Research Topics
| Kai YuSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
Population substructure and control selection in genome-wide association studiesKai Yu
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
PLoS ONE 3:e2551. 2008..A study using suboptimal controls can have acceptable type I error when an effective strategy for the correction of PS is employed...
Genetic association mapping under founder heterogeneity via weighted haplotype similarity analysis in candidate genesK Yu
Division of Biostatistics, School of Medicine, Washington University, St Louis, Missouri 63110, USA
Genet Epidemiol 27:182-91. 2004..The method can be applied to both haplotype and genotype data. Simulation studies suggest that our method has the correct type I error rate, and is generally more powerful than existing methods of haplotype similarity analysis...- Global transmission/disequilibrium tests based on haplotype sharing in multiple candidate genesKai Yu
Division of Statistical Genomics, Department of Genetics Washington University, School of Medicine, St Louis, Missouri 63110, USA
Genet Epidemiol 29:323-35. 2005..Compared with the gene-by-gene test, the new global tests appear to be more powerful in situations where all candidate genes are associated with the disease... - Using tree-based recursive partitioning methods to group haplotypes for increased power in association studiesKai Yu
Division of Biostatistics, School of Medicine, Washington University, St Louis, MO 63110, USA
Ann Hum Genet 69:577-89. 2005..Simulation studies suggest that the proposed method has the right type I error rate, and is more powerful than some existing haplotype-based tests... - A haplotype similarity based transmission/disequilibrium test under founder heterogeneityKai Yu
Division of Biostatistics, School of Medicine, Washington University, 660 S Euclid, Campus Box 8067, St Louis, MO 63110, USA
Ann Hum Genet 69:455-67. 2005..Finally, we apply the proposed method to study the association of the leptin gene with obesity from the National Heart, Lung, and Blood Institute Family Heart Study... - Classifying disease chromosomes arising from multiple founders, with application to fine-scale haplotype mappingK Yu
Division of Biostatistics, School of Medicine, Washington University, St Louis, Missouri 63110, USA
Genet Epidemiol 27:173-81. 2004..We also show that the method allows more precise estimates of the disease mutation loci than obtained by other fine-scale mapping methods... - Measuring marker information content by the ambiguity of block boundaries observed in dense SNP dataC Charles Gu
Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
Ann Hum Genet 71:127-40. 2007..This approach can quantify the information content of individual markers in the context of highly dense SNP data, which may have important implications in designing efficient genome-wide association mapping projects... - A parametric comparison of diagnostic accuracy with three ordinal diagnostic groupsChengjie Xiong
Division of Biostatistics, Washington University in St Louis, St Louis, MO 63110, USA
Biom J 49:682-93. 2007..Finally, we apply our proposed methodology to a real data set of 118 subjects to compare the diagnostic accuracy of early stage Alzheimer's disease (AD) from multiple neuropsychological tests... 
Characterization of LD structures and the utility of HapMap in genetic association studiesC Charles Gu
Division of Biostatistics and Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
Adv Genet 60:407-35. 2008....- Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart StudyDuanduan Ma
Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO 63108, USA
Hypertension 53:473-9. 2009..It also provides insight into the gender differences in hypertension, as well as the differential distribution and activity of leptin in men and women... - Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivoKory J Lavine
Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
Dev Cell 8:85-95. 2005..FGFs thus constitute all or part of the epicardial signal regulating myocardial growth and differentiation... - Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiationClaudia M Garcia
Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri 63110, USA
Dev Dyn 233:516-27. 2005..It also contributes to the normal elongation of primary lens fiber cells and to the survival of lens epithelial cells... - Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growthKai Yu
Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
Development 130:3063-74. 2003..Although differentiation of the osteoblast lineage was not disturbed, the proliferation of osteoprogenitors and the anabolic function of mature osteoblasts were severely affected... - Histomorphological study of palatal shelf elevation during murine secondary palate formationKai Yu
Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA
Dev Dyn 240:1737-44. 2011..Our study provides a framework that recognizes variation in timing of palatal morphogenesis along the AP axis that will aid in the investigation of the mechanisms regulating palatal shelf elevation... - FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopodIrene H Hung
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
Dev Biol 307:300-13. 2007..In developing stylopod elements, FGF9 promotes chondrocyte hypertrophy at early stages and regulates vascularization of the growth plate and osteogenesis at later stages of skeletal development... - Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palateAlison K Snyder-Warwick
Division of Plastic Surgery, Departments of Developmental Biology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:2515-20. 2010..Knowledge of how mesenchymal FGF signaling regulates palatal shelf development may ultimately lead to pharmacological approaches to reduce cleft palate incidence in genetically predisposed humans... - Power and sample size for clinical trials when efficacy is required in multiple endpoints: application to an Alzheimer's treatment trialChengjie Xiong
Division of Biostatistics, Washington University in St Louis, MO 63110, USA
Clin Trials 2:387-93. 2005..When the efficacy of a treatment in a randomized controlled trial is required for multiple primary endpoints, trial design and analysis differ from trial requiring efficacy in only one of the multiple endpoints... - Sequential roles of Hedgehog and Wnt signaling in osteoblast developmentHongliang Hu
Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
Development 132:49-60. 2005..Finally Wnt7b is identified as a potential endogenous ligand regulating osteogenesis. These data support a model that integrates Hh and Wnt signaling in the regulation of osteoblast development... - FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axisKai Yu
Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110 USA
Development 135:483-91. 2008.... - Improved correction for population stratification in genome-wide association studies by identifying hidden population structuresQizhai Li
Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland
Genet Epidemiol 32:215-26. 2008..We show through simulation studies that, compared with the EIGENSTRAT method, the new method requires a smaller number of markers and yields a more appropriate correction for population stratification... - Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studiesKim N Danforth
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Carcinogenesis 29:568-72. 2008.... - Multiple loci identified in a genome-wide association study of prostate cancerGilles Thomas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Nat Genet 40:310-5. 2008..Our findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals... - Efficient approximation of P-value of the maximum of correlated tests, with applications to genome-wide association studiesQizhai Li
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Ann Hum Genet 72:397-406. 2008..We use simulation studies as well as real datasets on 17 confirmed disease-associated SNPs to assess the accuracy of the proposed method. We also apply the method to the GWAS of coronary artery disease... - TNF polymorphisms and prostate cancer riskKim N Danforth
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
Prostate 68:400-7. 2008..Inflammation has been hypothesized to increase prostate cancer risk. Tumor necrosis factor (TNF) is an important mediator of the inflammatory process, but the relationship between TNF variants and prostate cancer remains unclear... - Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiationHaotian Zhao
Graduate Program in Molecular, Cellular and Developmental Biology, College of Biological Sciences, The Ohio State University, Columbus, OH 43210, USA
Dev Biol 318:276-88. 2008..Therefore, while signaling by FGF receptors is essential for lens fiber differentiation, different FGF receptors function redundantly... - MAX-rank: a simple and robust genome-wide scan for case-control association studiesQizhai Li
Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892, USA
Hum Genet 123:617-23. 2008..Thus, we recommend to use MAX-rank for genome-wide scans. After the top-ranked SNPs are identified, their P-values based on MAX can be calculated and compared with the significance level... - Characterization of the major histocompatibility complex class II DQB (MhcMamu-DQB1) alleles in a cohort of Chinese rhesus macaques (Macaca mulatta)Chen Li Qiu
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS STD Control and Prevention, Beijing 100050, People s Republic of China
Hum Immunol 69:513-21. 2008.... - Flexible design for following up positive findingsKai Yu
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Am J Hum Genet 81:540-51. 2007..We also find that, in the context of flexible design, the joint analysis is generally more powerful than the replication analysis... - Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrainJonna Saarimäki Vire
Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 27:8581-92. 2007..We propose a model for regulation of progenitor cell self-renewal and neuronal differentiation by combinatorial intercellular signals in the ventral midbrain... - A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancerDavid J Hunter
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 39:870-4. 2007..Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci... - Genome-wide association study of prostate cancer identifies a second risk locus at 8q24Meredith Yeager
SAIC Frederick, National Cancer Institute NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
Nat Genet 39:645-9. 2007..We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%)... - A partially linear tree-based regression model for assessing complex joint gene-gene and gene-environment effectsJinbo Chen
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Genet Epidemiol 31:238-51. 2007..The proposed model is also useful for exploring gene-environment interactions and has broad implications for applying the tree methodology to genetic epidemiology research... - Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasisYongshun Lin
Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology, Texas A and M Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030 3303, USA
Development 134:723-34. 2007.... - Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouseYingli Wang
Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
Development 132:3537-48. 2005..Our results suggest that altered cartilage and bone development play a significant role in the pathogenesis of the Apert syndrome phenotype... - Methods for analyzing the spatial distribution of chiasmata during meiosis based on recombination dataKai Yu
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
Biometrics 58:369-77. 2002..We apply our improved methods to reanalyze a dataset from the literature studying the association between crossover location and meiotic nondisjunction of chromosome 21... - FGF signalling generates ventral telencephalic cells independently of SHHGrigoriy Gutin
Departments of Neuroscience and Molecular Genetics, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
Development 133:2937-46. 2006..Moreover, the Fgfr1;Fgfr2 phenotype, unlike the Shh phenotype, is not rescued by loss of Gli3, further indicating that FGFs act downstream of Shh and Gli3 to generate ventral telencephalic cell types... - A twist code determines the onset of osteoblast differentiationPeter Bialek
Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Dev Cell 6:423-35. 2004..In vivo mutagenesis confirms the antiosteogenic function of the Twist box. Thus, relief of inhibition by Twist proteins is a mandatory event precluding osteoblast differentiation... - Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activityDrazen Sosic
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
Cell 112:169-80. 2003..These findings reveal an evolutionarily conserved signaling circuit in which twist proteins regulate cytokine signaling by establishing a negative feedback loop that represses the NF-kappaB-dependent cytokine pathway... - Association between maternal age and meiotic recombination for trisomy 21Neil E Lamb
Department of Human Genetics, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
Am J Hum Genet 76:91-9. 2005..It is this risk, due to recombination-independent factors, that would be most influenced by increasing age, leading to the observed maternal age effect... - Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongationKenneth E White
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
Am J Hum Genet 76:361-7. 2005.... - Assessing performance of prediction rules in machine learningRory Martin
Millennium Pharmaceuticals, Cambridge MA 02139, USA
Pharmacogenomics 7:543-50. 2006..This study illustrates and compares different methods for estimating true error with the aim of providing practical guidance to users of machine learning techniques... - Circulating angiogenic factors and placental abruptionCaroline Signore
Epidemiology Branch and the Biometry and Mathematical Statistics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Obstet Gynecol 108:338-44. 2006..3, P=.001). CONCLUSION: Serum levels of the proangiogenic factor PlGF were decreased, and those of the antiangiogenic ratio sFlt-1/PlGF were increased in nulliparous women who subsequently developed hypertension and placental abruption... - Toxicogenomics strategies for predicting drug toxicityRory Martin
Millennium Pharmaceuticals, Cambridge, MA 02139, USA
Pharmacogenomics 7:1003-16. 2006.... - Karyotyping of comparative genomic hybridization human metaphases using kernel nearest-neighbor algorithmKai Yu
State Key Laboratory of Intelligent Technology and Systems, Department of Automation, Tsinghua University, Beijing, People's Republic of China
Cytometry 48:202-8. 2002..CONCLUSIONS: The feature extraction method proposed here and K-NN classifiers offer a promising computerized intelligent system for automatic karyotyping of CGH human chromosomes...