Research Topics
Genomes and Genes
| Ming YouSummaryAffiliation: Washington University School of Medicine Country: USA Publications
| Collaborators
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Detail Information
Publications
Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate geneMing You
Washington University, St Louis, Missouri 63110, USA
Clin Cancer Res 15:2666-74. 2009..In this study, we further refined this locus to identify a single candidate gene, by fine mapping using microsatellite markers and association studies using high-density single nucleotide polymorphisms (SNP)...- Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1Yan Liu
Washington University, St Louis, Missouri, USA
Cancer Res 69:7844-50. 2009..We concluded that PSMA4 is a strong candidate mediator of lung cancer cell growth, and may directly affect lung cancer susceptibility through its modulation of cell proliferation and apoptosis... 
Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J miceHuijing Fu
Department of Energy, Environmental and Chemical Engineering, Washington University in St Louis, St Louis, Missouri 63110, USA
Mol Carcinog 50:913-21. 2011..Our results provide evidence that aerosolized budesonide and oral pioglitazone could be a promising drug combination for lung cancer chemoprevention...- A second genetic variant on chromosome 15q24-25.1 associates with lung cancerPengyuan Liu
Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer Res 70:3128-35. 2010..42 x 10(-11); OR, 1.60; 95% CI, 1.46-1.74; rs481134: P = 7.01 x 10(-4); OR, 0.81; 95% CI, 0.72-0.92). The second variant on 15q24-25.1, marked by rs481134, explains an additional 13.2% of population attributable risk for lung cancer... 
Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred micePengyuan Liu
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nat Genet 38:888-95. 2006..Our findings demonstrate the prospects for using dense SNP maps in laboratory mice to refine previous QTL regions and identify genetic determinants of complex traits...- Enhanced susceptibility to chemical induction of ovarian tumors in mice with a germ line p53 mutationYian Wang
Department of Surgery, The Washington University School of Medicine, St Louis, MO 63110, USA
Mol Cancer Res 6:99-109. 2008..These findings indicate that a germ line p53 mutation significantly enhanced DMBA-induced ovarian tumor development and progression... - EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activityHaris Vikis
Washington University, St Louis, Missouri, USA
Cancer Res 67:4665-70. 2007..Our observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer... - p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancerZhongqiu Zhang
Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Mol Cancer Res 4:401-10. 2006.... - Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locusPeng Yuan Liu
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer Res 69:6290-8. 2009..Deletion of LAS2 was observed in approximately 40% of human lung adenocarcinomas, implying that loss of function of LAS2 may be a key step for lung tumorigenesis... - Familial aggregation of common sequence variants on 15q24-25.1 in lung cancerPengyuan Liu
Washington University, St Louis, MO 63110, USA
J Natl Cancer Inst 100:1326-30. 2008..67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted... - Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistanceMin Wang
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer Res 67:2508-16. 2007..Our findings have narrowed the Par1 QTL region and will greatly facilitate the identification of the major genetic determinant of mouse lung adenoma resistance... - A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in miceYan Lu
Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Cancer Res 66:1956-63. 2006..These experiments identified patterns of gene expressions that both offer clues for green tea's potential mechanisms of action and provide a molecular signature specific for green tea exposure... - Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in miceZhongqiu Zhang
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 100:12642-7. 2003..Clearly, Kras2 affects lung tumor progression only, and Las1 is likely to affect lung tumor multiplicity... - Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53Zhongqiu Zhang
Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, 660 Euclid Avenue, Box 8109, St. Louis, Missouri 63110, USA
Mol Cancer Res 3:563-74. 2005..The present study provides the first in vivo evidence that a germ line p53 mutation and activated H-ras act synergistically to profoundly enhance tumor progression... - Enhanced lung tumor development in tobacco smoke-exposed p53 transgenic and Kras2 heterozygous deficient miceYing Yan
Department of Surgery, Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
Inhal Toxicol 19:183-7. 2007..These results indicate that a p53 mutation or loss of a Kras2 allele increases susceptibility to MS-induced lung tumor development... - Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbsYian Wang
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
Cancer Prev Res (Phila) 2:634-40. 2009..We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs... - Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor modelsZhongqiu Zhang
Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Oncogene 23:3841-50. 2004..Furthermore, ATB exhibited an enhanced inhibitory effect in animals harboring genetic alterations (Kras2, p53, and Ink4a/Arf), which are often seen in human lung adenocarcinomas... - Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in miceYian Wang
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
Mol Cancer Ther 9:3074-82. 2010..05) decrease in lung SCC. Induction of apoptosis occurred in both model systems. These data show that pioglitazone significantly inhibited progression of both adenocarcinoma and SCC in the two mouse model systems... - Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progressionYan Liu
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Cancer Res 67:10207-13. 2007..The differential degradation of Las1-A/J and Las-B6 has important implications for its intracellular function and may eventually explain Las1-A/J in lung tumorigenesis... - Aerosolized bexarotene inhibits lung tumorigenesis without increasing plasma triglyceride and cholesterol levels in miceQi Zhang
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Cancer Prev Res (Phila) 4:270-6. 2011..These results indicate that aerosolization may be a safe and effective route of administering bexarotene for chemoprevention of lung cancer... - Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancerYian Wang
Department of Surgery and The Alvin J Siteman Cancer Center and Division of Comparative Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Cancer Prev Res (Phila) 2:1059-64. 2009..Our results indicate that the retinoid X receptor agonist bexarotene may be a potent chemopreventive agent in this cancer type... - Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locusMin Wang
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St Louis, MO 63110, USA
Oncogene 24:1958-63. 2005..These results support that Pas1c1 as a candidate for the Pas1 locus and the strain-specific isoforms may have differential effects on cell proliferation... - Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/ArfZhongqiu Zhang
Department of Surgery and The Alvin J. Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Oncogene 22:6257-65. 2003..In fact, L-778,123 is more effective in inhibiting primary lung progression in mice with a p53 mutation and/or an Ink4a/Arf deletion than in wild-type animals... - Analysis of the Par2 modifier of pulmonary adenoma formation in miceMin Wang
Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
Exp Lung Res 31:193-204. 2005..The authors recently conducted studies to positionally clone the Par2 gene. This review summarizes the effort and progress towards the identification of Par2 candidates... - Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasiaMin Wang
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Cancer Res 64:1924-31. 2004..Thus, our data support the Pol iota gene as a modifier of lung tumorigenesis by altering DNA polymerase activity... - Cumulative effect of multiple loci on genetic susceptibility to familial lung cancerPengyuan Liu
Washington University, St Louis, MO 63110, USA
Cancer Epidemiol Biomarkers Prev 19:517-24. 2010..1, we further determined the cumulative association of these four genetic regions and the population attributable risk percent of familial lung cancer they account for... - Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targetsRuisheng Yao
Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
Carcinogenesis 27:1420-31. 2006..Elucidation of gene expression changes in FTI-treated or control rat mammary adenocarcinomas will help in identifying potential pharmacodynamic markers of FTI treatment as well as potential molecular targets of R115777 and other FTIs... - Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesisHaris G Vikis
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Mol Carcinog 51:993-1002. 2012..These data demonstrate that neutrophils are essential to promote tumor growth in the MCA/BHT two-step lung carcinogenesis model... - A dominant-negative c-jun mutant inhibits lung carcinogenesis in miceJay W Tichelaar
Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Cancer Prev Res (Phila) 3:1148-56. 2010..Our results support the concept that AP-1 is a key regulator of mouse lung tumorigenesis, and identify AP-1-dependent transcription as a potential target to prevent lung tumor progression... - Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imagingJoel R Garbow
Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Clin Cancer Res 14:1363-7. 2008..The goal of this work was to monitor quantitatively the development and progression of adenocarcinoma in a time course study of mice treated with the carcinogen urethane using in vivo small-animal magnetic resonance imaging (MRI)... - Identification of genetic polymorphisms through comparative DNA sequence analysis on the K-ras gene: implications for lung tumor susceptibilityMin Wang
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
Exp Lung Res 31:165-77. 2005.... - Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1Min Wang
School of Medicine, Washington University, 660 Euclid Avenue, St Louis, MO, USA
Cancer Res 67:93-9. 2007..Our results suggest that p34 may be a novel tumor suppressor gene involved in sporadic lung cancer but it seems not to be the candidate familial lung cancer susceptibility gene linked to chromosomal region 6q23-25... - Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamineRuisheng Yao
Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, St Louis, MO 63110, USA
Neoplasia 6:569-77. 2004.... - K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smokeRuisheng Yao
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
Exp Lung Res 31:271-81. 2005..These results suggest that tobacco smoke enhances lung tumorigenesis primarily through promoting spontaneously occurring K-ras mutations... - Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicityQi Zhang
Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
Cancer Prev Res (Phila) 5:717-25. 2012..The ability of 3-bromopyruvate to inhibit mouse lung tumorigenesis, in part through induction of apoptosis, merits further investigation of this compound as a chemopreventive agent for human lung cancer... - RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathwayMichael A James
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer Res 69:2108-16. 2009..The prevalence of the induction of RGS17 in tumor tissues of various types further implicates its importance in the maintenance of tumor growth... - Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred miceHaris G Vikis
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer Res 70:4859-67. 2010..One possible mechanism of resistance to pulmonary metastasis in BTBRT+tf/J mice may require T-cell function. Our experiments present a new mouse model for further characterization of the genetics and mechanisms of pulmonary metastasis... - Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressionsRuisheng Yao
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Oncogene 23:7746-52. 2004..Our results indicate that the chemopreventive effects of budesonide in the mouse lung tumorigenesis assay involved increase and decrease expression of a wide variety of genes in multiple signaling pathways... - Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J MiceQi Zhang
Department of Surgery and Alvin J Siteman Cancer Center, Washington University in St Louis, 660 South Euclid Avenue, Campus Box 8109, St Louis, Missouri 63110, USA
Pharm Res 27:1066-71. 2010..To compare the chemopreventive efficacy of Polyphenon E (Poly E), (-)-epigallocatechin-3-gallate (EGCG) and Polyphenon E without EGCG (Poly E-EGCG) on the development of benzo(a)pyrene (B(a)P)-induced lung tumors in A/J mice... - Gene expression profiling of chemically induced rat bladder tumorsRuisheng Yao
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
Neoplasia 9:207-21. 2007..These results suggest that multiple pathways are involved in rat bladder tumorigenesis, and a common molecular mechanism was found in both rat and mouse bladder tumors... - Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesisMichael A James
Department of Surgery, Campus Box 8109, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
Mol Carcinog 50:1-7. 2011.... - Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/ArfYian Wang
Department of Surgery, School of Medicine, Siteman Cancer Center, The Washington University in St Louis, 660 S Euclid Avenue, St Louis, MO, USA
Oncogene 24:3042-9. 2005.... - Strain-specific variation in murine natural killer gene complex contributes to differences in immunosurveillance for urethane-induced lung cancerDaniel Kreisel
Departments of Surgery, Pathology and Immunology, and Internal Medicine, The Alvin Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
Cancer Res 72:4311-7. 2012.... - Five loci, SLT1 to SLT5, controlling the susceptibility to spontaneously occurring lung cancer in miceDaolong Wang
Department of Surgery and the Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer Res 65:8158-65. 2005..Our results provide, for the first time, an insight into the genetic control of spontaneously occurring lung tumorigenesis... - A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibilityYian Wang
Department of Surgery and the Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer Res 64:1647-54. 2004..Furthermore, this model can be used in determining genetic modifiers that contribute to susceptibility or resistance to lung SCC development... - Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J miceYing Yan
Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
Neoplasia 9:401-5. 2007..These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer... - RASSF1A promoter methylation and Kras2 mutations in non small cell lung cancerJie Li
Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
Neoplasia 5:362-6. 2003..Our results indicate a trend of inverse relationship between Kras2 activation and RASSF1A promoter methylation in the majority of human lung adenocarcinomas and large cell carcinomas... - Animal models of lung cancer characterization and use for chemoprevention researchYian Wang
Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
Prog Mol Biol Transl Sci 105:211-26. 2012.... - Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5Jen C Wang
Department of Psychiatry, Washington University, 660 South Euclid, PO BOX 8134, St Louis, MO 63110, USA
Hum Mol Genet 18:3125-35. 2009.... - Detection of primary lung tumors in rodents by magnetic resonance imagingJoel R Garbow
Department of Chemistry, Washington University, St Louis, Missouri, USA
Cancer Res 64:2740-2. 2004.... - Genomic landscape of non-small cell lung cancer in smokers and never-smokersRamaswamy Govindan
Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
Cell 150:1121-34. 2012..Cell-cycle and JAK-STAT pathways are significantly altered in lung cancer, along with perturbations in 54 genes that are potentially targetable with currently available drugs... - Chemoprevention of lung cancer by teaJulie Clark
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
Mol Nutr Food Res 50:144-51. 2006..Future studies are needed to determine how green tea affects the genes associated with cell cycle regulation and apoptosis during the mouse lung carcinogenesis process... - Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J miceYian Wang
Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Cancer Res 63:4389-95. 2003..Thus, the mutant A/J mouse model should prove useful for chemoprevention studies... - A high performance test of differential gene expression for oligonucleotide arraysWilliam J Lemon
Department of Surgery, 4940 Parkview Place, 10130 Wohl Clinics, Washington University in St Louis, St Louis, MI 63110, USA
Genome Biol 4:R67. 2003..01 threshold. Logit-t provided 70% sensitivity, Microarray Suite 5 provided 46%, dChip provided 53% and Robust Multi-array Analysis provided 63%...