J V Aranda

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Clinical pharmacology of antimicrobials for urinary tract infections in newborns and young infants
    J V Aranda
    Children s Hospital of Michigan, Detroit, MI, USA
    J Chemother 18:14-5. 2006
  2. ncbi request reprint Systematic review: intravenous Ibuprofen in preterm newborns
    J V Aranda
    Pediatric Pharmacology Research Unit Network PPRU, Division of Clinical Pharmacology and Toxicology, Children s Hospital of Michigan, 3901 Beaubien Boulevard 3N47, Detroit, MI 48201, USA
    Semin Perinatol 30:114-20. 2006
  3. ncbi request reprint Analgesia and sedation during mechanical ventilation in neonates
    J V Aranda
    Pediatric Pharmacology Research Unit Network, Wayne State University and Children s Hospital of Michigan, Detroit, USA
    Clin Ther 27:877-99. 2005
  4. ncbi request reprint PGE2/TXB2 imbalance in neonatal hypoxemic respiratory failure
    B G Sood
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Hutzel Women s Hospital, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Acta Paediatr 96:669-73. 2007
  5. ncbi request reprint Pharmacokinetics of buspirone in autistic children
    David J Edwards
    Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
    J Clin Pharmacol 46:508-14. 2006
  6. ncbi request reprint Sildenafil citrate and fetal outcome in pregnant rats
    Jerrie S Refuerzo
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Wayne State University, Detroit, MI 48201, USA
    Fetal Diagn Ther 21:259-63. 2006
  7. ncbi request reprint Systemic levels following PGE1 inhalation in neonatal hypoxemic respiratory failure
    Beena G Sood
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Hutzel Women s Hospital and Children s Hospital of Michigan, Detroit, MI 48201, USA
    Acta Paediatr 95:1093-8. 2006
  8. ncbi request reprint Vancomycin elimination in human infants with intrauterine growth retardation
    Daniel A C Frattarelli
    Division of Clinical Pharmacology, Children s Hospital of Michigan, Detroit, MI, USA
    Pediatr Infect Dis J 24:979-83. 2005
  9. ncbi request reprint Therapeutic drug monitoring for caffeine in preterm neonates: an unnecessary exercise?
    Girija Natarajan
    Division of Neonatology, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Pediatrics 119:936-40. 2007
  10. ncbi request reprint A meta-analysis of ibuprofen versus indomethacin for closure of patent ductus arteriosus
    Ronald L Thomas
    Children s Research Center of Michigan, Children s Hospital of Michigan, 3901 Beaubien Blvd, 48201 Detroit, Michigan, USA
    Eur J Pediatr 164:135-40. 2005

Research Grants

  1. PEDIATRIC PHARMACOLOGY RESEARCH UNIT
    Mary Lieh Lai; Fiscal Year: 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Clinical pharmacology of antimicrobials for urinary tract infections in newborns and young infants
    J V Aranda
    Children s Hospital of Michigan, Detroit, MI, USA
    J Chemother 18:14-5. 2006
  2. ncbi request reprint Systematic review: intravenous Ibuprofen in preterm newborns
    J V Aranda
    Pediatric Pharmacology Research Unit Network PPRU, Division of Clinical Pharmacology and Toxicology, Children s Hospital of Michigan, 3901 Beaubien Boulevard 3N47, Detroit, MI 48201, USA
    Semin Perinatol 30:114-20. 2006
    ..On or after the second day of postnatal life, when early or therapeutic PDA closure is needed, ibuprofen and not indomethacin is probably the first choice due to its better adverse event profile...
  3. ncbi request reprint Analgesia and sedation during mechanical ventilation in neonates
    J V Aranda
    Pediatric Pharmacology Research Unit Network, Wayne State University and Children s Hospital of Michigan, Detroit, USA
    Clin Ther 27:877-99. 2005
    ..Clinical guidelines for pharmacologic analgesia and sedation in newborns based on robust scientific data are lacking, as are measures of clinical efficacy...
  4. ncbi request reprint PGE2/TXB2 imbalance in neonatal hypoxemic respiratory failure
    B G Sood
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Hutzel Women s Hospital, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Acta Paediatr 96:669-73. 2007
    ..An imbalance of vaso-constrictor and -dilator mediators has been implicated in the pathogenesis of the pulmonary hypertension accompanying neonatal hypoxemic respiratory failure (NHRF)...
  5. ncbi request reprint Pharmacokinetics of buspirone in autistic children
    David J Edwards
    Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
    J Clin Pharmacol 46:508-14. 2006
    ..Plasma concentrations with 2.5- to 5.0-mg doses were similar to those observed in older children receiving 7.5- to 15-mg doses...
  6. ncbi request reprint Sildenafil citrate and fetal outcome in pregnant rats
    Jerrie S Refuerzo
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Wayne State University, Detroit, MI 48201, USA
    Fetal Diagn Ther 21:259-63. 2006
    ..To determine the effects of sildenafil citrate on fetal growth in maternal rats exposed to hypoxia...
  7. ncbi request reprint Systemic levels following PGE1 inhalation in neonatal hypoxemic respiratory failure
    Beena G Sood
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Hutzel Women s Hospital and Children s Hospital of Michigan, Detroit, MI 48201, USA
    Acta Paediatr 95:1093-8. 2006
    ..To measure plasma prostaglandin E1 (PGE1) levels in newborns with hypoxemic respiratory failure (NHRF) following inhaled PGE1 (IPGE1), normal term newborns, and newborns with congenital heart disease (CHD) following intravenous PGE1...
  8. ncbi request reprint Vancomycin elimination in human infants with intrauterine growth retardation
    Daniel A C Frattarelli
    Division of Clinical Pharmacology, Children s Hospital of Michigan, Detroit, MI, USA
    Pediatr Infect Dis J 24:979-83. 2005
    ..Our objective was to test the hypothesis that IUGR results in prolonged renal elimination of vancomycin in newborns...
  9. ncbi request reprint Therapeutic drug monitoring for caffeine in preterm neonates: an unnecessary exercise?
    Girija Natarajan
    Division of Neonatology, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Pediatrics 119:936-40. 2007
    ..We hypothesized that measurement of plasma caffeine concentrations during apnea therapy is not clinically helpful...
  10. ncbi request reprint A meta-analysis of ibuprofen versus indomethacin for closure of patent ductus arteriosus
    Ronald L Thomas
    Children s Research Center of Michigan, Children s Hospital of Michigan, 3901 Beaubien Blvd, 48201 Detroit, Michigan, USA
    Eur J Pediatr 164:135-40. 2005
    ....
  11. ncbi request reprint Pharmacokinetics of rofecoxib in children with sickle cell hemoglobinopathy
    Randy P Prescilla
    Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, School of Medicine, Wayne State University, Children s Hospital of Michigan, Detroit, Michigan, USA
    J Pediatr Hematol Oncol 26:661-4. 2004
    ..32 mL/min/kg, with a t1/2 of 14.8 +/- 4.5 hours. No significant adverse events were observed. The disposition of rofecoxib in children appears to be similar to that in adults, with comparable values for Cmax, tmax, t1/2, and Cl/F...
  12. pmc Aerosolized PGE1: a selective pulmonary vasodilator in neonatal hypoxemic respiratory failure results of a Phase I/II open label clinical trial
    Beena G Sood
    Department of Pediatrics, Wayne State University, Children s Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201 USA
    Pediatr Res 56:579-85. 2004
    ..The results of our study indicate that IPGE(1) may be a safe, selective pulmonary vasodilator in neonatal hypoxemic respiratory failure...
  13. ncbi request reprint Antifungals in systemic neonatal candidiasis
    Daniel A C Frattarelli
    Division of Clinical Pharmacology, Children s Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien, Detroit, MI 48201, USA
    Drugs 64:949-68. 2004
    ..Further studies are necessary if the optimisation of antifungal therapy in this population is to continue...
  14. doi request reprint Chorioamnionitis and ontogeny of circulating prostaglandin and thromboxane in preterm infants
    Girija Natarajan
    Division of Neonatology, Children s Hospital of Michigan and Hutzel Women s Hospital, Detroit, MI 48201, USA
    Am J Perinatol 25:491-7. 2008
    ..Further research on their role in the causation of adverse neonatal outcomes is necessary...
  15. doi request reprint Effect of ibuprofen L-lysinate on bilirubin binding to albumin as measured by saturation index and horseradish peroxidase assays
    M T C Ambat
    Division of Neonatology, Clinical Pharmacology and Toxicology, The Pediatric Pharmacology Research Unit Network PPRU at Wayne State University, Children s Hospital of Michigan, Detroit, MI, USA
    J Perinatol 28:287-90. 2008
    ..To demonstrate, in vitro, the influence of increasing ibuprofen (IBU) concentration on bilirubin-albumin (B-A) binding...
  16. ncbi request reprint Nitric oxide and prostaglandin response to group B streptococcal infection in the lung
    Girija Natarajan
    Division of Clinical Pharmacology, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Ann Clin Lab Sci 37:170-6. 2007
    ..The interaction between the 2 pathways may play a pathogenic role in GBS lung infections and could be a potential target for pharmacological manipulation...
  17. ncbi request reprint Neonatal facial coding system scores and spectral characteristics of infant crying during newborn circumcision
    Victoria Tutag Lehr
    Division of Clinical Pharmacology and Toxicology, Children s Hospital of Michigan, 3901 Beaubien, Detroit, MI 48201, USA
    Clin J Pain 23:417-24. 2007
    ..To determine the relations between Neonatal Facial Coding System (NFCS) scores and measures of infant crying during newborn circumcision...
  18. ncbi request reprint Group B Streptococci and inducible nitric oxide synthase: modulation by nuclear factor kappa B and ibuprofen
    M Glibetic
    Division of Clinical Pharmacology/Toxicology, Children's Hospital of Michigan, Wayne State University, Detroit 48201, USA
    Semin Perinatol 25:65-9. 2001
    ..These data show that NFkappaB activation is an early step in the induction of iNOS gene expression by GBS and that this interaction may play a vital role in the pathogenesis of GBS neonatal infections...
  19. doi request reprint Refractory neonatal candidemia and high-dose micafungin pharmacotherapy
    G Natarajan
    Division of Neonatology, Children s Hospital of Michigan and Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Perinatol 29:738-43. 2009
    ..We further evaluate the clinical efficacy of high-dose micafungin pharmacotherapy of refractory candidemia...
  20. ncbi request reprint Lidocaine 4% cream compared with lidocaine 2.5% and prilocaine 2.5% or dorsal penile block for circumcision
    Victoria Tutag Lehr
    Department of Pharmacy Practice, The Eugene Applebaum College of Pharmacy and Health Sciences, Pediatric Pharmacology Research Unit, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Am J Perinatol 22:231-7. 2005
    ..Differences in RR may reflect a varying level of analgesia. The safety profile was similar for all treatments. LMX4 is an effective analgesic for newborn circumcision...
  21. ncbi request reprint Changing patterns of drug utilization in a neonatal intensive care population
    Wei Du
    Division of Clinical Pharmacology and Toxicology, Carmen and Ann Adams Department of Pediatrics, Wayne State University, Detroit, Children s Hospital of Michigan 48201, USA
    Am J Perinatol 23:279-85. 2006
    ..These data are useful in monitoring drug resistance patterns, adverse drug reactions, and prioritizing areas of relevant therapeutic research and educational programs...
  22. doi request reprint A randomized, double-blind, placebo-controlled trial on intravenous ibuprofen L-lysine for the early closure of nonsymptomatic patent ductus arteriosus within 72 hours of birth in extremely low-birth-weight infants
    Jacob V Aranda
    The Children s Hospital of Michigan, Wayne State University, Detroit, MI, USA
    Am J Perinatol 26:235-45. 2009
    ..A trend toward decreased periventricular leukomalacia by ibuprofen was noted. IV ibuprofen was effective and safe in the early closure of PDA in preterm neonates...
  23. ncbi request reprint Management of infiltration injury in neonates using duoderm hydroactive gel
    Victoria Tutag Lehr
    Pharmacy Practice, The Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
    Am J Perinatol 21:409-14. 2004
    ..We report our experience using DuoDerm Hydroactive gel for management of injury secondary to the infiltration of total parenteral nutrition solution and lipid emulsion in three neonates...
  24. ncbi request reprint Nitric oxide-dependent regulation of pro-inflammatory cytokines in group B streptococcal inflammation of rat lung
    Vania D Raykova
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan 48201, USA
    Ann Clin Lab Sci 33:62-7. 2003
    ..These data suggest a role for the nitric oxide pathway in the overproduction of pro-inflammatory mediators IL-6 and MIP-2 during GBS-induced lung inflammation. This pathway may be responsible for the initiation of lung injury...
  25. ncbi request reprint Early postnatal ibuprofen and indomethacin effects in suckling and weanling rat kidneys
    Jamal Hasan
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, University of California Irvine, Irvine, CA, United States
    Prostaglandins Other Lipid Mediat 85:81-8. 2008
    ..These long-term, sustained effects may explain in part, why indomethacin exerts more severe adverse renal effects than ibuprofen, when administered during early postnatal life...
  26. ncbi request reprint Comparative effects of early postnatal ibuprofen and indomethacin on VEGF, IGF-I, and GH during rat ocular development
    Kay D A Beharry
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, University of California Irvine, Irvine, and Department of Pediatrics, Division of Neonatal Perinatal Medicine, Miller Children s Hospital, Long Beach, California, USA
    Invest Ophthalmol Vis Sci 47:3036-43. 2006
    ..This study was conducted to examine and compare the effects of early postnatal ibuprofen and indomethacin on ocular and systemic VEGF, IGF-I, and GH during rat ocular development...
  27. ncbi request reprint Pharmacokinetics of intravenously administered azithromycin in pediatric patients
    Richard F Jacobs
    Division of Pediatric Infectious Disease, Arkansas Children s Hospital, 800 Marshall Street, Little Rock, AR 72202, USA
    Pediatr Infect Dis J 24:34-9. 2005
    ..The objective of this study was to characterize the pharmacokinetics and tolerance of a single intravenous (IV) azithromycin dose in children...
  28. ncbi request reprint Combined treatment with a nonselective nitric oxide synthase inhibitor (l-NMMA) and indomethacin increases ductus constriction in extremely premature newborns
    Roberta L Keller
    Department of Pediatrics, Cardiovascular Research Institute, Pharmacy, University of California San Francisco, CA 94143, USA
    Pediatr Res 58:1216-21. 2005
    ..However, the combined administration of L-NMMA and indomethacin was limited by acute side effects in this treatment protocol...
  29. ncbi request reprint Summary proceedings from the neonatal pain-control group
    Kanwaljeet J S Anand
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Pediatrics 117:S9-S22. 2006
    ..Full-length articles on procedural pain, sedation and analgesia for ventilated infants, perioperative pain, and study designs for neonatal pain research were published in Clinical Therapeutics (June 2005)...
  30. ncbi request reprint "Death due to baclofen and dipyrone ingestion", by de Giovanni N, et all
    Hakan Ergun
    Forensic Sci Int 132:233-4. 2003
  31. doi request reprint A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea
    Marek Lukacik
    Children s Medical Center Department of Pediatrics, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    Pediatrics 121:326-36. 2008
    ..The objective of this study was to examine the efficacy and safety of supplemental oral zinc therapy during recovery from acute or persistent diarrhea...
  32. ncbi request reprint Analgesia and anesthesia for neonates: study design and ethical issues
    K J S Anand
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, USA
    Clin Ther 27:814-43. 2005
    ....

Research Grants2

  1. PEDIATRIC PHARMACOLOGY RESEARCH UNIT
    Mary Lieh Lai; Fiscal Year: 2007
    ..Taken collectively, these initiatives will advance rational, safe, effective and cost beneficial drug therapies in the fetus, newborn and children. ..