Research Topics
Genomes and Genes | Kevin E YarasheskiSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Publications
18FDG PET-CT imaging detects arterial inflammation and early atherosclerosis in HIV-infected adults with cardiovascular disease risk factorsKevin E Yarasheski
Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Box 8127, St, Louis, MO, USA
J Inflamm (Lond) 9:26. 2012..abstract:..- Exercise training augments the peripheral insulin-sensitizing effects of pioglitazone in HIV-infected adults with insulin resistance and central adiposityKevin E Yarasheski
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Am J Physiol Endocrinol Metab 300:E243-51. 2011..Pioglitazone alone did not significantly increase limb adipose content. Potential cardiovascular benefits of these interventions in HIV need investigation... - Whole-body and muscle protein metabolism are not affected by acute deviations from habitual protein intake in older men: the Hormonal Regulators of Muscle and Metabolism in Aging (HORMA) StudyKevin E Yarasheski
Department of Medicine, Washington University, St Louis, MO, USA
Am J Clin Nutr 94:172-81. 2011..Acute deviations in protein intake before the quantification of protein kinetics in older humans may explain the controversy over the effects of older age on muscle protein synthesis and proteolysis rates... 
HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitusMichael J Carper
Washington University School of Medicine, Department of Internal Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Southwest Tower, Room 846A, Campus Box 8127, 660 South Euclid Drive, St Louis, MO 63110, USA
Am J Physiol Endocrinol Metab 294:E558-67. 2008..Our findings therefore indicate that induction of the SOCS-1 signaling cascade by PIs could be an important contributing factor in the development of metabolic dysregulation associated with long-term exposures to HIV-PIs...
Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAARTW Todd Cade
Department of Medicine, Washington University School of Medicine, 4444 Forest Park Blvd, St Louis, MO 63108 2212, USA
Am J Physiol Endocrinol Metab 292:E812-9. 2007..Regional differences in adipose tissue lipolysis during rest and moderate exercise may be important in HIV and warrant further study...- Effects of human immunodeficiency virus and metabolic complications on myocardial nutrient metabolism, blood flow, and oxygen consumption: a cross-sectional analysisW Todd Cade
Program in Physical Therapy, Washington University School of Medicine, 4444 Forest Park Boulevard, St, Louis, Missouri 63108, USA
Cardiovasc Diabetol 10:111. 2011..We examined whether myocardial nutrient metabolism and left ventricular dysfunction are related to one another and worse in HIV infected men treated with cART vs. HIV-negative men with or without MC... - Effects of progressive resistance training on body composition in frail older adults: results of a randomized, controlled trialEllen F Binder
Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, 4488 Forest Park Blvd, Suite 201, St Louis, MO 63108, USA
J Gerontol A Biol Sci Med Sci 60:1425-31. 2005..Limited information is available regarding the effects of PRT on lean and fat mass in frail elderly persons... - Protease inhibitors used in the treatment of HIV+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretionSheng Zhang
Washington University School of Medicine, Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, 660 S Euclid Ave, Box 8127, St Louis, MO 63110, USA
Am J Physiol Endocrinol Metab 296:E925-35. 2009..These findings therefore highlight the importance of considering beta-cell viability and function when assessing loss of glycemic control and the course of development of diabetes in HIV+ subjects receiving a protease inhibitor... - Whole-body proteolysis rate is elevated in HIV-associated insulin resistanceDominic N Reeds
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Diabetes 55:2849-55. 2006..Increased proteolysis may provide amino acids for gluconeogenesis, exacerbating hyperglycemia in HIV... - A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatmentThomas W Storer
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 90:4474-82. 2005.... - Insulin resistance predicts endothelial dysfunction and cardiovascular risk in HIV-infected persons on long-term highly active antiretroviral therapyKristin E Mondy
Washington University School of Medicine, St Louis, MO, USA
AIDS 22:849-56. 2008..To address this issue, we assessed multiple metabolic and clinical predictors of endothelial function and carotid intima-media thickness in HIV-infected subjects and compared results with HIV-negative controls... - Effects of extended outpatient rehabilitation after hip fracture: a randomized controlled trialEllen F Binder
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
JAMA 292:837-46. 2004..Hip fractures are common in the elderly, and despite standard rehabilitation, many patients fail to regain their prefracture ambulatory or functional status... - Reducing plasma HIV RNA improves muscle amino acid metabolismKevin E Yarasheski
Department of Internal Medicine, Division of Metabolism, Endocrinology and Lipid Research, Washington University School of Medicine, St Louis, MO 63110, USA
Am J Physiol Endocrinol Metab 288:E278-84. 2005.... - HIV-protease inhibitors suppress skeletal muscle fatty acid oxidation by reducing CD36 and CPT1 fatty acid transportersScott R Richmond
Department of Internal Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, MO 63110, USA
Biochim Biophys Acta 1801:559-66. 2010..HIV-PIs may also directly impair fatty acid handling and partitioning in skeletal muscle, and this may contribute to the cluster of metabolic complications that occur in people living with HIV... - In vivo human apolipoprotein E isoform fractional turnover rates in the CNSKristin R Wildsmith
Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri, United States of America
PLoS ONE 7:e38013. 2012..We also demonstrate a slower turnover rate for CSF ApoE than that for amyloid beta, another molecule critically important in AD pathogenesis... - Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null miceSasanka Ramanadham
Washington University School of Medicine, Department of Internal Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Am J Pathol 172:868-81. 2008.... - Cortisol and its action on the glucocorticoid receptor in malnutrition and acute infectionMark J Manary
Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
Metabolism 55:550-4. 2006..The increased nuclear glucocorticoid receptor abundance in marasmus demonstrates that nutritional status modulates glucocorticoid receptor action by mechanisms in addition to circulating glucocorticoid concentrations... - Alterations in thigh subcutaneous adipose tissue gene expression in protease inhibitor-based highly active antiretroviral therapyJuan Chaparro
Departments of Medicine and Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Metabolism 54:561-7. 2005..Prospective longitudinal studies of thigh fat adipose tissue gene expression could provide further insights on the pathogenesis of metabolic complications associated with PI-based HAART... - Exercise, aging, and muscle protein metabolismKevin E Yarasheski
Washington University School of Medicine, St Louis, Missouri 63110, USA
J Gerontol A Biol Sci Med Sci 58:M918-22. 2003..The cellular mechanisms responsible for these adaptations, as well as the role of nutrition and hormone replacement in reversing sarcopenia, require further investigation... - PPARalpha activation elevates blood pressure and does not correct glucocorticoid-induced insulin resistance in humansSavitha Subramanian
Endocrinology, Metabolism, and Lipid Research, Dept. of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Am J Physiol Endocrinol Metab 291:E1365-71. 2006..These data suggest that PPARalpha activation in humans does not correct insulin resistance induced by glucocorticoids and may adversely affect blood pressure... - Effects of exercise training added to ongoing hormone replacement therapy on bone mineral density in frail elderly womenDennis T Villareal
Washington University Claude Pepper Older Americans Independence Center, USA
J Am Geriatr Soc 51:985-90. 2003..To determine whether exercise training added to ongoing hormone replacement therapy (HRT) increases bone mineral density (BMD) in physically frail elderly women... - Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivoRandall J Bateman
Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, Missouri 63110, USA
Nat Med 12:856-61. 2006.... - Visceral adiposity, C-peptide levels, and low lipase activities predict HIV-dyslipidemiaKevin E Yarasheski
Division of Endocrinology, Metabolism and Lipid Research, Washington University Medical School, 660 South Euclid Avenue, Box 8127, St Louis, MO 63110, USA
Am J Physiol Endocrinol Metab 285:E899-905. 2003..g., central adiposity and hyperinsulinemia) and mediated only partially by factors that influence triglyceride clearance (e.g., lipase activity)... - Age-related skeletal muscle decline is similar in HIV-infected and uninfected individualsKevin E Yarasheski
Department of Medicine, Washington University, St Louis, Missouri, USA
J Gerontol A Biol Sci Med Sci 66:332-40. 2011..We hypothesized that muscle mass would be lower and decline faster in HIV-infected adults than in similar-aged controls... - Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscleShalender Bhasin
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, University of California, Los Angeles, CA 90059, USA
J Clin Endocrinol Metab 90:678-88. 2005..The best trade-off was achieved with a testosterone dose (125 mg) that was associated with high normal testosterone levels, low frequency of adverse events, and significant gains in fat-free mass and muscle strength... - A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous systemRandall J Bateman
Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
Ann Neurol 66:48-54. 2009..The objective of this study was to determine the effects of a gamma-secretase inhibitor on the production of Abeta in the human CNS... - Niacin in HIV-infected individuals with hyperlipidemia receiving potent antiretroviral therapyMarisa T Gerber
Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA
Clin Infect Dis 39:419-25. 2004.... - Treatment with oxandrolone and the durability of effects in older menE Todd Schroeder
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
J Appl Physiol 96:1055-62. 2004..Anabolic improvements were lost 12 wk after discontinuing oxandrolone, whereas improvements in fat mass were largely sustained... - Dipeptidyl peptidase IV inhibition does not adversely affect immune or virological status in HIV infected men and women: a pilot safety studyScott R Goodwin
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Endocrinol Metab 98:743-51. 2013..Dipeptidyl peptidase IV (DPP4) inhibitors are glucose-lowering medications with pleiotropic actions that may particularly benefit people with HIV, but the immune and virological safety of DPP4 inhibition in HIV is unknown... - Isoenergetic dietary protein restriction decreases myosin heavy chain IIx fraction and myosin heavy chain production in humansIrwin G Brodsky
Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
J Nutr 134:328-34. 2004..This has implications for the mechanisms by which amino acids govern muscle protein composition in vivo, and further exploration is required... - A potent sorbitol dehydrogenase inhibitor exacerbates sympathetic autonomic neuropathy in rats with streptozotocin-induced diabetesRobert E Schmidt
Department of Pathology and Immunology, Division of Neuropathology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
Exp Neurol 192:407-19. 2005.... - Decreased clearance of CNS beta-amyloid in Alzheimer's diseaseKwasi G Mawuenyega
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Science 330:1774. 2010..On average, there were no differences in Aβ40 or Aβ42 production rates. Thus, the common late-onset form of Alzheimer's disease is characterized by an overall impairment in Aβ clearance... - Exercise treatment to counteract protein wasting of chronic diseasesErin M Zinna
Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Curr Opin Clin Nutr Metab Care 6:87-93. 2003.... - Urea production and leucine oxidation in malnourished children with and without acute infectionMark J Manary
Washington University School of Medicine, St Louis, MO, USA
Metabolism 51:1418-22. 2002.... - Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cellsBart Everts
Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
Blood 120:1422-31. 2012..Our data identify NO as a profound metabolic regulator in inflammatory monocyte-derived DCs... - Whole-body leucine kinetics and the acute phase response during acute infection in marasmic Malawian childrenMark J Manary
Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
Pediatr Res 55:940-6. 2004..These data suggest that the cytokine stimulus for the acute-phase protein kinetic response to acute infection is present in marasmic children but that the acute-phase protein metabolic response is blunted by malnutrition... - Effects of exercise training on frailty in community-dwelling older adults: results of a randomized, controlled trialEllen F Binder
Department of Internal Medicine, Washington University School of Medicine, Claude Pepper Older Americans Independence Center, Washington University, St Louis, Missouri 63108, USA
J Am Geriatr Soc 50:1921-8. 2002..The aim of this study was to determine the effects of intensive exercise training (ET) on measures of physical frailty in older community-dwelling men and women... - Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance ratesRandall J Bateman
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Am Soc Mass Spectrom 18:997-1006. 2007..The technique is adaptable to other macromolecules, such as carbohydrates or lipids... - HIV-protease inhibitors impair vitamin D bioactivation to 1,25-dihydroxyvitamin DMario Cozzolino
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
AIDS 17:513-20. 2003..If PIs elicit a similar potency in inhibiting these critical steps for 1,25(OH) D homeostasis, defective 1,25(OH) D production could contribute to the bone demineralization in HIV patients...