Gyula Acsadi

Summary

Affiliation: Wayne State University
Country: USA

Publications

  1. ncbi request reprint Survival motor neuron protein regulates apoptosis in an in vitro model of spinal muscular atrophy
    Graham C Parker
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Neurotox Res 13:39-48. 2008
  2. ncbi request reprint Increased survival and function of SOD1 mice after glial cell-derived neurotrophic factor gene therapy
    Gyula Acsadi
    Department of Pediatrics, Center for Molecular Medicine and Genetics, Wayne State University, School of Medicine, 3901 Beaubien Road, Detroit, MI 48201, USA
    Hum Gene Ther 13:1047-59. 2002
  3. ncbi request reprint Gene transfer of glial cell-derived neurotrophic factor and cardiotrophin-1 protects PC12 cells from injury: involvement of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase pathways
    Gabor Toth
    Department of Pediatrics, Wayne State University, School of Medicine, Detroit, Michigan 48236, USA
    J Neurosci Res 69:622-32. 2002
  4. pmc Perspectives on clinical trials in spinal muscular atrophy
    Kathryn J Swoboda
    Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Child Neurol 22:957-66. 2007

Collaborators

Detail Information

Publications4

  1. ncbi request reprint Survival motor neuron protein regulates apoptosis in an in vitro model of spinal muscular atrophy
    Graham C Parker
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Neurotox Res 13:39-48. 2008
    ..These data suggest not only that decreased smn levels increase apoptosis in an in vitro model of SMA, but also that increased smn can protect against neural injury...
  2. ncbi request reprint Increased survival and function of SOD1 mice after glial cell-derived neurotrophic factor gene therapy
    Gyula Acsadi
    Department of Pediatrics, Center for Molecular Medicine and Genetics, Wayne State University, School of Medicine, 3901 Beaubien Road, Detroit, MI 48201, USA
    Hum Gene Ther 13:1047-59. 2002
    ..These results demonstrate that gene delivery to muscle and motor neurons has the potential to treat devastating neurodegenerative diseases such as ALS...
  3. ncbi request reprint Gene transfer of glial cell-derived neurotrophic factor and cardiotrophin-1 protects PC12 cells from injury: involvement of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase pathways
    Gabor Toth
    Department of Pediatrics, Wayne State University, School of Medicine, Detroit, Michigan 48236, USA
    J Neurosci Res 69:622-32. 2002
    ..In contrast, the protective effect of GDNF against glutamate toxicity was independent of these RET-dependent signal transduction pathways...
  4. pmc Perspectives on clinical trials in spinal muscular atrophy
    Kathryn J Swoboda
    Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Child Neurol 22:957-66. 2007
    ..Following is an overview of the challenges and opportunities, current and future therapeutic strategies, and progress to date in clinical trials in spinal muscular atrophy...