Israel Zighelboim

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis
    Nicholas P Taylor
    Division of Gynecologic Oncology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Mod Pathol 19:1333-8. 2006
  2. pmc ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Jewish Plaza, Box 8064, St Louis, MO 63110, USA
    J Clin Oncol 27:3091-6. 2009
  3. doi request reprint "Surgical Apgar Score" predicts postoperative complications after cytoreduction for advanced ovarian cancer
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, 4911 Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    Gynecol Oncol 116:370-3. 2010
  4. pmc DICER1 expression and outcomes in endometrioid endometrial adenocarcinoma
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Cancer 117:1446-53. 2011
  5. doi request reprint Adjuvant treatment for early-stage endometrial cancer
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, Missouri 63110, USA
    Clin Obstet Gynecol 54:245-55. 2011
  6. pmc Epitope-positive truncating MLH1 mutation and loss of PMS2: implications for IHC-directed genetic testing for Lynch syndrome
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Fam Cancer 8:501-4. 2009
  7. ncbi request reprint Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Oncol 25:2042-8. 2007
  8. ncbi request reprint Differential methylation hybridization array of endometrial cancers reveals two novel cancer-specific methylation markers
    Israel Zighelboim
    Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, Missouri 63110, USA
    Clin Cancer Res 13:2882-9. 2007
  9. ncbi request reprint Outcomes in 24 selected patients with stage IVB cervical cancer and excellent performance status treated with radiotherapy and chemotherapy
    Israel Zighelboim
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, Alvin J Siteman Cancer Center, St Louis, MO, USA
    Radiat Med 24:625-30. 2006
  10. pmc Clustering of Lynch syndrome malignancies with no evidence for a role of DNA mismatch repair
    Ashley S Case
    Divison of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, 3rd Floor Maternity, St Louis, MO 63110, USA
    Gynecol Oncol 108:438-44. 2008

Detail Information

Publications40

  1. ncbi request reprint DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis
    Nicholas P Taylor
    Division of Gynecologic Oncology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Mod Pathol 19:1333-8. 2006
    ..The high rate of concordance for these molecular defects between the carcinoma and sarcoma components adds to existing molecular evidence that carcinosarcomas are clonal malignancies...
  2. pmc ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Jewish Plaza, Box 8064, St Louis, MO 63110, USA
    J Clin Oncol 27:3091-6. 2009
    ..Knowledge of ATR mutation status may hold promise for individualized treatment and targeted therapies in patients with endometrial cancer...
  3. doi request reprint "Surgical Apgar Score" predicts postoperative complications after cytoreduction for advanced ovarian cancer
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, 4911 Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    Gynecol Oncol 116:370-3. 2010
    ..We sought to estimate the ability of this metric to predict major postoperative complications in women undergoing ovarian cancer cytoreductive procedures...
  4. pmc DICER1 expression and outcomes in endometrioid endometrial adenocarcinoma
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Cancer 117:1446-53. 2011
    ..The authors also explored DNA methylation and haploinsufficiency as potential mechanisms related to altered DICER1 expression in these tumors...
  5. doi request reprint Adjuvant treatment for early-stage endometrial cancer
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, Missouri 63110, USA
    Clin Obstet Gynecol 54:245-55. 2011
    ..This review focuses on the role of adjuvant therapies for patients with early-stage disease with emphasis on future directions for risk stratification and personalized treatment...
  6. pmc Epitope-positive truncating MLH1 mutation and loss of PMS2: implications for IHC-directed genetic testing for Lynch syndrome
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Fam Cancer 8:501-4. 2009
    ....
  7. ncbi request reprint Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Oncol 25:2042-8. 2007
    ..We sought to determine whether MSI and MLH1 methylation are associated with clinicopathologic variables and survival outcomes in a large series of patients with endometrial carcinomas of the endometrioid type...
  8. ncbi request reprint Differential methylation hybridization array of endometrial cancers reveals two novel cancer-specific methylation markers
    Israel Zighelboim
    Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, Missouri 63110, USA
    Clin Cancer Res 13:2882-9. 2007
    ..To identify novel endometrial cancer-specific methylation markers and to determine their association with clinicopathologic variables and survival outcomes...
  9. ncbi request reprint Outcomes in 24 selected patients with stage IVB cervical cancer and excellent performance status treated with radiotherapy and chemotherapy
    Israel Zighelboim
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, Alvin J Siteman Cancer Center, St Louis, MO, USA
    Radiat Med 24:625-30. 2006
    ..We sought to review outcomes in patients with stage IVB carcinoma of the cervix treated with irradiation in combination with chemotherapy...
  10. pmc Clustering of Lynch syndrome malignancies with no evidence for a role of DNA mismatch repair
    Ashley S Case
    Divison of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, 3rd Floor Maternity, St Louis, MO 63110, USA
    Gynecol Oncol 108:438-44. 2008
    ....
  11. pmc Timing of referral for genetic counseling and genetic testing in patients with ovarian, fallopian tube, or primary peritoneal carcinoma
    Akiva P Novetsky
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, USA
    Int J Gynecol Cancer 23:1016-21. 2013
    ..The objective of this study was to assess patients' preferences of the timing of referral for genetic counseling and testing in relation to the diagnosis, treatment, and recurrence of ovarian, tubal, or primary peritoneal cancers...
  12. pmc Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, USA
    Gynecol Oncol 130:64-8. 2013
    ..We evaluated the activity and safety of the combination of topotecan, cisplatin and bevacizumab in patients with recurrent or persistent carcinoma of the cervix...
  13. pmc Lymphovascular space invasion is an independent risk factor for nodal disease and poor outcomes in endometrioid endometrial cancer
    Saketh R Guntupalli
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Gynecol Oncol 124:31-5. 2012
    ..We sought to determine whether LVSI alone or in combination with other histologic factors predicts lymph node (LN) metastasis in patients with endometrioid endometrial cancer...
  14. pmc The effects of body mass index on complications and survival outcomes in patients with cervical carcinoma undergoing curative chemoradiation therapy
    Nora T Kizer
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 117:948-56. 2011
    ..The effect of body mass index (BMI) on treatment outcomes for patients with locally advanced cervical carcinoma who receive definitive chemoradiation is unclear...
  15. doi request reprint Chemoradiation in locally advanced cervical carcinoma: an analysis of cisplatin dosing and other clinical prognostic factors
    Elizabeth K Nugent
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, 4th Floor Maternity, St Louis, MO 63110, USA
    Gynecol Oncol 116:438-41. 2010
    ..The aim of this study was to evaluate the effect of number of chemotherapy cycles and other clinical and pathologic factors on progression-free (PFS) and overall survival (OS) in patients with newly diagnosed cervical cancer...
  16. ncbi request reprint A phase II trial of a surgical protocol to decrease the incidence of wound complications in obese gynecologic oncology patients
    Akiva P Novetsky
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, United States Electronic address
    Gynecol Oncol 134:233-7. 2014
    ..Obese women have a high incidence of wound separation after gynecologic surgery. We explored the effect of a prospective care pathway on the incidence of wound complications...
  17. pmc The utility and management of vaginal cytology after treatment for endometrial cancer
    Akiva P Novetsky
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Obstet Gynecol 121:129-35. 2013
    ..To estimate the accuracy of vaginal cytology in postoperative surveillance for detecting recurrent endometrial cancer and to estimate the optimal management of squamous abnormalities detected in this setting...
  18. pmc The risk of lymph node metastasis with positive peritoneal cytology in endometrial cancer
    Gunjal Garg
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Int J Gynecol Cancer 23:90-7. 2013
    ..To determine the correlation between positive peritoneal cytology (PPC) and lymph node metastasis in patients with endometrial cancer grossly confined to the uterus...
  19. doi request reprint The utility of peritoneal biopsy and omentectomy in the upstaging of apparent early ovarian cancer
    Rupal Shroff
    Washington University School of Medicine, St Louis, MO, USA
    Int J Gynecol Cancer 21:1208-12. 2011
    ..Few studies have been done examining this question of whether the biopsies of grossly normal-appearing peritoneal tissue are of benefit to the surgical staging procedure...
  20. doi request reprint Wound complications after gynecologic cancer surgery
    Elizabeth K Nugent
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, Barnes Jewish Hospital and Siteman Cancer Center, St Louis, MO 63110, USA
    Gynecol Oncol 121:347-52. 2011
    ..To explore clinical correlates of wound complications in high-risk women undergoing abdominal gynecologic surgery in a tertiary referral center...
  21. pmc Lower uterine segment involvement is associated with poor outcomes in early-stage endometrioid endometrial carcinoma
    Nora T Kizer
    Department of Obstetrics and Gynecology, Washington University School of Medicine, Saint Louis, MO, USA
    Ann Surg Oncol 18:1419-24. 2011
    ..The clinicopathologic significance of lower uterine segment involvement (LUSI) in endometrial cancer patients remains unclear. Although LUSI has been reported to be a prognostic indicator, literature is limited...
  22. ncbi request reprint The value of perioperative imaging in patients with uterine sarcomas
    Elizabeth K Nugent
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, USA
    Gynecol Oncol 115:37-40. 2009
    ..To explore the yield and impact of perioperative imaging on management among patients undergoing surgical resection and treatment of uterine sarcomas...
  23. ncbi request reprint The role of neoadjuvant chemotherapy in the management of patients with advanced stage ovarian cancer: survey results from members of the Society of Gynecologic Oncologists
    Summer B Dewdney
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, 4911 Barnes Jewish Hospital Plaza, Box 8064, St Louis, MO 63110, USA
    Gynecol Oncol 119:18-21. 2010
    ..The object of our study was to assess current patterns of care among members of the Society of Gynecologic Oncologists (SGO), specifically collating their opinions on and use of NACT for advanced stage ovarian cancer...
  24. pmc Disclosing a diagnosis of cancer: considerations specific to gynecologic oncology patients
    Lindsay M Kuroki
    Division of Gynecologic Oncology and the Division of Clinical Research, Department of Obstetrics and Gynecology, and the Division of Health Behavior Research, Department of Medicine, Washington University School of Medicine, and The Alvin J Siteman Cancer Center, St Louis, Missouri Dr Zighelboim s current affiliation St Luke s Cancer Care Associates, Temple University School of Medicine, Bethlehem, Pennsylvania
    Obstet Gynecol 122:1033-9. 2013
    ..To characterize gynecologic oncology patients' perceptions of the process of disclosure of a cancer diagnosis...
  25. pmc In vitro chemoresponse to cisplatin and outcomes in cervical cancer
    Perry W Grigsby
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 130:188-91. 2013
    ..The aim of this study was to report clinical outcomes of cervical cancer patients treated with weekly cisplatin chemo-radiation therapy (chemoRT) stratified by pre-treatment cisplatin in vitro chemosensitivity...
  26. pmc Excess of early onset multiple myeloma in endometrial cancer probands and their relatives suggests common susceptibility
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, 4911 Barnes Jewish Plaza, Box 8064, St Louis, MO 63110, USA
    Gynecol Oncol 105:390-4. 2007
    ..Determine whether there is an association between uterine cancer and multiple myeloma...
  27. pmc Lithium chloride and inhibition of glycogen synthase kinase 3β as a potential therapy for serous ovarian cancer
    Akiva P Novetsky
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Int J Gynecol Cancer 23:361-6. 2013
    ..This study was designed to determine whether LiCl, as a single agent or in combination with cytotoxic agents, reduces ovarian cancer cell growth and metabolic activity at clinically achievable levels...
  28. pmc Frequent mutations in the RPL22 gene and its clinical and functional implications
    Akiva P Novetsky
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, USA
    Gynecol Oncol 128:470-4. 2013
    ....
  29. doi request reprint Inferior vena cava filter placement in the gynecologic oncology patient: A 15-year institutional experience
    Summer B Dewdney
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Gynecol Oncol 121:344-6. 2011
    ..The aim of this study was to review our experience with gynecologic oncology patients who received an IVC filter, specifically to evaluate indications for filter placement and survival outcomes...
  30. doi request reprint Cardiac arrest during laparotomy with argon beam coagulation of metastatic ovarian cancer
    Nora Kizer
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Comprehensive Cancer Center, St Louis, MO, USA
    Int J Gynecol Cancer 19:237-8. 2009
    ..The argon beam coagulation (ABC) is a safe and effective tool for surgical cytoreduction of metastatic ovarian carcinomas...
  31. pmc Novel MicroRNAs regulating proliferation and apoptosis in uterine papillary serous carcinomas
    Claire M Mach
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Lett 335:314-22. 2013
    ..These results expand our insight into the repertoire of human miRNAs and identify novel pathways by which dysregulated miRNA expression promotes uterine cancer growth...
  32. ncbi request reprint The role of PET/CT in the management of patients with cervical cancer: practice patterns of the members of the Society of Gynecologic Oncologists
    Nora T Kizer
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, The Siteman Comprehensive Cancer Center, Saint Louis, MO 63110, USA
    Gynecol Oncol 114:310-4. 2009
    ..The objective of our study was to assess the acceptance of PET/CT into the management of patients with cervical cancer. We also explored potential barriers to the use of these imaging modalities in patients with cervical cancer...
  33. pmc A unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening
    Janet S Rader
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, MO, USA Department of Genetics, Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, MO, USA
    Proteomics Clin Appl 2:1658-69. 2008
    ..HNRPA2B1 was identified as a biomarker candidate with increased expression in cancer compared to normal cervix and validated by Western blot...
  34. pmc Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?
    Yevgeniya J Ioffe
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, USA
    Gynecol Oncol 124:340-6. 2012
    ..In the present study, we sought to determine whether PTENP1 is expressed in endometrial cancer (EMCA) cell lines and primary tumors along with the microRNAs (miRNAs) that are predicted to regulate PTEN and PTENP1 transcript levels...
  35. ncbi request reprint Retroperitoneal lymph node resection in patients with cervical cancer
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, MO, USA
    Surg Oncol 15:79-83. 2006
    ..To determine predictive factors precluding complete resection of metastatic lymph nodes identified by pre-operative imaging in patients with cervical cancer...
  36. doi request reprint Prognostic utility of squamous cell carcinoma antigen in carcinoma of the cervix: association with pre- and posttreatment FDG-PET
    Jeffrey R Olsen
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 81:772-7. 2011
    ....
  37. ncbi request reprint Human acellular dermal matrix for closure of a contaminated gynecologic wound
    Celestine S Tung
    Department of Obstetrics and Gynecology, Baylor College of Medicine, 1709 Dryden Road, Suite 1141, Houston, TX 77030, USA
    Gynecol Oncol 103:354-6. 2006
    ..A novel alternative, acellular dermal matrix, easily incorporates into native tissue when used for fascial reconstruction, forming a strong repair with minimal adhesions and lower infection rates...
  38. ncbi request reprint Acute colonic pseudoobstruction complicating twin pregnancy: a case report
    Celestine S Tung
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
    J Reprod Med 53:52-4. 2008
    ..When diagnosed early, treatment with expectant management or more invasive decompression is often successful. However, if not recognized promptly or managed appropriately, this condition can be fatal...
  39. doi request reprint Discussion: 'Perioperative morbidity model for vaginal hysterectomy' by Heisler et al
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA
    Am J Obstet Gynecol 202:e1-3. 2010
    ..In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research...
  40. ncbi request reprint Atypical sigmoid metastasis from a high-grade mixed adenocarcinoma of the ovary
    Israel Zighelboim
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA
    Gynecol Oncol 94:850-3. 2004
    ..Metastasis to the bowel mucosa can occur by invasion from the serosal surface or infiltration of the submucosal capillary network. Hematogenous dissemination usually occurs in the presence of advanced peritoneal disease...