-61. 2013
    ..We hypothesized that administration of clonidine would decrease the hypocapnic apnoeic threshold (HAT) and widen the CO(2) reserve during non-REM sleep...
  3. pmc Impact of repeated daily exposure to intermittent hypoxia and mild sustained hypercapnia on apnea severity
    Sanar S Yokhana
    Department of Physiology, Wayne State University School of Medicine, Wayne State University, Detroit, Michigan, USA
    J Appl Physiol (1985) 112:367-77. 2012
    ..Lastly, our results suggest that repeated daily exposure to mild sustained hypercapnia may lead to a decrease in breathing events...
  4. ncbi request reprint Posthypoxic ventilatory decline during NREM sleep: influence of sleep apnea
    Amal M Omran
    Medical Service, John D Dingell Veterans Affairs Medical Center, Detroit, MI 48201, USA
    J Appl Physiol 96:2220-5. 2004
    ....
  5. pmc Sustained hyperoxia stabilizes breathing in healthy individuals during NREM sleep
    Susmita Chowdhuri
    Medical Service, John D Dingell Veterans Affairs Medical Center, Detroit, MI 48201, USA
    J Appl Physiol (1985) 109:1378-83. 2010
    ..2) Thus hyperoxia may mitigate the effects of hypocapnia on ventilatory motor output by lowering the hypocapnic ventilatory response and lowering the resting eupneic PET(CO(2)), thereby decreasing plant gain...
  6. pmc Increased propensity for central apnea in patients with obstructive sleep apnea: effect of nasal continuous positive airway pressure
    Anan Salloum
    Wayne State University School of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep, Harper University Hospital, 3 Hudson 3990 John R, Detroit, MI 48201, USA
    Am J Respir Crit Care Med 181:189-93. 2010
    ..There is increasing evidence of increased ventilatory instability in patients with obstructive sleep apnea (OSA), but previous investigations have not studied whether the hypocapnic apneic threshold is altered in this group...
  7. ncbi request reprint Lack of gender difference in ventilatory chemoresponsiveness and post-hypoxic ventilatory decline
    Abdul Ghani S Tarbichi
    Wayne State University Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, 4646 John R, Detroit, MI 48201, USA
    Respir Physiol Neurobiol 137:41-50. 2003
    ..6+/-1.7 L/min vs. women, 4.9+/-1.9 L/min, P = ns). We conclude that the gender difference in SDB is not explained by a difference in the ventilatory response to hypocapnic hypoxia...
  8. pmc The influence of race on the severity of sleep disordered breathing
    Sukanya Pranathiageswaran
    Sleep Disorders Center at Detroit Receiving Hospital, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI, USA
    J Clin Sleep Med 9:303-9. 2013
    ..We hypothesized that in patients with diagnosed OSAHS, African Americans would have higher apnea-hypopnea index (AHI) and higher mortality than white individuals...
  9. ncbi request reprint Ventilatory sensitivity to carbon dioxide before and after episodic hypoxia in women treated with testosterone
    Deepti Ahuja
    John D Dingell VA Medical Center, Detroit, MI 48201, USA
    J Appl Physiol 102:1832-8. 2007
    ..We also conclude that exposure to episodic hypoxia enhances the VSco(2 hypoxia), but that this enhancement is unaffected by treatment with testosterone...
  10. ncbi request reprint Effect of episodic hypoxia on upper airway mechanics in humans during NREM sleep
    Mahdi Shkoukani
    Medical Service, John D Dingell Veterans Affairs Medical Center, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Appl Physiol 92:2565-70. 2002
    ....
  11. pmc Drug-induced sleep endoscopy vs awake Müller's maneuver in the diagnosis of severe upper airway obstruction
    Danny Soares
    Department of Otolaryngology Head and Neck Surgery, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Otolaryngol Head Neck Surg 148:151-6. 2013
    ....
  12. pmc Inhibition of ventilatory motor output increases expiratory retro palatal compliance during sleep
    Abdul Ghani Sankri-Tarbichi
    Wayne State University Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, 4646 John R, Detroit, MI 48201, USA
    Respir Physiol Neurobiol 176:136-43. 2011
    ..We hypothesized that inhibition of ventilatory motor output leads to increased pharyngeal compliance during NREM sleep, independent of lung volume...
  13. ncbi request reprint The ventilatory response to carbon dioxide and sustained hypoxia is enhanced after episodic hypoxia in OSA patients
    Bradley Khodadadeh
    John D Dingell Veterans Administration Medical Center, 4646 John R 11R, Room 4308, Detroit, MI 48201, USA
    Respir Physiol Neurobiol 150:122-34. 2006
    ..We conclude that the VRCO2 (hypoxia) is enhanced after exposure to acute episodic hypoxia and that enhancement of the VRCO2 (hypoxia) occurs even though long-term facilitation is not evident...
  14. ncbi request reprint Determinants of long-term facilitation in humans during NREM sleep
    Mark Babcock
    Sleep Research Laboratory, Medical Service, John D Dingell Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
    J Appl Physiol 94:53-9. 2003
    ....
  15. ncbi request reprint Ventilatory responses to carbon dioxide at low and high levels of oxygen are elevated after episodic hypoxia in men compared with women
    Chris Morelli
    John D Dingell Veterans Medical Center, Wayne State University School of Medicine, Detroit, MI, 48201, USA
    J Appl Physiol 97:1673-80. 2004
    ..71 l x min(-1) x Torr(-1); 150 Torr: men, 5.73 +/- 0.81 vs. women, 3.83 +/- 0.56 l x min(-1) x Torr(-1)). Thus we conclude that enhancement of the acute ventilatory response to carbon dioxide after episodic hypoxia is sex dependent...
  16. ncbi request reprint Long-term facilitation of ventilation and genioglossus muscle activity is evident in the presence of elevated levels of carbon dioxide in awake humans
    Daniel P Harris
    John D Dingell VA Medical Center, 4646 John R 11R Rm 4308, Detroit, MI 48201, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1111-9. 2006
    ....
  17. pmc Treatment of central sleep apnea in U.S. veterans
    Susmita Chowdhuri
    Medical Service, Sleep Medicine Section, John D Dingell Veterans Affairs Medical Center, Detroit, MI 48201, USA
    J Clin Sleep Med 8:555-63. 2012
    ..The goal was to report on the effectiveness of titration with PAP, used alone or in conjunction with O(2), for the management of CSA associated with varying comorbidities and opioid use...
  18. pmc The hypoxic ventilatory response and ventilatory long-term facilitation are altered by time of day and repeated daily exposure to intermittent hypoxia
    David G Gerst
    John D Dingell VA Medical Center, Detroit, MI 48201, USA
    J Appl Physiol (1985) 110:15-28. 2011
    ....
  19. pmc Progressive augmentation and ventilatory long-term facilitation are enhanced in sleep apnoea patients and are mitigated by antioxidant administration
    Dorothy S Lee
    John D Dingell Veterans Administration Medical Center, Wayne State University, Detroit, MI 48201, USA
    J Physiol 587:5451-67. 2009
    ..3 +/- 1.4 vs. 29.3 +/- 2.8 l min(-1), P <or= 0.05). We conclude that PA and vLTF are enhanced in participants with OSA and that these forms of respiratory plasticity are mitigated after treatment with an antioxidant cocktail...
  20. pmc Effect of episodic hypoxia on the susceptibility to hypocapnic central apnea during NREM sleep
    Susmita Chowdhuri
    Medical Service, John D Dingell Veterans Affairs Medical Center, Detroit, MI 48201, USA
    J Appl Physiol (1985) 108:369-77. 2010
    ..This form of respiratory plasticity may destabilize breathing and promote central apneas...
  21. ncbi request reprint The determinants of the apnea threshold during NREM sleep in normal subjects
    James A Rowley
    Sleep Research Laboratory, John D Dingell VA Medical Center Division of Pulmonary, Critical Care and Sleep Medicine, Department of Ilnternal Medicine, Detroit, MI, USA
    Sleep 29:95-103. 2006
    ..To determine whether (1) postmenopausal women have a higher apnea threshold than premenopausal women and men and (2) hormone replacement therapy would decrease the apnea threshold in postmenopausal women...
  22. ncbi request reprint A mathematical model to detect inspiratory flow limitation during sleep
    Khaled F Mansour
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University, Detroit, Michigan 48201, USA
    J Appl Physiol (1985) 93:1084-92. 2002
    ..We conclude that a polynomial function can be used to predict the relationship between pressure and flow in the upper airway and objectively determine the presence of IFL...
  23. ncbi request reprint Treatment compliance in patients lost to follow-up after polysomnography
    Ho Sheng Lin
    Department of Otolaryngology Head and Neck Surgery, Wayne State University School of Medicine, and Department of Surgery, John D Dingell VA Medical Center, Detroit, MI 48201, USA
    Otolaryngol Head Neck Surg 136:236-40. 2007
    ..In this study, we examined patients who failed to follow-up after their initial polysomnogram (PSG) and PAP titration to determine their treatment status in terms of PAP usage...
  24. ncbi request reprint Peripheral chemoreflex responsiveness is increased at elevated levels of carbon dioxide after episodic hypoxia in awake humans
    Jason H Mateika
    Department of Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA
    J Appl Physiol (1985) 96:1197-205; discussion 1196. 2004
    ..Nevertheless, despite this lack of expression, the acute ventilatory response to hypoxia in the presence of hypercapnia is increased after exposure to episodic hypoxia...
  25. ncbi request reprint Mathematical determination of inspiratory upper airway resistance using a polynomial equation
    Khaled Mansour
    Sleep Research Laboratory, John D Dingell VA Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
    Sleep Breath 7:151-8. 2003
    ..We conclude that R(UA) can be measured in a simple, objective, and reproducible fashion from a polynomial function that characterizes the upper airway pressure-flow relationship...
  26. pmc Treatment with leuprolide acetate decreases the threshold of the ventilatory response to carbon dioxide in healthy males
    Jason H Mateika
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Physiol 561:637-46. 2004
    ..56 +/- 0.25 versus 4.06 +/- 0.29 Torr; P = 0.004). We conclude that suppression of testosterone decreases the threshold of the ventilatory response to carbon dioxide during both wakefulness and sleep...
  27. ncbi request reprint The use of a predicted CPAP equation improves CPAP titration success
    James A Rowley
    Sleep Disorders Center at Hutzel Hospital, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Wayne State University, Detroit, MI 48201, USA
    Sleep Breath 9:26-32. 2005
    ..The equation does not accurately predict the prescribed CPAP level, reaffirming the need for a titration study to determine the optimal prescribed level in a given patient...
  28. pmc Long-term facilitation of genioglossus activity is present in normal humans during NREM sleep
    Susmita Chowdhuri
    Medical Service, John D Dingell Veterans Affairs Medical Center, Detroit, MI 48201, USA
    Respir Physiol Neurobiol 160:65-75. 2008
    ..01). In multivariate regression analysis, age and phasic EMG(GG) activity during hypoxia were significant predictors of EMG(GG) at recovery 20 min. No significant changes in any of the measured parameters were noted during sham studies...
  29. ncbi request reprint The influence of episodic hypoxia on upper airway collapsibility in subjects with obstructive sleep apnea
    James A Rowley
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Detroit, MI, USA
    J Appl Physiol (1985) 103:911-6. 2007
    ..These results corroborate previous evidence that changes in upper airway resistance and caliber can be dissociated from changes in upper airway collapsibility...
  30. ncbi request reprint Gender differences in upper airway compliance during NREM sleep: role of neck circumference
    James A Rowley
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Appl Physiol (1985) 92:2535-41. 2002
    ..We conclude that the gender difference in retropalatal compliance is more accurately attributed to differences in neck circumference between the genders...
  31. pmc Impact of intermittent hypoxia on long-term facilitation of minute ventilation and heart rate variability in men and women: do sex differences exist?
    Harpreet Wadhwa
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Appl Physiol (1985) 104:1625-33. 2008
    ..In contrast, sustained alterations in autonomic nervous system activity were evident in men but not in women...
  32. ncbi request reprint Maximal dynamic expiratory pressures with fast and slow inspirations
    Ashraf Altarifi
    John D Dingell Veterans Affairs Medical Center, Detroit, MI 48201, USA
    Eur J Appl Physiol 89:74-8. 2003
    ....
  33. ncbi request reprint Noninvasive determination of upper airway resistance and flow limitation
    Khaled F Mansour
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University, Detroit, Michigan 48201, USA
    J Appl Physiol 97:1840-8. 2004
    ..8 cmH2O x l(-1) x s(-1). We conclude that a polynomial equation can be used to model the flow-time relationship, allowing for the objective and accurate determination of upper airway resistance and the presence of IFL...
  34. ncbi request reprint Measurement of pharyngeal cross-sectional area by finite element analysis
    Khaled F Mansour
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University, Detroit, Michigan, USA
    J Appl Physiol 100:294-303. 2006
    ..0 mm2 (95% CI, -0.1, 0.1 mm2). For NREM validation breaths, the mean difference between mCSA and cCSA was 1.1 mm2 (95% CI 1.3, 1.5 mm2). Pharyngeal CSA can be accurately calculated from measured pharyngeal pressure and flow by FEA...
  35. ncbi request reprint The impact of obesity on cardiac dysfunction in patients with sleep-disordered breathing
    Shatha Alkatib
    Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Wayne State University, 4646 John R, Detroit, MI, 48201, USA
    Sleep Breath 18:137-42. 2014
    ..Obesity and heart failure are strongly associated with sleep-disordered breathing (SDB). However, the determinants of cardiac dysfunction in patients with SDB are not known...
  36. pmc Testosterone conversion blockade increases breathing stability in healthy men during NREM sleep
    Susmita Chowdhuri
    Medical Service, Sleep Medicine Section, John D Dingell Veterans Affairs Medical Center, Detroit, MI Division of Pulmonary Critical Care and Sleep Medicine, Department of Medicine, Wayne State University School of Medicine, Detroit, MI
    Sleep 36:1793-8. 2013
    ..Our objective was to determine the exact pathway for a testosterone-mediated increased propensity for central sleep apnea via blockade of the 5α-reductase pathway of testosterone conversion by finasteride...
  37. pmc Expiratory pharyngeal narrowing during central hypocapnic hypopnea
    Abdul Ghani Sankri-Tarbichi
    Wayne State University Sleep Research Laboratory, John D Dingell Veterans Affairs Medical Center, Detroit, Michigan, USA
    Am J Respir Crit Care Med 179:313-9. 2009
    ..Ventilatory motor output is an important determinant of upper airway patency during sleep...
  38. ncbi request reprint Central sleep apnoea
    Susmita Chowdhuri
    John D Dingell Veterans Affairs Medical Center and Wayne State University, Detroit, MI 48201, USA
    Indian J Med Res 131:150-64. 2010
    ....
  39. ncbi request reprint Cardiovascular complications of respiratory diseases
    Susmita Chowdhuri
    John D Dingell VA Medical Center, Detroit, Michigan, USA
    Am J Med Sci 334:361-80. 2007
    ..This review examines the current evidence that links both reduced lung function and SDB to CV diseases...
  40. doi request reprint Exhaled nitric oxide levels during treatment in patients hospitalized with asthma
    Alan P Baptist
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI, USA
    Allergy Asthma Proc 29:171-6. 2008
    ..This augmentation appears to be associated with improvements in FEV(1). Asthmatic patients who show a greater increase in FE(NO) may have better outcomes after discharge...
  41. ncbi request reprint Effect of surfactant on pharyngeal mechanics in sleeping humans: implications for sleep apnoea
    M J Morrell
    National Heart and Lung Institute, Imperial College School of Medicine, Sleep and Ventilation Unit, Royal Brompton Hospital, London, UK
    Eur Respir J 20:451-7. 2002
    ..The authors speculate that surfactant may delay occlusion by reducing the liquid "bridging" within the folded pharyngeal lining...