Ming You

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Large-scale in silico mapping of complex quantitative traits in inbred mice
    Pengyuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 2:e651. 2007
  2. pmc 26S proteasome activity is down-regulated in lung cancer stem-like cells propagated in vitro
    Jing Pan
    Department of Surgery, Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e13298. 2010
  3. pmc Common human cancer genes discovered by integrated gene-expression analysis
    Yan Lu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 2:e1149. 2007
  4. pmc Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene
    Ming You
    Washington University, St Louis, Missouri 63110, USA
    Clin Cancer Res 15:2666-74. 2009
  5. pmc A second genetic variant on chromosome 15q24-25.1 associates with lung cancer
    Pengyuan Liu
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:3128-35. 2010
  6. doi request reprint Enhanced susceptibility to chemical induction of ovarian tumors in mice with a germ line p53 mutation
    Yian Wang
    Department of Surgery, The Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cancer Res 6:99-109. 2008
  7. pmc Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1
    Yan Liu
    Washington University, St Louis, Missouri, USA
    Cancer Res 69:7844-50. 2009
  8. doi request reprint Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice
    Huijing Fu
    Department of Energy, Environmental and Chemical Engineering, Washington University in St Louis, St Louis, Missouri 63110, USA
    Mol Carcinog 50:913-21. 2011
  9. pmc EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
    Haris Vikis
    Washington University, St Louis, Missouri, USA
    Cancer Res 67:4665-70. 2007
  10. ncbi request reprint Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice
    Pengyuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 38:888-95. 2006

Collaborators

Detail Information

Publications69

  1. pmc Large-scale in silico mapping of complex quantitative traits in inbred mice
    Pengyuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 2:e651. 2007
    ..These high-resolution QTL data can serve as a primary resource for positional cloning and gene identification in the research community...
  2. pmc 26S proteasome activity is down-regulated in lung cancer stem-like cells propagated in vitro
    Jing Pan
    Department of Surgery, Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e13298. 2010
    ....
  3. pmc Common human cancer genes discovered by integrated gene-expression analysis
    Yan Lu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 2:e1149. 2007
    ..Discovery of genes commonly regulated in cancer may have an important implication in understanding the common molecular mechanism of cancer...
  4. pmc Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene
    Ming You
    Washington University, St Louis, Missouri 63110, USA
    Clin Cancer Res 15:2666-74. 2009
    ..In this study, we further refined this locus to identify a single candidate gene, by fine mapping using microsatellite markers and association studies using high-density single nucleotide polymorphisms (SNP)...
  5. pmc A second genetic variant on chromosome 15q24-25.1 associates with lung cancer
    Pengyuan Liu
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:3128-35. 2010
    ..42 x 10(-11); OR, 1.60; 95% CI, 1.46-1.74; rs481134: P = 7.01 x 10(-4); OR, 0.81; 95% CI, 0.72-0.92). The second variant on 15q24-25.1, marked by rs481134, explains an additional 13.2% of population attributable risk for lung cancer...
  6. doi request reprint Enhanced susceptibility to chemical induction of ovarian tumors in mice with a germ line p53 mutation
    Yian Wang
    Department of Surgery, The Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cancer Res 6:99-109. 2008
    ..These findings indicate that a germ line p53 mutation significantly enhanced DMBA-induced ovarian tumor development and progression...
  7. pmc Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1
    Yan Liu
    Washington University, St Louis, Missouri, USA
    Cancer Res 69:7844-50. 2009
    ..We concluded that PSMA4 is a strong candidate mediator of lung cancer cell growth, and may directly affect lung cancer susceptibility through its modulation of cell proliferation and apoptosis...
  8. doi request reprint Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice
    Huijing Fu
    Department of Energy, Environmental and Chemical Engineering, Washington University in St Louis, St Louis, Missouri 63110, USA
    Mol Carcinog 50:913-21. 2011
    ..Our results provide evidence that aerosolized budesonide and oral pioglitazone could be a promising drug combination for lung cancer chemoprevention...
  9. pmc EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
    Haris Vikis
    Washington University, St Louis, Missouri, USA
    Cancer Res 67:4665-70. 2007
    ..Our observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer...
  10. ncbi request reprint Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice
    Pengyuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 38:888-95. 2006
    ..Our findings demonstrate the prospects for using dense SNP maps in laboratory mice to refine previous QTL regions and identify genetic determinants of complex traits...
  11. pmc Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:12642-7. 2003
    ..Clearly, Kras2 affects lung tumor progression only, and Las1 is likely to affect lung tumor multiplicity...
  12. ncbi request reprint Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus
    Peng Yuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:6290-8. 2009
    ..Deletion of LAS2 was observed in approximately 40% of human lung adenocarcinomas, implying that loss of function of LAS2 may be a key step for lung tumorigenesis...
  13. pmc Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer
    Pengyuan Liu
    Washington University, St Louis, MO 63110, USA
    J Natl Cancer Inst 100:1326-30. 2008
    ..67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted...
  14. ncbi request reprint Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer
    Ying Yan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cancer Res 4:971-81. 2006
    ..Thus, gefitinib showed highly promising chemopreventive and chemotherapeutic activity in this mouse model of lung carcinogenesis...
  15. ncbi request reprint p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer
    Zhongqiu Zhang
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Res 4:401-10. 2006
    ....
  16. ncbi request reprint Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression
    Yan Liu
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 67:10207-13. 2007
    ..The differential degradation of Las1-A/J and Las-B6 has important implications for its intracellular function and may eventually explain Las1-A/J in lung tumorigenesis...
  17. doi request reprint Modulation of gene expression and cell-cycle signaling pathways by the EGFR inhibitor gefitinib (Iressa) in rat urinary bladder cancer
    Yan Lu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri, USA
    Cancer Prev Res (Phila) 5:248-59. 2012
    ..The identified hub genes may also serve as pharmacodynamic or efficacy biomarkers in clinical trials of chemoprevention in human bladder cancer...
  18. ncbi request reprint Enhanced lung tumor development in tobacco smoke-exposed p53 transgenic and Kras2 heterozygous deficient mice
    Ying Yan
    Department of Surgery, Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Inhal Toxicol 19:183-7. 2007
    ..These results indicate that a p53 mutation or loss of a Kras2 allele increases susceptibility to MS-induced lung tumor development...
  19. doi request reprint Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center and Division of Comparative Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 2:1059-64. 2009
    ..Our results indicate that the retinoid X receptor agonist bexarotene may be a potent chemopreventive agent in this cancer type...
  20. doi request reprint Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Ther 9:3074-82. 2010
    ..05) decrease in lung SCC. Induction of apoptosis occurred in both model systems. These data show that pioglitazone significantly inhibited progression of both adenocarcinoma and SCC in the two mouse model systems...
  21. ncbi request reprint Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance
    Min Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 67:2508-16. 2007
    ..Our findings have narrowed the Par1 QTL region and will greatly facilitate the identification of the major genetic determinant of mouse lung adenoma resistance...
  22. ncbi request reprint Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 Euclid Avenue, Box 8109, St Louis, Missouri 63110, USA
    Mol Cancer Res 3:563-74. 2005
    ..The present study provides the first in vivo evidence that a germ line p53 mutation and activated H-ras act synergistically to profoundly enhance tumor progression...
  23. ncbi request reprint A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice
    Yan Lu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 66:1956-63. 2006
    ..These experiments identified patterns of gene expressions that both offer clues for green tea's potential mechanisms of action and provide a molecular signature specific for green tea exposure...
  24. pmc Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice
    Ying Yan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neoplasia 8:52-8. 2006
    ..The results of these investigations demonstrate that polyphenon E, red ginseng, and rapamycin significantly inhibit pulmonary adenoma formation and growth in A/J mice...
  25. pmc Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamine
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, St Louis, MO 63110, USA
    Neoplasia 6:569-77. 2004
    ....
  26. doi request reprint Aerosolized bexarotene inhibits lung tumorigenesis without increasing plasma triglyceride and cholesterol levels in mice
    Qi Zhang
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 4:270-6. 2011
    ..These results indicate that aerosolization may be a safe and effective route of administering bexarotene for chemoprevention of lung cancer...
  27. pmc Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 2:634-40. 2009
    ..We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs...
  28. ncbi request reprint Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Oncogene 23:3841-50. 2004
    ..Furthermore, ATB exhibited an enhanced inhibitory effect in animals harboring genetic alterations (Kras2, p53, and Ink4a/Arf), which are often seen in human lung adenocarcinomas...
  29. doi request reprint Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imaging
    Joel R Garbow
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 14:1363-7. 2008
    ..The goal of this work was to monitor quantitatively the development and progression of adenocarcinoma in a time course study of mice treated with the carcinogen urethane using in vivo small-animal magnetic resonance imaging (MRI)...
  30. doi request reprint Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice
    Qi Zhang
    Department of Surgery and Alvin J Siteman Cancer Center, Washington University in St Louis, 660 South Euclid Avenue, Campus Box 8109, St Louis, Missouri 63110, USA
    Pharm Res 27:1066-71. 2010
    ..To compare the chemopreventive efficacy of Polyphenon E (Poly E), (-)-epigallocatechin-3-gallate (EGCG) and Polyphenon E without EGCG (Poly E-EGCG) on the development of benzo(a)pyrene (B(a)P)-induced lung tumors in A/J mice...
  31. pmc Gene expression profiling of chemically induced rat bladder tumors
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Neoplasia 9:207-21. 2007
    ..These results suggest that multiple pathways are involved in rat bladder tumorigenesis, and a common molecular mechanism was found in both rat and mouse bladder tumors...
  32. doi request reprint Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis
    Yian Wang
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Carcinog 52:49-56. 2013
    ..There was no significant body weight loss and there was no other obvious sign of toxicity in Antitumor B-treated mice. These results suggest that Antitumor B is a promising agent for human oral cancer chemoprevention...
  33. ncbi request reprint Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Oncogene 22:6257-65. 2003
    ..In fact, L-778,123 is more effective in inhibiting primary lung progression in mice with a p53 mutation and/or an Ink4a/Arf deletion than in wild-type animals...
  34. ncbi request reprint Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia
    Min Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Res 64:1924-31. 2004
    ..Thus, our data support the Pol iota gene as a modifier of lung tumorigenesis by altering DNA polymerase activity...
  35. ncbi request reprint Analysis of the Par2 modifier of pulmonary adenoma formation in mice
    Min Wang
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Exp Lung Res 31:193-204. 2005
    ..The authors recently conducted studies to positionally clone the Par2 gene. This review summarizes the effort and progress towards the identification of Par2 candidates...
  36. ncbi request reprint Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus
    Min Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St Louis, MO 63110, USA
    Oncogene 24:1958-63. 2005
    ..These results support that Pas1c1 as a candidate for the Pas1 locus and the strain-specific isoforms may have differential effects on cell proliferation...
  37. ncbi request reprint Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Carcinogenesis 27:1420-31. 2006
    ..Elucidation of gene expression changes in FTI-treated or control rat mammary adenocarcinomas will help in identifying potential pharmacodynamic markers of FTI treatment as well as potential molecular targets of R115777 and other FTIs...
  38. pmc Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer
    Pengyuan Liu
    Washington University, St Louis, MO 63110, USA
    Cancer Epidemiol Biomarkers Prev 19:517-24. 2010
    ..1, we further determined the cumulative association of these four genetic regions and the population attributable risk percent of familial lung cancer they account for...
  39. pmc A gene expression signature predicts survival of patients with stage I non-small cell lung cancer
    Yan Lu
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Med 3:e467. 2006
    ..As a consequence, it is not possible to select those high-risk patients for more aggressive therapies and assign less aggressive treatments to patients at low risk for recurrence...
  40. ncbi request reprint Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South, Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Ther 5:1060-72. 2006
    ..These expression signatures could provide useful pharmacodynamic biomarkers for retinoid treatment and chemoprevention...
  41. ncbi request reprint Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice
    Haris G Vikis
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:4859-67. 2010
    ..One possible mechanism of resistance to pulmonary metastasis in BTBRT+tf/J mice may require T-cell function. Our experiments present a new mouse model for further characterization of the genetics and mechanisms of pulmonary metastasis...
  42. pmc Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesis
    Haris G Vikis
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Carcinog 51:993-1002. 2012
    ..These data demonstrate that neutrophils are essential to promote tumor growth in the MCA/BHT two-step lung carcinogenesis model...
  43. ncbi request reprint K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
    Exp Lung Res 31:271-81. 2005
    ..These results suggest that tobacco smoke enhances lung tumorigenesis primarily through promoting spontaneously occurring K-ras mutations...
  44. ncbi request reprint Identification of genetic polymorphisms through comparative DNA sequence analysis on the K-ras gene: implications for lung tumor susceptibility
    Min Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Exp Lung Res 31:165-77. 2005
    ....
  45. pmc A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice
    Jay W Tichelaar
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 3:1148-56. 2010
    ..Our results support the concept that AP-1 is a key regulator of mouse lung tumorigenesis, and identify AP-1-dependent transcription as a potential target to prevent lung tumor progression...
  46. pmc Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1
    Min Wang
    School of Medicine, Washington University, 660 Euclid Avenue, St Louis, MO, USA
    Cancer Res 67:93-9. 2007
    ..Our results suggest that p34 may be a novel tumor suppressor gene involved in sporadic lung cancer but it seems not to be the candidate familial lung cancer susceptibility gene linked to chromosomal region 6q23-25...
  47. ncbi request reprint A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility
    Yian Wang
    Department of Surgery and the Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 64:1647-54. 2004
    ..Furthermore, this model can be used in determining genetic modifiers that contribute to susceptibility or resistance to lung SCC development...
  48. pmc Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1
    Kooresh I Shoghi
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri, United States of America Department of Biomedical Engineering, Washington University School of Medicine, St Louis, Missouri, United States of America Division of Biology and Biomedical Sciences, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e74188. 2013
    ..Our data suggest that PET studies of [(18)F]ISO-1 provide a measure of both the proliferative status and tumor growth rate, which would be valuable in designing an appropriate treatment strategy. ..
  49. doi request reprint Transcriptomic analysis by RNA-seq reveals AP-1 pathway as key regulator that green tea may rely on to inhibit lung tumorigenesis
    Jing Pan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri Medical College of Wisconsin Cancer Center, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin
    Mol Carcinog 53:19-29. 2014
    ..Polyphenon E lost its chempreventive function both in vitro and in vivo when AP-1 was inhibited, indicating that AP-1 inhibition is a major pathway through which green tea exhibits chemopreventive effects...
  50. doi request reprint Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity
    Qi Zhang
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Prev Res (Phila) 5:717-25. 2012
    ..The ability of 3-bromopyruvate to inhibit mouse lung tumorigenesis, in part through induction of apoptosis, merits further investigation of this compound as a chemopreventive agent for human lung cancer...
  51. pmc RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway
    Michael A James
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:2108-16. 2009
    ..The prevalence of the induction of RGS17 in tumor tissues of various types further implicates its importance in the maintenance of tumor growth...
  52. ncbi request reprint Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Oncogene 23:7746-52. 2004
    ..Our results indicate that the chemopreventive effects of budesonide in the mouse lung tumorigenesis assay involved increase and decrease expression of a wide variety of genes in multiple signaling pathways...
  53. pmc Strain-specific variation in murine natural killer gene complex contributes to differences in immunosurveillance for urethane-induced lung cancer
    Daniel Kreisel
    Departments of Surgery, Pathology and Immunology, and Internal Medicine, The Alvin Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 72:4311-7. 2012
    ....
  54. doi request reprint Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis
    Qi Zhang
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Carcinog 52:686-91. 2013
    ..Our data show that betanin significantly inhibits lung tumorigenesis in A/J mice and merits investigation as a chemopreventive agent for human lung cancer...
  55. pmc Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice
    Ying Yan
    Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neoplasia 7:1053-7. 2005
    ..Thus, deguelin appears to be a promising new preventive agent for lung cancer and may be considered for further studies in other animal models and in clinical trials...
  56. ncbi request reprint Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf
    Yian Wang
    Department of Surgery, School of Medicine, Siteman Cancer Center, The Washington University in St Louis, 660 S Euclid Avenue, St Louis, MO, USA
    Oncogene 24:3042-9. 2005
    ....
  57. doi request reprint Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis
    Michael A James
    Department of Surgery, Campus Box 8109, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
    Mol Carcinog 50:1-7. 2011
    ....
  58. ncbi request reprint Five loci, SLT1 to SLT5, controlling the susceptibility to spontaneously occurring lung cancer in mice
    Daolong Wang
    Department of Surgery and the Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 65:8158-65. 2005
    ..Our results provide, for the first time, an insight into the genetic control of spontaneously occurring lung tumorigenesis...
  59. pmc RASSF1A promoter methylation and Kras2 mutations in non small cell lung cancer
    Jie Li
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Neoplasia 5:362-6. 2003
    ..Our results indicate a trend of inverse relationship between Kras2 activation and RASSF1A promoter methylation in the majority of human lung adenocarcinomas and large cell carcinomas...
  60. pmc Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice
    Ying Yan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neoplasia 9:401-5. 2007
    ..These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer...
  61. ncbi request reprint Characterization of rat ovarian adenocarcinomas developed in response to direct instillation of 7,12-dimethylbenz[a]anthracene (DMBA) coated suture
    Keith A Crist
    Department of Surgery, Medical College of Ohio, Toledo, OH 43614, USA
    Carcinogenesis 26:951-7. 2005
    ..Thus, the DMBA suture model in rats yields epithelial derived tumors histologically similar to humans and should prove suitable for the testing of preventive or therapeutic agents...
  62. doi request reprint Animal models of lung cancer characterization and use for chemoprevention research
    Yian Wang
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Prog Mol Biol Transl Sci 105:211-26. 2012
    ....
  63. pmc Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5
    Jen C Wang
    Department of Psychiatry, Washington University, 660 South Euclid, PO BOX 8134, St Louis, MO 63110, USA
    Hum Mol Genet 18:3125-35. 2009
    ....
  64. ncbi request reprint Detection of primary lung tumors in rodents by magnetic resonance imaging
    Joel R Garbow
    Department of Chemistry, Washington University, St Louis, Missouri, USA
    Cancer Res 64:2740-2. 2004
    ....
  65. doi request reprint Mouse models of lung squamous cell carcinomas
    Michael S You
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Metastasis Rev 32:77-82. 2013
    ..Here, we review the application of mouse lung squamous cell carcinoma models with different stages of squamous lesions and squamous cell carcinomas to cancer development and chemoprevention studies...
  66. pmc Genomic landscape of non-small cell lung cancer in smokers and never-smokers
    Ramaswamy Govindan
    Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 150:1121-34. 2012
    ..Cell-cycle and JAK-STAT pathways are significantly altered in lung cancer, along with perturbations in 54 genes that are potentially targetable with currently available drugs...
  67. ncbi request reprint Chemoprevention of lung cancer by tea
    Julie Clark
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Nutr Food Res 50:144-51. 2006
    ..Future studies are needed to determine how green tea affects the genes associated with cell cycle regulation and apoptosis during the mouse lung carcinogenesis process...
  68. ncbi request reprint Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice
    Yian Wang
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Res 63:4389-95. 2003
    ..Thus, the mutant A/J mouse model should prove useful for chemoprevention studies...
  69. pmc A high performance test of differential gene expression for oligonucleotide arrays
    William J Lemon
    Department of Surgery, 4940 Parkview Place, 10130 Wohl Clinics, Washington University in St Louis, St Louis, MI 63110, USA
    Genome Biol 4:R67. 2003
    ..01 threshold. Logit-t provided 70% sensitivity, Microarray Suite 5 provided 46%, dChip provided 53% and Robust Multi-array Analysis provided 63%...