Wayne State University

Summary

Organization: Wayne State University
Country: USA

Top Publications

  1. ncbi Effects on condom use of an HIV prevention programme 36 months postintervention: a cluster randomized controlled trial among Bahamian youth
    X Chen
    The Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Int J STD AIDS 21:622-30. 2010
  2. ncbi Topotecan weekly bolus chemotherapy for relapsed platinum-sensitive ovarian and peritoneal cancers
    Robert Morris
    Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
    Gynecol Oncol 109:346-52. 2008
  3. ncbi Globalization of medical and psychiatric education and the focus of Academic Psychiatry on the success of "international" authors
    Richard Balon
    Wayne State University, Detroit, MI, USA
    Acad Psychiatry 32:151-3. 2008
  4. ncbi Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model
    Alan A Arnold
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Mol Cancer 7:20. 2008
  5. ncbi Predicting metabolic control in the first 5 yr after diagnosis for youths with type 1 diabetes: the role of ethnicity and family structure
    Maureen A Frey
    Carman and Anne Adams Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Pediatr Diabetes 8:220-7. 2007
  6. ncbi NKT cells are critical to initiate an inflammatory response after Pseudomonas aeruginosa ocular infection in susceptible mice
    Linda D Hazlett
    Department of Anatomy and Cell Biology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    J Immunol 179:1138-46. 2007
  7. ncbi Therapeutic drug monitoring for caffeine in preterm neonates: an unnecessary exercise?
    Girija Natarajan
    Division of Neonatology, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Pediatrics 119:936-40. 2007
  8. ncbi Intravenous immunoglobulin, HLA allele typing and HLAMatchmaker facilitate successful transplantation in highly sensitized pediatric renal allograft recipients
    Rudolph P Valentini
    Division of Nephrology, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children s Hospital of Michigan, Detroit, MI 48201 2196, USA
    Pediatr Transplant 11:77-81. 2007
  9. ncbi Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress
    Renu A Kowluru
    Department of Ophthalmology, Kresge Eye Institute, Wayne State University, Detroit, MI 48201, USA
    Free Radic Biol Med 41:1191-6. 2006
  10. ncbi Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela
    Ikuko Kato
    Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI, 48201, USA
    Cancer Causes Control 17:1183-91. 2006

Research Grants

Detail Information

Publications62

  1. ncbi Effects on condom use of an HIV prevention programme 36 months postintervention: a cluster randomized controlled trial among Bahamian youth
    X Chen
    The Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Int J STD AIDS 21:622-30. 2010
    ..03, 0.37). Youth who received FOYC plus the parental monitoring intervention had higher condom use rates (odds ratio = 1.49, 95% CI: 0.97, 2.28). Feedback effects from key variables were also detected, supporting the sustained effect...
  2. ncbi Topotecan weekly bolus chemotherapy for relapsed platinum-sensitive ovarian and peritoneal cancers
    Robert Morris
    Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
    Gynecol Oncol 109:346-52. 2008
    ..This prospective study, therefore, investigates the safety and efficacy of an alternate weekly schedule of topotecan in patients with recurrent ovarian or peritoneal cancer...
  3. ncbi Globalization of medical and psychiatric education and the focus of Academic Psychiatry on the success of "international" authors
    Richard Balon
    Wayne State University, Detroit, MI, USA
    Acad Psychiatry 32:151-3. 2008
  4. ncbi Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model
    Alan A Arnold
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Mol Cancer 7:20. 2008
    ..These studies suggest that ApoG2 can be an effective therapeutic agent against FL...
  5. ncbi Predicting metabolic control in the first 5 yr after diagnosis for youths with type 1 diabetes: the role of ethnicity and family structure
    Maureen A Frey
    Carman and Anne Adams Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Pediatr Diabetes 8:220-7. 2007
    ..Diabetes care providers should consider developing targeted interventions such as parent social support resources or school-based youth monitoring programs for youth in single-parent families...
  6. ncbi NKT cells are critical to initiate an inflammatory response after Pseudomonas aeruginosa ocular infection in susceptible mice
    Linda D Hazlett
    Department of Anatomy and Cell Biology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    J Immunol 179:1138-46. 2007
    ....
  7. ncbi Therapeutic drug monitoring for caffeine in preterm neonates: an unnecessary exercise?
    Girija Natarajan
    Division of Neonatology, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Pediatrics 119:936-40. 2007
    ..We hypothesized that measurement of plasma caffeine concentrations during apnea therapy is not clinically helpful...
  8. ncbi Intravenous immunoglobulin, HLA allele typing and HLAMatchmaker facilitate successful transplantation in highly sensitized pediatric renal allograft recipients
    Rudolph P Valentini
    Division of Nephrology, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children s Hospital of Michigan, Detroit, MI 48201 2196, USA
    Pediatr Transplant 11:77-81. 2007
    ..Further studies in larger numbers of patients with longer follow-up are needed to determine the individual role played by, and relative importance of each component of this combined strategy...
  9. ncbi Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress
    Renu A Kowluru
    Department of Ophthalmology, Kresge Eye Institute, Wayne State University, Detroit, MI 48201, USA
    Free Radic Biol Med 41:1191-6. 2006
    ..Thus, understanding how changes in mitochondrial function result in the development of diabetic retinopathy could help identify SOD mimics to inhibit its development...
  10. ncbi Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela
    Ikuko Kato
    Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI, 48201, USA
    Cancer Causes Control 17:1183-91. 2006
    ..The aim of the study was to assess the effects of genetic polymorphisms in anti-inflammatory mediators, i.e., IL10, IL4 and IL4R on the prevalence of gastric precancerous lesions and their interactions with other environmental factors...
  11. ncbi Pain affects spouses too: personal experience with pain and catastrophizing as correlates of spouse distress
    Michelle T Leonard
    Department of Psychology and Institute of Gerontology, Wayne State University, Detroit, MI, USA
    Pain 126:139-46. 2006
    ..The results are discussed in light of interpersonal processes that may affect spouses' distress...
  12. ncbi Stay away from tobacco: a pilot trial of a school-based adolescent smoking prevention program in Beijing, China
    Xinguang Chen
    Prevention Research Center, The Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, MI 48201, USA
    Nicotine Tob Res 8:227-37. 2006
    ..A full-scale evaluation is recommended...
  13. ncbi Computational approaches for predicting protein-protein interactions: a survey
    Jingkai Yu
    Department of Computer Science, Wayne State University Detroit, Michigan, USA
    J Med Syst 30:39-44. 2006
    ..This paper presents a survey of major works in computational prediction of protein-protein interactions, explaining their assumptions, main ideas, and limitations...
  14. ncbi PCB levels and trends within the Detroit River-Western Lake Erie basin: a historical perspective of ecosystem monitoring
    Thomas Heidtke
    Department of Civil and Environmental Engineering, Wayne State University, Detroit, MI, USA
    Environ Monit Assess 112:23-33. 2006
    ....
  15. ncbi Thromboelastography in children with coagulation factor deficiencies
    Meera Chitlur
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Br J Haematol 142:250-6. 2008
    ..This may be a potentially useful tool to evaluate the bleeding tendency and determine need for prophylaxis in children with hemophilia...
  16. ncbi Central endothelin: effects on vasopressin and the arterial baroreflex in doxorubicin heart failure rats
    Noreen F Rossi
    Department of Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Can J Physiol Pharmacol 86:343-52. 2008
    ..001). BQ123 prevented the rise in AVP and restored the gain in doxo-HF rats to that seen in controls. Thus, central ETAR contribute to the sympathoexcitation and AVP responses observed in heart failure due to doxorubicin cardiomyopathy...
  17. ncbi Integrative basic sciences: change in mental status
    Erika Crane
    Children s Hospital of Michigan, Detroit, MI 48201, USA
    Clin Pediatr (Phila) 48:284-90. 2009
    ..This case discussion demonstrates how basic science principles of anatomy and physiology can be applied in clinical settings...
  18. ncbi Self-protective strategies are adaptive and increasingly complex: A beginner's look at the DMM and ABCD models of attachment
    Ann M Stacks
    Merrill Palmer Skillman Institute and Wayne State University, USA
    Clin Child Psychol Psychiatry 15:209-14. 2010
    ..This article describes the similarities and differences in the two models of attachment...
  19. ncbi Family network support and mental health recovery
    Francesca Pernice-Duca
    Marriage and Family PsychologyProgram, Wayne State University, 5425 Gullen Mall, Office 337, Detroit, Michigan 48202, USA
    J Marital Fam Ther 36:13-27. 2010
    ..This study revealed that support and reciprocity with family members are important dimensions of a personal support network that relates to the recovery process...
  20. ncbi Alterations in frontal lobe tracts and corpus callosum in young children with autism spectrum disorder
    Ajay Kumar
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Cereb Cortex 20:2103-13. 2010
    ..Volume of bilateral UF and right AF and fiber density of left UF were positively associated with autistic features...
  21. ncbi Distinct roles for mitogen-activated protein kinase phosphatase-1 (MKP-1) and ERK-MAPK in PTH1R signaling during osteoblast proliferation and differentiation
    Nabanita S Datta
    Wayne State University School of Medicine, Department Internal Medicine, Division Endocrinology, Detroit, MI 48201, USA
    Cell Signal 22:457-66. 2010
    ....
  22. ncbi Quantifying effective magnetic moments of narrow cylindrical objects in MRI
    Yu Chung N Cheng
    Department of Radiology, Wayne State University, Detroit, MI 48201, USA
    Phys Med Biol 54:7025-44. 2009
    ..Alternate approaches and their limitations to extract magnet moments of objects with different orientations are also discussed. Our method has the potential to be applied to any long object whose cross section is close to a disk...
  23. ncbi Erythropoietin, forkhead proteins, and oxidative injury: biomarkers and biology
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan, USA
    ScientificWorldJournal 9:1072-104. 2009
    ....
  24. ncbi Are prophylactic antibiotics indicated after a urinary tract infection?
    Tej K Mattoo
    Pediatric Nephrology and Hypertension, Children s Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201, USA
    Curr Opin Pediatr 21:203-6. 2009
    ..The purpose of this review is to discuss these recommendations in the context of recent research findings...
  25. ncbi Single-pill combination of amlodipine and valsartan in the management of hypertension
    John M Flack
    Department of Internal Medicine, Wayne State University School of Medicine, 4201 St Antoine, Suite 2E, Detroit, MI 48201, USA
    Expert Opin Pharmacother 10:1979-94. 2009
    ..Amlodipine/valsartan is indicated as initial therapy in patients who are unlikely to be controlled with a single drug and as second-line therapy in patients not responding adequately to monotherapy...
  26. ncbi Sympathetic nerves and the progression of chronic kidney disease during 5/6 nephrectomy: studies in sympathectomized rats
    Robert A Augustyniak
    Department of Medicine and Physiology, Wayne State University, Detroit, Michigan 48201, USA
    Clin Exp Pharmacol Physiol 37:12-8. 2010
    ..Furthermore, sympathetic nerves to the kidney during 5/6 nephrectomy may contribute to proteinuria in a blood pressure-independent manner...
  27. ncbi Increases in cytoplasmic dopamine compromise the normal resistance of the nucleus accumbens to methamphetamine neurotoxicity
    David M Thomas
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA
    J Neurochem 109:1745-55. 2009
    ..Recruitment of the NAc as a target of METH neurotoxicity by alterations in DA homeostasis is significant in light of the important roles played by this brain structure...
  28. ncbi Polymorphisms in metabolic genes CYP1A1 and GSTM1 and changes in maternal smoking during pregnancy
    Xinguang Chen
    Associate Professor, Prevention Research Center, Ann Adams Department of Pediatrics, Wayne State University, UHC 6D, 4201 Saint Antoine Street, Detroit, MI 48201, USA
    Nicotine Tob Res 11:225-33. 2009
    ..We assessed the association of the MspI polymorphism in CYP1A1(*2A) and the null GSTM1 with maternal smoking behavior during pregnancy...
  29. ncbi Evidence of developmental alterations in cortical and subcortical regions of children with attention-deficit/hyperactivity disorder: a multivoxel in vivo phosphorus 31 spectroscopy study
    Jeffrey A Stanley
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
    Arch Gen Psychiatry 65:1419-28. 2008
    ..In vivo phosphorus 31 magnetic resonance spectroscopy ((31)P MRS) is a noninvasive neuroimaging approach that is sensitive in assessing developmental changes of overproducing/pruning of synapses...
  30. ncbi A "FOXO" in sight: targeting Foxo proteins from conception to cancer
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Med Res Rev 29:395-418. 2009
    ..As our knowledge continues to develop for this novel family of proteins, potential clinical applications for the FoxO family should heighten our ability to limit disease progression without clinical compromise...
  31. ncbi Birth month and suicide among major league baseball players
    Ernest L Abel
    Department of Obstetrics, Wayne State University, USA
    Percept Mot Skills 101:21-4. 2005
    ..The association between birth month and suicide raises the possibility that prenatal factors may influence the inclination for suicide later in life...
  32. ncbi Retinoic acid signaling is required for proper morphogenesis of mammary gland
    Y Alan Wang
    Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Dev Dyn 234:892-9. 2005
    ..Collectively, our data indicate for the first time that retinoic acid signaling is required to maintain the homeostasis of mammary gland morphogenesis...
  33. ncbi Lesions of the posterior basolateral amygdala block feeding induced by systemic 8-OH-DPAT
    G C Parker
    Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Pharmacol Biochem Behav 68:729-34. 2001
    ..second hour that was unaffected by lesions. These findings imply that either fibers of passage and/or cellular elements in both the PDA and pBLA normally inhibit overeating and weight gain via intact serotonergic mechanisms...
  34. ncbi Pro-apoptotic interactions between XK469 and the peripheral benzodiazepine receptor
    D Kessel
    Departments of Pharmacology and Medicine, Wayne State University School of Medicine, Detroit MI 48201, USA
    Cancer Lett 168:141-4. 2001
    ....
  35. ncbi High-dose-rate brachytherapy may be radiobiologically superior to low-dose rate due to slow repair of late-responding normal tissue cells
    C G Orton
    Karmanos Cancer Institute, Detroit, MI, USA
    Int J Radiat Oncol Biol Phys 49:183-9. 2001
    ..The effect this has upon radiobiologic comparison of LDR and HDR is the topic of this paper...
  36. ncbi Therapy for childhood acute myeloid leukemia: role of allogeneic bone marrow transplantation
    E Abella
    Barbara Ann Karmanos Cancer Institute, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI 48201, USA
    Curr Oncol Rep 2:529-38. 2000
    ..It is in this changing mileu that we address the proper role of stem-cell transplantation, a modality that is changing (like chemotherapy) with expanding stem-cell sources and approaches to decrease transplant-related toxicity...
  37. ncbi Voltage-dependent Na(+) currents in mammalian retinal cone bipolar cells
    Z H Pan
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurophysiol 84:2564-71. 2000
    ..These findings raise the possibility that voltage-dependent Na(+) currents may play a role in bipolar cell function...
  38. ncbi Cognitive complexity and cognitive-affective integration: related or separate domains of adult development?
    G Labouvie-Vief
    Department of Psychology, Wayne State University, Detroit, Michigan 48202, USA
    Psychol Aging 15:490-504. 2000
    ..Age and education were significant predictors of the cognitive complexity factors, whereas evaluations of the climate in one's current family and family of origin were related to the factors of cognitive-affective integration...
  39. ncbi Advances in ovarian cancer chemotherapy
    G Deppe
    Department of Obstetrics and Gynecology, Detroit Medical Center Harper Hutzel Hospital, Wayne State University, Michigan 48201, USA
    Curr Opin Oncol 12:481-91. 2000
    ..Chemotherapy of germ cell and malignant ovarian stromal tumors is also discussed. Extensive tables provide a comprehensive overview of ongoing clinical trials in the US as well as elsewhere...
  40. ncbi Protein-binding patterns of the antitumor antibiotic cryptophycin 52 as measured with a two-phase partitioning system
    D Kessel
    Departments of Pharmacology and Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Chromatogr B Biomed Sci Appl 735:121-6. 1999
    ..Affinity for human high- and low-density lipoprotein and albumin was demonstrated, but the drug binds only to the albumin fraction of mouse plasma, in spite of the high HDL level in the latter species...
  41. ncbi Key factors in the acquisition of contrast kinetic data for oncology
    J L Evelhoch
    Cancer Biology Program, Barbara Ann Karmanos Cancer Institute, and Departments of Internal Medicine and Radiology, Wayne State University, Vaitkevicius MR Center, Detroit, Michigan 48201, USA
    J Magn Reson Imaging 10:254-9. 1999
    ..This review considers these factors and, when possible, makes specific recommendations for addressing them experimentally...
  42. ncbi Ethanol and lactation: effects of milk lipids and serum constituents
    S H Heil
    Department of Obstetrics Gynecology, School of Medicine, Wayne State University, Detroit, MI, USA
    Alcohol 18:43-8. 1999
    ..Finally, of the phospholipids in milk, only one, phosphatidylserine, was slightly but significantly increased by EtOH. If and how these changes impact the development of the offspring remain to be studied...
  43. ncbi Examination of Listeria monocytogenes intracellular gene expression by using the green fluorescent protein of Aequorea victoria
    N E Freitag
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Infect Immun 67:1844-52. 1999
    ..These results emphasize the ability of L. monocytogenes to sense the different host cell compartment environments encountered during the course of infection and to regulate virulence gene expression in response...
  44. ncbi Objective method for localization of cortical asymmetries using positron emission tomography to aid surgical resection of epileptic foci
    O Muzik
    Department of Radiology, Children s Hospital of Michigan, Detroit 48201, USA
    Comput Aided Surg 3:74-82. 1998
    ..90). This objective PET method allows the accurate determination of cortical asymmetries, and it proved to be highly efficient in guiding epilepsy surgery...
  45. ncbi Test equating: what, why, how?
    W Zhu
    Division of Health, Physical Education, and Recreation, Wayne State University, USA
    Res Q Exerc Sport 69:11-23. 1998
    ..Finally, benefits and potential applications of test equating in assessing motor functions and skills, as well as future research challenges, were described...
  46. ncbi A molecular basis for hereditary motor and sensory neuropathy disorders
    M E Shy
    Department of Neurology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 421 East Canfield, Elliman Building 3206, Detroit, MI 48201, USA
    Curr Neurol Neurosci Rep 1:77-88. 2001
    ..Identifying these mechanisms will be important both for understanding demyelination and for developing future treatments for CMT...
  47. ncbi GTP-binding proteins in cell survival and demise: the emerging picture in the pancreatic beta-cell
    Anjaneyulu Kowluru
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Wayne State University, 619 Shapero Hall, Detroit, MI 48202, USA
    Biochem Pharmacol 63:1027-35. 2002
    ..In the present commentary, we will review this evidence and discuss the current understanding of the role of G-proteins in the life and death of the beta-cell...
  48. ncbi IL-1Ra and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model
    S Yang
    Department of Orthopaedic Surgery, Wayne State University and the John D Dingle VA Medical Center, Hutzel Hospital, Detroit, MI 48201, USA
    Inflamm Res 51:342-50. 2002
    ..This study examined anti- inflammatory gene therapy to ameliorate tissue responses to ultra high molecular weight polyethylene (UHMWPE) particles in the murine air pouch...
  49. ncbi Therapeutic controversies in hypertension management: angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers in diabetic nephropathy? ACE inhibitors
    Errol D Crook
    Wayne State University School of Medicine, University Health Center, John D Dingell VA Medical Center, Detroit, Michigan 48201, USA
    Ethn Dis 14:S2-1-4. 2004
    ..2% vs 70.1% prevalence of CVD, ACE inhibitor vs ARB respectively, P=.042). We conclude that ACE inhibitors should be strongly considered as the primary method of RAS inhibition in persons with diabetes...
  50. ncbi Glyceraldehyde-3-phosphate dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity
    Ellen J Tisdale
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 279:54046-52. 2004
    ..These data suggest that GAPDH imparts a unique function necessary for membrane trafficking from VTCs that does not require GAPDH glycolytic activity...
  51. ncbi Autoantibodies to Annexin XI-A and Other Autoantigens in the Diagnosis of Breast Cancer
    FELIX FERNANDEZ-MADRID
    Department of Internal Medicine, Division of Rheumatology, Wayne Stste University, 4201 St Antoine Boulevard, Detroit, MI 48201, USA
    Cancer Res 64:5089-96. 2004
    ....
  52. ncbi Characterization of melanophore morphology by fractal dimension analysis
    Victoria A Kimler
    Biology Department, College of Engineering and Science, University of Detroit Mercy, Detroit, MI, USA
    Pigment Cell Res 17:165-72. 2004
    ..The aggregation of melanosomes may contribute to centripetal retraction of the cytoskeleton and plasma membrane. The FD analysis is, therefore, a convenient method to measure contrasting morphologic changes within stimulated cells...
  53. ncbi Low-dose hyper-radiosensitivity: a consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells
    B Marples
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201 2013, USA
    Radiat Res 161:247-55. 2004
    ..The putative role of known damage response factors such as ATM, PARP, H2AX, 53BP1 and HDAC4 is also included within the framework of the HRS model...
  54. ncbi Activity in the dorsal cochlear nucleus of hamsters previously tested for tinnitus following intense tone exposure
    James A Kaltenbach
    Department of Otolaryngology, 5E UHC, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurosci Lett 355:121-5. 2004
    ..These findings are consistent with the hypothesis that hyperactivity in the DCN may be a physiological correlate of noise-induced tinnitus...
  55. ncbi Race, socioeconomic status and stage at diagnosis for five common malignancies
    Kendra L Schwartz
    Karmanos Cancer Institute, Department of Family Medicine, Wayne State University, Detroit, MI, USA
    Cancer Causes Control 14:761-6. 2003
    ..Previous studies investigating this association have used aggregate SES indicators from census tract of residence; we used census block-group data, representing a smaller, potentially more homogenous group...
  56. ncbi Calcium and bone health in infants
    Winston W W K Koo
    Department of Nutritional Sciences, Wayne State University, Detroit, Michigan, USA
    Neonatal Netw 22:23-37. 2003
    ..Also key are the practical issues related to optimizing calcium nutriture in infants born at term and prematurely...
  57. ncbi Expression of transforming growth factor beta isoform mRNA in injured peritoneum that healed with adhesions and without adhesions and in uninjured peritoneum
    Michael L Freeman
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA
    Fertil Steril 80:708-13. 2003
    ....
  58. ncbi Vasopressin vs norepinephrine in endotoxic shock: systemic, renal, and splanchnic hemodynamic and oxygen transport effects
    Jorge A Guzman
    Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Appl Physiol 95:803-9. 2003
    ..Our data demonstrate that, in contrast to NE, administration of AVP effectively restores renal blood flow and Do2 with comparable systemic and splanchnic hemodynamic and metabolic effects in endotoxin-induced circulatory shock...
  59. ncbi Synthesis of 2'-deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation. Synthesis of [18F]labelled FAU, FMAU, FBAU, FIAU
    Thomas J Mangner
    Children s Hospital of Michigan, PET Center, Wayne State University, Detroit, MI 48201, USA
    Nucl Med Biol 30:215-24. 2003
    ..When approximately 220 mCi (8.15 GBq) of starting [(18)F]fluoride is used, 25 -30 mCi (0.93 -1.11 GBq) of product (enough to image two patients sequentially) is typically obtained...
  60. ncbi Mechanisms of cancer chemoprevention by soy isoflavone genistein
    Fazlul H Sarkar
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cancer Metastasis Rev 21:265-80. 2002
    ..Hence, significant advances have been made, both by in vitro and in vivo studies showing that genistein is a promising agent for cancer chemoprevention and/or treatment...
  61. ncbi Attentional focus on supra-postural tasks affects postural control
    Nancy H McNevin
    Department of Physical Therapy, Wayne State University, Detroit, MI 48202, USA
    Hum Mov Sci 21:187-202. 2002
    ..The findings indicate improved static balance responses under external focus conditions and compromised static balance response under internal focus conditions...
  62. ncbi Possible discrimination in recruitment of psychiatry residents?
    R Balon
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Am J Psychiatry 154:1608-9. 1997
    ..The authors sought to determine whether there is a selection bias against international medical graduate applicants for U.S. residency training positions in psychiatry...

Research Grants62

  1. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 1993
    ..These results will ultimately help in development of procedures to maintain or improve kidney function...
  2. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2007
    ..Achievement of these aims should build on our previous work in human kidney cells and extend it to provide a much more complete understanding of the various and complex ways in which DCVC affects the human kidney ..
  3. Glycemic Control and Progression of Diabetic Retinopathy
    Renu Kowluru; Fiscal Year: 2007
    ....
  4. Role of Ras in Retinal Cell Death in Diabetes
    Renu Kowluru; Fiscal Year: 2006
    ....
  5. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2005
    ..abstract_text> ..
  6. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 1999
    ..These results will ultimately help in development of procedures to maintain or improve kidney function. ..
  7. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2001
    ....
  8. Role of Ras in Retinal Cell Death in Diabetes
    Renu A Kowluru; Fiscal Year: 2010
    ..The results are expected to elucidate new insight into the pathogenesis of diabetic retinopathy, and reveal novel targets for therapies to prevent the development and progression of retinopathy. ..
  9. Glycemic Control and Progression of Diabetic Retinopathy
    Renu A Kowluru; Fiscal Year: 2010
    ....
  10. Glycemic Control and Progression of Diabetic Retinopathy
    Renu A Kowluru; Fiscal Year: 2010
    ....
  11. Role of Ras in Retinal Cell Death in Diabetes
    Renu Kowluru; Fiscal Year: 2009
    ..The results are expected to elucidate new insight into the pathogenesis of diabetic retinopathy, and reveal novel targets for therapies to prevent the development and progression of retinopathy. ..
  12. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 2003
    ..This information may have therapeutic applications for prevention of renal cellular injury or for understanding mitochondrial diseases or age-related decreases that occur in mitochondrial function. ..
  13. Glycemic Control and Progression of Diabetic Retinopathy
    Renu Kowluru; Fiscal Year: 2009
    ....
  14. Subcellular Targets and PDT-Induced Apoptosis
    David Kessel; Fiscal Year: 2005
    ..Collaborative arrangements with Drs. Reiners (co- investigator) and Kim (consultant) continue arrangements that have been productive during the previous interval of support. ..
  15. Subcellular targets and PDT-induces cell death
    David Kessel; Fiscal Year: 2007
    ..Information on mechanisms of cell death pathways and their role in cancer control is also expected to assist in drug development and to provide better understanding of the role of death pathways in cancer control. ..
  16. Subcellular targets and PDT-induces cell death
    David Kessel; Fiscal Year: 2009
    ..Information on mechanisms of cell death pathways and their role in cancer control is also expected to assist in drug development and to provide better understanding of the role of death pathways in cancer control. ..
  17. Modes of cell death initiated by photodynamic therapy
    David Kessel; Fiscal Year: 2010
    ..Optimal targets for PDT remain to be identified. ..
  18. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..If the results of preliminary studies are borne out by further investigation, UDCA could offer a safe and effective means for promoting clinical PDT efficacy. ..
  19. PORPHYRIN PHOTOSENSITIZATION AND PHOTOTHERAPY
    David Kessel; Fiscal Year: 1990
    ..Porphyrins provided via a sub-contract at the University of California (Davis) will represent an approach to the directed design of new agents with a view toward the improvement of clinical phototherapy...
  20. PORPHYRIN PHOTOSENSITIZATION AND PHOTOTHERAPY
    David Kessel; Fiscal Year: 1993
    ..An understanding of the determinants of selective localization and photosensitization will represent a useful contribution to our knowledge of tumor cell biology...
  21. MODE OF ACTION OF THE PHOTO-ACTIVATED PORPHYRINS
    David Kessel; Fiscal Year: 1980
    ..g., study of transport phenomena, membrane protein cross-linking, cell-surface charge & hydrophobicity, and fluorescence signals form porphyrins in cell-free systems and within tumor cells...
  22. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  23. SUBCELLULAR TARGETS AND PDT INDUCED APOPTOSIS
    David Kessel; Fiscal Year: 2001
    ....