Younan Xia

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Shape-controlled synthesis of metal nanocrystals: simple chemistry meets complex physics?
    Younan Xia
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130 4899, USA
    Angew Chem Int Ed Engl 48:60-103. 2009
  2. pmc Neurite outgrowth on nanofiber scaffolds with different orders, structures, and surface properties
    Jingwei Xie
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    ACS Nano 3:1151-9. 2009
  3. pmc Gold nanocages covered by smart polymers for controlled release with near-infrared light
    Mustafa S Yavuz
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nat Mater 8:935-9. 2009
  4. doi request reprint An enzyme-sensitive probe for photoacoustic imaging and fluorescence detection of protease activity
    Xiaohu Xia
    Department of Biomedical Engineering, Washington University in St Louis, MO 63130, USA
    Nanoscale 3:950-3. 2011
  5. doi request reprint Nanomaterials at work in biomedical research
    Younan Xia
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nat Mater 7:758-60. 2008
  6. pmc Gold nanocages: from synthesis to theranostic applications
    Younan Xia
    Department of Biomedical Engineering, Washington University, Saint Louis, Missouri 63130, USA
    Acc Chem Res 44:914-24. 2011
  7. pmc Quantifying the coverage density of poly(ethylene glycol) chains on the surface of gold nanostructures
    Xiaohu Xia
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    ACS Nano 6:512-22. 2012
  8. doi request reprint Synthesis of Pd-Pt bimetallic nanocrystals with a concave structure through a bromide-induced galvanic replacement reaction
    Hui Zhang
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, United States
    J Am Chem Soc 133:6078-89. 2011
  9. doi request reprint Facile synthesis of Pd-Pt alloy nanocages and their enhanced performance for preferential oxidation of CO in excess hydrogen
    Hui Zhang
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, United States
    ACS Nano 5:8212-22. 2011
  10. pmc Production of Ag nanocubes on a scale of 0.1 g per batch by protecting the NaHS-mediated polyol synthesis with argon
    Qiang Zhang
    Departments of Biomedical Engineering and of Chemistry, Washington University, St Louis, Missouri 63130, USA
    ACS Appl Mater Interfaces 1:2044-8. 2009

Collaborators

Detail Information

Publications117 found, 100 shown here

  1. pmc Shape-controlled synthesis of metal nanocrystals: simple chemistry meets complex physics?
    Younan Xia
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130 4899, USA
    Angew Chem Int Ed Engl 48:60-103. 2009
    ..We conclude this article with personal perspectives on the directions toward which future research in this field might take...
  2. pmc Neurite outgrowth on nanofiber scaffolds with different orders, structures, and surface properties
    Jingwei Xie
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    ACS Nano 3:1151-9. 2009
    ....
  3. pmc Gold nanocages covered by smart polymers for controlled release with near-infrared light
    Mustafa S Yavuz
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nat Mater 8:935-9. 2009
    ..This system works well with various effectors without involving sophisticated syntheses, and is well suited for in vivo studies owing to the high transparency of soft tissue in the near-infrared region...
  4. doi request reprint An enzyme-sensitive probe for photoacoustic imaging and fluorescence detection of protease activity
    Xiaohu Xia
    Department of Biomedical Engineering, Washington University in St Louis, MO 63130, USA
    Nanoscale 3:950-3. 2011
    ..These hybrids can be potentially used as multimodal contrast agents for molecular imaging...
  5. doi request reprint Nanomaterials at work in biomedical research
    Younan Xia
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nat Mater 7:758-60. 2008
    ..With some nanomaterial-based medicines having entered the marketplace, and more on the verge of doing so, nanomedicine is expected to become an exciting playground for chemists and material scientists...
  6. pmc Gold nanocages: from synthesis to theranostic applications
    Younan Xia
    Department of Biomedical Engineering, Washington University, Saint Louis, Missouri 63130, USA
    Acc Chem Res 44:914-24. 2011
    ..Finally, Au nanocages can serve as drug delivery vehicles for controlled and localized release in response to external stimuli such as NIR radiation or high-intensity focused ultrasound (HIFU)...
  7. pmc Quantifying the coverage density of poly(ethylene glycol) chains on the surface of gold nanostructures
    Xiaohu Xia
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    ACS Nano 6:512-22. 2012
    ....
  8. doi request reprint Synthesis of Pd-Pt bimetallic nanocrystals with a concave structure through a bromide-induced galvanic replacement reaction
    Hui Zhang
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, United States
    J Am Chem Soc 133:6078-89. 2011
    ..Significantly, the sample with a 3.4 wt.% of Pt exhibited the largest specific electrochemical surface area and was found to be four times as active as the commercial Pt/C catalyst for the ORR in terms of equivalent Pt mass...
  9. doi request reprint Facile synthesis of Pd-Pt alloy nanocages and their enhanced performance for preferential oxidation of CO in excess hydrogen
    Hui Zhang
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, United States
    ACS Nano 5:8212-22. 2011
    ..In addition, as the sizes of the Pd-Pt nanocages decreased, they exhibited higher CO conversion rates and lower maximum conversion temperatures due to the increase in specific surface area...
  10. pmc Production of Ag nanocubes on a scale of 0.1 g per batch by protecting the NaHS-mediated polyol synthesis with argon
    Qiang Zhang
    Departments of Biomedical Engineering and of Chemistry, Washington University, St Louis, Missouri 63130, USA
    ACS Appl Mater Interfaces 1:2044-8. 2009
    ..The use of argon protection was the key to the success of this scale-up synthesis, suggesting the importance of controlling oxidative etching during synthesis...
  11. pmc Dimers of silver nanospheres: facile synthesis and their use as hot spots for surface-enhanced Raman scattering
    Weiyang Li
    Department of Biomedical Engineering, Washington University, Saint Louis, Missouri 63130
    Nano Lett 9:485-90. 2009
    ..By correlating SERS measurements with SEM imaging, we found that the SERS enhancement factor within the hot spot region of such a dimer was on the order of 2 x 10(7)...
  12. doi request reprint Controlling the morphology of rhodium nanocrystals by manipulating the growth kinetics with a syringe pump
    Hui Zhang
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nano Lett 11:898-903. 2011
    ..The concave nanocubes with {110} facets and a unique cavity structure on the surface are important for a variety of applications...
  13. pmc Investigation of neovascularization in three-dimensional porous scaffolds in vivo by a combination of multiscale photoacoustic microscopy and optical coherence tomography
    Xin Cai
    Department of Biomedical Engineering, Washington University in St Louis, Missouri, USA
    Tissue Eng Part C Methods 19:196-204. 2013
    ..80 μm) of a scaffold on neovascularization. The data collected from PAM were consistent with those obtained from traditional invasive, labor-intensive histologic analyses...
  14. pmc Enhancing the stiffness of electrospun nanofiber scaffolds with a controlled surface coating and mineralization
    Wenying Liu
    Department of Energy, Environmental and Chemical Engineering, Washington University, St Louis, Missouri, USA
    Langmuir 27:9088-93. 2011
    ..A combination of the nanoscale fibrous structure and bonelike mineral coating could mimic the structure, composition, and function of mineralized tissues...
  15. doi request reprint Electrocatalytic properties of Pt nanowires supported on Pt and W gauzes
    Eric P Lee
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    ACS Nano 2:2167-73. 2008
    ..This was due partially to the incomplete removal of poly(vinyl pyrrolidone) (PVP) from the more concentrated sample. In contrast, the Pt nanowires supported on W gauze performed the worst...
  16. pmc In vivo molecular photoacoustic tomography of melanomas targeted by bioconjugated gold nanocages
    Chulhong Kim
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    ACS Nano 4:4559-64. 2010
    ..The in vivo PAT quantification of the amount of AuNCs accumulated in melanomas was further validated with inductively coupled plasma mass spectrometry (ICP-MS)...
  17. doi request reprint A comparison study of the catalytic properties of Au-based nanocages, nanoboxes, and nanoparticles
    Jie Zeng
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nano Lett 10:30-5. 2010
    ..In addition, a compensation effect was observed in this Au-based catalytic system, which can be primarily interpreted by a model based on kinetic regime switching...
  18. ncbi request reprint Kinetically controlled overgrowth of Ag or Au on Pd nanocrystal seeds: from hybrid dimers to nonconcentric and concentric bimetallic nanocrystals
    Cun Zhu
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, United States
    J Am Chem Soc 134:15822-31. 2012
    ..We believe this work will provide a promising route to the fabrication of bimetallic nanocrystals with novel structures and properties for applications in plasmonics, catalysis, and other areas...
  19. doi request reprint Copper can still be epitaxially deposited on palladium nanocrystals to generate core-shell nanocubes despite their large lattice mismatch
    Mingshang Jin
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    ACS Nano 6:2566-73. 2012
    ..The edge lengths of the Pd@Cu nanocubes could be tuned from 50 to 100 nm by varying the amount of Pd seeds while keeping the amount of CuCl(2) precursor...
  20. doi request reprint Seed-mediated synthesis of gold octahedra in high purity and with well-controlled sizes and optical properties
    Do Youb Kim
    Department of Biomedical Engineering, Washington University, Saint Louis, MO 63130, USA
    Chemistry 17:4759-64. 2011
    ..We have also investigated the effects of water and poly(vinyl pyrrolidone) (PVP) in the system, as well as the reaction temperature, on the evolution of octahedral shape...
  21. pmc A new theranostic system based on gold nanocages and phase-change materials with unique features for photoacoustic imaging and controlled release
    Geon Dae Moon
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    J Am Chem Soc 133:4762-5. 2011
    ..We can control the release profile by varying the power of HIFU, the duration of exposure to HIFU, or both...
  22. pmc Au@Ag core-shell nanocubes with finely tuned and well-controlled sizes, shell thicknesses, and optical properties
    Yanyun Ma
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, United States
    ACS Nano 4:6725-34. 2010
    ..Moreover, these Au@Ag core-shell nanocubes could be converted into Au-based hollow nanostructures containing the original Au seeds in the interiors through a galvanic replacement reaction...
  23. pmc Seed-mediated synthesis of Ag nanocubes with controllable edge lengths in the range of 30-200 nm and comparison of their optical properties
    Qiang Zhang
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    J Am Chem Soc 132:11372-8. 2010
    ..For the first time, we could obtain Ag nanocubes with uniform edge lengths controllable in the range of 30-200 nm and then compare their localized surface plasmon resonance and surface-enhanced Raman scattering properties...
  24. doi request reprint Pd-Pt bimetallic nanodendrites with high activity for oxygen reduction
    Byungkwon Lim
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Science 324:1302-5. 2009
    ..The Pd-Pt nanodendrites were two and a half times more active on the basis of equivalent Pt mass for the ORR than the state-of-the-art Pt/C catalyst and five times more active than the first-generation supportless Pt-black catalyst...
  25. pmc Chronic label-free volumetric photoacoustic microscopy of melanoma cells in three-dimensional porous scaffolds
    Yu Zhang
    Department of Biomedical Engineering, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    Biomaterials 31:8651-8. 2010
    ..The cell proliferation profile obtained from PAM correlated well with what was obtained using the traditional 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
  26. doi request reprint Synthesis of Pd-Au bimetallic nanocrystals via controlled overgrowth
    Byungkwon Lim
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    J Am Chem Soc 132:2506-7. 2010
    ..Through this morphological control, we were able to tune the localized surface plasmon resonance peaks of Pd-Au bimetallic nanostructures in the visible region...
  27. pmc "Aligned-to-random" nanofiber scaffolds for mimicking the structure of the tendon-to-bone insertion site
    Jingwei Xie
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nanoscale 2:923-6. 2010
    ..Tendon fibroblasts cultured on such a scaffold exhibited highly organized and haphazardly oriented morphologies, respectively, on the aligned and random portions...
  28. pmc Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment
    Yucai Wang
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, United States
    ACS Nano 7:2068-77. 2013
    ..Combined together, we can conclude that Au nanohexapods are promising candidates for cancer theranostics in terms of both photothermal destruction and contrast-enhanced diagnosis...
  29. pmc Quantitative analysis of the role played by poly(vinylpyrrolidone) in seed-mediated growth of Ag nanocrystals
    Xiaohu Xia
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    J Am Chem Soc 134:1793-801. 2012
    ..These values dropped slightly to 100 and 20 repeating units per nm(2), respectively, when 100 nm Ag cubes were used as the seeds...
  30. doi request reprint Gold nanocages as contrast agents for photoacoustic imaging
    Weiyang Li
    Department of Biomedical Engineering, Washington University in St Louis, MO 63130, USA
    Contrast Media Mol Imaging 6:370-7. 2011
    ..This review discusses the application of gold nanocages as a new class of contrast agents for PA imaging in the context of cancer diagnosis...
  31. doi request reprint Understanding the role of surface charges in cellular adsorption versus internalization by selectively removing gold nanoparticles on the cell surface with a I2/KI etchant
    Eun Chul Cho
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nano Lett 9:1080-4. 2009
    ..In addition, by fitting the uptake data with a kinetic model, we were able to derive the overall and internalization rate constants for Au nanospheres and both of them were found to be governed by the surface charges on Au nanospheres...
  32. ncbi request reprint Facile synthesis of gold octahedra by direct reduction of HAuCl4 in an aqueous solution
    Weiyang Li
    Department of Biomedical Engineering, Washington University, Saint Louis, Missouri 63130, USA
    Chem Asian J 5:1312-6. 2010
    ..Our mechanistic study indicates that the formation of Au octahedra could be explained by oxidative etching, a pathway that has already been validated for the synthesis of nanocrystals for a number of different noble metals...
  33. doi request reprint Metal-polymer hybrid colloidal particles with an eccentric structure
    Akira Ohnuma
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Langmuir 25:13880-7. 2009
    ..Because of the simplicity of this procedure, it should be possible to use it for the large-scale production of colloidal particles having a hybrid, complex structure...
  34. doi request reprint Ultrathin gold nanowires can be obtained by reducing polymeric strands of oleylamine-AuCl complexes formed via aurophilic interaction
    Xianmao Lu
    Department of Biomedical Engineering, Washington University, Saint Louis, Missouri 63130, USA
    J Am Chem Soc 130:8900-1. 2008
    ..Using this method, we were able to produce Au nanowires with an average diameter of approximately 1.8 nm and an aspect ratio of >1000 in high yields (approximately 70%)...
  35. ncbi request reprint Facile synthesis of gold nanorice enclosed by high-index facets and its application for CO oxidation
    Yiqun Zheng
    Department of Chemistry, Washington University, St Louis, Missouri 63130, USA
    Small 7:2307-12. 2011
    ..The nanorice shows much higher catalytic activity for CO oxidation than multiply twinned particles of Au enclosed by {111} facets at temperatures below 300 °C. ..
  36. pmc Surface-enhanced Raman scattering: comparison of three different molecules on single-crystal nanocubes and nanospheres of silver
    Matthew Rycenga
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    J Phys Chem A 113:3932-9. 2009
    ..Through analysis of SERS bands, we concluded that sharp features on the Ag nanocubes could greatly increase the contribution of the chemical enhancement to the SERS intensity...
  37. doi request reprint Nanocrystals composed of alternating shells of Pd and Pt can be obtained by sequentially adding different precursors
    Hui Zhang
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    J Am Chem Soc 133:10422-5. 2011
    ....
  38. pmc The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles
    Eun Chul Cho
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nat Nanotechnol 6:385-91. 2011
    ..Our results suggest that sedimentation needs to be considered when performing in vitro studies for large and/or heavy nanoparticles...
  39. doi request reprint Controlling the shapes of silver nanocrystals with different capping agents
    Jie Zeng
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    J Am Chem Soc 132:8552-3. 2010
    ....
  40. pmc Quantifying the cellular uptake of antibody-conjugated Au nanocages by two-photon microscopy and inductively coupled plasma mass spectrometry
    Leslie Au
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    ACS Nano 4:35-42. 2010
    ..The cellular uptake process was dependent on a number of parameters, including incubation time, incubation temperature, size of the Au nanocages, and the number of antibodies immobilized on each nanocage...
  41. pmc Facile synthesis of Ag nanocubes of 30 to 70 nm in edge length with CF(3)COOAg as a precursor
    Qiang Zhang
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Chemistry 16:10234-9. 2010
    ....
  42. ncbi request reprint Thiol-induced assembly of Au nanoparticles into chainlike structures and their fixing by encapsulation in silica shells or gelatin microspheres
    Eun Chul Cho
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Langmuir 26:10005-12. 2010
    ..After fixing, the chainlike assemblies of Au NPs could be preserved for a long period of time, during which their characteristic optical properties remained unchanged...
  43. pmc In vitro mineralization by preosteoblasts in poly(DL-lactide-co-glycolide) inverse opal scaffolds reinforced with hydroxyapatite nanoparticles
    Sung Wook Choi
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Langmuir 26:12126-31. 2010
    ..The Ap-coated PLGA/HAp scaffold with uniform pore structure could be a promising material for bone tissue engineering...
  44. doi request reprint Selective sulfuration at the corner sites of a silver nanocrystal and its use in stabilization of the shape
    Jie Zeng
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, United States
    Nano Lett 11:3010-5. 2011
    ....
  45. doi request reprint Facile synthesis of highly faceted multioctahedral Pt nanocrystals through controlled overgrowth
    Byungkwon Lim
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nano Lett 8:4043-7. 2008
    ..These multioctahedral Pt nanocrystals were tested as electrocatalysts for the oxygen reduction reaction in a proton exchange membrane fuel cell and exhibited improved specific activity and durability compared to commercial Pt/C catalyst...
  46. doi request reprint Chemical synthesis of novel plasmonic nanoparticles
    Xianmao Lu
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Annu Rev Phys Chem 60:167-92. 2009
    ..We conclude by highlighting a few fundamental studies and applications enabled by plasmonic nanoparticles having well-defined and controllable shapes...
  47. doi request reprint Gold nanostructures: a class of multifunctional materials for biomedical applications
    Claire M Cobley
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Chem Soc Rev 40:44-56. 2011
    ....
  48. doi request reprint Probing the surface-enhanced Raman scattering properties of Au-Ag nanocages at two different excitation wavelengths
    Matthew Rycenga
    Department of Biomedical Engineering, Washington University, St Louis, Missouri, USA
    Phys Chem Chem Phys 11:5903-8. 2009
    ....
  49. pmc Neovascularization in biodegradable inverse opal scaffolds with uniform and precisely controlled pore sizes
    Sung Wook Choi
    Department of Biomedical Engineering, Washington University, St Louis, MS, USA
    Adv Healthc Mater 2:145-54. 2013
    ..Based on the different patterns of vessel ingrowth as regulated by the pore size, a model is proposed to describe vascularization in a 3D porous scaffold, which can potentially serve as a guideline for future design of porous scaffolds...
  50. pmc Electrospun nanofibers for regenerative medicine
    Wenying Liu
    Department of Energy, Environmental and Chemical Engineering, Washington University in St Louis, St Louis, MO 63130, USA
    Adv Healthc Mater 1:10-25. 2012
    ..The Progress Report concludes with perspectives on challenges and future directions for design, fabrication, and utilization of scaffolds based on electrospun nanofibers...
  51. doi request reprint Synthesis of Ag nanobars in the presence of single-crystal seeds and a bromide compound, and their surface-enhanced Raman scattering (SERS) properties
    Qiang Zhang
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, United States
    Langmuir 28:9047-54. 2012
    ..The SERS enhancement factor of the Ag nanobar was found to depend on its aspect ratio, its orientation relative to the laser polarization, and the wavelength of excitation...
  52. doi request reprint Silver nanocrystals with concave surfaces and their optical and surface-enhanced Raman scattering properties
    Xiaohu Xia
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Angew Chem Int Ed Engl 50:12542-6. 2011
    ..Four types of concave nanocrystals, including octahedron, cube, octapod, and trisoctahedron, were obtained (see picture)...
  53. doi request reprint SV119-gold nanocage conjugates: a new platform for targeting cancer cells via sigma-2 receptors
    Yucai Wang
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Nanoscale 4:421-4. 2012
    ..We have functionalized the surface of gold nanocages with SV119, a synthetic small molecule specific to sigma-2 receptors, and then demonstrated the capability of this new class of conjugates for targeting cancer cells...
  54. doi request reprint On-chip screening of experimental conditions for the synthesis of noble-metal nanostructures with different morphologies
    Jianhua Zhou
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Small 7:3308-16. 2011
    ..In principle, this approach can be extended to other systems for rapid screening and optimization of experimental conditions involved in the syntheses of different types of nanostructures...
  55. doi request reprint Gold nanocages for cancer imaging and therapy
    Leslie Au
    Department of Biomedical Engineering, Washington University, St Louis, MO, USA
    Methods Mol Biol 624:83-99. 2010
    ..In this chapter, we focus on their use as a photothermal agent for the ablation of cancer cells and as a contrast agent for the in vivo noninvasive photoacoustic imaging of blood vessels and the sentinel lymph nodes in rats...
  56. doi request reprint Mechanistic study of the synthesis of Au nanotadpoles, nanokites, and microplates by reducing aqueous HAuCl4 with poly(vinyl pyrrolidone)
    Byungkwon Lim
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Langmuir 24:10437-42. 2008
    ..Through this morphological control, the localized surface plasmon resonance peaks of these Au nanostructures can be tuned in the visible and near-IR regions...
  57. pmc Three-dimensional scaffolds for tissue engineering: the importance of uniformity in pore size and structure
    Sung Wook Choi
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, United States
    Langmuir 26:19001-6. 2010
    ..Our results clearly indicate that inverse opal scaffolds could provide a better microenvironment for cells in comparison to a scaffold with nonuniform size and structure...
  58. pmc Gold nanocages covered with thermally-responsive polymers for controlled release by high-intensity focused ultrasound
    Weiyang Li
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nanoscale 3:1724-30. 2011
    ..Because it can penetrate more deeply into soft tissues than near-infrared light, HIFU is a potentially more effective external stimulus for rapid, on-demand drug release...
  59. pmc In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure
    Yu Wang
    Department of Biomedical Engineering, Washington University in St Louis, Campus Box 1097, One Brookings Drive, St Louis, Missouri 63130 4899, USA
    Opt Lett 36:1029-31. 2011
    ..In addition, the total concentration of hemoglobin is imaged by PAM at an isosbestic wavelength...
  60. doi request reprint Modifying the pores of an inverse opal scaffold with chitosan microstructures for truly three-dimensional cell culture
    Yu Zhang
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Macromol Rapid Commun 33:296-301. 2012
    ..The resultant inverse opal scaffold with hierarchically structured pores can enhance both cell proliferation and tissue infiltration...
  61. doi request reprint Controlling the size and morphology of Au@Pd core-shell nanocrystals by manipulating the kinetics of seeded growth
    Jing Li
    Department of Chemistry, Washington University, St Louis, MO 63130, USA
    Chemistry 18:8150-6. 2012
    ..In addition, the as-prepared Au@Pd nanocubes can be used as seeds to generate Au@Pd@Au and Au@Pd@Au@Pd nanocrystals with multishelled structures...
  62. pmc In vivo quantitative evaluation of the transport kinetics of gold nanocages in a lymphatic system by noninvasive photoacoustic tomography
    Xin Cai
    Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri 63130, United States
    ACS Nano 5:9658-67. 2011
    ..These results are critical to the further development of this AuNC-based PA tomography system for noninvasive SLN imaging, providing valuable information for metastatic cancer staging...
  63. ncbi request reprint Controlling the nucleation and growth of silver on palladium nanocubes by manipulating the reaction kinetics
    Jie Zeng
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130 USA
    Angew Chem Int Ed Engl 51:2354-8. 2012
    ....
  64. doi request reprint The role of surface nonuniformity in controlling the initiation of a galvanic replacement reaction
    Claire M Cobley
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Chem Asian J 6:1479-84. 2011
    ..Consequently, even if pitting occurred across a large percentage of the nanocrystal surface, it was still possible to maintain the morphology of the template throughout the reaction...
  65. doi request reprint Coating electrospun poly(epsilon-caprolactone) fibers with gelatin and calcium phosphate and their use as biomimetic scaffolds for bone tissue engineering
    Xiaoran Li
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Langmuir 24:14145-50. 2008
    ..These results indicated that the hybrid system containing poly(epsilon-caprolactone), gelatin, and calcium phosphate could serve as a new class of biomimetic scaffolds for bone tissue engineering...
  66. pmc Isolating and probing the hot spot formed between two silver nanocubes
    Pedro H C Camargo
    Department of Biomedical Engineering, Washington University, Saint Louis, Missouri 63130, USA
    Angew Chem Int Ed Engl 48:2180-4. 2009
    ..A new strategy based on plasma etching (see picture) can be used to isolate and exclusively probe the SERS-active molecules adsorbed in the hot-spot region between two silver nanocubes...
  67. doi request reprint Synthesis of anatase TiO2 nanocrystals with exposed {001} facets
    Yunqian Dai
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nano Lett 9:2455-9. 2009
    ..When acetic acid was replaced by inorganic acids, the TiO(2) nanocrystals further aggregated into larger structures with various morphologies...
  68. pmc A facile synthesis of asymmetric hybrid colloidal particles
    Akira Ohnuma
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    J Am Chem Soc 131:1352-3. 2009
    ..This method can be extended to metal nanoparticles other than Au and Ag and with a range of sizes, as long as they have appropriate stabilizers on the surface...
  69. ncbi request reprint Electrospun nanofibers for neural tissue engineering
    Jingwei Xie
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Nanoscale 2:35-44. 2010
    ....
  70. doi request reprint Metal nanocrystals with highly branched morphologies
    Byungkwon Lim
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Angew Chem Int Ed Engl 50:76-85. 2011
    ....
  71. pmc Inorganic nanoparticle-based contrast agents for molecular imaging
    Eun Chul Cho
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Trends Mol Med 16:561-73. 2010
    ..As research efforts intensify, contrast agents based on inorganic NPs that are highly sensitive, target-specific and safe to use are expected to enter clinical applications in the near future...
  72. ncbi request reprint Epitaxial overgrowth of platinum on palladium nanocrystals
    Majiong Jiang
    Department of Chemistry, Washington University, St Louis, Missouri 63130, USA
    Nanoscale 2:2406-11. 2010
    ..This work shows that both the binding affinity of a reducing agent to the Pt surface and the reduction kinetics for a Pt precursor play important roles in determining the mode of Pt overgrowth on Pd nanocrystal surface...
  73. pmc Synthesis of gold microplates using bovine serum albumin as a reductant and a stabilizer
    Leslie Au
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Chem Asian J 5:123-9. 2010
    ..We also found that the surfaces of the as-synthesized Au microplates were covered by a dense array of BSA bumps...
  74. pmc Targeting gold nanocages to cancer cells for photothermal destruction and drug delivery
    Claire M Cobley
    Washington University, Department of Biomedical Engineering, St Louis, MO 63130, USA
    Expert Opin Drug Deliv 7:577-87. 2010
    ..Combined with the targeting mechanisms possible with nanoscale materials, this technique has the potential to enable highly targeted therapies to minimize undesirable side effects...
  75. doi request reprint Facile synthesis of bimetallic Ag/Ni core/sheath nanowires and their magnetic and electrical properties
    Maureen McKiernan
    Department of Chemistry, Washington University, St Louis, MO 63130, USA
    Small 6:1927-34. 2010
    ..These Ag/Ni core/sheath nanowires show promise in areas such as electronics, spintronics, and displays...
  76. pmc Radially aligned, electrospun nanofibers as dural substitutes for wound closure and tissue regeneration applications
    Jingwei Xie
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    ACS Nano 4:5027-36. 2010
    ....
  77. doi request reprint Facile synthesis of gold icosahedra in an aqueous solution by reacting HAuCl(4) with N-vinyl pyrrolidone
    Mustafa S Yavuz
    Department of Biomedical Engineering, Washington University in St Louis, Saint Louis, Missouri 63130, USA
    Chemistry 15:13181-7. 2009
    ....
  78. pmc Etching and growth: an intertwined pathway to silver nanocrystals with exotic shapes
    Claire M Cobley
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Angew Chem Int Ed Engl 48:4824-7. 2009
    ..Three adjacent faces of the nanocube grew more rapidly than the three other faces, generating a non-centrosymmetric structure (see picture)...
  79. pmc The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages
    Jingwei Xie
    Department of Biomedical Engineering, Washington University in St Louis, Campus Box 1097, One Brookings Drive, St Louis, MO 63130, USA
    Biomaterials 30:354-62. 2009
    ..A combination of electrospun fiber scaffolds and ES cells-derived neural progenitor cells could lead to the development of a better strategy for nerve injury repair...
  80. ncbi request reprint Facile synthesis of bimetallic nanoplates consisting of Pd cores and Pt shells through seeded epitaxial growth
    Byungkwon Lim
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nano Lett 8:2535-40. 2008
    ..The close lattice match between Pd and Pt (lattice mismatch of only 0.77%) and the slow reduction rate associated with the mild reducing power of citric acid play key roles in achieving the epitaxial growth of Pt shells on Pd nanoplates...
  81. doi request reprint Functionalization of electrospun TiO2 nanofibers with Pt nanoparticles and nanowires for catalytic applications
    Eric Formo
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nano Lett 8:668-72. 2008
    ..It was found to show excellent catalytic activity for the hydrogenation of azo bonds in methyl red, which could be operated in a continuous mode by passing the dye solution through the membrane at a flow rate of 0.5 mL/s...
  82. doi request reprint Near-infrared gold nanocages as a new class of tracers for photoacoustic sentinel lymph node mapping on a rat model
    Kwang Hyun Song
    Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri 63130 4899, USA
    Nano Lett 9:183-8. 2009
    ....
  83. doi request reprint Soft lithography for micro- and nanoscale patterning
    Dong Qin
    Nano Research Facility and Department of Energy, Environmental, and Chemical Engineering, Washington University, St Louis, Missouri, USA
    Nat Protoc 5:491-502. 2010
    ....
  84. pmc Nanofiber scaffolds with gradations in mineral content for mimicking the tendon-to-bone insertion site
    Xiaoran Li
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nano Lett 9:2763-8. 2009
    ..This new class of nanofiber-based scaffolds can potentially be employed for repairing the tendon-to-bone insertion site via a tissue engineering approach...
  85. ncbi request reprint Maneuvering the surface plasmon resonance of silver nanostructures through shape-controlled synthesis
    Benjamin J Wiley
    Departments of Chemical Engineering and Chemistry, University of Washington, Seattle, Washington 98195, and Institute of Physics, Chinese Academy of Sciences, Beijing 100080, P R China
    J Phys Chem B 110:15666-75. 2006
    ..Control of nanostructure shape allows optimization of plasmon resonance for molecular detection and spectroscopy...
  86. ncbi request reprint Perylenediimide nanowires and their use in fabricating field-effect transistors and complementary inverters
    Alejandro L Briseno
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    Nano Lett 7:2847-53. 2007
    ..These results demonstrate the first example of the use of one-dimensional organic semiconductors in complementary inverters...
  87. doi request reprint A facile, water-based synthesis of highly branched nanostructures of silver
    Yilong Wang
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    Langmuir 24:12042-6. 2008
    ..With their potentially high surface areas, these branched structures could find use as catalysts or as substrates for surface-enhanced Raman scattering applications...
  88. ncbi request reprint Facile synthesis of tadpole-like nanostructures consisting of Au heads and Pd tails
    Pedro H C Camargo
    Department of Chemistry, University of Washington, Seattle, Washington 98195 1700, USA
    J Am Chem Soc 129:15452-3. 2007
  89. ncbi request reprint Size-dependence of surface plasmon resonance and oxidation for Pd nanocubes synthesized via a seed etching process
    Yujie Xiong
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    Nano Lett 5:1237-42. 2005
    ..While the nanocubes of 25 and 50 nm in size oxidized in air to form Pd@PdO core-shell structures, the 8-nm nanocubes were stable in air for over 90 days...
  90. ncbi request reprint Facile synthesis of Ag nanocubes and Au nanocages
    Sara E Skrabalak
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    Nat Protoc 2:2182-90. 2007
    ..The Ag nanocubes can then serve as sacrificial templates for the preparation of Au nanocages, with a method for their preparation also described herein. The procedure for Au nanocage preparation and isolation requires approximately 5 h...
  91. ncbi request reprint Understanding the role of oxidative etching in the polyol synthesis of Pd nanoparticles with uniform shape and size
    Yujie Xiong
    Department of Chemistry, University of Washington, Seattle, 98195 1700, USA
    J Am Chem Soc 127:7332-3. 2005
    ..If the etching was allowed to continue, the single-crystal cubooctahedra were also attacked and partially dissolved. Understanding the role of oxidative etching is critical to the achievement of both uniform shape and size...
  92. doi request reprint On the polyol synthesis of silver nanostructures: glycolaldehyde as a reducing agent
    Sara E Skrabalak
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    Nano Lett 8:2077-81. 2008
    ..For example, with the primary reductant identified, it becomes possible to evaluate and understand its explicit role in generating nanostructures of a specific shape to the exclusion of others...
  93. ncbi request reprint Gold and silver nanoparticles: a class of chromophores with colors tunable in the range from 400 to 750 nm
    Yugang Sun
    Department of Chemistry, University of Washington, Seattle, Washington 98195 1700, USA
    Analyst 128:686-91. 2003
    ..Gold nanoshells with hollow interiors were, in particular, shown to exhibit a much higher sensitivity to environmental changes than gold solid colloids with roughly the same size...
  94. ncbi request reprint Welding and patterning in a flash
    Dan Li
    Nat Mater 3:753-4. 2004
  95. ncbi request reprint Amorphous Se: a new platform for synthesizing superparamagnetic colloids with controllable surfaces
    Unyong Jeong
    Department of Chemistry, University of Washington, Seattle, Washington 98195 1700, USA
    J Am Chem Soc 127:1098-9. 2005
    ..The presence of Pt and SiO2 on the outer surfaces of these colloidal particles allows one to control their surface functionalities through the formation of alkanethiolate and siloxane monolayers, respectively...
  96. doi request reprint Electronic materials: buckling down for flexible electronics
    Xianmao Lu
    Nat Nanotechnol 1:163-4. 2006
  97. ncbi request reprint Shape-controlled synthesis of metal nanostructures: the case of silver
    Benjamin Wiley
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    Chemistry 11:454-63. 2005
    ..The ability to generate silver nanostructures with well-defined morphologies provides a great opportunity to experimentally and systematically study the relationship between their properties and geometric shapes...
  98. doi request reprint Optical near-field mapping of plasmonic nanoprisms
    Matthias Rang
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    Nano Lett 8:3357-63. 2008
    ....
  99. ncbi request reprint Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents
    Jingyi Chen
    Department of Chemistry, Department of Bioengineering, Department of Chemical Engineering, Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Nano Lett 5:473-7. 2005
    ..26 x 10(-15) m2, suggesting their potential use as a new class of contrast agents for optical imaging. When bioconjugated with antibodies, the gold nanocages have also been demonstrated for specific targeting of breast cancer cells...
  100. ncbi request reprint Monodispersed spherical colloids of Se@CdSe: synthesis and use as building blocks in fabricating photonic crystals
    Unyong Jeong
    Department of Chemistry, University of Washington, Seattle, Washington 98195 1700, USA
    Nano Lett 5:937-42. 2005
    ..Because of the uniformity in size and high refractive index associated with the Se@CdSe core-shell colloids, they could serve as a new class of building blocks to fabricate photonic crystals with wide and strong stop bands...
  101. ncbi request reprint Gold nanostructures: engineering their plasmonic properties for biomedical applications
    Min Hu
    Department of Chemistry, University of Washington, Seattle, WA 98195 1700, USA
    Chem Soc Rev 35:1084-94. 2006
    ..A combination of this optical tunability with the inertness of gold makes gold nanostructures well suited for various biomedical applications...

Research Grants2

  1. GOLD NANOCAGES AS A NEW CLASS OF THERAPEUTIC AGENTS FOR PHOTOTHERMAL CANCER TREAT
    Younan Xia; Fiscal Year: 2010
    ..To this end, gold nanocages have the potential to become a novel class of dual agents for both diagnostic and therapeutic applications. ..
  2. GOLD NANOCAGES AS A NEW CLASS OF THERAPEUTIC AGENTS FOR PHOTOTHERMAL CANCER TREAT
    Younan Xia; Fiscal Year: 2011
    ..To this end, gold nanocages have the potential to become a novel class of dual agents for both diagnostic and therapeutic applications. ..