H Xian

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Heritability of SF-36 among middle-age, middle-class, male-male twins
    James C Romeis
    Comparative Aging and Health Status Laboratory, Department of Health Management and Policy, School of Public Health, Saint Louis University, St Louis, MO 63104 1314, USA
    Med Care 43:1147-54. 2005
  2. ncbi Genetic and environmental influences on posttraumatic stress disorder, alcohol and drug dependence in twin pairs
    H Xian
    Department of Internal Medicine, Division of General Medical Sciences, Washington University School of Medicine, St Louis, MO, USA
    Drug Alcohol Depend 61:95-102. 2000
  3. ncbi Self-Reported zygosity and the equal-environments assumption for psychiatric disorders in the Vietnam Era Twin Registry
    H Xian
    Research Service, St Louis Veterans Affairs Medical Center, Missouri 63106, USA
    Behav Genet 30:303-10. 2000
  4. ncbi Contribution of parental psychopathology to offspring smoking and nicotine dependence in a genetically informative design
    Hong Xian
    Research Service 151JC, St Louis Veterans Affairs Medical Center, 915 North Grand Boulevard, St Louis, Missouri 63106, USA
    J Stud Alcohol Drugs 71:664-73. 2010
  5. ncbi Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam era twin study of aging
    Hong Xian
    Research Service, St Louis Veterans Affairs Medical Center, St Louis, Missouri 63103, USA
    Psychosom Med 72:370-5. 2010
  6. ncbi Nicotine dependence subtypes: association with smoking history, diagnostic criteria and psychiatric disorders in 5440 regular smokers from the Vietnam Era Twin Registry
    Hong Xian
    Research Service, St Louis Veterans Affairs Medical Center, 915 North Grand Boulevard, St Louis, MO 63106, USA
    Addict Behav 32:137-47. 2007
  7. ncbi Latent class typology of nicotine withdrawal: genetic contributions and association with failed smoking cessation and psychiatric disorders
    Hong Xian
    Department of Internal Medicine, Division of General Medical Sciences, Washington University School of Medicine, St Louis, MO, USA
    Psychol Med 35:409-19. 2005
  8. ncbi Common genetic vulnerability for nicotine and alcohol dependence in men
    W R True
    School of Public Health, St Louis University Health Sciences Center, MO, USA
    Arch Gen Psychiatry 56:655-61. 1999
  9. ncbi A twin study of generalized anxiety disorder symptoms, panic disorder symptoms and post-traumatic stress disorder in men
    S I Chantarujikapong
    Research Service 151-JC, St. Louis VAMC, 915 North Grand Blvd, St. Louis, MO 63106, USA
    Psychiatry Res 103:133-45. 2001
  10. ncbi Association between exposure to childhood and lifetime traumatic events and lifetime pathological gambling in a twin cohort
    Jeffrey F Scherrer
    Department of Psychiatry, Washington University School of Medicine, and Research Service, St Louis Veterans Affairs Medical Center, St Louis, Missouri 63110, USA
    J Nerv Ment Dis 195:72-8. 2007

Research Grants

  1. Environmental Risks for Smoking: A Genetically Informed Children of Twins Design
    Hong Xian; Fiscal Year: 2009

Detail Information

Publications39

  1. ncbi Heritability of SF-36 among middle-age, middle-class, male-male twins
    James C Romeis
    Comparative Aging and Health Status Laboratory, Department of Health Management and Policy, School of Public Health, Saint Louis University, St Louis, MO 63104 1314, USA
    Med Care 43:1147-54. 2005
    ....
  2. ncbi Genetic and environmental influences on posttraumatic stress disorder, alcohol and drug dependence in twin pairs
    H Xian
    Department of Internal Medicine, Division of General Medical Sciences, Washington University School of Medicine, St Louis, MO, USA
    Drug Alcohol Depend 61:95-102. 2000
    ..These results suggest that PTSD, AD and DD each have etiologically distinct components and also have significant genetic and unique environmental contributions in common...
  3. ncbi Self-Reported zygosity and the equal-environments assumption for psychiatric disorders in the Vietnam Era Twin Registry
    H Xian
    Research Service, St Louis Veterans Affairs Medical Center, Missouri 63106, USA
    Behav Genet 30:303-10. 2000
    ..These results support the usefulness of perceived zygosity in tests of the EEA. In male twin pairs, perceived zygosity has little impact on twin similarity for common psychiatric disorders...
  4. ncbi Contribution of parental psychopathology to offspring smoking and nicotine dependence in a genetically informative design
    Hong Xian
    Research Service 151JC, St Louis Veterans Affairs Medical Center, 915 North Grand Boulevard, St Louis, Missouri 63106, USA
    J Stud Alcohol Drugs 71:664-73. 2010
    ....
  5. ncbi Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam era twin study of aging
    Hong Xian
    Research Service, St Louis Veterans Affairs Medical Center, St Louis, Missouri 63103, USA
    Psychosom Med 72:370-5. 2010
    ..To determine if depression contributes to incident heart disease after accounting for genetic, behavioral, and medical factors associated with both conditions...
  6. ncbi Nicotine dependence subtypes: association with smoking history, diagnostic criteria and psychiatric disorders in 5440 regular smokers from the Vietnam Era Twin Registry
    Hong Xian
    Research Service, St Louis Veterans Affairs Medical Center, 915 North Grand Boulevard, St Louis, MO 63106, USA
    Addict Behav 32:137-47. 2007
    ..Empirically derived subtypes of nicotine dependence are mostly characterized by increasing severity. Suggestions for refinement of nicotine dependence diagnostic criteria are discussed...
  7. ncbi Latent class typology of nicotine withdrawal: genetic contributions and association with failed smoking cessation and psychiatric disorders
    Hong Xian
    Department of Internal Medicine, Division of General Medical Sciences, Washington University School of Medicine, St Louis, MO, USA
    Psychol Med 35:409-19. 2005
    ..However, relatively little is known about how to characterize the severity of withdrawal, including whether withdrawal subtypes exist in male smokers. If so, do these subtypes represent quantitative or qualitative differences?..
  8. ncbi Common genetic vulnerability for nicotine and alcohol dependence in men
    W R True
    School of Public Health, St Louis University Health Sciences Center, MO, USA
    Arch Gen Psychiatry 56:655-61. 1999
    ..We examined data from male twin pairs to determine whether there are genetic or environmental influences common to nicotine and alcohol dependence, and, if so, to estimate the magnitude and correlation of these influences...
  9. ncbi A twin study of generalized anxiety disorder symptoms, panic disorder symptoms and post-traumatic stress disorder in men
    S I Chantarujikapong
    Research Service 151-JC, St. Louis VAMC, 915 North Grand Blvd, St. Louis, MO 63106, USA
    Psychiatry Res 103:133-45. 2001
    ..These results suggest that these disorders each have etiologically distinct components and also have significant genetic and unique environmental contributions in common...
  10. ncbi Association between exposure to childhood and lifetime traumatic events and lifetime pathological gambling in a twin cohort
    Jeffrey F Scherrer
    Department of Psychiatry, Washington University School of Medicine, and Research Service, St Louis Veterans Affairs Medical Center, St Louis, Missouri 63110, USA
    J Nerv Ment Dis 195:72-8. 2007
    ..These associations are partially accounted for by psychiatric covariates and genetic and family environmental factors...
  11. ncbi The genetics of pathological gambling
    S A Eisen
    Medical and Research Services, St Louis Department of Veterans Affairs Medical Center, St Louis, MO 63106, USA
    Semin Clin Neuropsychiatry 6:195-204. 2001
    ..Neurophysiological correlates of gambling problems and genetically based differences in neurotransmitter systems may provide biological mechanisms that explain the genetic basis for a predisposition to PG...
  12. ncbi Genetic and environmental contributions to nicotine, alcohol and cannabis dependence in male twins
    Hong Xian
    Research Service, St Louis Veterans Affairs Medical Center VAMC, St Louis, MO 63106, USA
    Addiction 103:1391-8. 2008
    ..To compute the common and specific genetic and environmental contributions to nicotine dependence (ND) alcohol dependence (AD) and cannabis dependence (CD)...
  13. ncbi Genetic studies of pathological gambling: a review of methodology and analyses of data from the Vietnam Era Twin Registry
    Kamini R Shah
    St Louis Veterans Affairs Medical Center, Washington University School of Medicine, 915 North Grand Boulevard, St Louis, MO 63106, USA
    J Gambl Stud 21:179-203. 2005
    ....
  14. ncbi The heritability of failed smoking cessation and nicotine withdrawal in twins who smoked and attempted to quit
    Hong Xian
    Research Service, St Louis, MO 63106, USA
    Nicotine Tob Res 5:245-54. 2003
    ..The risk of experiencing nicotine withdrawal after a quit attempt was related partly to genetic vulnerability; lifetime risk for both failed cessation and nicotine withdrawal was related partly to genetic factors that were correlated...
  15. ncbi Rate of kidney function decline associates with mortality
    Ziyad Al-Aly
    Division of Nephrology, Saint Louis Veterans Affairs Medical Center, St Louis, MO 63106, USA
    J Am Soc Nephrol 21:1961-9. 2010
    ..Incorporating the rate of decline into the definition of CKD may transform a static definition into a dynamic one that more accurately describes the potential consequences of the disease for an individual...
  16. ncbi Psychiatric and familial predictors of transition times between smoking stages: results from an offspring-of-twins study
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addict Behav 33:235-51. 2008
    ..Findings characterize a rarely examined aspect of the course of ND development and highlight critical distinctions in risk profiles across stages of tobacco involvement...
  17. ncbi Posttraumatic stress disorder; combat exposure; and nicotine dependence, alcohol dependence, and major depression in male twins
    Jeffrey F Scherrer
    St Louis Veterans Affairs Medical Center, Research Service, St Louis, MO 63106, USA
    Compr Psychiatry 49:297-304. 2008
    ..These findings suggest comorbid PTSD may represent a genetically mediated vulnerability to psychopathology after trauma...
  18. ncbi The effects of maternal smoking during pregnancy on offspring outcomes
    Arpana Agrawal
    Washington University School of Medicine, Dept of Psychiatry, Saint Louis, MO 63110, USA
    Prev Med 50:13-8. 2010
    ....
  19. ncbi Association of cognitive distortions with problem and pathological gambling in adult male twins
    Hong Xian
    Research Service, St Louis Veterans Affairs Medical Center, 915 North Grand Boulevard, St Louis, MO 63106, United States
    Psychiatry Res 160:300-7. 2008
    ..Public health messages and therapeutic interventions that reinforce the randomness of gambling and draw attention to distorted thinking may prevent the development of problem gambling and improve treatment outcomes...
  20. ncbi Herpes zoster risk factors in a national cohort of veterans with rheumatoid arthritis
    Jay R McDonald
    St Louis Veterans Affairs Medical Center, St Louis, Missouri 63106, USA
    Clin Infect Dis 48:1364-71. 2009
    ..Herpes zoster occurs more commonly in patients taking immunosuppressive medications, although the risk associated with different medications is poorly understood...
  21. ncbi Does marijuana use have residual adverse effects on self-reported health measures, socio-demographics and quality of life? A monozygotic co-twin control study in men
    Seth A Eisen
    Research and Medical Service, St Louis VAMC and Department of Internal Medicine, Washington University School of Medicine, St Louis 63106, USA
    Addiction 97:1137-44. 2002
    ..To assess the effects of former heavy marijuana use on selected aspects of health...
  22. ncbi Factors associated with pathological gambling at 10-year follow-up in a national sample of middle-aged men
    Jeffrey F Scherrer
    Research Service, Veterans Affairs Medical Center, St Louis, MO 63106, USA
    Addiction 102:970-8. 2007
    ..Co-twin analyses accounted for familial contributions to past-year gambling problems...
  23. ncbi Depression increases risk of incident myocardial infarction among Veterans Administration patients with rheumatoid arthritis
    Jeffrey F Scherrer
    Research Service, St Louis Veterans Affairs Medical Center, St Louis, MO 63106, USA
    Gen Hosp Psychiatry 31:353-9. 2009
    ..This study evaluates whether depression is a risk factor for incident myocardial infarction (MI) in Department of Veterans Affairs (VA) patients with rheumatoid arthritis (RA) between 30 and 79 years of age...
  24. ncbi Effect of genes, environment, and lifetime co-occurring disorders on health-related quality of life in problem and pathological gamblers
    Jeffrey F Scherrer
    Research Service, St Louis Veterans Affairs Medical Center, St Louis, Missouri 63106, USA
    Arch Gen Psychiatry 62:677-83. 2005
    ..Although these consequences and correlates have been reported, little is known about the health-related functional impairment associated with gambling...
  25. ncbi Course of pathological gambling symptoms and reliability of the Lifetime Gambling History measure
    Carolyn E Sartor
    Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, United States
    Psychiatry Res 152:55-61. 2007
    ..Evidence is also provided for the utility of the LGH in assessing lifetime pathological gambling symptoms...
  26. ncbi Initial response to cigarettes predicts rate of progression to regular smoking: findings from an offspring-of-twins design
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, Saint Louis, Missouri 63110, USA
    Addict Behav 35:771-8. 2010
    ..exclusively negative (physiological) responses suggests the importance of considering both dimensions in combination to characterize risk for smoking-related outcomes...
  27. ncbi Genetic and environmental contributions to pathological gambling symptoms in a 10-year follow-up
    Hong Xian
    Research Service, St Louis Veterans Affairs Medical Center, St Louis, Missouri 63106, USA
    Twin Res Hum Genet 10:174-9. 2007
    ..This may reflect the changed social-cultural environment between 1992 and 2002, characterized by increasing access to legalized gambling...
  28. ncbi Lifetime and 12-month prevalence of psychiatric disorders in 8,169 male Vietnam War era veterans
    Seth A Eisen
    Research and Medical Service, Department of Veteran Affairs Medical Center, St. Louis, MO 63106, USA
    Mil Med 169:896-902. 2004
    ....
  29. ncbi Arm exercise testing predicts clinical outcome
    Nasreen A Ilias
    Department of Internal Medicine, Washington University School of Medicine, St Louis Veterans Administration Medical Center, St Louis, MO 63106, USA
    Am Heart J 157:69-76. 2009
    ....
  30. ncbi A twin study of smoking, nicotine dependence, and major depression in men
    Michael Lyons
    Department of Psychology, Boston University, Boston, MA 02215, USA
    Nicotine Tob Res 10:97-108. 2008
    ..Findings extend Kendler and colleague's (1993) study of female twins by demonstrating in men that shared genetic factors predispose not only to major depression and daily smoking but also to major depression and nicotine dependence...
  31. ncbi A twin study of the neuropsychological consequences of stimulant abuse
    Rosemary Toomey
    Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, 02129, USA
    Arch Gen Psychiatry 60:303-10. 2003
    ..Previous studies document neuropsychological deficits associated with stimulant abuse, but findings are inconsistent...
  32. ncbi Genetics of body mass stability and risk for chronic disease: a 28-year longitudinal study
    Carol E Franz
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093, United States of America
    Twin Res Hum Genet 10:537-45. 2007
    ..Our results also provide prospective evidence that early excess BMI may have serious long-term health consequences, and that this risk is not limited to minorities or adults of lower socioeconomic status...
  33. ncbi A twin study of depression symptoms, hypertension, and heart disease in middle-aged men
    Jeffrey F Scherrer
    School of Public Health, St Louis University Health Sciences Center, Missouri, USA
    Psychosom Med 65:548-57. 2003
    ..We utilized a twin design to test whether there are common genetic and environmental risk factors underlying depression symptoms, hypertension and heart disease...
  34. ncbi Shared genetic contributions to pathological gambling and major depression in men
    Marc N Potenza
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06519, USA
    Arch Gen Psychiatry 62:1015-21. 2005
    ..Although pathological gambling (PG) and major depression (MD) frequently co-occur, little is known regarding the relative contributions of environmental and genetic factors to the codevelopment of the disorders...
  35. ncbi Storage and executive components of working memory: integrating cognitive psychology and behavior genetics in the study of aging
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA
    J Gerontol B Psychol Sci Soc Sci 63:P84-91. 2008
    ..We discuss the findings in the context of research suggesting that new genetic influences come into play if demand continues to increase beyond a certain threshold, a threshold that may change with task difficulty and with age...
  36. ncbi Genetics of verbal working memory processes: a twin study of middle-aged men
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, CA 92093 0738, USA
    Neuropsychology 21:569-80. 2007
    ..The genetic influences that were specific to reading span were concluded to most likely reflect an executive function component. Implications for genetic studies of aging and prefrontal brain function are discussed...
  37. ncbi A discordant twin study of premorbid cognitive ability in schizophrenia
    William S Kremen
    Institute of Behavioral Genomics, Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093 0603, USA
    J Clin Exp Neuropsychol 28:208-24. 2006
    ..Educational advancement may be slightly slowed by this familial vulnerability, but results were equivocal with regard to attenuation of one's ultimate educational attainment...
  38. ncbi Heritability of word recognition in middle-aged men varies as a function of parental education
    William S Kremen
    Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0603, USA
    Behav Genet 35:417-33. 2005
    ..Our results suggest that shared environmental factors in families with low parental education have long-lasting effects on word recognition ability, well beyond any critical period for developing reading proficiency...
  39. ncbi Stability, consistency, and heritability of electrodermal response lability in middle-aged male twins
    Andrew Crider
    Department of Psychology, Williams College, Williamstown, Massachusetts, USA
    Psychophysiology 41:501-9. 2004
    ..We discuss these findings in terms of an information processing account of individual differences in phasic EDR activation...

Research Grants2

  1. Environmental Risks for Smoking: A Genetically Informed Children of Twins Design
    Hong Xian; Fiscal Year: 2009
    ..The strengths of the application are the availability of smoking, psychiatric data & environmental constructs that have been previously collected from twins, offspring & mothers. ..