Chengjie Xiong

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
    Randall J Bateman
    Department of Neurology, Washington University School of Medicine, 660 S, Euclid, Campus Box 8111, St Louis, MO 63110, USA
    Alzheimers Res Ther 3:1. 2011
  2. ncbi request reprint Sample sizes for comparing means of two lifetime distributions with type II censored data: application in an aging intervention study
    Chengjie Xiong
    Division of Biostatistics, Campus Box 8067, Washington University in St Louis, St Louis, MO 63110, USA
    Control Clin Trials 24:283-93. 2003
  3. ncbi request reprint Power and sample size for clinical trials when efficacy is required in multiple endpoints: application to an Alzheimer's treatment trial
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, MO 63110, USA
    Clin Trials 2:387-93. 2005
  4. pmc Evaluating the quality of longitudinal statistical applications in original publications on Alzheimer's disease
    Chengjie Xiong
    Division of Biostatistics, Washington University, St Louis, MO 63110, USA
    Neuroepidemiology 30:112-9. 2008
  5. pmc Designing clinical trials to test disease-modifying agents: application to the treatment trials of Alzheimer's disease
    Chengjie Xiong
    Division of Biostatistics, School of Medicine, Washington University, St Louis, MO, USA
    Clin Trials 8:15-26. 2011
  6. ncbi request reprint Effect of a guarantee time on sample size determination for testing the ratio of means from two lifetime distributions
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Biopharm Stat 14:177-88. 2004
  7. ncbi request reprint Testing correlation of cognitive decline at adjacent stages of dementia
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, St Louis, MO 63110, USA
    J Alzheimers Dis 5:409-18. 2003
  8. ncbi request reprint Measuring and estimating diagnostic accuracy when there are three ordinal diagnostic groups
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, St Louis, MO 63110, USA
    Stat Med 25:1251-73. 2006
  9. ncbi request reprint Assessing statistical applications in publications on Alzheimer's disease
    Chengjie Xiong
    Division of Biostatistics, Washington University, St Louis, MO 63110, USA
    Neuroepidemiology 28:235-45. 2007
  10. pmc Role of family history for Alzheimer biomarker abnormalities in the adult children study
    Chengjie Xiong
    Charles F and Joanne Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri, USA
    Arch Neurol 68:1313-9. 2011

Research Grants

  1. Statistics in Alzheimer's Publications
    Chengjie Xiong; Fiscal Year: 2007
  2. TWO PRECLINICAL LATENT SCORES TO PREDICT OCCURRENCE OF DAT
    Chengjie Xiong; Fiscal Year: 2010

Collaborators

Detail Information

Publications55

  1. pmc Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
    Randall J Bateman
    Department of Neurology, Washington University School of Medicine, 660 S, Euclid, Campus Box 8111, St Louis, MO 63110, USA
    Alzheimers Res Ther 3:1. 2011
    ..Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention...
  2. ncbi request reprint Sample sizes for comparing means of two lifetime distributions with type II censored data: application in an aging intervention study
    Chengjie Xiong
    Division of Biostatistics, Campus Box 8067, Washington University in St Louis, St Louis, MO 63110, USA
    Control Clin Trials 24:283-93. 2003
    ..Specific applications to log-normal distribution and Weibull distribution are also discussed...
  3. ncbi request reprint Power and sample size for clinical trials when efficacy is required in multiple endpoints: application to an Alzheimer's treatment trial
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, MO 63110, USA
    Clin Trials 2:387-93. 2005
    ..When the efficacy of a treatment in a randomized controlled trial is required for multiple primary endpoints, trial design and analysis differ from trial requiring efficacy in only one of the multiple endpoints...
  4. pmc Evaluating the quality of longitudinal statistical applications in original publications on Alzheimer's disease
    Chengjie Xiong
    Division of Biostatistics, Washington University, St Louis, MO 63110, USA
    Neuroepidemiology 30:112-9. 2008
    ..To evaluate the quality of longitudinal statistical applications in published studies on Alzheimer's disease (AD)...
  5. pmc Designing clinical trials to test disease-modifying agents: application to the treatment trials of Alzheimer's disease
    Chengjie Xiong
    Division of Biostatistics, School of Medicine, Washington University, St Louis, MO, USA
    Clin Trials 8:15-26. 2011
    ..Randomized start and randomized withdrawal designs are two examples of such designs. Crucial design parameters such as sample size and the time of treatment switch are important to understand in designing such clinical trials...
  6. ncbi request reprint Effect of a guarantee time on sample size determination for testing the ratio of means from two lifetime distributions
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Biopharm Stat 14:177-88. 2004
    ..We show that the guarantee times, if they exist, can significantly affect the sample size computations. The Aging Intervention Testing Program from the National Institute on Aging is used to demonstrate our results...
  7. ncbi request reprint Testing correlation of cognitive decline at adjacent stages of dementia
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, St Louis, MO 63110, USA
    J Alzheimers Dis 5:409-18. 2003
    ..This method is applied to several composite psychometric factor scores in the longitudinal database from the Alzheimer's Disease Research Center (ADRC) at Washington University in St. Louis...
  8. ncbi request reprint Measuring and estimating diagnostic accuracy when there are three ordinal diagnostic groups
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, St Louis, MO 63110, USA
    Stat Med 25:1251-73. 2006
    ..Finally, we demonstrate the proposed methodology by applying it to the clinical diagnosis of early stage Alzheimer's disease based on the neuropsychological database of the Washington University Alzheimer's Disease Research Center...
  9. ncbi request reprint Assessing statistical applications in publications on Alzheimer's disease
    Chengjie Xiong
    Division of Biostatistics, Washington University, St Louis, MO 63110, USA
    Neuroepidemiology 28:235-45. 2007
    ..To evaluate statistical applications in publications on Alzheimer's disease (AD)...
  10. pmc Role of family history for Alzheimer biomarker abnormalities in the adult children study
    Chengjie Xiong
    Charles F and Joanne Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri, USA
    Arch Neurol 68:1313-9. 2011
    ..To assess whether family history (FH) of Alzheimer disease (AD) alone influences AD biomarker abnormalities...
  11. ncbi request reprint A parametric comparison of diagnostic accuracy with three ordinal diagnostic groups
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, St Louis, MO 63110, USA
    Biom J 49:682-93. 2007
    ..Finally, we apply our proposed methodology to a real data set of 118 subjects to compare the diagnostic accuracy of early stage Alzheimer's disease (AD) from multiple neuropsychological tests...
  12. pmc Cerebrospinal fluid biomarkers and rate of cognitive decline in very mild dementia of the Alzheimer type
    Barbara J Snider
    Department of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S Euclid, St Louis, MO 63110, USA
    Arch Neurol 66:638-45. 2009
    ..Cerebrospinal fluid (CSF) levels of Abeta peptide 1-42 (Abeta 42), tau, and phosphorylated tau (ptau) are potential biomarkers of Alzheimer disease...
  13. pmc Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease
    Joseph L Price
    Department of Anatomy and Neurobiology, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO, USA
    Neurobiol Aging 30:1026-36. 2009
    ..To determine the frequency and possible cognitive effect of histological Alzheimer's disease (AD) in autopsied older nondemented individuals...
  14. pmc APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging
    John C Morris
    Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Ann Neurol 67:122-31. 2010
    ..To examine interactions of apolipoprotein E (APOE) genotype with age and with in vivo measures of preclinical Alzheimer disease (AD) in cognitively normal aging...
  15. pmc Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake
    Catherine M Roe
    Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Neurol 65:1467-71. 2008
    ..Design, Setting, and..
  16. pmc Comparison of analytical platforms for cerebrospinal fluid measures of β-amyloid 1-42, total tau, and p-tau181 for identifying Alzheimer disease amyloid plaque pathology
    Anne M Fagan
    Knight Alzheimer s Disease Research Center, St Louis, Missouri, USA
    Arch Neurol 68:1137-44. 2011
    ..Cerebrospinal fluid (CSF) biomarkers of Alzheimer disease (AD) are currently being considered for inclusion in revised diagnostic criteria for research and/or clinical purposes to increase the certainty of antemortem diagnosis...
  17. pmc Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease
    Tammie L S Benzinger
    Departments of Radiology, Biostatistics, Neurology, Pathology and Immunology, and Psychiatry, Washington University School of Medicine, St Louis, MO, 63110
    Proc Natl Acad Sci U S A 110:E4502-9. 2013
    ..Additional analyses of individuals in which longitudinal data were available suggested that an accelerated appearance of volumetric declines approximately coincides with the onset of the symptomatic phase of the disease. ..
  18. pmc Alzheimer disease family history impacts resting state functional connectivity
    Liang Wang
    Department of Neurology, Washington University in Saint Louis, Saint Louis, MO 63110, USA
    Ann Neurol 72:571-7. 2012
    ..In particular, we determined whether a family history effect is detectable in apolipoprotein E (APOE) ε4 allele noncarriers...
  19. pmc Interaction of neuritic plaques and education predicts dementia
    Catherine M Roe
    Alzheimer s Disease Research Center, Washington University School of Medicine, 4488 Forest Park Avenue, St Louis, MO 63108, USA
    Alzheimer Dis Assoc Disord 22:188-93. 2008
    ..Among individuals with Alzheimer disease neuropathology, educational attainment, as a surrogate of cognitive reserve, modifies the influence of neuritic, but not diffuse, plaque neuropathology on the expression of dementia...
  20. ncbi request reprint Predictors of preclinical Alzheimer disease and dementia: a clinicopathologic study
    James E Galvin
    Department of Neurology, Alzheimer s Disease Research Center, School of Medicine, Washington University, St Louis, MO 63108, USA
    Arch Neurol 62:758-65. 2005
    ..To understand the earliest signs of cognitive decline caused by Alzheimer disease (AD) and other illnesses causing dementia, information is needed from well-characterized individuals without dementia studied longitudinally until autopsy...
  21. pmc Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis
    Rebecca Craig-Schapiro
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 6:e18850. 2011
    ..We utilized a targeted proteomics approach to discover novel cerebrospinal fluid (CSF) biomarkers that can augment the diagnostic and prognostic accuracy of current leading CSF biomarkers (Aβ42, tau, p-tau181)...
  22. pmc Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia
    John G Csernansky
    Alzheimer s Disease Research Center and the Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 163:2164-9. 2006
    ....
  23. pmc Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data
    Andrei G Vlassenko
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63108, USA
    Ann Neurol 70:857-61. 2011
    ..0% per year). Our findings suggest that the major growth in Aβ burden occurs during a preclinical stage of Alzheimer disease (AD), prior to the onset of AD-related symptoms...
  24. pmc Education and reported onset of symptoms among individuals with Alzheimer disease
    Catherine M Roe
    Division of Biostatistics, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Arch Neurol 65:108-11. 2008
    ..To examine whether reported age at onset of dementia symptoms among participants with Alzheimer disease (AD) is later for those with fewer years of education and, if so, to see if education is attributed to delayed detection of symptoms...
  25. ncbi request reprint Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
    Arch Neurol 64:343-9. 2007
    ....
  26. pmc Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease
    Rawan Tarawneh
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 70:274-85. 2011
    ..Visinin-like protein-1 (VILIP-1) has demonstrated potential utility as a marker of neuronal injury. Here we investigate CSF VILIP-1 and VILIP-1/amyloid-β42 (Aβ42) ratio as diagnostic and prognostic markers in early AD...
  27. pmc Clinical and biomarker changes in dominantly inherited Alzheimer's disease
    Randall J Bateman
    Washington University School of Medicine, Department of Neurology, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
    N Engl J Med 367:795-804. 2012
    ..Autosomal dominant Alzheimer's disease has a predictable age at onset and provides an opportunity to determine the sequence and magnitude of pathologic changes that culminate in symptomatic disease...
  28. pmc YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease
    Rebecca Craig-Schapiro
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 68:903-12. 2010
    ..Therefore, biomarkers that detect AD pathology in its early stages and predict dementia onset and progression will be invaluable for patient care and efficient clinical trial design...
  29. ncbi request reprint White matter lesions are prevalent but differentially related with cognition in aging and early Alzheimer disease
    Jeffrey M Burns
    Department of Neurology, Washington University, St Louis, MO, USA
    Arch Neurol 62:1870-6. 2005
    ..White matter lesions (WMLs) are prevalent in nondemented aging and in Alzheimer disease (AD). Their relationship with cognition in the earliest stages of AD is unknown...
  30. ncbi request reprint Education and Alzheimer disease without dementia: support for the cognitive reserve hypothesis
    Catherine M Roe
    Division of Biostatistics, Washington University School of Medicine, 660 S Euclid Ave, Box 8067, St Louis, MO 63110, USA
    Neurology 68:223-8. 2007
    ..The cognitive reserve hypothesis suggests that at a particular level of AD pathology, highly educated individuals are less likely to manifest clinical symptoms of dementia vs less-educated individuals...
  31. pmc Quantitative label-free proteomics for discovery of biomarkers in cerebrospinal fluid: assessment of technical and inter-individual variation
    Richard J Perrin
    Division of Neuropathology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 8:e64314. 2013
    ....
  32. pmc Sleep quality and preclinical Alzheimer disease
    Yo El S Ju
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    JAMA Neurol 70:587-93. 2013
    ..Sleep and circadian problems are very common in Alzheimer disease (AD). Recent animal studies suggest a bidirectional relationship between sleep and β-amyloid (Aβ), a key molecule involved in AD pathogenesis...
  33. pmc Long-term cognitive decline in older subjects was not attributable to noncardiac surgery or major illness
    Michael S Avidan
    Cardiothoracic Anesthesiology and Cardiothoracic Intensive Care, Department of Anesthesiology, Washington University in St Louis, Missouri 63110 1093, USA
    Anesthesiology 111:964-70. 2009
    ..This study assessed whether long-term cognitive decline occurred after surgery or illness by using an innovative approach and including participants with early Alzheimer disease to overcome some limitations...
  34. ncbi request reprint Combining correlated diagnostic tests: application to neuropathologic diagnosis of Alzheimer's disease
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, Missouri 63110, USA
    Med Decis Making 24:659-69. 2004
    ....
  35. ncbi request reprint Longitudinal driving performance in early-stage dementia of the Alzheimer type
    Janet M Duchek
    Department of Psychology, Washington University School of Medicine, St Louis, Missouri 63130, USA
    J Am Geriatr Soc 51:1342-7. 2003
    ..To longitudinally assess on-road driving performance in healthy older adults and those with early-stage dementia of the Alzheimer type (DAT)...
  36. pmc Unified Parkinson's Disease Rating Scale-Motor Exam: inter-rater reliability of advanced practice nurse and neurologist assessments
    Janice L Palmer
    Saint Louis University School of Nursing, St Louis, Missouri, USA
    J Adv Nurs 66:1382-7. 2010
    ..This paper is a report of a study to establish the inter-rater reliability of advanced practice nurse and neurologist neurological assessments which included ratings with the Unified Parkinson's Disease Rating Scale-Motor Exam...
  37. ncbi request reprint Validity and reliability of the AD8 informant interview in dementia
    James E Galvin
    Departments of Neurology, Alzheimer Disease Research Center, Washington University School of Medicine, 4488 Forest Park, Suite 130, St Louis, MO 63108, USA
    Neurology 67:1942-8. 2006
    ..To establish the validity, reliability, and discriminative properties of the AD8, a brief informant interview to detect dementia, in a clinic sample...
  38. ncbi request reprint Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease
    Monique M Williams
    Department of Medicine, Alzheimer Disease Research Center, Washington University School of Medicine, 4488 Forest Park, Suite 130, St Louis, MO 63108, USA
    Neurology 67:1935-41. 2006
    ..To determine whether dementia with Lewy bodies (DLB) progresses more rapidly than Alzheimer disease (AD)...
  39. ncbi request reprint Neuropathologic criteria for diagnosing Alzheimer disease in persons with pure dementia of Alzheimer type
    Daniel W McKeel
    Dept of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neuropathol Exp Neurol 63:1028-37. 2004
    ..Thus cut-points based on both diffuse and neuritic SP in neocortical regions distinguished nondemented and AD subjects with high sensitivity and specificity...
  40. pmc Agreement on diagnosis among patients, companions, and professionals after a dementia evaluation
    Alexandra K Zaleta
    Department of Psychology, Alzheimer s Disease Research Center, Washington University, St Louis, MO 63130, USA
    Alzheimer Dis Assoc Disord 26:232-7. 2012
    ..This study documents discrepancies that can arise in diagnostic communication, which could influence adjustment to a diagnosis of dementia and decisions regarding future planning and care...
  41. ncbi request reprint A haplotype similarity based transmission/disequilibrium test under founder heterogeneity
    Kai Yu
    Division of Biostatistics, School of Medicine, Washington University, 660 S Euclid, Campus Box 8067, St Louis, MO 63110, USA
    Ann Hum Genet 69:455-67. 2005
    ..Finally, we apply the proposed method to study the association of the leptin gene with obesity from the National Heart, Lung, and Blood Institute Family Heart Study...
  42. ncbi request reprint Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia
    Xianlin Han
    Division of Bioorganic Chemistry and Molecular Pharmacology, and the Departments of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 54:115-9. 2003
    ..The cerebrospinal fluid ST to phosphatidylinositol ratio may be a very useful biomarker for the earliest clinical stage of Alzheimer's disease...
  43. doi request reprint Reaction to a dementia diagnosis in individuals with Alzheimer's disease and mild cognitive impairment
    Brian D Carpenter
    Department of Psychology, Washington University, St Louis, Missouri 63130, USA
    J Am Geriatr Soc 56:405-12. 2008
    ..To examine short-term changes in depression and anxiety after receiving a dementia diagnosis...
  44. pmc Genetic and pharmacological factors that influence reproductive aging in nematodes
    Stacie E Hughes
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 3:e25. 2007
    ..The implications of these findings for evolutionary theories of aging are discussed...
  45. ncbi request reprint A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice
    Kevin L Quick
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, United States
    Neurobiol Aging 29:117-28. 2008
    ..SOD mimetics with such characteristics may provide unique complements to genetic strategies to study the contribution of oxidative processes to nervous system aging...
  46. ncbi request reprint Global transmission/disequilibrium tests based on haplotype sharing in multiple candidate genes
    Kai Yu
    Division of Statistical Genomics, Department of Genetics Washington University, School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 29:323-35. 2005
    ..Compared with the gene-by-gene test, the new global tests appear to be more powerful in situations where all candidate genes are associated with the disease...
  47. pmc A ketogenic diet does not impair rat behavior or long-term potentiation
    Liu Lin Thio
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Epilepsia 51:1619-23. 2010
    ..KD-fed rats performed similarly to SD-fed rats on the behavioral tests and electrophysiologic assays. These data suggest that the KD does not alter behavioral performance or synaptic plasticity...
  48. pmc Mated Progeny Production Is a Biomarker of Aging in Caenorhabditis elegans
    Christopher L Pickett
    Department of Developmental, Biology Washington University School of Medicine, St Louis, Missouri 63110
    G3 (Bethesda) 3:2219-32. 2013
    ..elegans aging. These results indicate that some mechanisms or pathways control age-related degeneration of both reproductive and somatic tissues in C. elegans. ..
  49. pmc In vivo human apolipoprotein E isoform fractional turnover rates in the CNS
    Kristin R Wildsmith
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS ONE 7:e38013. 2012
    ..We also demonstrate a slower turnover rate for CSF ApoE than that for amyloid beta, another molecule critically important in AD pathogenesis...
  50. ncbi request reprint Multivariate estimation of cumulative incidence, prevalence, and morbidity time of a disease when death is likely
    Yan Yan
    Department of Surgery, Washington University Medical School, 4960 Children s Place, Box 8242, St Louis, MO 63110, USA
    J Clin Epidemiol 56:546-52. 2003
    ..Data from the Johns Hopkins Hospital AIDS service were used to illustrate this extended method. The importance of estimates was discussed in the context of planning health care needs...
  51. pmc Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans
    Cheng Huang
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:8084-9. 2004
    ..These measurements were used to generate a system of four stages that describes the aging process and is useful for the analysis of genetic and environmental effects on aging...
  52. ncbi request reprint Hypothesis testing of a change point during cognitive decline among Alzheimer's disease patients
    Ming Ji
    Division of Epidemiology and Bisotatistics, Graduate School of Public Health, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4162, USA
    J Alzheimers Dis 5:375-82. 2003
    ..Our finding supports the clinical belief of the existence of a change point during cognitive decline among AD patients and suggests the use of change point models for the longitudinal modeling of cognitive decline in AD research...
  53. ncbi request reprint High-dosage vitamin E supplementation and all-cause mortality
    Wee Shiong Lim
    Ann Intern Med 143:152; author reply 156-8. 2005
  54. pmc Childhood adversity predicts earlier onset of major depression but not reduced hippocampal volume
    Shannon N Lenze
    Department of Psychology, University of Pittsburgh, 3rd Floor Sennott Square, Pittsburgh, PA 15260, USA
    Psychiatry Res 162:39-49. 2008
    ..Further research is needed to more fully understand the interrelationships among childhood adversity, hippocampal morphology, neuroendocrine regulation, and other genetic and environmental factors influencing vulnerability to depression...
  55. ncbi request reprint Gender differences in free radical homeostasis during aging: shorter-lived female C57BL6 mice have increased oxidative stress
    Sameh S Ali
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Aging Cell 5:565-74. 2006
    ..Our results indicate that differences in ROS homeostasis contribute to gender divergence in survival, but also suggest that mitochondrial superoxide production may not be primarily responsible for gender differences in lifespan...

Research Grants2

  1. Statistics in Alzheimer's Publications
    Chengjie Xiong; Fiscal Year: 2007
    ..abstract_text> ..
  2. TWO PRECLINICAL LATENT SCORES TO PREDICT OCCURRENCE OF DAT
    Chengjie Xiong; Fiscal Year: 2010
    ..The knowledge obtained will greatly help develop early therapeutic treatments or preventions of the disease before it is too late. ..