Research Topics
| Israel ZighelboimSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesisNicholas P Taylor
Division of Gynecologic Oncology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
Mod Pathol 19:1333-8. 2006..The high rate of concordance for these molecular defects between the carcinoma and sarcoma components adds to existing molecular evidence that carcinosarcomas are clonal malignancies...
Adjuvant treatment for early-stage endometrial cancerIsrael Zighelboim
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, Missouri 63110, USA
Clin Obstet Gynecol 54:245-55. 2011..This review focuses on the role of adjuvant therapies for patients with early-stage disease with emphasis on future directions for risk stratification and personalized treatment...
DICER1 expression and outcomes in endometrioid endometrial adenocarcinomaIsrael Zighelboim
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
Cancer 117:1446-53. 2011..The authors also explored DNA methylation and haploinsufficiency as potential mechanisms related to altered DICER1 expression in these tumors...- Epitope-positive truncating MLH1 mutation and loss of PMS2: implications for IHC-directed genetic testing for Lynch syndromeIsrael Zighelboim
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
Fam Cancer 8:501-4. 2009.... - Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid typeIsrael Zighelboim
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
J Clin Oncol 25:2042-8. 2007..We sought to determine whether MSI and MLH1 methylation are associated with clinicopathologic variables and survival outcomes in a large series of patients with endometrial carcinomas of the endometrioid type... - Differential methylation hybridization array of endometrial cancers reveals two novel cancer-specific methylation markersIsrael Zighelboim
Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, Missouri 63110, USA
Clin Cancer Res 13:2882-9. 2007..To identify novel endometrial cancer-specific methylation markers and to determine their association with clinicopathologic variables and survival outcomes... - "Surgical Apgar Score" predicts postoperative complications after cytoreduction for advanced ovarian cancerIsrael Zighelboim
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, 4911 Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
Gynecol Oncol 116:370-3. 2010..We sought to estimate the ability of this metric to predict major postoperative complications in women undergoing ovarian cancer cytoreductive procedures... - Outcomes in 24 selected patients with stage IVB cervical cancer and excellent performance status treated with radiotherapy and chemotherapyIsrael Zighelboim
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, Alvin J Siteman Cancer Center, St Louis, MO, USA
Radiat Med 24:625-30. 2006..We sought to review outcomes in patients with stage IVB carcinoma of the cervix treated with irradiation in combination with chemotherapy... - ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomesIsrael Zighelboim
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Jewish Plaza, Box 8064, St Louis, MO 63110, USA
J Clin Oncol 27:3091-6. 2009..Knowledge of ATR mutation status may hold promise for individualized treatment and targeted therapies in patients with endometrial cancer... - Clustering of Lynch syndrome malignancies with no evidence for a role of DNA mismatch repairAshley S Case
Divison of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, 3rd Floor Maternity, St Louis, MO 63110, USA
Gynecol Oncol 108:438-44. 2008.... - Lymphovascular space invasion is an independent risk factor for nodal disease and poor outcomes in endometrioid endometrial cancerSaketh R Guntupalli
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, Saint Louis, MO 63110, USA
Gynecol Oncol 124:31-5. 2012..We sought to determine whether LVSI alone or in combination with other histologic factors predicts lymph node (LN) metastasis in patients with endometrioid endometrial cancer... - The effects of body mass index on complications and survival outcomes in patients with cervical carcinoma undergoing curative chemoradiation therapyNora T Kizer
Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer 117:948-56. 2011..The effect of body mass index (BMI) on treatment outcomes for patients with locally advanced cervical carcinoma who receive definitive chemoradiation is unclear... - Chemoradiation in locally advanced cervical carcinoma: an analysis of cisplatin dosing and other clinical prognostic factorsElizabeth K Nugent
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, 4th Floor Maternity, St Louis, MO 63110, USA
Gynecol Oncol 116:438-41. 2010..The aim of this study was to evaluate the effect of number of chemotherapy cycles and other clinical and pathologic factors on progression-free (PFS) and overall survival (OS) in patients with newly diagnosed cervical cancer... - Wound complications after gynecologic cancer surgeryElizabeth K Nugent
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, Barnes Jewish Hospital and Siteman Cancer Center, St Louis, MO 63110, USA
Gynecol Oncol 121:347-52. 2011..To explore clinical correlates of wound complications in high-risk women undergoing abdominal gynecologic surgery in a tertiary referral center... - The value of perioperative imaging in patients with uterine sarcomasElizabeth K Nugent
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, USA
Gynecol Oncol 115:37-40. 2009..To explore the yield and impact of perioperative imaging on management among patients undergoing surgical resection and treatment of uterine sarcomas... - Lower uterine segment involvement is associated with poor outcomes in early-stage endometrioid endometrial carcinomaNora T Kizer
Department of Obstetrics and Gynecology, Washington University School of Medicine, Saint Louis, MO, USA
Ann Surg Oncol 18:1419-24. 2011..The clinicopathologic significance of lower uterine segment involvement (LUSI) in endometrial cancer patients remains unclear. Although LUSI has been reported to be a prognostic indicator, literature is limited... - The utility of peritoneal biopsy and omentectomy in the upstaging of apparent early ovarian cancerRupal Shroff
Washington University School of Medicine, St Louis, MO, USA
Int J Gynecol Cancer 21:1208-12. 2011..Few studies have been done examining this question of whether the biopsies of grossly normal-appearing peritoneal tissue are of benefit to the surgical staging procedure... - The role of neoadjuvant chemotherapy in the management of patients with advanced stage ovarian cancer: survey results from members of the Society of Gynecologic OncologistsSummer B Dewdney
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, 4911 Barnes Jewish Hospital Plaza, Box 8064, St Louis, MO 63110, USA
Gynecol Oncol 119:18-21. 2010..The object of our study was to assess current patterns of care among members of the Society of Gynecologic Oncologists (SGO), specifically collating their opinions on and use of NACT for advanced stage ovarian cancer... - Excess of early onset multiple myeloma in endometrial cancer probands and their relatives suggests common susceptibilityIsrael Zighelboim
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, 4911 Barnes Jewish Plaza, Box 8064, St Louis, MO 63110, USA
Gynecol Oncol 105:390-4. 2007..Determine whether there is an association between uterine cancer and multiple myeloma... - Frequent mutations in the RPL22 gene and its clinical and functional implicationsAkiva P Novetsky
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, USA
Gynecol Oncol 128:470-4. 2013.... - Lithium chloride and inhibition of glycogen synthase kinase 3β as a potential therapy for serous ovarian cancerAkiva P Novetsky
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
Int J Gynecol Cancer 23:361-6. 2013..This study was designed to determine whether LiCl, as a single agent or in combination with cytotoxic agents, reduces ovarian cancer cell growth and metabolic activity at clinically achievable levels... - The utility and management of vaginal cytology after treatment for endometrial cancerAkiva P Novetsky
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Obstet Gynecol 121:129-35. 2013..To estimate the accuracy of vaginal cytology in postoperative surveillance for detecting recurrent endometrial cancer and to estimate the optimal management of squamous abnormalities detected in this setting... - Cardiac arrest during laparotomy with argon beam coagulation of metastatic ovarian cancerNora Kizer
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Comprehensive Cancer Center, St Louis, MO, USA
Int J Gynecol Cancer 19:237-8. 2009..The argon beam coagulation (ABC) is a safe and effective tool for surgical cytoreduction of metastatic ovarian carcinomas... - Inferior vena cava filter placement in the gynecologic oncology patient: A 15-year institutional experienceSummer B Dewdney
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
Gynecol Oncol 121:344-6. 2011..The aim of this study was to review our experience with gynecologic oncology patients who received an IVC filter, specifically to evaluate indications for filter placement and survival outcomes... - The role of PET/CT in the management of patients with cervical cancer: practice patterns of the members of the Society of Gynecologic OncologistsNora T Kizer
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, The Siteman Comprehensive Cancer Center, Saint Louis, MO 63110, USA
Gynecol Oncol 114:310-4. 2009..The objective of our study was to assess the acceptance of PET/CT into the management of patients with cervical cancer. We also explored potential barriers to the use of these imaging modalities in patients with cervical cancer... - A unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screeningJanet S Rader
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, MO, USA Department of Genetics, Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, MO, USA
Proteomics Clin Appl 2:1658-69. 2008..HNRPA2B1 was identified as a biomarker candidate with increased expression in cancer compared to normal cervix and validated by Western blot... - The risk of lymph node metastasis with positive peritoneal cytology in endometrial cancerGunjal Garg
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
Int J Gynecol Cancer 23:90-7. 2013..To determine the correlation between positive peritoneal cytology (PPC) and lymph node metastasis in patients with endometrial cancer grossly confined to the uterus... - Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?Yevgeniya J Ioffe
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, USA
Gynecol Oncol 124:340-6. 2012..In the present study, we sought to determine whether PTENP1 is expressed in endometrial cancer (EMCA) cell lines and primary tumors along with the microRNAs (miRNAs) that are predicted to regulate PTEN and PTENP1 transcript levels... - Retroperitoneal lymph node resection in patients with cervical cancerIsrael Zighelboim
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Washington University School of Medicine and Alvin J. Siteman Cancer Center, St. Louis, MO, USA
Surg Oncol 15:79-83. 2006..002). CONCLUSIONS: The ability to completely resect suspected metastatic lymph nodes at the time of extraperitoneal lymph node dissection in patients with cervical cancer is associated with size and location of largest lymph node... - Prognostic utility of squamous cell carcinoma antigen in carcinoma of the cervix: association with pre- and posttreatment FDG-PETJeffrey R Olsen
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 81:772-7. 2011.... - Human acellular dermal matrix for closure of a contaminated gynecologic woundCelestine S Tung
Department of Obstetrics and Gynecology, Baylor College of Medicine, 1709 Dryden Road, Suite 1141, Houston, TX 77030, USA
Gynecol Oncol 103:354-6. 2006..CONCLUSION: Use of acellular dermal matrix rather than traditional polypropylene mesh should be considered for patients with contaminated or irradiated operative fields... - Discussion: 'Perioperative morbidity model for vaginal hysterectomy' by Heisler et alIsrael Zighelboim
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA
Am J Obstet Gynecol 202:e1-3. 2010..In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research... - Acute colonic pseudoobstruction complicating twin pregnancy: a case reportCelestine S Tung
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
J Reprod Med 53:52-4. 2008..When diagnosed early, treatment with expectant management or more invasive decompression is often successful. However, if not recognized promptly or managed appropriately, this condition can be fatal... - Atypical sigmoid metastasis from a high-grade mixed adenocarcinoma of the ovaryIsrael Zighelboim
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA
Gynecol Oncol 94:850-3. 2004..Immunohistochemical staining using cytokeratins-7 and -20 may prove useful in differentiating such lesions from primary colonic malignancies...