George J Alangaden
Affiliation: Wayne State University
- Aspergillosis: The most common community-acquired pneumonia with gram-negative Bacilli as copathogens in stem cell transplant recipients with graft-versus-host diseaseGeorge J Alangaden
Division of Infectious Diseases, Wayne State University School of Medicine, Karmanos Cancer Institute, and The Detroit Medical Center, Detroit, MI, USA
Clin Infect Dis 35:659-64. 2002..Aspergillosis is the most common cause of community-acquired pneumonia among allogeneic HSCT recipients with GVHD. CT must be used to exclude an underlying fungal cause in patients who present with a gram-negative pneumonia...
- Molecular characterisation of cyp51A and cyp51B genes coding for P450 14alpha-lanosterol demethylases A (CYP51Ap) and B (CYP51Bp) from voriconazole-resistant laboratory isolates of Aspergillus flavusSuganthini Krishnan-Natesan
Division of Infectious Diseases, Department of Medicine, Wayne State University, Detroit, MI 48201, USA
Int J Antimicrob Agents 32:519-24. 2008..flavus isolates can be readily isolated in the laboratory under selection pressure. Multiple mechanisms, including drug target modification, may be responsible for the in vitro resistance of A. flavus to VCZ...
- Sirolimus exposure during the early post-transplant period reduces the risk of CMV infection relative to tacrolimus in renal allograft recipientsAbdolreza Haririan
Division of Nephrology, Department of Medicine, Wayne State Uinversity School of Medicine, Detroit, MI, USA
Clin Transplant 21:466-71. 2007..We examined the association between exposure to sirolimus (SRL) and risk of CMV infection after kidney transplantation when compared with tacrolimus (TCL)...
- Recent epidemiology of Clostridium difficile infection during hematopoietic stem cell transplantationTeena Chopra
Division of Infectious Diseases, Wayne State University, Detroit, MI, USA
Clin Transplant 25:E82-7. 2011..Prospective studies to better define the epidemiology and identify unique risk factors for CDI and more accurate tests to confirm the diagnosis in this population are needed...
- A comparison of the fungicidal activity of amphotericin B and posaconazole against Zygomycetes in vitroSuganthini Krishnan-Natesan
Department of Medicine, Division of Infectious Diseases, Wayne State University, John D Dingell VA Medical Center, Detroit, MI, USA
Diagn Microbiol Infect Dis 63:361-4. 2009....
- Novel effect of voriconazole on conidiation of Aspergillus speciesNeeraja L Varanasi
Department of Medicine, Wayne State University, 427 Lande Building, 550 E Canfield, Detroit, MI 48201, USA
Int J Antimicrob Agents 23:72-9. 2004....
- Fluvastatin potentiates the activity of caspofungin against Aspergillus fumigatus in vitroSuganthini Krishnan Natesan
Department of Internal Medicine Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI 48201, USA
Diagn Microbiol Infect Dis 60:369-73. 2008..9% killing of A. fumigatus conidia, whereas either drug alone showed poor activity at subinhibitory concentrations. FST potentiated the antifungal activity of CFG but displayed no specific interaction with voriconazole or amphotericin B...
- Treatment of resistant enterococcal urinary tract infectionsSubramanian Swaminathan
Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI, USA
Curr Infect Dis Rep 12:455-64. 2010..Aminoglycosides or rifampin may be considered as adjunctive therapy in serious infections...
- Nosocomial fungal infections: epidemiology, infection control, and preventionGeorge J Alangaden
Division of Infectious Diseases, Wayne State University, 3990 John R, Suite 5930, Detroit, MI 48201, USA
Infect Dis Clin North Am 25:201-25. 2011..Recently published recommendations and guidelines for the control and prevention of these nosocomial fungal infections are summarized...
- Differential activity of triazoles in two-drug combinations with the echinocandin caspofungin against Aspergillus fumigatusElias K Manavathu
Division of Infectious Diseases, Department of Medicine, Wayne State University, 427 Lande Building, 550 E Canfield, Detroit, MI 48201, USA
J Antimicrob Chemother 51:1423-5. 2003..The in vitro susceptibility of A. fumigatus to two-drug combinations of itraconazole, voriconazole, posaconazole and ravuconazole with caspofungin was evaluated by the fractional inhibitory concentration index (FICI) method...
- Detection of oseltamivir resistance during treatment of 2009 H1N1 influenza virus infection in immunocompromised patients: utility of cycle threshold values of qualitative real-time reverse transcriptase PCRTejal Mehta
Division of Infectious Diseases, Beaumont Hospital, Detroit, Michigan 48201, USA
J Clin Microbiol 48:4326-8. 2010..Oseltamivir resistance was later confirmed by pyrosequencing...
- Clostridium difficile infection in cancer patients and hematopoietic stem cell transplant recipientsTeena Chopra
Division of Infectious Diseases, Wayne State University, Detroit, MI 48201, USA
Expert Rev Anti Infect Ther 8:1113-9. 2010..The purpose of this article is to describe the epidemiology, pathogenesis and management of CDI in patients receiving cancer chemotherapeutic agents, and in hematopoietic stem cell transplant recipients...
- Immediate cross-hypersensitivity between micafungin and caspofungin: a case reportShruti Patel
Wayne State University, Detroit, MI, USA
J Oncol Pharm Pract 15:187-9. 2009..It is recommended to avoid challenging patients with history of immediate hypersensitivity to one echinocandin with another...
- Infectious complications after kidney transplantation: current epidemiology and associated risk factorsGeorge J Alangaden
Division of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI, USA
Clin Transplant 20:401-9. 2006..The impact of newer immunosuppressive and antimicrobial prophylactic agents on the pattern of infectious complications following kidney transplantation has not been well studied...
- Resistance to amphotericin B does not emerge during treatment for invasive aspergillosisMahomed Yunus S Moosa
Division of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Antimicrob Chemother 49:209-13. 2002..Laboratory attempts to produce amphotericin B resistance in Aspergillus were unsuccessful. These data indicate that emergence of resistance to amphotericin B is uncommon during therapy for invasive aspergillosis...