Kevin E Yarasheski

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc 18FDG PET-CT imaging detects arterial inflammation and early atherosclerosis in HIV-infected adults with cardiovascular disease risk factors
    Kevin E Yarasheski
    Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Box 8127, St, Louis, MO, USA
    J Inflamm (Lond) 9:26. 2012
  2. pmc Whole-body and muscle protein metabolism are not affected by acute deviations from habitual protein intake in older men: the Hormonal Regulators of Muscle and Metabolism in Aging (HORMA) Study
    Kevin E Yarasheski
    Department of Medicine, Washington University, St Louis, MO, USA
    Am J Clin Nutr 94:172-81. 2011
  3. pmc Exercise training augments the peripheral insulin-sensitizing effects of pioglitazone in HIV-infected adults with insulin resistance and central adiposity
    Kevin E Yarasheski
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 300:E243-51. 2011
  4. pmc HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus
    Michael J Carper
    Washington University School of Medicine, Department of Internal Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Southwest Tower, Room 846A, Campus Box 8127, 660 South Euclid Drive, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 294:E558-67. 2008
  5. ncbi request reprint Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAART
    W Todd Cade
    Department of Medicine, Washington University School of Medicine, 4444 Forest Park Blvd, St Louis, MO 63108 2212, USA
    Am J Physiol Endocrinol Metab 292:E812-9. 2007
  6. pmc Protease inhibitors used in the treatment of HIV+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretion
    Sheng Zhang
    Washington University School of Medicine, Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, 660 S Euclid Ave, Box 8127, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 296:E925-35. 2009
  7. pmc Effects of human immunodeficiency virus and metabolic complications on myocardial nutrient metabolism, blood flow, and oxygen consumption: a cross-sectional analysis
    W Todd Cade
    Program in Physical Therapy, Washington University School of Medicine, 4444 Forest Park Boulevard, St, Louis, Missouri 63108, USA
    Cardiovasc Diabetol 10:111. 2011
  8. ncbi request reprint Effects of progressive resistance training on body composition in frail older adults: results of a randomized, controlled trial
    Ellen F Binder
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, 4488 Forest Park Blvd, Suite 201, St Louis, MO 63108, USA
    J Gerontol A Biol Sci Med Sci 60:1425-31. 2005
  9. doi request reprint Pilot study of pioglitazone and exercise training effects on basal myocardial substrate metabolism and left ventricular function in HIV-positive individuals with metabolic complications
    W Todd Cade
    Program in Physical Therapy, Washington University School of Medicine, St Louis, Missouri
    HIV Clin Trials 14:303-12. 2013
  10. pmc Whole-body proteolysis rate is elevated in HIV-associated insulin resistance
    Dominic N Reeds
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetes 55:2849-55. 2006

Detail Information

Publications42

  1. pmc 18FDG PET-CT imaging detects arterial inflammation and early atherosclerosis in HIV-infected adults with cardiovascular disease risk factors
    Kevin E Yarasheski
    Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Box 8127, St, Louis, MO, USA
    J Inflamm (Lond) 9:26. 2012
    ..abstract:..
  2. pmc Whole-body and muscle protein metabolism are not affected by acute deviations from habitual protein intake in older men: the Hormonal Regulators of Muscle and Metabolism in Aging (HORMA) Study
    Kevin E Yarasheski
    Department of Medicine, Washington University, St Louis, MO, USA
    Am J Clin Nutr 94:172-81. 2011
    ..Acute deviations in protein intake before the quantification of protein kinetics in older humans may explain the controversy over the effects of older age on muscle protein synthesis and proteolysis rates...
  3. pmc Exercise training augments the peripheral insulin-sensitizing effects of pioglitazone in HIV-infected adults with insulin resistance and central adiposity
    Kevin E Yarasheski
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 300:E243-51. 2011
    ..Pioglitazone alone did not significantly increase limb adipose content. Potential cardiovascular benefits of these interventions in HIV need investigation...
  4. pmc HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus
    Michael J Carper
    Washington University School of Medicine, Department of Internal Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Southwest Tower, Room 846A, Campus Box 8127, 660 South Euclid Drive, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 294:E558-67. 2008
    ..Our findings therefore indicate that induction of the SOCS-1 signaling cascade by PIs could be an important contributing factor in the development of metabolic dysregulation associated with long-term exposures to HIV-PIs...
  5. ncbi request reprint Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAART
    W Todd Cade
    Department of Medicine, Washington University School of Medicine, 4444 Forest Park Blvd, St Louis, MO 63108 2212, USA
    Am J Physiol Endocrinol Metab 292:E812-9. 2007
    ..Regional differences in adipose tissue lipolysis during rest and moderate exercise may be important in HIV and warrant further study...
  6. pmc Protease inhibitors used in the treatment of HIV+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretion
    Sheng Zhang
    Washington University School of Medicine, Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, 660 S Euclid Ave, Box 8127, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 296:E925-35. 2009
    ..These findings therefore highlight the importance of considering beta-cell viability and function when assessing loss of glycemic control and the course of development of diabetes in HIV+ subjects receiving a protease inhibitor...
  7. pmc Effects of human immunodeficiency virus and metabolic complications on myocardial nutrient metabolism, blood flow, and oxygen consumption: a cross-sectional analysis
    W Todd Cade
    Program in Physical Therapy, Washington University School of Medicine, 4444 Forest Park Boulevard, St, Louis, Missouri 63108, USA
    Cardiovasc Diabetol 10:111. 2011
    ..We examined whether myocardial nutrient metabolism and left ventricular dysfunction are related to one another and worse in HIV infected men treated with cART vs. HIV-negative men with or without MC...
  8. ncbi request reprint Effects of progressive resistance training on body composition in frail older adults: results of a randomized, controlled trial
    Ellen F Binder
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, 4488 Forest Park Blvd, Suite 201, St Louis, MO 63108, USA
    J Gerontol A Biol Sci Med Sci 60:1425-31. 2005
    ..Limited information is available regarding the effects of PRT on lean and fat mass in frail elderly persons...
  9. doi request reprint Pilot study of pioglitazone and exercise training effects on basal myocardial substrate metabolism and left ventricular function in HIV-positive individuals with metabolic complications
    W Todd Cade
    Program in Physical Therapy, Washington University School of Medicine, St Louis, Missouri
    HIV Clin Trials 14:303-12. 2013
    ..It is unknown whether interventions shown to be effective in improving peripheral insulin sensitivity can improve basal myocardial insulin sensitivity and diastolic function in people with HIV and peripheral metabolic complications...
  10. pmc Whole-body proteolysis rate is elevated in HIV-associated insulin resistance
    Dominic N Reeds
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetes 55:2849-55. 2006
    ..Increased proteolysis may provide amino acids for gluconeogenesis, exacerbating hyperglycemia in HIV...
  11. ncbi request reprint A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatment
    Thomas W Storer
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 90:4474-82. 2005
    ....
  12. ncbi request reprint Effects of extended outpatient rehabilitation after hip fracture: a randomized controlled trial
    Ellen F Binder
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    JAMA 292:837-46. 2004
    ..Hip fractures are common in the elderly, and despite standard rehabilitation, many patients fail to regain their prefracture ambulatory or functional status...
  13. pmc HIV-protease inhibitors suppress skeletal muscle fatty acid oxidation by reducing CD36 and CPT1 fatty acid transporters
    Scott R Richmond
    Department of Internal Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Biochim Biophys Acta 1801:559-66. 2010
    ..HIV-PIs may also directly impair fatty acid handling and partitioning in skeletal muscle, and this may contribute to the cluster of metabolic complications that occur in people living with HIV...
  14. pmc Insulin resistance predicts endothelial dysfunction and cardiovascular risk in HIV-infected persons on long-term highly active antiretroviral therapy
    Kristin E Mondy
    Washington University School of Medicine, St Louis, MO, USA
    AIDS 22:849-56. 2008
    ..To address this issue, we assessed multiple metabolic and clinical predictors of endothelial function and carotid intima-media thickness in HIV-infected subjects and compared results with HIV-negative controls...
  15. pmc Reducing plasma HIV RNA improves muscle amino acid metabolism
    Kevin E Yarasheski
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Lipid Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 288:E278-84. 2005
    ....
  16. pmc Relationships among HIV infection, metabolic risk factors, and left ventricular structure and function
    William Todd Cade
    Program in Physical Therapy, Washington University School of Medicine, St Louis, MO 63108, USA
    AIDS Res Hum Retroviruses 29:1151-60. 2013
    ..Also, HIV was independently associated with lower systolic function. Clinical monitoring of LV function in individuals with metabolic risk factors, regardless of HIV status, is warranted...
  17. pmc In vivo human apolipoprotein E isoform fractional turnover rates in the CNS
    Kristin R Wildsmith
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS ONE 7:e38013. 2012
    ..We also demonstrate a slower turnover rate for CSF ApoE than that for amyloid beta, another molecule critically important in AD pathogenesis...
  18. pmc Dipeptidyl peptidase IV inhibition does not adversely affect immune or virological status in HIV infected men and women: a pilot safety study
    Scott R Goodwin
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 98:743-51. 2013
    ..Dipeptidyl peptidase IV (DPP4) inhibitors are glucose-lowering medications with pleiotropic actions that may particularly benefit people with HIV, but the immune and virological safety of DPP4 inhibition in HIV is unknown...
  19. pmc Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice
    Sasanka Ramanadham
    Washington University School of Medicine, Department of Internal Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Am J Pathol 172:868-81. 2008
    ....
  20. pmc Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers
    Rachel Potter
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Sci Transl Med 5:189ra77. 2013
    ....
  21. ncbi request reprint Cortisol and its action on the glucocorticoid receptor in malnutrition and acute infection
    Mark J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 55:550-4. 2006
    ..The increased nuclear glucocorticoid receptor abundance in marasmus demonstrates that nutritional status modulates glucocorticoid receptor action by mechanisms in addition to circulating glucocorticoid concentrations...
  22. pmc Alterations in thigh subcutaneous adipose tissue gene expression in protease inhibitor-based highly active antiretroviral therapy
    Juan Chaparro
    Departments of Medicine and Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 54:561-7. 2005
    ..Prospective longitudinal studies of thigh fat adipose tissue gene expression could provide further insights on the pathogenesis of metabolic complications associated with PI-based HAART...
  23. ncbi request reprint PPARalpha activation elevates blood pressure and does not correct glucocorticoid-induced insulin resistance in humans
    Savitha Subramanian
    Endocrinology, Metabolism, and Lipid Research, Dept of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 291:E1365-71. 2006
    ..These data suggest that PPARalpha activation in humans does not correct insulin resistance induced by glucocorticoids and may adversely affect blood pressure...
  24. ncbi request reprint Exercise, aging, and muscle protein metabolism
    Kevin E Yarasheski
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Gerontol A Biol Sci Med Sci 58:M918-22. 2003
    ..The cellular mechanisms responsible for these adaptations, as well as the role of nutrition and hormone replacement in reversing sarcopenia, require further investigation...
  25. ncbi request reprint Visceral adiposity, C-peptide levels, and low lipase activities predict HIV-dyslipidemia
    Kevin E Yarasheski
    Division of Endocrinology, Metabolism and Lipid Research, Washington University Medical School, 660 South Euclid Avenue, Box 8127, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 285:E899-905. 2003
    ..g., central adiposity and hyperinsulinemia) and mediated only partially by factors that influence triglyceride clearance (e.g., lipase activity)...
  26. ncbi request reprint Effects of exercise training added to ongoing hormone replacement therapy on bone mineral density in frail elderly women
    Dennis T Villareal
    Washington University Claude Pepper Older Americans Independence Center, USA
    J Am Geriatr Soc 51:985-90. 2003
    ..To determine whether exercise training added to ongoing hormone replacement therapy (HRT) increases bone mineral density (BMD) in physically frail elderly women...
  27. pmc Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo
    Randall J Bateman
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, Missouri 63110, USA
    Nat Med 12:856-61. 2006
    ....
  28. pmc Age-related skeletal muscle decline is similar in HIV-infected and uninfected individuals
    Kevin E Yarasheski
    Department of Medicine, Washington University, St Louis, Missouri, USA
    J Gerontol A Biol Sci Med Sci 66:332-40. 2011
    ..We hypothesized that muscle mass would be lower and decline faster in HIV-infected adults than in similar-aged controls...
  29. ncbi request reprint Niacin in HIV-infected individuals with hyperlipidemia receiving potent antiretroviral therapy
    Marisa T Gerber
    Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA
    Clin Infect Dis 39:419-25. 2004
    ..Extended release (ER)-niacin therapy, which has been associated with reduced glucose tolerance in human immunodeficiency virus (HIV)-seronegative individuals, has not been evaluated in the HIV-infected population...
  30. ncbi request reprint Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, University of California, Los Angeles, CA 90059, USA
    J Clin Endocrinol Metab 90:678-88. 2005
    ..The best trade-off was achieved with a testosterone dose (125 mg) that was associated with high normal testosterone levels, low frequency of adverse events, and significant gains in fat-free mass and muscle strength...
  31. ncbi request reprint Treatment with oxandrolone and the durability of effects in older men
    E Todd Schroeder
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    J Appl Physiol 96:1055-62. 2004
    ..Anabolic improvements were lost 12 wk after discontinuing oxandrolone, whereas improvements in fat mass were largely sustained...
  32. pmc A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system
    Randall J Bateman
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Ann Neurol 66:48-54. 2009
    ..The objective of this study was to determine the effects of a gamma-secretase inhibitor on the production of Abeta in the human CNS...
  33. ncbi request reprint Exercise treatment to counteract protein wasting of chronic diseases
    Erin M Zinna
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Opin Clin Nutr Metab Care 6:87-93. 2003
    ..The muscle proteins most affected and the precise alterations in their synthetic and proteolytic rates that occur in each cachectic condition are still under investigation...
  34. ncbi request reprint Isoenergetic dietary protein restriction decreases myosin heavy chain IIx fraction and myosin heavy chain production in humans
    Irwin G Brodsky
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Nutr 134:328-34. 2004
    ..This has implications for the mechanisms by which amino acids govern muscle protein composition in vivo, and further exploration is required...
  35. pmc Decreased clearance of CNS beta-amyloid in Alzheimer's disease
    Kwasi G Mawuenyega
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 330:1774. 2010
    ..On average, there were no differences in Aβ40 or Aβ42 production rates. Thus, the common late-onset form of Alzheimer's disease is characterized by an overall impairment in Aβ clearance...
  36. ncbi request reprint A potent sorbitol dehydrogenase inhibitor exacerbates sympathetic autonomic neuropathy in rats with streptozotocin-induced diabetes
    Robert E Schmidt
    Department of Pathology and Immunology, Division of Neuropathology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Exp Neurol 192:407-19. 2005
    ....
  37. ncbi request reprint Urea production and leucine oxidation in malnourished children with and without acute infection
    Mark J Manary
    Washington University School of Medicine, St Louis, MO, USA
    Metabolism 51:1418-22. 2002
    ....
  38. pmc Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells
    Bart Everts
    Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Blood 120:1422-31. 2012
    ..Our data identify NO as a profound metabolic regulator in inflammatory monocyte-derived DCs...
  39. pmc Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates
    Randall J Bateman
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Mass Spectrom 18:997-1006. 2007
    ..The technique is adaptable to other macromolecules, such as carbohydrates or lipids...
  40. ncbi request reprint Effects of exercise training on frailty in community-dwelling older adults: results of a randomized, controlled trial
    Ellen F Binder
    Department of Internal Medicine, Washington University School of Medicine, Claude Pepper Older Americans Independence Center, Washington University, St Louis, Missouri 63108, USA
    J Am Geriatr Soc 50:1921-8. 2002
    ..The aim of this study was to determine the effects of intensive exercise training (ET) on measures of physical frailty in older community-dwelling men and women...
  41. ncbi request reprint Whole-body leucine kinetics and the acute phase response during acute infection in marasmic Malawian children
    Mark J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Pediatr Res 55:940-6. 2004
    ..These data suggest that the cytokine stimulus for the acute-phase protein kinetic response to acute infection is present in marasmic children but that the acute-phase protein metabolic response is blunted by malnutrition...
  42. ncbi request reprint HIV-protease inhibitors impair vitamin D bioactivation to 1,25-dihydroxyvitamin D
    Mario Cozzolino
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    AIDS 17:513-20. 2003
    ..The 25- and 1alpha-hydroxylases regulate 1,25(OH) D synthesis and 24-hydroxylase 1,25(OH) D catabolism...