R Arking

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi Genomic plasticity, energy allocations, and the extended longevity phenotypes of Drosophila
    Robert Arking
    Department of Biological Sciences, College of Science, Wayne State University, Biological Science Building, Detroit, MI 48202, USA
    Ageing Res Rev 1:209-28. 2002
  2. ncbi The human life span is not that limited: the effect of multiple longevity phenotypes
    Robert Arking
    Department of Biological Sciences, Biological Sciences Building, 5705 Gullen Mall, Wayne State University, Detroit, MI 48202, USA
    J Gerontol A Biol Sci Med Sci 59:697-704. 2004
  3. ncbi A new age for aging? Ethical questions, scientific insights, and societal outcomes
    Robert Arking
    Wayne State University, Detroit, Michigan, USA
    Rejuvenation Res 7:53-60. 2004
  4. ncbi Metabolic alterations and shifts in energy allocations are corequisites for the expression of extended longevity genes in Drosophila
    Robert Arking
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Ann N Y Acad Sci 959:251-62; discussion 463-5. 2002
  5. ncbi Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns
    R Arking
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Exp Gerontol 35:167-85. 2000
  6. ncbi Identical longevity phenotypes are characterized by different patterns of gene expression and oxidative damage
    R Arking
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Exp Gerontol 35:353-73. 2000
  7. ncbi Gene expression and regulation in the extended longevity phenotypes of Drosophila
    R Arking
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Ann N Y Acad Sci 928:157-67. 2001
  8. ncbi A coordinate upregulation of antioxidant gene activities is associated with the delayed onset of senescence in a long-lived strain of Drosophila
    S P Dudas
    Institute of Gerontology, University of Michigan, Detroit, USA
    J Gerontol A Biol Sci Med Sci 50:B117-27. 1995
  9. ncbi Factors contributing to the plasticity of the extended longevity phenotypes of Drosophila
    R Arking
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Exp Gerontol 31:623-43. 1996
  10. ncbi Direct selection for paraquat resistance in Drosophila results in a different extended longevity phenotype
    J Vettraino
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    J Gerontol A Biol Sci Med Sci 56:B415-25. 2001

Collaborators

Detail Information

Publications20

  1. ncbi Genomic plasticity, energy allocations, and the extended longevity phenotypes of Drosophila
    Robert Arking
    Department of Biological Sciences, College of Science, Wayne State University, Biological Science Building, Detroit, MI 48202, USA
    Ageing Res Rev 1:209-28. 2002
    ..Literature review suggests the involvement of mitochondrial and antioxidant changes are likely universal in the Type 1 extended longevity phenotype...
  2. ncbi The human life span is not that limited: the effect of multiple longevity phenotypes
    Robert Arking
    Department of Biological Sciences, Biological Sciences Building, 5705 Gullen Mall, Wayne State University, Detroit, MI 48202, USA
    J Gerontol A Biol Sci Med Sci 59:697-704. 2004
    ..The existence of multiple phenotypes means that an overview of potential life expectancy outcomes for a species should be based on the analysis of all longevity phenotypes likely to occur in that species...
  3. ncbi A new age for aging? Ethical questions, scientific insights, and societal outcomes
    Robert Arking
    Wayne State University, Detroit, Michigan, USA
    Rejuvenation Res 7:53-60. 2004
  4. ncbi Metabolic alterations and shifts in energy allocations are corequisites for the expression of extended longevity genes in Drosophila
    Robert Arking
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Ann N Y Acad Sci 959:251-62; discussion 463-5. 2002
    ..Selection pressures that do not lead to these shifts in energy allocations result in extended longevity phenotypes characterized by increased early survival or increased late survival but not by a delayed onset of senescence...
  5. ncbi Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns
    R Arking
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Exp Gerontol 35:167-85. 2000
    ....
  6. ncbi Identical longevity phenotypes are characterized by different patterns of gene expression and oxidative damage
    R Arking
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Exp Gerontol 35:353-73. 2000
    ..The theoretical and empirical implications of these findings are discussed...
  7. ncbi Gene expression and regulation in the extended longevity phenotypes of Drosophila
    R Arking
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Ann N Y Acad Sci 928:157-67. 2001
    ..The organism may have multiple genetic strategies to cope with similar levels of oxidative stress...
  8. ncbi A coordinate upregulation of antioxidant gene activities is associated with the delayed onset of senescence in a long-lived strain of Drosophila
    S P Dudas
    Institute of Gerontology, University of Michigan, Detroit, USA
    J Gerontol A Biol Sci Med Sci 50:B117-27. 1995
    ....
  9. ncbi Factors contributing to the plasticity of the extended longevity phenotypes of Drosophila
    R Arking
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Exp Gerontol 31:623-43. 1996
    ..It also illustrates that the species has the potential to employ any one of a number of different proximal mechanisms, each of which give rise to a similar longevity phenotype...
  10. ncbi Direct selection for paraquat resistance in Drosophila results in a different extended longevity phenotype
    J Vettraino
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    J Gerontol A Biol Sci Med Sci 56:B415-25. 2001
    ..We interpret these findings as suggesting that similar stress response phenotypes may be generated by different molecular mechanisms, some of which may generate very different types of extended longevity phenotypes...
  11. ncbi The expression of the EF1 alpha genes of Drosophila is not associated with the extended longevity phenotype in a selected long-lived strain
    S P Dudas
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Exp Gerontol 29:645-57. 1994
    ..These conclusions suggest that the expression of the EF-1 alpha genes is not associated with the extended longevity phenotype...
  12. ncbi Genetic and environmental factors regulating the expression of an extended longevity phenotype in a long lived strain of Drosophila
    R Arking
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202
    Genetica 91:127-42. 1993
    ..Future work will involve the experimental verification of the genetic-environmental circuitry discussed here, using novel molecular genetic techniques to define, characterize, and isolate the genes involved in the expression of the ELP...
  13. ncbi Immunological confirmation of elevated levels of CuZn superoxide dismutase protein in an artificially selected long-lived strain of Drosophila melanogaster
    R Hari
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Exp Gerontol 33:227-37. 1998
    ....
  14. ncbi Dietary restriction in Drosophila is dependent on mitochondrial efficiency and constrained by pre-existing extended longevity
    Jung Won Soh
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Mech Ageing Dev 128:581-93. 2007
    ..Higher density (4-10x) foods yielded a decreased longevity in all strains at the highest level, showing that malnutrition occurs at both low and high caloric levels...
  15. ncbi Anti-aging teleconference: what is anti-aging medicine?
    Robert Arking
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    J Anti Aging Med 6:91-106. 2003
    ....
  16. ncbi Different age-specific demographic profiles are generated in the same normal-lived Drosophila strain by different longevity stimuli
    Robert Arking
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    J Gerontol A Biol Sci Med Sci 57:B390-8. 2002
    ..These data document the complexity of the aging process and argue for a relationship between molecular mechanisms and longevity phenotypes...
  17. ncbi Multiple longevity phenotypes and the transition from health to senescence
    Robert Arking
    3103 BSB, Department of Biological Sciences, 5470 Gullen Mall, Wayne State University, Detroit, Michigan 48202, USA
    Ann N Y Acad Sci 1057:16-27. 2005
    ....
  18. ncbi Human reproductive costs and the predicted response to dietary restriction
    Robert Arking
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Rejuvenation Res 10:261-79. 2007
    ....
  19. ncbi Life span extension and neuronal cell protection by Drosophila nicotinamidase
    Vitaly Balan
    Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    J Biol Chem 283:27810-9. 2008
    ..Together, our findings establish a life span extending the ability of nicotinamidase in flies and offer a role for nicotinamide-modulating genes in oxidative stress regulated pathways influencing longevity and neuronal cell survival...
  20. ncbi Individual fecundity and senescence in Drosophila and medfly
    Vassili N Novoseltsev
    Institute of Control Sciences, Moscow, Russia
    J Gerontol A Biol Sci Med Sci 60:953-62. 2005
    ..This difference demonstrates different ways of aging in various Diptera species. Finally, we discuss the possible implications of this finding...